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Tute Genomics

Tute Genomics was an American genomics startup that provided a cloud-based web application for rapid and accurate annotation of human genomic data. It was built on the expertise of ANNOVAR. Tute Genomics assisted researchers in identifying disease genes and biomarkers, and assisted clinicians/labs in performing genetic diagnosis. Based in Provo, Utah, Tute was co-founded by Dr. Kai Wang, an assistant professor at the University of Southern California (USC); and Dr. Reid J. Robison, a board-certified psychiatrist with fellowship training in both neurodevelopmental genetics and bioinformatics. Tute Genomics was acquired by PierianDX in 2016. == History == The word "tute" means "personal" in the Na’vi language created for the 2009 film Avatar by Paul Frommer, a linguist and communications professor at the USC Marshall School of Business. === Timeline === 2013 Tute Genomics launched in 2013 and entered the accelerator, BoomStartup. By "demo day" of BoomStartup, Tute had raised their seed round of funding and expanded the round to include angel investors from SLC Angels, Park City Angels, Life Science Angels. Tute was the tenth ever online syndicate for AngelList and in all raised a seed round of $1.5 million. 2014 In March 2014, the company announced that Affiliated Genetics, a Utah-based CLIA-certified laboratory, selected Tute Genomics for its next-generation sequencing (NGS) analytics pipeline. In May 2014, the company announced joining the Global Alliance for Genomics and Health. In June 2014, Advanced Biological Laboratories (ABL), S.A., announced a licensing and collaboration agreement with Tute Genomics and the commercial launch of OncoChek for managing and analysing genomics data in the field of oncology. In July 2014, the company announced an agreement with Lineagen, Inc., to provide next-generation sequencing analytics for Lineagen’s NextStepDx Plus assay. Also, Brigham Young University selected the Tute Genomics genome annotation and discovery platform for analysis and interpretation of 1,000 exomes and genomes. In November 2014, the company announced addition of the Tute platform to Illumina’s BaseSpace. The company announced a Series A1 funding round of $2.3 million in December 2014. The round was led by UK-based Eurovestech. Peak Ventures and a number of angel investors also participated in this round. 2015 Tute recruits David Mittelman, founder of Arpeggi, Inc. and former CSO at FamilyTreeDNA, to Tute Genomics as Chief Scientific Officer. Tute acquires Knome and integrates the KnoSys platform into its software product. 2016 Reid Robison, Tute CEO, launches a Kickstarter campaign to sell Tute interpreted whole genome and whole exome sequencing directly to consumers. The campaign was suspended within the same month after receiving a letter from the United States Food and Drug Administration. Tute is acquired by PierianDX.
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World Programming System

The World Programming System, also known as WPS Analytics or WPS, is a software product developed by a company called World Programming (acquired by Altair Engineering). WPS Analytics supports users of mixed ability to access and process data and to perform data science tasks. It has interactive visual programming tools using data workflows, and it has coding tools supporting the use of the SAS language mixed with Python, R and SQL. == About == WPS can use programs written in the language of SAS without the need for translating them into any other language. In this regard WPS is compatible with the SAS system. WPS has a built-in language interpreter able to process the language of SAS and produce similar results. WPS is available to run on z/OS, Windows, macOS, Linux (x86, Armv8 64-bit, IBM Power LE, IBM Z), and AIX. On all supported platforms, programs written in the language of SAS can be executed from a WPS command line interface, often referred to as running in batch mode. WPS can also be used from a graphical user interface known as the WPS Workbench for managing, editing and running programs written in the language of SAS. The WPS Workbench user interface is based on Eclipse. WPS version 4 (released in March 2018) introduced a drag-and-drop workflow canvas providing interactive blocks for data retrieval, blending and preparation, data discovery and profiling, predictive modelling powered by machine learning algorithms, model performance validation and scorecards. WPS version 3 (released in February 2012) provided a new client/server architecture that allows the WPS Workbench GUI to execute SAS programs on remote server installations of WPS in a network or cloud. The resulting output, data sets, logs, etc., can then all be viewed and manipulated from inside the Workbench as if the workloads had been executed locally. SAS programs do not require any special language statements to use this feature. == Summary of main features == Runs on Windows, macOS, z/OS, Linux (x86, Armv8 64-bit, IBM Power LE, IBM Z), and AIX An integrated development environment based on Eclipse for Linux, macOS and Windows. Support for language of SAS elements. Support for the language of SAS Macros. Matrix Programming support using PROC IML. Support for generating band plots, bar charts, box plots, bubble plots, contour plots, dendrogram plots, ellipse plots, fringe plots, heat maps, high-low plots, histograms, loess plots, needle plots, pie charts, penalised b-spline, radar charts, reference lines, scatter plots, series plots, step plots, regression plots and vector plots. Support for statistical procedures ACECLUS, ASSOCRULES, ANOVA, BIN, BOXPLOT, CANCORR, CANDISC, CLUSTER, CORRESP, DISCRIM, DISTANCE, FACTOR, FASTCLUS, FREQ, GAM, GANNO, GENMOD, GLIMMIX, GLM, GLMMOD, GLMSELECT, ICLIFETEST, KDE, LIFEREG, LIFETEST, LOESS, LOGISTIC, MDS, MEANS, MI, MIANALYSE, MIXED, MODECLUS, NESTED, NLIN, NPAR1WAY, PHREG, PLAN, PLS, POWER, PRINCOMP, PROBIT, QUANTREG, RBF, REG, ROBUSTREG, RSREG, SCORE, SEGMENT, SIMNORMAL, STANDARD, STDSIZE, STDRATE, STEPDISC, SUMMARY, SURVEYMEANS, SURVEYSELECT, TPSPLINE, TRANSREG, TREE, TTEST, UNIVARIATE, VARCLUS, VARCOMP Support for time series procedures ARIMA, AUTOREG, ESM, EXPAND, FORECAST, LOAN, SEVERITY, SPECTRA, TIMESERIES, X12 Support for machine learning procedures DECISIONFOREST, DECISIONTREE, GMM, MLP, OPTIMALBIN, SEGMENT, SVM Support for ODS. Reads and writes SAS datasets (compressed or uncompressed). Access: Actian Matrix (previously known as ParAccel), DASD, DB2, Excel, Greenplum, Hadoop, Informix, Kognitio Archived 2012-08-24 at the Wayback Machine, MariaDB, MySQL, Netezza, ODBC, OLEDB, Oracle, PostgreSQL, SAND, Snowflake, SPSS/PSPP, SQL Server, Sybase, Sybase IQ, Teradata, VSAM, Vertica and XML. Support for SAS Tape Format. Direct output of reports to CSV, PDF and HTML. Support to connect WPS systems programmatically, remote submit parts of a program to execute on connected remote servers, upload and download data between the connected systems. Support for Hadoop Support for R Support for Python == Industry recognition == Gartner recognized World Programming in their Cool Vendors in Data Science, 2014 Report. == Lawsuit == In 2010 World Programming defended its use of the language of SAS in the High Court of England and Wales in SAS Institute Inc. v World Programming Ltd. The software was the subject of a lawsuit by SAS Institute. The EU Court of Justice ruled in favor of World Programming, stating that the copyright protection does not extend to the software functionality, the programming language used and the format of the data files used by the program. It stated that there is no copyright infringement when a company which does not have access to the source code of a program studies, observes and tests that program to create another program with the same functionality.
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Winner-take-all (computing)

Winner-take-all is a computational principle applied in computational models of neural networks by which neurons compete with each other for activation. In the classical form, only the neuron with the highest activation stays active while all other neurons shut down; however, other variations allow more than one neuron to be active, for example the soft winner take-all, by which a power function is applied to the neurons. == Neural networks == In the theory of artificial neural networks, winner-take-all networks are a case of competitive learning in recurrent neural networks. Output nodes in the network mutually inhibit each other, while simultaneously activating themselves through reflexive connections. After some time, only one node in the output layer will be active, namely the one corresponding to the strongest input. Thus the network uses nonlinear inhibition to pick out the largest of a set of inputs. Winner-take-all is a general computational primitive that can be implemented using different types of neural network models, including both continuous-time and spiking networks. Winner-take-all networks are commonly used in computational models of the brain, particularly for distributed decision-making or action selection in the cortex. Important examples include hierarchical models of vision, and models of selective attention and recognition. They are also common in artificial neural networks and neuromorphic analog VLSI circuits. It has been formally proven that the winner-take-all operation is computationally powerful compared to other nonlinear operations, such as thresholding. In many practical cases, there is not only one single neuron which becomes active but there are exactly k neurons which become active for a fixed number k. This principle is referred to as k-winners-take-all. === Example algorithm === Consider a single linear neuron, with inputs x 1 , … , x n {\displaystyle x_{1},\dots ,x_{n}} . Each input has weight w i {\displaystyle w_{i}} , and the output of the neuron is ∑ i w i x i {\displaystyle \sum _{i}w_{i}x_{i}} . In the Instar learning rule, on each input vector, the weight vectors are modified according to Δ w i = η ( x i − w i ) {\displaystyle \Delta w_{i}=\eta (x_{i}-w_{i})} where η {\displaystyle \eta } is the learning rate. This rule is unsupervised, since we need just the input vector, not a reference output. Now, consider multiple linear neurons y 1 , … , y m {\displaystyle y_{1},\dots ,y_{m}} . The output of each satisfies y i = ∑ j w i j x j {\displaystyle y_{i}=\sum _{j}w_{ij}x_{j}} . In the winner-take-all algorithm, the weights are modified as follows. Given an input vector x {\displaystyle x} , each output is computed. The neuron with the largest output is selected, and the weights going into that neuron are modified according to the Instar learning rule. All other weights remain unchanged. The k-winners-take-all rule is similar, except that the Instar learning rule is applied to the weights going into the k neurons with the largest outputs. == Circuit example == A simple, but popular CMOS winner-take-all circuit is shown on the right. This circuit was originally proposed by Lazzaro et al. (1989) using MOS transistors biased to operate in the weak-inversion or subthreshold regime. In the particular case shown there are only two inputs (IIN,1 and IIN,2), but the circuit can be easily extended to multiple inputs in a straightforward way. It operates on continuous-time input signals (currents) in parallel, using only two transistors per input. In addition, the bias current IBIAS is set by a single global transistor that is common to all the inputs. The largest of the input currents sets the common potential VC. As a result, the corresponding output carries almost all the bias current, while the other outputs have currents that are close to zero. Thus, the circuit selects the larger of the two input currents, i.e., if IIN,1 > IIN,2, we get IOUT,1 = IBIAS and IOUT,2 = 0. Similarly, if IIN,2 > IIN,1, we get IOUT,1 = 0 and IOUT,2 = IBIAS. A SPICE-based DC simulation of the CMOS winner-take-all circuit in the two-input case is shown on the right. As shown in the top subplot, the input IIN,1 was fixed at 6nA, while IIN,2 was linearly increased from 0 to 10nA. The bottom subplot shows the two output currents. As expected, the output corresponding to the larger of the two inputs carries the entire bias current (10nA in this case), forcing the other output current nearly to zero. == Other uses == In stereo matching algorithms, following the taxonomy proposed by Scharstein and Szelliski, winner-take-all is a local method for disparity computation. Adopting a winner-take-all strategy, the disparity associated with the minimum or maximum cost value is selected at each pixel. It is axiomatic that in the electronic commerce market, early dominant players such as AOL or Yahoo! get most of the rewards. By 1998, one study found the top 5% of all web sites garnered more than 74% of all traffic. The winner-take-all hypothesis in economics suggests that once a technology or a firm gets ahead, it will do better and better over time, whereas lagging technology and firms will fall further behind. See First-mover advantage.
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BrownBoost

BrownBoost is a boosting algorithm that may be robust to noisy datasets. BrownBoost is an adaptive version of the boost by majority algorithm. As is the case for all boosting algorithms, BrownBoost is used in conjunction with other machine learning methods. BrownBoost was introduced by Yoav Freund in 2001. == Motivation == AdaBoost performs well on a variety of datasets; however, it can be shown that AdaBoost does not perform well on noisy data sets. This is a result of AdaBoost's focus on examples that are repeatedly misclassified. In contrast, BrownBoost effectively "gives up" on examples that are repeatedly misclassified. The core assumption of BrownBoost is that noisy examples will be repeatedly mislabeled by the weak hypotheses and non-noisy examples will be correctly labeled frequently enough to not be "given up on." Thus only noisy examples will be "given up on," whereas non-noisy examples will contribute to the final classifier. In turn, if the final classifier is learned from the non-noisy examples, the generalization error of the final classifier may be much better than if learned from noisy and non-noisy examples. The user of the algorithm can set the amount of error to be tolerated in the training set. Thus, if the training set is noisy (say 10% of all examples are assumed to be mislabeled), the booster can be told to accept a 10% error rate. Since the noisy examples may be ignored, only the true examples will contribute to the learning process. == Algorithm description == BrownBoost uses a non-convex potential loss function, thus it does not fit into the AdaBoost framework. The non-convex optimization provides a method to avoid overfitting noisy data sets. However, in contrast to boosting algorithms that analytically minimize a convex loss function (e.g. AdaBoost and LogitBoost), BrownBoost solves a system of two equations and two unknowns using standard numerical methods. The only parameter of BrownBoost ( c {\displaystyle c} in the algorithm) is the "time" the algorithm runs. The theory of BrownBoost states that each hypothesis takes a variable amount of time ( t {\displaystyle t} in the algorithm) which is directly related to the weight given to the hypothesis α {\displaystyle \alpha } . The time parameter in BrownBoost is analogous to the number of iterations T {\displaystyle T} in AdaBoost. A larger value of c {\displaystyle c} means that BrownBoost will treat the data as if it were less noisy and therefore will give up on fewer examples. Conversely, a smaller value of c {\displaystyle c} means that BrownBoost will treat the data as more noisy and give up on more examples. During each iteration of the algorithm, a hypothesis is selected with some advantage over random guessing. The weight of this hypothesis α {\displaystyle \alpha } and the "amount of time passed" t {\displaystyle t} during the iteration are simultaneously solved in a system of two non-linear equations ( 1. uncorrelated hypothesis w.r.t example weights and 2. hold the potential constant) with two unknowns (weight of hypothesis α {\displaystyle \alpha } and time passed t {\displaystyle t} ). This can be solved by bisection (as implemented in the JBoost software package) or Newton's method (as described in the original paper by Freund). Once these equations are solved, the margins of each example ( r i ( x j ) {\displaystyle r_{i}(x_{j})} in the algorithm) and the amount of time remaining s {\displaystyle s} are updated appropriately. This process is repeated until there is no time remaining. The initial potential is defined to be 1 m ∑ j = 1 m 1 − erf ( c ) = 1 − erf ( c ) {\displaystyle {\frac {1}{m}}\sum _{j=1}^{m}1-{\mbox{erf}}({\sqrt {c}})=1-{\mbox{erf}}({\sqrt {c}})} . Since a constraint of each iteration is that the potential be held constant, the final potential is 1 m ∑ j = 1 m 1 − erf ( r i ( x j ) / c ) = 1 − erf ( c ) {\displaystyle {\frac {1}{m}}\sum _{j=1}^{m}1-{\mbox{erf}}(r_{i}(x_{j})/{\sqrt {c}})=1-{\mbox{erf}}({\sqrt {c}})} . Thus the final error is likely to be near 1 − erf ( c ) {\displaystyle 1-{\mbox{erf}}({\sqrt {c}})} . However, the final potential function is not the 0–1 loss error function. For the final error to be exactly 1 − erf ( c ) {\displaystyle 1-{\mbox{erf}}({\sqrt {c}})} , the variance of the loss function must decrease linearly w.r.t. time to form the 0–1 loss function at the end of boosting iterations. This is not yet discussed in the literature and is not in the definition of the algorithm below. The final classifier is a linear combination of weak hypotheses and is evaluated in the same manner as most other boosting algorithms. == BrownBoost learning algorithm definition == Input: m {\displaystyle m} training examples ( x 1 , y 1 ) , … , ( x m , y m ) {\displaystyle (x_{1},y_{1}),\ldots ,(x_{m},y_{m})} where x j ∈ X , y j ∈ Y = { − 1 , + 1 } {\displaystyle x_{j}\in X,\,y_{j}\in Y=\{-1,+1\}} The parameter c {\displaystyle c} Initialise: s = c {\displaystyle s=c} . (The value of s {\displaystyle s} is the amount of time remaining in the game) r i ( x j ) = 0 {\displaystyle r_{i}(x_{j})=0} ∀ j {\displaystyle \forall j} . The value of r i ( x j ) {\displaystyle r_{i}(x_{j})} is the margin at iteration i {\displaystyle i} for example x j {\displaystyle x_{j}} . While s > 0 {\displaystyle s>0} : Set the weights of each example: W i ( x j ) = e − ( r i ( x j ) + s ) 2 c {\displaystyle W_{i}(x_{j})=e^{-{\frac {(r_{i}(x_{j})+s)^{2}}{c}}}} , where r i ( x j ) {\displaystyle r_{i}(x_{j})} is the margin of example x j {\displaystyle x_{j}} Find a classifier h i : X → { − 1 , + 1 } {\displaystyle h_{i}:X\to \{-1,+1\}} such that ∑ j W i ( x j ) h i ( x j ) y j > 0 {\displaystyle \sum _{j}W_{i}(x_{j})h_{i}(x_{j})y_{j}>0} Find values α , t {\displaystyle \alpha ,t} that satisfy the equation: ∑ j h i ( x j ) y j e − ( r i ( x j ) + α h i ( x j ) y j + s − t ) 2 c = 0 {\displaystyle \sum _{j}h_{i}(x_{j})y_{j}e^{-{\frac {(r_{i}(x_{j})+\alpha h_{i}(x_{j})y_{j}+s-t)^{2}}{c}}}=0} . (Note this is similar to the condition E W i + 1 [ h i ( x j ) y j ] = 0 {\displaystyle E_{W_{i+1}}[h_{i}(x_{j})y_{j}]=0} set forth by Schapire and Singer. In this setting, we are numerically finding the W i + 1 = exp ⁡ ( ⋯ ⋯ ) {\displaystyle W_{i+1}=\exp \left({\frac {\cdots }{\cdots }}\right)} such that E W i + 1 [ h i ( x j ) y j ] = 0 {\displaystyle E_{W_{i+1}}[h_{i}(x_{j})y_{j}]=0} .) This update is subject to the constraint ∑ ( Φ ( r i ( x j ) + α h ( x j ) y j + s − t ) − Φ ( r i ( x j ) + s ) ) = 0 {\displaystyle \sum \left(\Phi \left(r_{i}(x_{j})+\alpha h(x_{j})y_{j}+s-t\right)-\Phi \left(r_{i}(x_{j})+s\right)\right)=0} , where Φ ( z ) = 1 − erf ( z / c ) {\displaystyle \Phi (z)=1-{\mbox{erf}}(z/{\sqrt {c}})} is the potential loss for a point with margin r i ( x j ) {\displaystyle r_{i}(x_{j})} Update the margins for each example: r i + 1 ( x j ) = r i ( x j ) + α h ( x j ) y j {\displaystyle r_{i+1}(x_{j})=r_{i}(x_{j})+\alpha h(x_{j})y_{j}} Update the time remaining: s = s − t {\displaystyle s=s-t} Output: H ( x ) = sign ( ∑ i α i h i ( x ) ) {\displaystyle H(x)={\textrm {sign}}\left(\sum _{i}\alpha _{i}h_{i}(x)\right)} == Empirical results == In preliminary experimental results with noisy datasets, BrownBoost outperformed AdaBoost's generalization error; however, LogitBoost performed as well as BrownBoost. An implementation of BrownBoost can be found in the open source software JBoost.
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1.58-bit large language model

A 1.58-bit large language model (also known as a ternary LLM) is a type of large language model (LLM) designed to be computationally efficient. It achieves this by using weights that are restricted to only three values: -1, 0, and +1. This restriction significantly reduces the model's memory footprint and allows for faster processing, as computationally expensive multiplication operations can be replaced with lower-cost additions. This contrasts with traditional models that use 16-bit floating-point numbers (FP16 or BF16) for their weights. Studies have shown that for models up to several billion parameters, the performance of 1.58-bit LLMs on various tasks is comparable to their full-precision counterparts. This approach could enable powerful AI to run on less specialized and lower-power hardware. The name "1.58-bit" comes from the fact that a system with three states contains log 2 ⁡ 3 ≈ 1.58 {\displaystyle \log _{2}3\approx 1.58} bits of information. These models are sometimes also referred to as 1-bit LLMs in research papers, although this term can also refer to true binary models (with weights of -1 and +1). == BitNet == In 2024, Ma et al., researchers at Microsoft, declared that their 1.58-bit model, BitNet b1.58 is comparable in performance to the 16-bit Llama 2 and opens the era of 1-bit LLM. BitNet creators did not use the post-training quantization of weights but instead relied on the new BitLinear transform that replaced the nn.Linear layer of the traditional transformer design. In 2025, Microsoft researchers had released an open-weights and open inference code model BitNet b1.58 2B4T demonstrating performance competitive with the full precision models at 2B parameters and 4T training tokens. == Post-training quantization == BitNet derives its performance from being trained natively in 1.58 bit instead of being quantized from a full-precision model after training. Still, training is an expensive process and it would be desirable to be able to somehow convert an existing model to 1.58 bits. In 2024, HuggingFace reported a way to gradually ramp up the 1.58-bit quantization in fine-tuning an existing model down to 1.58 bits. == Critique == Some researchers point out that the scaling laws of large language models favor the low-bit weights only in case of undertrained models. As the number of training tokens increases, the deficiencies of low-bit quantization surface.
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FERET (facial recognition technology)

The Facial Recognition Technology (FERET) program was a government-sponsored project that aimed to create a large, automatic face-recognition system for intelligence, security, and law enforcement purposes. The program began in 1993 under the combined leadership of Dr. Harry Wechsler at George Mason University (GMU) and Dr. Jonathon Phillips at the Army Research Laboratory (ARL) in Adelphi, Maryland and resulted in the development of the Facial Recognition Technology (FERET) database. The goal of the FERET program was to advance the field of face recognition technology by establishing a common database of facial imagery for researchers to use and setting a performance baseline for face-recognition algorithms. Potential areas where this face-recognition technology could be used include: Automated searching of mug books using surveillance photos Controlling access to restricted facilities or equipment Checking the credentials of personnel for background and security clearances Monitoring airports, border crossings, and secure manufacturing facilities for particular individuals Finding and logging multiple appearances of individuals over time in surveillance videos Verifying identities at ATM machines Searching photo ID records for fraud detection The FERET database has been used by more than 460 research groups and is currently managed by the National Institute of Standards and Technology (NIST). By 2017, the FERET database has been used to train artificial intelligence programs and computer vision algorithms to identify and sort faces. == History == The origin of facial recognition technology is largely attributed to Woodrow Wilson Bledsoe and his work in the 1960s, when he developed a system to identify faces from a database of thousands of photographs. The FERET program first began as a way to unify a large body of face-recognition technology research under a standard database. Before the program's inception, most researchers created their own facial imagery database that was attuned to their own specific area of study. These personal databases were small and usually consisted of images from less than 50 individuals. The only notable exceptions were the following: Alex Pentland’s database of around 7500 facial images at the Massachusetts Institute of Technology (MIT) Joseph Wilder's database of around 250 individuals at Rutgers University Christoph von der Malsburg’s database of around 100 facial images at the University of Southern California (USC) The lack of a common database made it difficult to compare the results of face recognition studies in the scientific literature because each report involved different assumptions, scoring methods, and images. Most of the papers that were published did not use images from a common database nor follow a standard testing protocol. As a result, researchers were unable to make informed comparisons between the performances of different face-recognition algorithms. In September 1993, the FERET program was spearheaded by Dr. Harry Wechsler and Dr. Jonathon Phillips under the sponsorship of the U.S. Department of Defense Counterdrug Technology Development Program through DARPA with ARL serving as technical agent. === Phase I === The first facial images for the FERET database were collected from August 1993 to December 1994, a time period known as Phase I. The pictures were initially taken with a 35-mm camera at both GMU and ARL facilities, and the same physical setup was used in each photography session to keep the images consistent. For each individual, the pictures were taken in sets, including two frontal views, a right and left profile, a right and left quarter profile, a right and left half profile, and sometimes at five extra locations. Therefore, a set of images consisted of 5 to 11 images per person. At the end of Phase I, the FERET database had collected 673 sets of images, resulting in over 5000 total images. At the end of Phase I, five organizations were given the opportunity to test their face-recognition algorithm on the newly created FERET database in order to compare how they performed against each other. There five principal investigators were: MIT, led by Alex Pentland Rutgers University, led by Joseph Wilder The Analytic Science Company (TASC), led by Gale Gordon The University of Illinois at Chicago (UIC) and the University of Illinois at Urbana-Champaign, led by Lewis Sadler and Thomas Huang USC, led by Christoph von der Malsburg During this evaluation, three different automatic tests were given to the principal investigators without human intervention: The large gallery test, which served to baseline how algorithms performed against a database when it has not been properly tuned. The false-alarm test, which tested how well the algorithm monitored an airport for suspected terrorists. The rotation test, which measured how well the algorithm performed when the images of an individual in the gallery had different poses compared to those in the probe set. For most of the test trials, the algorithms developed by USC and MIT managed to outperform the other three algorithms for the Phase I evaluation. === Phase II === Phase II began after Phase I, and during this time, the FERET database acquired more sets of facial images. By the start of the Phase II evaluation in March 1995, the database contained 1109 sets of images for a total of 8525 images of 884 individuals. During the second evaluation, the same algorithms from the Phase I evaluation were given a single test. However, the database now contained significantly more duplicate images (463, compared to the previous 60), making the test more challenging. === Phase III === Afterwards, the FERET program entered Phase III where another 456 sets of facial images were added to the database. The Phase III evaluation, which took place in September 1996, aimed to not only gauge the progress of the algorithms since the Phase I assessment but also identify the strengths and weaknesses of each algorithm and determine future objectives for research. By the end of 1996, the FERET database had accumulated a total of 14,126 facial images pertaining to 1199 different individuals as well as 365 duplicate sets of images. As a result of the FERET program, researchers were able to establish a common baseline for comparing different face-recognition algorithms and create a large standard database of facial images that is open for research. In 2003, DARPA released a high-resolution, 24-bit color version of the images in the FERET database (existing reference).
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Multiple kernel learning

Multiple kernel learning refers to a set of machine learning methods that use a predefined set of kernels and learn an optimal linear or non-linear combination of kernels as part of the algorithm. Reasons to use multiple kernel learning include a) the ability to select for an optimal kernel and parameters from a larger set of kernels, reducing bias due to kernel selection while allowing for more automated machine learning methods, and b) combining data from different sources (e.g. sound and images from a video) that have different notions of similarity and thus require different kernels. Instead of creating a new kernel, multiple kernel algorithms can be used to combine kernels already established for each individual data source. Multiple kernel learning approaches have been used in many applications, such as event recognition in video, object recognition in images, and biomedical data fusion. == Algorithms == Multiple kernel learning algorithms have been developed for supervised, semi-supervised, as well as unsupervised learning. Most work has been done on the supervised learning case with linear combinations of kernels, however, many algorithms have been developed. The basic idea behind multiple kernel learning algorithms is to add an extra parameter to the minimization problem of the learning algorithm. As an example, consider the case of supervised learning of a linear combination of a set of n {\displaystyle n} kernels K {\displaystyle K} . We introduce a new kernel K ′ = ∑ i = 1 n β i K i {\displaystyle K'=\sum _{i=1}^{n}\beta _{i}K_{i}} , where β {\displaystyle \beta } is a vector of coefficients for each kernel. Because the kernels are additive (due to properties of reproducing kernel Hilbert spaces), this new function is still a kernel. For a set of data X {\displaystyle X} with labels Y {\displaystyle Y} , the minimization problem can then be written as min β , c E ( Y , K ′ c ) + R ( K , c ) {\displaystyle \min _{\beta ,c}\mathrm {E} (Y,K'c)+R(K,c)} where E {\displaystyle \mathrm {E} } is an error function and R {\displaystyle R} is a regularization term. E {\displaystyle \mathrm {E} } is typically the square loss function (Tikhonov regularization) or the hinge loss function (for SVM algorithms), and R {\displaystyle R} is usually an ℓ n {\displaystyle \ell _{n}} norm or some combination of the norms (i.e. elastic net regularization). This optimization problem can then be solved by standard optimization methods. Adaptations of existing techniques such as the Sequential Minimal Optimization have also been developed for multiple kernel SVM-based methods. === Supervised learning === For supervised learning, there are many other algorithms that use different methods to learn the form of the kernel. The following categorization has been proposed by Gonen and Alpaydın (2011) ==== Fixed rules approaches ==== Fixed rules approaches such as the linear combination algorithm described above use rules to set the combination of the kernels. These do not require parameterization and use rules like summation and multiplication to combine the kernels. The weighting is learned in the algorithm. Other examples of fixed rules include pairwise kernels, which are of the form k ( ( x 1 i , x 1 j ) , ( x 2 i , x 2 j ) ) = k ( x 1 i , x 2 i ) k ( x 1 j , x 2 j ) + k ( x 1 i , x 2 j ) k ( x 1 j , x 2 i ) {\displaystyle k((x_{1i},x_{1j}),(x_{2i},x_{2j}))=k(x_{1i},x_{2i})k(x_{1j},x_{2j})+k(x_{1i},x_{2j})k(x_{1j},x_{2i})} . These pairwise approaches have been used in predicting protein-protein interactions. ==== Heuristic approaches ==== These algorithms use a combination function that is parameterized. The parameters are generally defined for each individual kernel based on single-kernel performance or some computation from the kernel matrix. Examples of these include the kernel from Tenabe et al. (2008). Letting π m {\displaystyle \pi _{m}} be the accuracy obtained using only K m {\displaystyle K_{m}} , and letting δ {\displaystyle \delta } be a threshold less than the minimum of the single-kernel accuracies, we can define β m = π m − δ ∑ h = 1 n ( π h − δ ) {\displaystyle \beta _{m}={\frac {\pi _{m}-\delta }{\sum _{h=1}^{n}(\pi _{h}-\delta )}}} Other approaches use a definition of kernel similarity, such as A ( K 1 , K 2 ) = ⟨ K 1 , K 2 ⟩ ⟨ K 1 , K 1 ⟩ ⟨ K 2 , K 2 ⟩ {\displaystyle A(K_{1},K_{2})={\frac {\langle K_{1},K_{2}\rangle }{\sqrt {\langle K_{1},K_{1}\rangle \langle K_{2},K_{2}\rangle }}}} Using this measure, Qui and Lane (2009) used the following heuristic to define β m = A ( K m , Y Y T ) ∑ h = 1 n A ( K h , Y Y T ) {\displaystyle \beta _{m}={\frac {A(K_{m},YY^{T})}{\sum _{h=1}^{n}A(K_{h},YY^{T})}}} ==== Optimization approaches ==== These approaches solve an optimization problem to determine parameters for the kernel combination function. This has been done with similarity measures and structural risk minimization approaches. For similarity measures such as the one defined above, the problem can be formulated as follows: max β , tr ⁡ ( K t r a ′ ) = 1 , K ′ ≥ 0 A ( K t r a ′ , Y Y T ) . {\displaystyle \max _{\beta ,\operatorname {tr} (K'_{tra})=1,K'\geq 0}A(K'_{tra},YY^{T}).} where K t r a ′ {\displaystyle K'_{tra}} is the kernel of the training set. Structural risk minimization approaches that have been used include linear approaches, such as that used by Lanckriet et al. (2002). We can define the implausibility of a kernel ω ( K ) {\displaystyle \omega (K)} to be the value of the objective function after solving a canonical SVM problem. We can then solve the following minimization problem: min tr ⁡ ( K t r a ′ ) = c ω ( K t r a ′ ) {\displaystyle \min _{\operatorname {tr} (K'_{tra})=c}\omega (K'_{tra})} where c {\displaystyle c} is a positive constant. Many other variations exist on the same idea, with different methods of refining and solving the problem, e.g. with nonnegative weights for individual kernels and using non-linear combinations of kernels. ==== Bayesian approaches ==== Bayesian approaches put priors on the kernel parameters and learn the parameter values from the priors and the base algorithm. For example, the decision function can be written as f ( x ) = ∑ i = 0 n α i ∑ m = 1 p η m K m ( x i m , x m ) {\displaystyle f(x)=\sum _{i=0}^{n}\alpha _{i}\sum _{m=1}^{p}\eta _{m}K_{m}(x_{i}^{m},x^{m})} η {\displaystyle \eta } can be modeled with a Dirichlet prior and α {\displaystyle \alpha } can be modeled with a zero-mean Gaussian and an inverse gamma variance prior. This model is then optimized using a customized multinomial probit approach with a Gibbs sampler. These methods have been used successfully in applications such as protein fold recognition and protein homology problems ==== Boosting approaches ==== Boosting approaches add new kernels iteratively until some stopping criteria that is a function of performance is reached. An example of this is the MARK model developed by Bennett et al. (2002) f ( x ) = ∑ i = 1 N ∑ m = 1 P α i m K m ( x i m , x m ) + b {\displaystyle f(x)=\sum _{i=1}^{N}\sum _{m=1}^{P}\alpha _{i}^{m}K_{m}(x_{i}^{m},x^{m})+b} The parameters α i m {\displaystyle \alpha _{i}^{m}} and b {\displaystyle b} are learned by gradient descent on a coordinate basis. In this way, each iteration of the descent algorithm identifies the best kernel column to choose at each particular iteration and adds that to the combined kernel. The model is then rerun to generate the optimal weights α i {\displaystyle \alpha _{i}} and b {\displaystyle b} . === Semisupervised learning === Semisupervised learning approaches to multiple kernel learning are similar to other extensions of supervised learning approaches. An inductive procedure has been developed that uses a log-likelihood empirical loss and group LASSO regularization with conditional expectation consensus on unlabeled data for image categorization. We can define the problem as follows. Let L = ( x i , y i ) {\displaystyle L={(x_{i},y_{i})}} be the labeled data, and let U = x i {\displaystyle U={x_{i}}} be the set of unlabeled data. Then, we can write the decision function as follows. f ( x ) = α 0 + ∑ i = 1 | L | α i K i ( x ) {\displaystyle f(x)=\alpha _{0}+\sum _{i=1}^{|L|}\alpha _{i}K_{i}(x)} The problem can be written as min f L ( f ) + λ R ( f ) + γ Θ ( f ) {\displaystyle \min _{f}L(f)+\lambda R(f)+\gamma \Theta (f)} where L {\displaystyle L} is the loss function (weighted negative log-likelihood in this case), R {\displaystyle R} is the regularization parameter (Group LASSO in this case), and Θ {\displaystyle \Theta } is the conditional expectation consensus (CEC) penalty on unlabeled data. The CEC penalty is defined as follows. Let the marginal kernel density for all the data be g m π ( x ) = ⟨ ϕ m π , ψ m ( x ) ⟩ {\displaystyle g_{m}^{\pi }(x)=\langle \phi _{m}^{\pi },\psi _{m}(x)\rangle } where ψ m ( x ) = [ K m ( x 1 , x ) , … , K m ( x L , x ) ] T {\displaystyle \psi _{m}(x)=[K_{m}(x_{1},x),\ldots ,K_{m}(x_{L},x)]^{T}} (the kernel distance between the labe
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Low-rank approximation

In mathematics, low-rank approximation refers to the process of approximating a given matrix by a matrix of lower rank. More precisely, it is a minimization problem, in which the cost function measures the fit between a given matrix (the data) and an approximating matrix (the optimization variable), subject to a constraint that the approximating matrix has reduced rank. The problem is used for mathematical modeling and data compression. The rank constraint is related to a constraint on the complexity of a model that fits the data. In applications, often there are other constraints on the approximating matrix apart from the rank constraint, e.g., non-negativity and Hankel structure. Low-rank approximation is closely related to numerous other techniques, including principal component analysis, factor analysis, total least squares, latent semantic analysis, orthogonal regression, and dynamic mode decomposition. == Definition == Given structure specification S : R n p → R m × n {\displaystyle {\mathcal {S}}:\mathbb {R} ^{n_{p}}\to \mathbb {R} ^{m\times n}} , vector of structure parameters p ∈ R n p {\displaystyle p\in \mathbb {R} ^{n_{p}}} , norm ‖ ⋅ ‖ {\displaystyle \|\cdot \|} , and desired rank r {\displaystyle r} , minimize over p ^ ‖ p − p ^ ‖ subject to rank ⁡ ( S ( p ^ ) ) ≤ r . {\displaystyle {\text{minimize}}\quad {\text{over }}{\widehat {p}}\quad \|p-{\widehat {p}}\|\quad {\text{subject to}}\quad \operatorname {rank} {\big (}{\mathcal {S}}({\widehat {p}}){\big )}\leq r.} == Applications == Linear system identification, in which case the approximating matrix is Hankel structured. Machine learning, in which case the approximating matrix is nonlinearly structured. Recommender systems, in which cases the data matrix has missing values and the approximation is categorical. Distance matrix completion, in which case there is a positive definiteness constraint. Natural language processing, in which case the approximation is nonnegative. Computer algebra, in which case the approximation is Sylvester structured. Matrix product states, in which case the approximation is usually rescaled to have fixed Frobenius norm. == Basic low-rank approximation problem == The unstructured problem with fit measured by the Frobenius norm, i.e., minimize over D ^ ‖ D − D ^ ‖ F subject to rank ⁡ ( D ^ ) ≤ r {\displaystyle {\text{minimize}}\quad {\text{over }}{\widehat {D}}\quad \|D-{\widehat {D}}\|_{\text{F}}\quad {\text{subject to}}\quad \operatorname {rank} {\big (}{\widehat {D}}{\big )}\leq r} has an analytic solution in terms of the singular value decomposition of the data matrix. The result is referred to as the matrix approximation lemma or Eckart–Young–Mirsky theorem. This problem was originally solved by Erhard Schmidt in the infinite dimensional context of integral operators (although his methods easily generalize to arbitrary compact operators on Hilbert spaces) and later rediscovered by C. Eckart and G. Young. L. Mirsky generalized the result to arbitrary unitarily invariant norms. Let D = U Σ V ⊤ ∈ R m × n , m ≥ n {\displaystyle D=U\Sigma V^{\top }\in \mathbb {R} ^{m\times n},\quad m\geq n} be the singular value decomposition of D {\displaystyle D} , where Σ =: diag ⁡ ( σ 1 , … , σ r ) {\displaystyle \Sigma =:\operatorname {diag} (\sigma _{1},\ldots ,\sigma _{r})} , where r ≤ min { m , n } = n {\displaystyle r\leq \min\{m,n\}=n} , is the m × n {\displaystyle m\times n} rectangular diagonal matrix with r {\displaystyle r} non-zero singular values σ 1 ≥ … ≥ σ r > σ r + 1 = … = σ n = 0 {\displaystyle \sigma _{1}\geq \ldots \geq \sigma _{r}>\sigma _{r+1}=\ldots =\sigma _{n}=0} . For a given k ∈ { 1 , … , r } {\displaystyle k\in \{1,\dots ,r\}} , partition U {\displaystyle U} , Σ {\displaystyle \Sigma } , and V {\displaystyle V} as follows: U =: [ U 1 U 2 ] , Σ =: [ Σ 1 0 0 Σ 2 ] , and V =: [ V 1 V 2 ] , {\displaystyle U=:{\begin{bmatrix}U_{1}&U_{2}\end{bmatrix}},\quad \Sigma =:{\begin{bmatrix}\Sigma _{1}&0\\0&\Sigma _{2}\end{bmatrix}},\quad {\text{and}}\quad V=:{\begin{bmatrix}V_{1}&V_{2}\end{bmatrix}},} where U 1 {\displaystyle U_{1}} is m × k {\displaystyle m\times k} , Σ 1 {\displaystyle \Sigma _{1}} is k × k {\displaystyle k\times k} , and V 1 {\displaystyle V_{1}} is n × k {\displaystyle n\times k} . Then the rank k {\displaystyle k} matrix D ^ ∗ := U 1 Σ 1 V 1 ⊤ , {\displaystyle {\widehat {D}}^{}:=U_{1}\Sigma _{1}V_{1}^{\top },} obtained from the truncated singular value decomposition is such that ‖ D − D ^ ∗ ‖ F = min rank ⁡ ( D ^ ) ≤ k ‖ D − D ^ ‖ F = σ k + 1 2 + ⋯ + σ r 2 . {\displaystyle \|D-{\widehat {D}}^{}\|_{\text{F}}=\min _{\operatorname {rank} ({\widehat {D}})\leq k}\|D-{\widehat {D}}\|_{\text{F}}={\sqrt {\sigma _{k+1}^{2}+\cdots +\sigma _{r}^{2}}}.} The minimizer D ^ ∗ {\displaystyle {\widehat {D}}^{}} is unique if and only if σ k > σ k + 1 {\displaystyle \sigma _{k}>\sigma _{k+1}} . == Proof of Eckart–Young–Mirsky theorem (for spectral norm) == Let A ∈ R m × n {\displaystyle A\in \mathbb {R} ^{m\times n}} be a real (possibly rectangular) matrix with m ≤ n {\displaystyle m\leq n} . Suppose that A = U Σ V ⊤ {\displaystyle A=U\Sigma V^{\top }} is the singular value decomposition of A {\displaystyle A} . Recall that U {\displaystyle U} and V {\displaystyle V} are orthogonal matrices, and Σ {\displaystyle \Sigma } is an m × n {\displaystyle m\times n} diagonal matrix with entries ( σ 1 , σ 2 , ⋯ , σ m ) {\displaystyle (\sigma _{1},\sigma _{2},\cdots ,\sigma _{m})} such that σ 1 ≥ σ 2 ≥ ⋯ ≥ σ m ≥ 0 {\displaystyle \sigma _{1}\geq \sigma _{2}\geq \cdots \geq \sigma _{m}\geq 0} . We claim that the best rank- k {\displaystyle k} approximation to A {\displaystyle A} in the spectral norm, denoted by ‖ ⋅ ‖ 2 {\displaystyle \|\cdot \|_{2}} , is given by A k := ∑ i = 1 k σ i u i v i ⊤ {\displaystyle A_{k}:=\sum _{i=1}^{k}\sigma _{i}u_{i}v_{i}^{\top }} where u i {\displaystyle u_{i}} and v i {\displaystyle v_{i}} denote the i {\displaystyle i} th column of U {\displaystyle U} and V {\displaystyle V} , respectively. First, note that we have ‖ A − A k ‖ 2 = ‖ ∑ i = 1 n σ i u i v i ⊤ − ∑ i = 1 k σ i u i v i ⊤ ‖ 2 = ‖ ∑ i = k + 1 n σ i u i v i ⊤ ‖ 2 = σ k + 1 {\displaystyle \|A-A_{k}\|_{2}=\left\|\sum _{i=1}^{\color {red}{n}}\sigma _{i}u_{i}v_{i}^{\top }-\sum _{i=1}^{\color {red}{k}}\sigma _{i}u_{i}v_{i}^{\top }\right\|_{2}=\left\|\sum _{i=\color {red}{k+1}}^{n}\sigma _{i}u_{i}v_{i}^{\top }\right\|_{2}=\sigma _{k+1}} Therefore, we need to show that if B k = X Y ⊤ {\displaystyle B_{k}=XY^{\top }} where X {\displaystyle X} and Y {\displaystyle Y} have k {\displaystyle k} columns then ‖ A − A k ‖ 2 = σ k + 1 ≤ ‖ A − B k ‖ 2 {\displaystyle \|A-A_{k}\|_{2}=\sigma _{k+1}\leq \|A-B_{k}\|_{2}} . Since Y {\displaystyle Y} has k {\displaystyle k} columns, then there must be a nontrivial linear combination of the first k + 1 {\displaystyle k+1} columns of V {\displaystyle V} , i.e., w = γ 1 v 1 + ⋯ + γ k + 1 v k + 1 , {\displaystyle w=\gamma _{1}v_{1}+\cdots +\gamma _{k+1}v_{k+1},} such that Y ⊤ w = 0 {\displaystyle Y^{\top }w=0} . Without loss of generality, we can scale w {\displaystyle w} so that ‖ w ‖ 2 = 1 {\displaystyle \|w\|_{2}=1} or (equivalently) γ 1 2 + ⋯ + γ k + 1 2 = 1 {\displaystyle \gamma _{1}^{2}+\cdots +\gamma _{k+1}^{2}=1} . Therefore, ‖ A − B k ‖ 2 2 ≥ ‖ ( A − B k ) w ‖ 2 2 = ‖ A w ‖ 2 2 = γ 1 2 σ 1 2 + ⋯ + γ k + 1 2 σ k + 1 2 ≥ σ k + 1 2 . {\displaystyle \|A-B_{k}\|_{2}^{2}\geq \|(A-B_{k})w\|_{2}^{2}=\|Aw\|_{2}^{2}=\gamma _{1}^{2}\sigma _{1}^{2}+\cdots +\gamma _{k+1}^{2}\sigma _{k+1}^{2}\geq \sigma _{k+1}^{2}.} The result follows by taking the square root of both sides of the above inequality. == Proof of Eckart–Young–Mirsky theorem (for Frobenius norm) == Let A ∈ R m × n {\displaystyle A\in \mathbb {R} ^{m\times n}} be a real (possibly rectangular) matrix with m ≤ n {\displaystyle m\leq n} . Suppose that A = U Σ V ⊤ {\displaystyle A=U\Sigma V^{\top }} is the singular value decomposition of A {\displaystyle A} . We claim that the best rank k {\displaystyle k} approximation to A {\displaystyle A} in the Frobenius norm, denoted by ‖ ⋅ ‖ F {\displaystyle \|\cdot \|_{F}} , is given by A k = ∑ i = 1 k σ i u i v i ⊤ {\displaystyle A_{k}=\sum _{i=1}^{k}\sigma _{i}u_{i}v_{i}^{\top }} where u i {\displaystyle u_{i}} and v i {\displaystyle v_{i}} denote the i {\displaystyle i} th column of U {\displaystyle U} and V {\displaystyle V} , respectively. First, note that we have ‖ A − A k ‖ F 2 = ‖ ∑ i = k + 1 n σ i u i v i ⊤ ‖ F 2 = ∑ i = k + 1 n σ i 2 {\displaystyle \|A-A_{k}\|_{F}^{2}=\left\|\sum _{i=k+1}^{n}\sigma _{i}u_{i}v_{i}^{\top }\right\|_{F}^{2}=\sum _{i=k+1}^{n}\sigma _{i}^{2}} Therefore, we need to show that if B k = X Y ⊤ {\displaystyle B_{k}=XY^{\top }} where X {\displaystyle X} and Y {\displaystyle Y} have k {\displaystyle k} columns then ‖ A − A k ‖ F 2 = ∑ i = k + 1 n σ i 2 ≤ ‖ A − B k ‖ F 2 . {\displaystyle \|A-A_{k}\|_{F}^{2}=\sum _{i=k+1}^{n}\sigma _{i}^{2}\leq \|A-B_{k}\|_{F}^{2}.} By the triangle inequality with the spectral norm
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JDoodle

JDoodle is a cloud-based online integrated development environment and compiler platform that supports execution of source code in 70+ programming languages including Java, Python, C/C++, PHP, Ruby, Perl, HTML, and more. It provides zero‑setup code for compilation, execution, and sharing via a web browser interface. == Features == Provides real‑time collaboration and code embedding via shareable URLs and APIs Offers an integrated terminal interface supporting database engines such as MySQL and MongoDB. JDroid — AI‑assistant to generate code snippets, optimize code, and assist debugging. == Languages and frameworks supported ==
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Linguamatics

Linguamatics, headquartered in Cambridge, England, with offices in the United States and UK, is a provider of text mining systems through software licensing and services, primarily for pharmaceutical and healthcare applications. Founded in 2001, the company was purchased by IQVIA in January 2019. == Technology == The company develops enterprise search tools for the life sciences sector. The core natural language processing engine (I2E) uses a federated architecture to incorporate data from 3rd party resources. Initially developed to be used interactively through a graphic user interface, the core software also has an application programming interface that can be used to automate searches. LabKey, Penn Medicine, Atrius Health and Mercy all use Linguamatics software to extract electronic health record data into data warehouses. Linguamatics software is used by 17 of the top 20 global pharmaceutical companies, the US Food and Drug Administration, as well as healthcare providers. == Software community == The core software, "I2E", is used by a number of companies to either extend their own software or to publish their data. Copyright Clearance Center uses I2E to produce searchable indexes of material that would otherwise be unsearchable due to copyright. Thomson Reuters produces Cortellis Informatics Clinical Text Analytics, which depends on I2E to make clinical data accessible and searchable. Pipeline Pilot can integrate I2E as part of a workflow. ChemAxon can be used alongside I2E to allow named entity recognition of chemicals within unstructured data. Data sources include MEDLINE, ClinicalTrials.gov, FDA Drug Labels, PubMed Central, and Patent Abstracts.
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State–action–reward–state–action

State–action–reward–state–action (SARSA) is an algorithm for learning a Markov decision process policy, used in the reinforcement learning area of machine learning. It was proposed by Rummery and Niranjan in a technical note with the name "Modified Connectionist Q-Learning" (MCQ-L). The alternative name SARSA, proposed by Rich Sutton, was only mentioned as a footnote. This name reflects the fact that the main function for updating the Q-value depends on the current state of the agent "S1", the action the agent chooses "A1", the reward "R2" the agent gets for choosing this action, the state "S2" that the agent enters after taking that action, and finally the next action "A2" the agent chooses in its new state. The acronym for the quintuple (St, At, Rt+1, St+1, At+1) is SARSA. Some authors use a slightly different convention and write the quintuple (St, At, Rt, St+1, At+1), depending on which time step the reward is formally assigned. The rest of the article uses the former convention. == Algorithm == Q new ( S t , A t ) ← ( 1 − α ) Q ( S t , A t ) + α [ R t + 1 + γ Q ( S t + 1 , A t + 1 ) ] {\displaystyle Q^{\textrm {new}}(S_{t},A_{t})\leftarrow (1-\alpha )Q(S_{t},A_{t})+\alpha \,[R_{t+1}+\gamma \,Q(S_{t+1},A_{t+1})]} A SARSA agent interacts with the environment and updates the policy based on actions taken, hence this is known as an on-policy learning algorithm. The Q value for a state-action is updated by an error, adjusted by the learning rate α. Q values represent the possible reward received in the next time step for taking action a in state s, plus the discounted future reward received from the next state-action observation. Watkin's Q-learning updates an estimate of the optimal state-action value function Q ∗ {\displaystyle Q^{}} based on the maximum reward of available actions. While SARSA learns the Q values associated with taking the policy it follows itself, Watkin's Q-learning learns the Q values associated with taking the optimal policy while following an exploration/exploitation policy. Some optimizations of Watkin's Q-learning may be applied to SARSA. == Hyperparameters == === Learning rate (alpha) === The learning rate determines to what extent newly acquired information overrides old information. A factor of 0 will make the agent not learn anything, while a factor of 1 would make the agent consider only the most recent information. === Discount factor (gamma) === The discount factor determines the importance of future rewards. A discount factor of 0 makes the agent "opportunistic", or "myopic", e.g., by only considering current rewards, while a factor approaching 1 will make it strive for a long-term high reward. If the discount factor meets or exceeds 1, the Q {\displaystyle Q} values may diverge. === Initial conditions (Q(S0, A0)) === Since SARSA is an iterative algorithm, it implicitly assumes an initial condition before the first update occurs. A high (infinite) initial value, also known as "optimistic initial conditions", can encourage exploration: no matter what action takes place, the update rule causes it to have higher values than the other alternative, thus increasing their choice probability. In 2013 it was suggested that the first reward r {\displaystyle r} could be used to reset the initial conditions. According to this idea, the first time an action is taken the reward is used to set the value of Q {\displaystyle Q} . This allows immediate learning in case of fixed deterministic rewards. This resetting-of-initial-conditions (RIC) approach seems to be consistent with human behavior in repeated binary choice experiments.
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Multi-surface method

The multi-surface method (MSM) is a form of decision making using the concept of piecewise-linear separability of datasets to categorize data. == Introduction == Two datasets are linearly separable if their convex hulls do not intersect. The method may be formulated as a feedforward neural network with weights that are trained via linear programming. Comparisons between neural networks trained with the MSM versus backpropagation show MSM is better able to classify data. The decision problem associated linear program for the MSM is NP-complete. == Mathematical formulation == Given two finite disjoint point sets A , B ∈ R n {\displaystyle {\mathcal {A,B}}\in \mathbb {R} ^{n}} , find a discriminant, f : R n → R {\displaystyle f:\mathbb {R} ^{n}\to \mathbb {R} } such that f ( A ) > 0 , f ( B ) ≤ 0 {\displaystyle f({\mathcal {A}})>0,f({\mathcal {B}})\leq 0} . If the intersection of convex hulls of the two sets is the empty set, then it is possible to use a single linear program to obtain a linear discriminant of the form, f ( x ) = c x + γ {\displaystyle f(x)=cx+\gamma } . Usually, in real applications, the sets' convex hulls do intersect, and a (often non-convex) piecewise-linear discriminant can be used, through the use of several linear programs.
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Imaging

Imaging is the process of creating visual representations of objects, scenes, or phenomena. The term encompasses both the formation of images through physical processes and the technologies used to capture, store, process, and display them. While traditional imaging relies on visible light, modern imaging systems can visualize information across the electromagnetic spectrum and through other physical phenomena such as sound waves, magnetic fields, and particle emissions, enabling the visualization of subjects invisible to the human eye. Imaging science is the multidisciplinary field concerned with the theoretical foundations and practical applications of image creation and analysis. The field draws on physics, mathematics, electrical engineering, computer science, computer vision, and perceptual psychology to develop systems that generate, collect, duplicate, analyze, modify, and visualize images. == Principles == === The imaging chain === The imaging chain is a conceptual framework describing the interconnected components of any imaging system. Understanding each link in this chain allows engineers and scientists to optimize system performance for specific applications. The chain begins with the subject and its observable properties, typically energy that is emitted, reflected, or transmitted. A light source or other energy source may illuminate the subject to make these properties detectable. The capture device then collects this energy using appropriate sensors: optical systems for electromagnetic radiation, transducers for acoustic waves, or antenna arrays for radio frequencies. In digital systems, a processor converts the captured signals into a format suitable for rendering, applying algorithms for noise reduction, enhancement, or reconstruction. Finally, a display renders the processed information as a visible image on media such as paper, screens, or projection surfaces. Throughout this process, the characteristics of the human visual system inform design decisions, as the ultimate purpose of most imaging systems is to convey information to human observers. === Coherent and non-coherent imaging === Imaging systems are often classified by whether they use coherent or non-coherent illumination. Coherent imaging employs an active source that produces waves with a consistent phase relationship, as in radar, synthetic aperture radar, medical ultrasound, and optical coherence tomography. These systems can capture phase information in addition to amplitude, enabling techniques such as holography and interferometry. Non-coherent imaging systems, including conventional photography, fluorescence microscopy, and telescopes, rely on illumination sources where light waves have random phase relationships. == Methods and applications == Imaging methods span a wide range of physical principles, each suited to particular applications. Optical imaging encompasses photography, cinematography, microscopy, and telescopic observation. These methods capture electromagnetic radiation in or near the visible spectrum and form the basis of most consumer and scientific imaging. Extensions include thermography, which visualizes infrared radiation to reveal temperature distributions, and multispectral imaging, which captures data across multiple wavelength bands for applications in remote sensing and materials analysis. Medical imaging comprises techniques designed to visualize the interior of the human body for diagnostic and therapeutic purposes. Radiography and computed tomography use X-rays to image dense structures such as bone. Magnetic resonance imaging exploits nuclear magnetic properties to produce detailed soft-tissue images without ionizing radiation. Ultrasound imaging uses high-frequency sound waves and is particularly valuable for real-time imaging and fetal monitoring. Nuclear medicine techniques such as positron emission tomography track radioactive tracers to reveal metabolic activity. Emerging modalities include photoacoustic imaging, which combines optical and acoustic principles, and Magneto-acousto-electrical tomography, which maps electrical conductivity in biological tissues. Acoustic imaging uses sound waves to create images. Beyond medical ultrasound, applications include sonar for underwater navigation and mapping, seismic imaging for geological exploration, and industrial non-destructive testing. Radar and microwave imaging employ radio waves to detect and image objects. Synthetic aperture radar produces high-resolution images from aircraft or satellites regardless of weather or lighting conditions, making it essential for Earth observation and reconnaissance. Ground-penetrating radar images subsurface structures for archaeological and engineering applications. Electron and particle imaging use beams of electrons or other particles to achieve resolutions far beyond the diffraction limit of visible light. Electron microscopes can image individual atoms, enabling advances in materials science and structural biology. Chemical imaging combines spectroscopy with spatial imaging to map the chemical composition of samples, with applications in pharmaceutical development, food safety, and forensics. LIDAR (Light Detection and Ranging) measures distances using laser pulses to create three-dimensional representations of surfaces and objects, widely used in autonomous vehicles, topographic mapping, and forestry. Computational and digital imaging encompasses image processing, computer graphics, three-dimensional rendering, and digital image restoration. Computer vision applies algorithmic analysis to extract information from images automatically. == History == Photography and imaging have always been intertwined. When Joseph Nicéphore Niépce created the first permanent photograph using heliography in 1826, and Louis Daguerre refined the process into the daguerreotype a decade later, they weren't just inventing a new art form, they were laying the groundwork for an entire scientific discipline built on silver halide chemistry. For most of the nineteenth century, photography remained the province of specialists. That changed with George Eastman's Kodak camera, introduced in 1888 with the slogan "You press the button, we do the rest." Suddenly, anyone could take pictures. Around the same time, Wilhelm Röntgen stumbled onto X-rays in 1895, an accident that would spawn the entire field of medical imaging. World War II proved to be a turning point. Radar technology, developed frantically on both sides of the conflict, introduced concepts that engineers would later adapt for synthetic aperture radar and medical ultrasound. Then the charge-coupled device came: Willard Boyle and George E. Smith built the first one at Bell Labs in 1969, and within a few decades it had made film nearly obsolete. Magnetic resonance imaging arrived in the 1970s, offering doctors something X-rays never could, detailed views of soft tissue without any radiation. Digital cameras took over fast. By the 2000s, film was already in decline; by the 2010s, smartphones had put a surprisingly capable camera in nearly every pocket. Features that once required real skill, proper exposure, sharp focus, accurate color, became automatic. Today, billions of photos get uploaded to social media every day. As a result, a growing issue is that generative artificial intelligence can fabricate photorealistic images from scratch. What counts as a "real" photograph is no longer necessarily obvious.
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LPBoost

Linear Programming Boosting (LPBoost) is a supervised classifier from the boosting family of classifiers. LPBoost maximizes a margin between training samples of different classes, and thus also belongs to the class of margin classifier algorithms. Consider a classification function f : X → { − 1 , 1 } , {\displaystyle f:{\mathcal {X}}\to \{-1,1\},} which classifies samples from a space X {\displaystyle {\mathcal {X}}} into one of two classes, labelled 1 and -1, respectively. LPBoost is an algorithm for learning such a classification function, given a set of training examples with known class labels. LPBoost is a machine learning technique especially suited for joint classification and feature selection in structured domains. == LPBoost overview == As in all boosting classifiers, the final classification function is of the form f ( x ) = ∑ j = 1 J α j h j ( x ) , {\displaystyle f({\boldsymbol {x}})=\sum _{j=1}^{J}\alpha _{j}h_{j}({\boldsymbol {x}}),} where α j {\displaystyle \alpha _{j}} are non-negative weightings for weak classifiers h j : X → { − 1 , 1 } {\displaystyle h_{j}:{\mathcal {X}}\to \{-1,1\}} . Each individual weak classifier h j {\displaystyle h_{j}} may be just a little bit better than random, but the resulting linear combination of many weak classifiers can perform very well. LPBoost constructs f {\displaystyle f} by starting with an empty set of weak classifiers. Iteratively, a single weak classifier to add to the set of considered weak classifiers is selected, added and all the weights α {\displaystyle {\boldsymbol {\alpha }}} for the current set of weak classifiers are adjusted. This is repeated until no weak classifiers to add remain. The property that all classifier weights are adjusted in each iteration is known as totally-corrective property. Early boosting methods, such as AdaBoost do not have this property and converge slower. == Linear program == More generally, let H = { h ( ⋅ ; ω ) | ω ∈ Ω } {\displaystyle {\mathcal {H}}=\{h(\cdot ;\omega )|\omega \in \Omega \}} be the possibly infinite set of weak classifiers, also termed hypotheses. One way to write down the problem LPBoost solves is as a linear program with infinitely many variables. The primal linear program of LPBoost, optimizing over the non-negative weight vector α {\displaystyle {\boldsymbol {\alpha }}} , the non-negative vector ξ {\displaystyle {\boldsymbol {\xi }}} of slack variables and the margin ρ {\displaystyle \rho } is the following. min α , ξ , ρ − ρ + D ∑ n = 1 ℓ ξ n sb.t. ∑ ω ∈ Ω y n α ω h ( x n ; ω ) + ξ n ≥ ρ , n = 1 , … , ℓ , ∑ ω ∈ Ω α ω = 1 , ξ n ≥ 0 , n = 1 , … , ℓ , α ω ≥ 0 , ω ∈ Ω , ρ ∈ R . {\displaystyle {\begin{array}{cl}{\underset {{\boldsymbol {\alpha }},{\boldsymbol {\xi }},\rho }{\min }}&-\rho +D\sum _{n=1}^{\ell }\xi _{n}\\{\textrm {sb.t.}}&\sum _{\omega \in \Omega }y_{n}\alpha _{\omega }h({\boldsymbol {x}}_{n};\omega )+\xi _{n}\geq \rho ,\qquad n=1,\dots ,\ell ,\\&\sum _{\omega \in \Omega }\alpha _{\omega }=1,\\&\xi _{n}\geq 0,\qquad n=1,\dots ,\ell ,\\&\alpha _{\omega }\geq 0,\qquad \omega \in \Omega ,\\&\rho \in {\mathbb {R} }.\end{array}}} Note the effects of slack variables ξ ≥ 0 {\displaystyle {\boldsymbol {\xi }}\geq 0} : their one-norm is penalized in the objective function by a constant factor D {\displaystyle D} , which—if small enough—always leads to a primal feasible linear program. Here we adopted the notation of a parameter space Ω {\displaystyle \Omega } , such that for a choice ω ∈ Ω {\displaystyle \omega \in \Omega } the weak classifier h ( ⋅ ; ω ) : X → { − 1 , 1 } {\displaystyle h(\cdot ;\omega ):{\mathcal {X}}\to \{-1,1\}} is uniquely defined. When the above linear program was first written down in early publications about boosting methods it was disregarded as intractable due to the large number of variables α {\displaystyle {\boldsymbol {\alpha }}} . Only later it was discovered that such linear programs can indeed be solved efficiently using the classic technique of column generation. === Column generation for LPBoost === In a linear program a column corresponds to a primal variable. Column generation is a technique to solve large linear programs. It typically works in a restricted problem, dealing only with a subset of variables. By generating primal variables iteratively and on-demand, eventually the original unrestricted problem with all variables is recovered. By cleverly choosing the columns to generate the problem can be solved such that while still guaranteeing the obtained solution to be optimal for the original full problem, only a small fraction of columns has to be created. ==== LPBoost dual problem ==== Columns in the primal linear program corresponds to rows in the dual linear program. The equivalent dual linear program of LPBoost is the following linear program. max λ , γ γ sb.t. ∑ n = 1 ℓ y n h ( x n ; ω ) λ n + γ ≤ 0 , ω ∈ Ω , 0 ≤ λ n ≤ D , n = 1 , … , ℓ , ∑ n = 1 ℓ λ n = 1 , γ ∈ R . {\displaystyle {\begin{array}{cl}{\underset {{\boldsymbol {\lambda }},\gamma }{\max }}&\gamma \\{\textrm {sb.t.}}&\sum _{n=1}^{\ell }y_{n}h({\boldsymbol {x}}_{n};\omega )\lambda _{n}+\gamma \leq 0,\qquad \omega \in \Omega ,\\&0\leq \lambda _{n}\leq D,\qquad n=1,\dots ,\ell ,\\&\sum _{n=1}^{\ell }\lambda _{n}=1,\\&\gamma \in \mathbb {R} .\end{array}}} For linear programs the optimal value of the primal and dual problem are equal. For the above primal and dual problems, the optimal value is equal to the negative 'soft margin'. The soft margin is the size of the margin separating positive from negative training instances minus positive slack variables that carry penalties for margin-violating samples. Thus, the soft margin may be positive although not all samples are linearly separated by the classification function. The latter is called the 'hard margin' or 'realized margin'. ==== Convergence criterion ==== Consider a subset of the satisfied constraints in the dual problem. For any finite subset we can solve the linear program and thus satisfy all constraints. If we could prove that of all the constraints which we did not add to the dual problem no single constraint is violated, we would have proven that solving our restricted problem is equivalent to solving the original problem. More formally, let γ ∗ {\displaystyle \gamma ^{}} be the optimal objective function value for any restricted instance. Then, we can formulate a search problem for the 'most violated constraint' in the original problem space, namely finding ω ∗ ∈ Ω {\displaystyle \omega ^{}\in \Omega } as ω ∗ = argmax ω ∈ Ω ∑ n = 1 ℓ y n h ( x n ; ω ) λ n . {\displaystyle \omega ^{}={\underset {\omega \in \Omega }{\textrm {argmax}}}\sum _{n=1}^{\ell }y_{n}h({\boldsymbol {x}}_{n};\omega )\lambda _{n}.} That is, we search the space H {\displaystyle {\mathcal {H}}} for a single decision stump h ( ⋅ ; ω ∗ ) {\displaystyle h(\cdot ;\omega ^{})} maximizing the left hand side of the dual constraint. If the constraint cannot be violated by any choice of decision stump, none of the corresponding constraint can be active in the original problem and the restricted problem is equivalent. ==== Penalization constant ==== D {\displaystyle D} The positive value of penalization constant D {\displaystyle D} has to be found using model selection techniques. However, if we choose D = 1 ℓ ν {\displaystyle D={\frac {1}{\ell \nu }}} , where ℓ {\displaystyle \ell } is the number of training samples and 0 < ν < 1 {\displaystyle 0<\nu <1} , then the new parameter ν {\displaystyle \nu } has the following properties. ν {\displaystyle \nu } is an upper bound on the fraction of training errors; that is, if k {\displaystyle k} denotes the number of misclassified training samples, then k ℓ ≤ ν {\displaystyle {\frac {k}{\ell }}\leq \nu } . ν {\displaystyle \nu } is a lower bound on the fraction of training samples outside or on the margin. == Algorithm == Input: Training set X = { x 1 , … , x ℓ } {\displaystyle X=\{{\boldsymbol {x}}_{1},\dots ,{\boldsymbol {x}}_{\ell }\}} , x i ∈ X {\displaystyle {\boldsymbol {x}}_{i}\in {\mathcal {X}}} Training labels Y = { y 1 , … , y ℓ } {\displaystyle Y=\{y_{1},\dots ,y_{\ell }\}} , y i ∈ { − 1 , 1 } {\displaystyle y_{i}\in \{-1,1\}} Convergence threshold θ ≥ 0 {\displaystyle \theta \geq 0} Output: Classification function f : X → { − 1 , 1 } {\displaystyle f:{\mathcal {X}}\to \{-1,1\}} Initialization Weights, uniform λ n ← 1 ℓ , n = 1 , … , ℓ {\displaystyle \lambda _{n}\leftarrow {\frac {1}{\ell }},\quad n=1,\dots ,\ell } Edge γ ← 0 {\displaystyle \gamma \leftarrow 0} Hypothesis count J ← 1 {\displaystyle J\leftarrow 1} Iterate h ^ ← argmax ω ∈ Ω ∑ n = 1 ℓ y n h ( x n ; ω ) λ n {\displaystyle {\hat {h}}\leftarrow {\underset {\omega \in \Omega }{\textrm {argmax}}}\sum _{n=1}^{\ell }y_{n}h({\boldsymbol {x}}_{n};\omega )\lambda _{n}} if ∑ n = 1 ℓ y n h ^ ( x n ) λ n + γ ≤ θ {\displaystyle \sum _{n=1}^{\ell }y_{n}{\hat {h}}({\boldsymbol {x}}_{n})\lambda _{n}+\gamma \leq \theta } then break h J ← h ^ {\displaystyle h_{J}\leftarrow {\hat {h}}} J
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Tanagra (machine learning)

Tanagra is a free suite of machine learning software for research and academic purposes developed by Ricco Rakotomalala at the Lumière University Lyon 2, France. Tanagra supports several standard data mining tasks such as: Visualization, Descriptive statistics, Instance selection, feature selection, feature construction, regression, factor analysis, clustering, classification and association rule learning. Tanagra is an academic project. It is widely used in French-speaking universities. Tanagra is frequently used in real studies and in software comparison papers. == History == The development of Tanagra was started in June 2003. The first version was distributed in December 2003. Tanagra is the successor of Sipina, another free data mining tool which is intended only for supervised learning tasks (classification), especially the interactive and visual construction of decision trees. Sipina is still available online and is maintained. Tanagra is an "open source project" as every researcher can access the source code and add their own algorithms, as long as they agree and conform to the software distribution license. The main purpose of the Tanagra project is to give researchers and students a user-friendly data mining software, conforming to the present norms of the software development in this domain (especially in the design of its GUI and the way to use it), and allowing the analyzation of either real or synthetic data. From 2006, Ricco Rakotomalala made an important documentation effort. A large number of tutorials are published on a dedicated website. They describe the statistical and machine learning methods and their implementation with Tanagra on real case studies. The use of other free data mining tools on the same problems is also widely described. The comparison of the tools enables readers to understand the possible differences in the presentation of results. == Description == Tanagra works similarly to current data mining tools. The user can design visually a data mining process in a diagram. Each node is a statistical or machine learning technique, the connection between two nodes represents the data transfer. But unlike the majority of tools which are based on the workflow paradigm, Tanagra is very simplified. The treatments are represented in a tree diagram. The results are displayed in an HTML format. This makes it is easy to export the outputs in order to visualize the results in a browser. It is also possible to copy the result tables to a spreadsheet. Tanagra makes a good compromise between statistical approaches (e.g. parametric and nonparametric statistical tests), multivariate analysis methods (e.g. factor analysis, correspondence analysis, cluster analysis, regression) and machine learning techniques (e.g. neural network, support vector machine, decision trees, random forest).
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