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Biomedical data science

Biomedical data science is a multidisciplinary field which leverages large volumes of data to promote biomedical innovation and discovery. Biomedical data science draws from various fields including Biostatistics, Biomedical informatics, and machine learning, with the goal of understanding biological and medical data. It can be viewed as the study and application of data science to solve biomedical problems. Modern biomedical datasets often have specific features which make their analyses difficult, including: Large numbers of feature (sometimes billions), typically far larger than the number of samples (typically tens or hundreds) Noisy and missing data Privacy concerns (e.g., electronic health record confidentiality) Requirement of interpretability from decision makers and regulatory bodies Many biomedical data science projects apply machine learning to such datasets. These characteristics, while also present in many data science applications more generally, make biomedical data science a specific field. Examples of biomedical data science research include: Computational genomics Computational imaging Electronic health records data mining Biomedical network science Clinical Natural Language Processing (NLP) == Computational Imaging and Deep Learning == Computational imaging is a cornerstone of biomedical data science, focusing on the development of algorithms to enhance, analyze, and interpret medical imagery. In recent years, the field has been transformed by the integration of deep learning, particularly through the use of Convolutional Neural Networks. Deep learning started from researchers manually defining characteristics like edge detection or texture representation learning. In a more modern approach of computational imaging, models automatically learn a hierarchy of features directly from raw pixel data. This overlap between data science and deep learning is applied across several key tasks: Classification: Identifying the presence of specific diseases, such as distinguishing between benign and malignant tumors in histopathology slides or detecting pneumonia in chest X-rays. Segmentation: The precise delineation of anatomical structures or lesions. A notable example is the U-Net architecture, which is widely used for biomedical image segmentation to help clinicians quantify organ volume or track tumor growth. Detection: Automating the localization of small objects, such as identifying microcalcifications in mammograms or polyps during colonoscopies. Registration: The process of aligning multiple images to provide a comprehensive view of the patient's anatomy. Even with all of these enhancements, the application of deep learning in medical imaging requires accomplishing vigorous challenges. An example of these changes is building large, annotated datasets and creating the imperative for model interpretability in clinical decision-making. == Electronic Health Records == Electronic Health Records (EHRs) are a digital alternative to patient paper charts, usually including individual records or population health information. EHRs can be used in a wide variety of applications, including research and analysation as they often include demographics, diagnoses, medications, test results, and personal statistics. === History === ==== 1960s ==== The earliest precursor is considered Dr. Lawrence Weed's problem-oriented medical record (POMR) published in the 1968 which sorts and groups medical records by medical diagnoses and symptoms. The POMR was the first system to organize based off of patient information rather than the source (doctors, nurses, attendings, etc.). In 1969, the Regenstrief Institute developed and published the Regenstrief Medical Record System which established electronic writing, storage, and retrieval of records which served as the basis for modern EHR systems. ==== 2000s ==== In 2009, the Health Information Technology for Economic and Clinical Health Act (HITECH Act) was passed in the United States. This act standardized privacy and distribution of EHRs and increased the acceptance and utilization of EHRs within medical and academic settings. == Artificial Intelligence and Machine Learning Applications == Machine Learning and Artificial Intelligence have become central tools in biomedical data science. Recent advances in large language models (LLMs) have expanded their role beyond text, with models trained directly on genomic sequences enabling tasks such as gene function prediction, variant effect analysis, and drug discovery. In clinical settings, Natural Language Processing (NLP) models are applied to electronic health records to extract structured insights from unstructured clinical notes and data, supporting diagnosis and treatment planning. Beyond genomics, AI models have been applied to protein structure prediction. AlphaFold, developed by Google DeepMind, uses deep learning to predict three-dimensional protein structures from amino acid sequences with high accuracy. These predictions have been used to support drug target identification and the study of disease mechanisms. == Knowledge Graphs == Knowledge graphs (KGs) are widely used in biomedical data science to represent and analyze complex relationships among biological and medical entities. By structuring data as nodes (e.g., genes, diseases, drugs) and edges (relationships), KGs enable computational methods to extract insights and support decision-making. These biomedical relationships can be efficiently modeled and queried using technologies such as Neo4j. === Biomedical Research Applications === KGs provide biomedical researchers with a way to model complex biological systems. They have been used to identify the relationships between diseases and biomolecules, support drug repurposing, and to uncover new biological insights. Additional applications include: Identification of novel antibiotic resistance genes through graph-based link prediction. Finding associations between miRNA and diseases. Prediction of protein-protein interactions. === Clinical Applications === In clinical settings, KGs can be used to make visual representations of a patient's electronic health records. The data obtained from these graphs can assist healthcare providers in improving patient diagnoses and prescribing more effective drugs. Additionally, embeddings derived from resources like the Unified Medical Language System (UMLS) enable natural language processing of clinical text and similarity analysis between medical concepts. === Limitations === Despite their advantages, knowledge graphs face several challenges. Some of these include: High algorithmic complexity and large biological datasets make the process computationally expensive. KG construction can be a time-consuming process that requires careful attention to assign appropriate node types and vocabularies. Using data from a wide range of datasets in one KG requires them to be effectively integrated. == Privacy == A primary challenge in biomedical data science is maintaining medical privacy. Conducting research requires that data be collected on a number of people for training and testing purposes and is stored within biomedical datasets. This poses a risk for violating patient confidentiality and may dissuade people from participating in studies. The main sources of health statistics are surveys administrative and medical records health care claims data, vital records surveillance disease registries grey literature and peer-reviewed literature. Large data collection is a useful tool for researching various medical conditions. Researchers use these large datasets of information to identify factors that may make people more susceptible to certain diseases. Large amounts of collected data can help researchers identify patterns for disease probabilities. The findings can show a person is more likely for a condition, or identify environmental, social, and personal habits that may lead to adverse health issues. Institutions researching using personal medical information come with a moral and legal responsibility to protect the use of that information. Protection of the collected information has become a big concern. Sophisticated and coordinated attacks on certain medical systems happen more frequently. Medical companies, medical insurance and private businesses have invested a great deal into the protection of personal data. Despite this, data breaches continue to be documented. The chart below shows the top healthcare breaches in 2025. For these reasons, many people have reservations about giving up their personal data. Aside from the legitimate use of personal data there have been instances where companies have found methods to profit from brokering medical information. Concerns exist regarding unauthorized use of sensitive information within these data companies. If a person is identified within a dataset, then sensitive data can be used to discriminate against them. For example, insurance companies may charge a hi
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Level set (data structures)

In computer science, a level set is a data structure designed to represent discretely sampled dynamic level sets of functions. A common use of this form of data structure is in efficient image rendering. The underlying method constructs a signed distance field that extends from the boundary, and can be used to solve the motion of the boundary in this field. == Chronological developments == The powerful level-set method is due to Osher and Sethian 1988. However, the straightforward implementation via a dense d-dimensional array of values, results in both time and storage complexity of O ( n d ) {\displaystyle O(n^{d})} , where n {\displaystyle n} is the cross sectional resolution of the spatial extents of the domain and d {\displaystyle d} is the number of spatial dimensions of the domain. === Narrow band === The narrow band level set method, introduced in 1995 by Adalsteinsson and Sethian, restricted most computations to a thin band of active voxels immediately surrounding the interface, thus reducing the time complexity in three dimensions to O ( n 2 ) {\displaystyle O(n^{2})} for most operations. Periodic updates of the narrowband structure, to rebuild the list of active voxels, were required which entailed an O ( n 3 ) {\displaystyle O(n^{3})} operation in which voxels over the entire volume were accessed. The storage complexity for this narrowband scheme was still O ( n 3 ) . {\displaystyle O(n^{3}).} Differential constructions over the narrow band domain edge require careful interpolation and domain alteration schemes to stabilise the solution. === Sparse field === This O ( n 3 ) {\displaystyle O(n^{3})} time complexity was eliminated in the approximate "sparse field" level set method introduced by Whitaker in 1998. The sparse field level set method employs a set of linked lists to track the active voxels around the interface. This allows incremental extension of the active region as needed without incurring any significant overhead. While consistently O ( n 2 ) {\displaystyle O(n^{2})} efficient in time, O ( n 3 ) {\displaystyle O(n^{3})} storage space is still required by the sparse field level set method. See for implementation details. === Sparse block grid === The sparse block grid method, introduced by Bridson in 2003, divides the entire bounding volume of size n 3 {\displaystyle n^{3}} into small cubic blocks of m 3 {\displaystyle m^{3}} voxels each. A coarse grid of size ( n / m ) 3 {\displaystyle (n/m)^{3}} then stores pointers only to those blocks that intersect the narrow band of the level set. Block allocation and deallocation occur as the surface propagates to accommodate to the deformations. This method has a suboptimal storage complexity of O ( ( n m ) 3 + m 3 n 2 ) {\displaystyle O\left((nm)3+m^{3}n^{2}\right)} , but retains the constant time access inherent to dense grids. === Octree === The octree level set method, introduced by Strain in 1999 and refined by Losasso, Gibou and Fedkiw, and more recently by Min and Gibou uses a tree of nested cubes of which the leaf nodes contain signed distance values. Octree level sets currently require uniform refinement along the interface (i.e. the narrow band) in order to obtain sufficient precision. This representation is efficient in terms of storage, O ( n 2 ) , {\displaystyle O(n^{2}),} and relatively efficient in terms of access queries, O ( log n ) . {\displaystyle O(\log \,n).} An advantage of the level method on octree data structures is that one can solve the partial differential equations associated with typical free boundary problems that use the level set method. The CASL research group has developed this line of work in computational materials, computational fluid dynamics, electrokinetics, image-guided surgery and controls. === Run-length encoded === The run-length encoding (RLE) level set method, introduced in 2004, applies the RLE scheme to compress regions away from the narrow band to just their sign representation while storing with full precision the narrow band. The sequential traversal of the narrow band is optimal and storage efficiency is further improved over the octree level set. The addition of an acceleration lookup table allows for fast O ( log ⁡ r ) {\displaystyle O(\log r)} random access, where r is the number of runs per cross section. Additional efficiency is gained by applying the RLE scheme in a dimensional recursive fashion, a technique introduced by Nielsen & Museth's similar DT-Grid. === Hash Table Local Level Set === The Hash Table Local Level Set method was introduced in 2011 by Eyiyurekli and Breen and extended in 2012 by Brun, Guittet, and Gibou, only computes the level set data in a band around the interface, as in the Narrow Band Level-Set Method, but also only stores the data in that same band. A hash table data structure is used, which provides an O ( 1 ) {\displaystyle O(1)} access to the data. However, Brun et al. conclude that their method, while being easier to implement, performs worse than a quadtree implementation. They find that as it is, [...] a quadtree data structure seems more adapted than the hash table data structure for level-set algorithms. Three main reasons for worse efficiency are listed: to obtain accurate results, a rather large band is required close to the interface, which counterbalances the absence of grid nodes far from the interface; the performances are deteriorated by extrapolation procedures on the outer edges of the local grid and the width of the band restricts the time step and slows down the method. === Point-based === Corbett in 2005 introduced the point-based level set method. Instead of using a uniform sampling of the level set, the continuous level set function is reconstructed from a set of unorganized point samples via moving least squares.
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Haskins Laboratories

Haskins Laboratories, Inc. is an independent research laboratory, founded in 1935 and located in New Haven, Connecticut since 1970. Many current Haskins researchers are affiliated with Yale University's Child Study Center and/or the University of Connecticut. Haskins is a multidisciplinary and international community of researchers who conduct basic research on spoken and written language and global literacy. A guiding perspective of their research has been to view speech and language as emerging from biological processes, including those of adaptation, response to stimuli, and conspecific interaction. Haskins Laboratories has a long history of technological and theoretical innovation, from creating systems of rules for speech synthesis and development of an early working prototype of a reading machine for the blind to developing the landmark concept of phonemic awareness as the critical preparation for learning to read an alphabetic writing system. == Research tools and facilities == Haskins Laboratories is equipped, in-house, with a comprehensive suite of tools and capabilities to advance its mission of research into language and literacy. As of 2014, these included: Anechoic chamber Electroencephalography BioSemi 264 electrode, 24 bit Active Two System EGI 128 electrode, Geodesic EEG System 300 Electromagnetic articulography (EMMA) Carstens AG501 NDI WAVE Eye tracking: HL is equipped with 3 SR Research eye-trackers. 2 Model Eyelink 1000 systems. 1 Model Eyelink 1000plus system. Magnetic resonance imaging: Haskins has access to MRI scanners through agreements with the University of Connecticut and the Yale School of Medicine. On-site, HL has a Linux computer cluster dedicated to analysis of MRI data. Motion capture: HL is equipped with a Vicon motion capture system with one Basler high-speed digital camera, six Vicon MX T-20 cameras and a Vicon MX Giganet for synching camera data and connecting cameras to the data capture computer. Near infrared spectroscopy: HL has a TechEn CW6 8x8 system (four emitters; eight detectors). Ultrasound sonogram == History == Many researchers have contributed to scientific breakthroughs at Haskins Laboratories since its founding. All of them are indebted to the pioneering work and leadership of Caryl Parker Haskins, Franklin S. Cooper, Alvin Liberman, Seymour Hutner and Luigi Provasoli. The history presented here focuses on the research program of the division of Haskins Laboratories that, since the 1940s, has been most well known for its work in the areas of speech, language, and reading. === 1930s === Caryl Haskins and Franklin S. Cooper established Haskins Laboratories in 1935. It was originally affiliated with Harvard University, MIT, and Union College in Schenectady, NY. Caryl Haskins conducted research in microbiology, radiation physics, and other fields in Cambridge, MA and Schenectady. In 1939 Haskins Laboratories moved its center to New York City. Seymour Hutner joined the staff to set up a research program in microbiology, genetics, and nutrition. The descendant of the division led by Hutner program eventually became a department of Pace University in New York. The two identically named organizations are no longer formally affiliated. === 1940s === The U. S. Office of Scientific Research and Development, under Vannevar Bush asked Haskins Laboratories to evaluate and develop technologies for assisting blinded World War II veterans. Experimental psychologist Alvin Liberman joined Haskins Laboratories to assist in developing a "sound alphabet" to represent the letters in a text for use in a reading machine for the blind. Luigi Provasoli joined Haskins Laboratories to set up a research program in marine biology. The program in marine biology moved to Yale University in 1970 and disbanded with Provasoli's retirement in 1978. === 1950s === Franklin S. Cooper invented the pattern playback, a machine that converts pictures of the acoustic patterns of speech back into sound. With this device, Alvin Liberman, Cooper, and Pierre Delattre (and later joined by Katherine Safford Harris, Leigh Lisker, Arthur Abramson, and others), discovered the acoustic cues for the perception of phonetic segments (consonants and vowels). Liberman and colleagues proposed a motor theory of speech perception to resolve the acoustic complexity: they hypothesized that we perceive speech by tapping into a biological specialization, a speech module, that contains knowledge of the acoustic consequences of articulation. Liberman, aided by Frances Ingemann and others, organized the results of the work on speech cues into a groundbreaking set of rules for speech synthesis by the Pattern Playback. === 1960s === Franklin S. Cooper and Katherine Safford Harris, working with Peter MacNeilage, were the first researchers in the U.S. to use electromyographic techniques, pioneered at the University of Tokyo, to study the neuromuscular organization of speech. Leigh Lisker and Arthur Abramson looked for simplification at the level of articulatory action in the voicing of certain contrasting consonants. They showed that many acoustic properties of voicing contrasts arise from variations in voice onset time, the relative phasing of the onset of vocal cord vibration and the end of a consonant. Their work has been widely replicated and elaborated, here and abroad, over the following decades. Donald Shankweiler and Michael Studdert-Kennedy used a dichotic listening technique (presenting different nonsense syllables simultaneously to opposite ears) to demonstrate the dissociation of phonetic (speech) and auditory (nonspeech) perception by finding that phonetic structure devoid of meaning is an integral part of language, typically processed in the left cerebral hemisphere. Liberman, Cooper, Shankweiler, and Studdert-Kennedy summarized and interpreted fifteen years of research in "Perception of the Speech Code", still among the most cited papers in the speech literature. It set the agenda for many years of research at Haskins and elsewhere by describing speech as a code in which speakers overlap (or coarticulate) segments to form syllables. Researchers at Haskins connected their first computer to a speech synthesizer designed by Haskins Laboratories' engineers. Ignatius Mattingly, with British collaborators, John N. Holmes and J.N. Shearme, adapted the Pattern playback rules to write the first computer program for synthesizing continuous speech from a phonetically spelled input. A further step toward a reading machine for the blind combined Mattingly's program with an automatic look-up procedure for converting alphabetic text into strings of phonetic symbols. === 1970s === In 1970, Haskins Laboratories moved to New Haven, Connecticut, and entered into affiliation agreements with Yale University and the University of Connecticut; Haskins remains fully independent of both Yale and UConn, administratively and financially. The lab's original location in New Haven, at 270 Crown Street (from 1970 to 2005), was leased from Yale University. Isabelle Liberman, Donald Shankweiler, and Alvin Liberman teamed up with Ignatius Mattingly to study the relationship between speech perception and reading, a topic implicit in Haskins Laboratories' research program since its inception. They developed the concept of phonemic awareness, the knowledge that would-be readers must be aware of the phonemic structure of their language in order to be able to read. Leonard Katz related the work to contemporary cognitive theory and provided expertise in experimental design and data analysis. Under the broad rubric of the "alphabetic principle", this is the core of the lab's present program of reading pedagogy. Patrick Nye joined Haskins Laboratories to lead a team working on the reading machine for the blind. The project culminated when the addition of an optical character recognizer allowed investigators to assemble the first automatic text-to-speech reading machine. By the end of the decade this technology had advanced to the point where commercial concerns assumed the task of designing and manufacturing reading machines for the blind. In 1973, Franklin S. Cooper was selected to form a panel of six experts charged with investigating the famous 18-minute gap in the White House office tapes of President Richard Nixon related to the Watergate scandal. Building on earlier work, Philip Rubin developed the sinewave synthesis program, which was then used by Robert Remez, Rubin, and colleagues to show that listeners can perceive continuous speech without traditional speech cues from a pattern of sinewaves that track the changing resonances of the vocal tract. This paved the way for a view of speech as a dynamic pattern of trajectories through articulatory-acoustic space. Philip Rubin and colleagues developed Paul Mermelstein's anatomically simplified vocal tract model, originally worked on at Bell Laboratories, into the first articulatory synthesizer that can be controlled in a phy
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Rapid prototyping

Rapid prototyping is a group of techniques used to quickly fabricate a scale model of a physical part or assembly using three-dimensional computer aided design (CAD) data. Construction of the part or assembly is usually done using 3D printing or "additive layer manufacturing" technology. The first methods for rapid prototyping became available in mid 1987 and were used to produce models and prototype parts. Today, they are used for a wide range of applications and are used to manufacture production-quality parts in relatively small numbers if desired without the typical unfavorable short-run economics. This economy has encouraged online service bureaus. Historical surveys of RP technology start with discussions of simulacra production techniques used by 19th-century sculptors. Some modern sculptors use the progeny technology to produce exhibitions and various objects. The ability to reproduce designs from a dataset has given rise to issues of rights, as it is now possible to interpolate volumetric data from 2D images. As with CNC subtractive methods, the computer-aided-design – computer-aided manufacturing CAD -CAM workflow in the traditional rapid prototyping process starts with the creation of geometric data, either as a 3D solid using a CAD workstation, or 2D slices using a scanning device. For rapid prototyping this data must represent a valid geometric model; namely, one whose boundary surfaces enclose a finite volume, contain no holes exposing the interior, and do not fold back on themselves. In other words, the object must have an "inside". The model is valid if for each point in 3D space the computer can determine uniquely whether that point lies inside, on, or outside the boundary surface of the model. CAD post-processors will approximate the application vendors' internal CAD geometric forms (e.g., B-splines) with a simplified mathematical form, which in turn is expressed in a specified data format which is a common feature in additive manufacturing: STL file format, a de facto standard for transferring solid geometric models to SFF machines. To obtain the necessary motion control trajectories to drive the actual SFF, rapid prototyping, 3D printing or additive manufacturing mechanism, the prepared geometric model is typically sliced into layers, and the slices are scanned into lines (producing a "2D drawing" used to generate trajectory as in CNC's toolpath), mimicking in reverse the layer-to-layer physical building process. == Application areas == Rapid prototyping is also commonly applied in software engineering to try out new business models and application architectures such as Aerospace, Automotive, Financial Services, Product development, and Healthcare. Aerospace design and industrial teams rely on prototyping in order to create new AM methodologies in the industry. Using SLA they can quickly make multiple versions of their projects in a few days and begin testing quicker. Rapid Prototyping allows designers/developers to provide an accurate idea of how the finished product will turn out before putting too much time and money into the prototype. 3D printing being used for Rapid Prototyping allows for Industrial 3D printing to take place. With this, you could have large-scale moulds to spare parts being pumped out quickly within a short period of time. == Types of Rapid Prototyping == Stereolithography (SLA) → a laser-cured photopolymer for materials such as thermoplastic-like photopolymers. Selective Laser Sintering (SLS) → a laser-sintered powder for materials such as Nylon or TPU. Direct Metal Laser Sintering (DMLS) → laser-sintered metal powder for materials like stainless steel, titanium, chrome, and aluminum. Fused Deposition Modeling (FDM) → fused extrusions of filaments like ABS, PC, and PPCU. Multi Jet Fusion (MJF) → it is an inkjet array selective fusing across bed of nylon powder for Black Nylon 12. PolyJet (PJET) → it is a uv-cured jetted photopolymer to work with acrylic-based and elastomeric photopolymers. Computer Numerical Controlled Machine (CNC) → it is used for manipulating engineering-grade thermoplastics and metals. Injection Molding (IM) → the injection is done using aluminum molds and it is used for thermoplastics, metals and liquid silicone rubber. Vacuum Casting→ is a manufacturing process used to create high-quality prototypes and small batches of parts. == History == In the 1970s, Joseph Henry Condon and others at Bell Labs developed the Unix Circuit Design System (UCDS), automating the laborious and error-prone task of manually converting drawings to fabricate circuit boards for the purposes of research and development. By the 1980s, U.S. policy makers and industrial managers were forced to take note that America's dominance in the field of machine tool manufacturing evaporated, in what was named the machine tool crisis. Numerous projects sought to counter these trends in the traditional CNC CAM area, which had begun in the US. Later when Rapid Prototyping Systems moved out of labs to be commercialized, it was recognized that developments were already international and U.S. rapid prototyping companies would not have the luxury of letting a lead slip away. The National Science Foundation was an umbrella for the National Aeronautics and Space Administration (NASA), the US Department of Energy, the US Department of Commerce NIST, the US Department of Defense, Defense Advanced Research Projects Agency (DARPA), and the Office of Naval Research coordinated studies to inform strategic planners in their deliberations. One such report was the 1997 Rapid Prototyping in Europe and Japan Panel Report in which Joseph J. Beaman founder of DTM Corporation [DTM RapidTool pictured] provides a historical perspective: The roots of rapid prototyping technology can be traced to practices in topography and photosculpture. Within TOPOGRAPHY Blanther (1892) suggested a layered method for making a mold for raised relief paper topographical maps .The process involved cutting the contour lines on a series of plates which were then stacked. Matsubara (1974) of Mitsubishi proposed a topographical process with a photo-hardening photopolymer resin to form thin layers stacked to make a casting mold. PHOTOSCULPTURE was a 19th-century technique to create exact three-dimensional replicas of objects. Most famously Francois Willeme (1860) placed 24 cameras in a circular array and simultaneously photographed an object. The silhouette of each photograph was then used to carve a replica. Morioka (1935, 1944) developed a hybrid photo sculpture and topographic process using structured light to photographically create contour lines of an object. The lines could then be developed into sheets and cut and stacked, or projected onto stock material for carving. The Munz (1956) Process reproduced a three-dimensional image of an object by selectively exposing, layer by layer, a photo emulsion on a lowering piston. After fixing, a solid transparent cylinder contains an image of the object. "The Origins of Rapid Prototyping - RP stems from the ever-growing CAD industry, more specifically, the solid modeling side of CAD. Before solid modeling was introduced in the late 1980's, three-dimensional models were created with wire frames and surfaces. But not until the development of true solid modeling could innovative processes such as RP be developed. Charles Hull, who helped found 3D Systems in 1986, developed the first RP process. This process, called stereolithography, builds objects by curing thin consecutive layers of certain ultraviolet light-sensitive liquid resins with a low-power laser. With the introduction of RP, CAD solid models could suddenly come to life". The technologies referred to as Solid Freeform Fabrication are what we recognize today as rapid prototyping, 3D printing or additive manufacturing: Swainson (1977), Schwerzel (1984) worked on polymerization of a photosensitive polymer at the intersection of two computer controlled laser beams. Ciraud (1972) considered magnetostatic or electrostatic deposition with electron beam, laser or plasma for sintered surface cladding. These were all proposed but it is unknown if working machines were built. Hideo Kodama of Nagoya Municipal Industrial Research Institute was the first to publish an account of a solid model fabricated using a photopolymer rapid prototyping system (1981). The first 3D rapid prototyping system relying on Fused Deposition Modeling (FDM) was made in April 1992 by Stratasys but the patent did not issue until June 9, 1992. Sanders Prototype, Inc introduced the first desktop inkjet 3D Printer (3DP) using an invention from August 4, 1992 (Helinski), Modelmaker 6Pro in late 1993 and then the larger industrial 3D printer, Modelmaker 2, in 1997. Z-Corp using the MIT 3DP powder binding for Direct Shell Casting (DSP) invented 1993 was introduced to the market in 1995. Even at that early date the technology was seen as having a place in manufacturing practice. A low resol
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Internet Security Awareness Training

Internet Security Awareness Training (ISAT) is the training given to members of an organization regarding the protection of various information assets of that organization. ISAT is a subset of general security awareness training (SAT). Even small and medium enterprises are generally recommended to provide such training, but organizations that need to comply with government regulations (e.g., the Gramm–Leach–Bliley Act, the Payment Card Industry Data Security Standard, Health Insurance Portability and Accountability Act, Sarbanes–Oxley Act) normally require formal ISAT for annually for all employees. Often such training is provided in the form of online courses. ISAT, also referred to as Security Education, Training, and Awareness (SETA), organizations train and create awareness of information security management within their environment. It is beneficial to organizations when employees are well trained and feel empowered to take important actions to protect themselves and organizational data. The SETA program target must be based on user roles within organizations and for positions that expose the organizations to increased risk levels, specialized courses must be required. == Coverage == There are general topics to cover for the training, but it is necessary for each organization to have a coverage strategy based on its needs, as this will ensure the training is practical and captures critical topics relevant to the organization. As the threat landscape changes very frequently, organizations should continuously review their training programs to ensure relevance with current trends. Topics covered in ISAT include: Appropriate methods for protecting sensitive information on personal computer systems, including password policy Various computer security concerns, including spam, malware, phishing, social engineering, etc. Consequences of failure to properly protect information, including potential job loss, economic consequences to the firm, damage to individuals whose private records are divulged, and possible civil and criminal law penalties. Being Internet Security Aware means you understand that there are people actively trying to steal data that is stored within your organization's computers. (This often focuses on user names and passwords, so that criminal elements can ultimately get access to bank accounts and other high-value IT assets.) That is why it is important to protect the assets of the organization and stop that from happening. The general scope should include topics such as password security, Email phishing, Social engineering, Mobile device security, Sensitive data security, and Business communications. In contrast, those requiring specialized knowledge are usually required to take technical and in-depth training courses. Suppose an organization determines that it is best to use one of the available training tools on the market, it must ensure it sets objectives that the training can meet, including confirming the training will provide employees with the knowledge to understand risks and the behaviors needed in managing them, actions to take to prevent or detect security incidents, using language easily understandable by the trainees, and ensuring the pricing is reasonable. Organizations are recommended to base ISAT training content on employee roles and their culture; the policy should guide that training for all employees and gave the following as examples of sources of reference materials: National Institute of Standards and Technology (NIST) Special Publication 800-50, Building an Information Technology Security Awareness and Training Program International Standards Organization (ISO) 27002:2013, Information technology—Security techniques—Code of practice for information security controls International Standards Organization (ISO) 27001:2013, Information technology — Security techniques — Information security management systems COBIT 5 Appendix F.2, Detailed Guidance: Services, Infrastructure and Applications Enabler, Security Awareness The training must focus on current threats specific to an organization and the impacts if that materializes as a result of user actions. Including practical examples and ways of dealing with scenarios help users know the appropriate measures to take. It is a good practice to periodically train customers of specific organizations on threats they face from people with malicious intentions. Coverage strategy for SAT should be driven by an organization's policy. It can help truly determine the level of depth of the training and where it should be conducted at a global level or business unit level, or a combination of both. A policy also empowers a responsible party within the organization to run the training. == Importance == Studies show that well-structured security awareness training can significantly reduce the likelihood of cyber incidents caused by human error. According to the Ponemon Institute, organizations that implement regular security training experience up to 70% fewer successful phishing attacks. Additionally, a 2023 Verizon Data Breach Investigations Report found that 74% of breaches involve the human element, highlighting the need for continuous education. Employees are key in whether organizations are breached or not; there must be a policy on creating awareness and training them on emerging threats and actions to take in safeguarding sensitive information and reporting any observed unusual activity within the corporate environment. Research has shown that SAT has helped reduce cyber-attacks within organizations, especially when it comes to phishing, as trainees learned to identify these attack modes and give them the self-assurance to take action appropriately. There is an increase in phishing attacks, and it has become increasingly important for people to understand how to these attacks work, and the actions required to prevent these and SAT has shown a significant impact on the number of successful phishing attacks against organizations. == Compliance Requirements == Various regulations and laws mandate SAT for organizations in specific industries, including the Gramm–Leach–Bliley Act (GLBA) for the financial services, the Federal Information Security Modernization Act of 2014 for federal agencies, and the European Union's General Data Protection Regulation (GDPR). === Federal Information Security Modernization Act === Employees and contractors in federal agencies are required to receive Security Awareness Training annually, and the program needs to address job-related information security risks linked that provide them with the knowledge to lessen security risks. === Health Insurance Portability and Accountability Act === The Health Insurance Portability and Accountability Act has the Security Rule, and Privacy Rule requiring the creation of a security awareness training program and ensuring employees are trained accordingly. === Payment Card Industry Data Security Standard === The Payment Card Industry Security Standards Council, the governing council for stakeholders in the payment industry, formed by American Express, Discover, JCB International, MasterCard, and Visa that developed the DSS as a requirement for the payment industry. Requirement 12.6 requires member organizations to institute a formal security awareness program. There is a published guide for organizations to adhere to when setting up the program. === US States Training Regulations === Some States mandate Security Awareness Training whiles other do not but simply recommend voluntary training. Among states that require the training for its employees include: Colorado (The Colorado Information Security Act, Colorado Revised Statutes 24-37.5-401 et seq.) Connecticut (13 FAM 301.1-1 Cyber Security Awareness Training (PS800)) Florida (Florida Statutes Chapter 282) Georgia (Executive Order GA E.O.182 mandated training within 90 days of issue) Illinois (Cook County) Indiana (IN H 1240) Louisiana (Louisiana Division of Administration, Office of Technology Services p. 52: LA H 633) Maryland (20-07 IT Security Policy) Montana (Mandatory cyber training for executive branch state employees) Nebraska Nevada (agency-by-agency state employee requirement - State Security Standard 123 – IT Security) New Hampshire New Jersey ( NJ A 1654) North Carolina Ohio (IT-15 - Security Awareness and Training) Pennsylvania Texas Utah Vermont Virginia West Virginia (WV Code Section 5A-6-4a) == Training Techniques == Below are some common training techniques, even though some can be blended depending on the operating environment: Interactive video training – This technique allows users to be trained using two-way interactive audio and video instruction. Web-based training – This method allows employees or users to take the training independently and usually has a testing component to determine if learning has taken place. If not, users can be allowed to retake the course and test to ensure there is a complete understanding
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Spectral shape analysis

Spectral shape analysis relies on the spectrum (eigenvalues and/or eigenfunctions) of the Laplace–Beltrami operator to compare and analyze geometric shapes. Since the spectrum of the Laplace–Beltrami operator is invariant under isometries, it is well suited for the analysis or retrieval of non-rigid shapes, i.e. bendable objects such as humans, animals, plants, etc. == Laplace == The Laplace–Beltrami operator is involved in many important differential equations, such as the heat equation and the wave equation. It can be defined on a Riemannian manifold as the divergence of the gradient of a real-valued function f: Δ f := div ⁡ grad ⁡ f . {\displaystyle \Delta f:=\operatorname {div} \operatorname {grad} f.} Its spectral components can be computed by solving the Helmholtz equation (or Laplacian eigenvalue problem): Δ φ i + λ i φ i = 0. {\displaystyle \Delta \varphi _{i}+\lambda _{i}\varphi _{i}=0.} The solutions are the eigenfunctions φ i {\displaystyle \varphi _{i}} (modes) and corresponding eigenvalues λ i {\displaystyle \lambda _{i}} , representing a diverging sequence of positive real numbers. The first eigenvalue is zero for closed domains or when using the Neumann boundary condition. For some shapes, the spectrum can be computed analytically (e.g. rectangle, flat torus, cylinder, disk or sphere). For the sphere, for example, the eigenfunctions are the spherical harmonics. The most important properties of the eigenvalues and eigenfunctions are that they are isometry invariants. In other words, if the shape is not stretched (e.g. a sheet of paper bent into the third dimension), the spectral values will not change. Bendable objects, like animals, plants and humans, can move into different body postures with only minimal stretching at the joints. The resulting shapes are called near-isometric and can be compared using spectral shape analysis. == Discretizations == Geometric shapes are often represented as 2D curved surfaces, 2D surface meshes (usually triangle meshes) or 3D solid objects (e.g. using voxels or tetrahedra meshes). The Helmholtz equation can be solved for all these cases. If a boundary exists, e.g. a square, or the volume of any 3D geometric shape, boundary conditions need to be specified. Several discretizations of the Laplace operator exist (see Discrete Laplace operator) for the different types of geometry representations. Many of these operators do not approximate well the underlying continuous operator. == Spectral shape descriptors == === ShapeDNA and its variants === The ShapeDNA is one of the first spectral shape descriptors. It is the normalized beginning sequence of the eigenvalues of the Laplace–Beltrami operator. Its main advantages are the simple representation (a vector of numbers) and comparison, scale invariance, and in spite of its simplicity a very good performance for shape retrieval of non-rigid shapes. Competitors of shapeDNA include singular values of Geodesic Distance Matrix (SD-GDM) and Reduced BiHarmonic Distance Matrix (R-BiHDM). However, the eigenvalues are global descriptors, therefore the shapeDNA and other global spectral descriptors cannot be used for local or partial shape analysis. === Global point signature (GPS) === The global point signature at a point x {\displaystyle x} is a vector of scaled eigenfunctions of the Laplace–Beltrami operator computed at x {\displaystyle x} (i.e. the spectral embedding of the shape). The GPS is a global feature in the sense that it cannot be used for partial shape matching. === Heat kernel signature (HKS) === The heat kernel signature makes use of the eigen-decomposition of the heat kernel: h t ( x , y ) = ∑ i = 0 ∞ exp ⁡ ( − λ i t ) φ i ( x ) φ i ( y ) . {\displaystyle h_{t}(x,y)=\sum _{i=0}^{\infty }\exp(-\lambda _{i}t)\varphi _{i}(x)\varphi _{i}(y).} For each point on the surface the diagonal of the heat kernel h t ( x , x ) {\displaystyle h_{t}(x,x)} is sampled at specific time values t j {\displaystyle t_{j}} and yields a local signature that can also be used for partial matching or symmetry detection. === Wave kernel signature (WKS) === The WKS follows a similar idea to the HKS, replacing the heat equation with the Schrödinger wave equation. === Improved wave kernel signature (IWKS) === The IWKS improves the WKS for non-rigid shape retrieval by introducing a new scaling function to the eigenvalues and aggregating a new curvature term. === Spectral graph wavelet signature (SGWS) === SGWS is a local descriptor that is not only isometric invariant, but also compact, easy to compute and combines the advantages of both band-pass and low-pass filters. An important facet of SGWS is the ability to combine the advantages of WKS and HKS into a single signature, while allowing a multiresolution representation of shapes. == Spectral Matching == The spectral decomposition of the graph Laplacian associated with complex shapes (see Discrete Laplace operator) provides eigenfunctions (modes) which are invariant to isometries. Each vertex on the shape could be uniquely represented with a combinations of the eigenmodal values at each point, sometimes called spectral coordinates: s ( x ) = ( φ 1 ( x ) , φ 2 ( x ) , … , φ N ( x ) ) for vertex x . {\displaystyle s(x)=(\varphi _{1}(x),\varphi _{2}(x),\ldots ,\varphi _{N}(x)){\text{ for vertex }}x.} Spectral matching consists of establishing the point correspondences by pairing vertices on different shapes that have the most similar spectral coordinates. Early work focused on sparse correspondences for stereoscopy. Computational efficiency now enables dense correspondences on full meshes, for instance between cortical surfaces. Spectral matching could also be used for complex non-rigid image registration, which is notably difficult when images have very large deformations. Such image registration methods based on spectral eigenmodal values indeed capture global shape characteristics, and contrast with conventional non-rigid image registration methods which are often based on local shape characteristics (e.g., image gradients).
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Google Vids

Google Vids (not to be confused with Google Video) is an online timeline-based video editing application included as part of the Google Workspace suite. It is designed to help users create informational videos for work-related purposes. The app uses Google's Gemini technology to enable users to create video storyboards manually or with AI assistance using simple prompts. Features include uploading media, choosing stock videos, images, background music, and a voiceover feature with script generation using AI. The app is currently in testing with select Google Workspace Labs users. Like Kapwing and Capcut, Google Vids is primarily for creating work-related content like sales training, onboarding videos, vendor outreach, and project updates. It offers various styles and templates, collaborative features, and is not limited to videos without the short integration at the moment. Google Vids was announced on April 9, 2024. In September 2025, Google began to roll out a basic version of the application to Google Workspace users.
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Color picker

A color picker (also color chooser or color tool) is a graphical user interface widget, usually found within graphics software or online, used to select colors and, in some cases, to create color schemes (the color picker might be more sophisticated than the palette included with the program). Operating systems such as Microsoft Windows or macOS have a system color picker, which can be used by third-party programs (e.g., Adobe Photoshop). == History == The concept of color pickers dates back to the early days of computer graphics and digital design. Early versions were rudimentary, often featuring basic color palettes and limited functionality. One of the first drawing programs to include a color picker was SketchPad (also referred to as LisaSketch), designed by Bill Atkinson in 1983 to showcase LisaGraf's capabilities. It used a black and white pattern system, using dithering to create the illusion of color depth. With the increased popularity of personal computers with color graphics, there soon came software similar to SketchPad that supported more than two colors, like Broderbund's Dazzle Draw for the Apple II or Electronic Arts' Deluxe Paint. However, the color pickers present in those programs relied on indexed colors. Color pickers, resembling ones used in modern software with support for direct, 24-bit color, appeared soon after the release of the Macintosh II, with the release of programs like Adobe Photoshop and Corel Painter. As the increase of color depth allowed the choice of significantly more colors, the shape and form of color pickers started to diverge. For example, Adobe Photoshop used a hue-saturation color wheel with a slider for brightness in version 0.63, later on switching to a rectangular design accompanied by a hue slider. Corel Painter pioneered the triangular saturation and brightness picker with a hue ring around it, aiming to better represent the continuity of the hue spectrum and the relationship between saturation and brightness. == Purpose == A color picker is used to select and adjust color values. In graphic design and image editing, users typically choose colors via an interface with a visual representation of a color—organized with quasi-perceptually-relevant hue, saturation and lightness dimensions (HSL) – instead of keying in alphanumeric text values. Because color appearance depends on comparison of neighboring colors (see color vision), many interfaces attempt to clarify the relationships between colors. == Interface == Color tools can vary in their interface. Some may use sliders, buttons, text boxes for color values, or direct manipulation. Often a two-dimensional square is used to create a range of color values (such as lightness and saturation) that can be clicked on or selected in some other manner. Drag and drop, color droppers, and various other forms of interfaces are commonly used as well. Usually, color values are also displayed numerically, so they can be precisely remembered and keyed-in later, such as three values of 0-255 representing red, green, and blue, respectively. === Eyedropper === The eyedropper is a tool present in most color pickers and graphics software that allows a user to read a color at a specific point in an image, or position on a display. This enables the color to be transferred to other applications particularly quickly. Modern implementations of eyedropper tools are also available as browser extensions, allowing users to pick colors directly from web pages, such as in Google Chrome and Microsoft Edge. == Working == A color picker has two main parts, first a color slider and second a color canvas. The color slider has a linear or radial gradient of the seven rainbow colors i.e. Violet, Indigo, Blue, Green, Yellow, Orange and Red. It allows one to choose any of the seven primary colors. The color value chosen from the color slider instantly reflects in the color canvas. The color canvas is a mixture of two linear color gradients. First a linear gradient of the current chosen color and second a linear gradient of the black color. This mixture of color gradients lets one choose a lighter and darker version of the current chosen color from the color slider.
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Intelligent control

Intelligent control is a class of control techniques that use various artificial intelligence computing approaches like neural networks, Bayesian probability, fuzzy logic, machine learning, reinforcement learning, evolutionary computation and genetic algorithms. == Overview == Intelligent control can be divided into the following major sub-domains: Neural network control Machine learning control Reinforcement learning Bayesian control Fuzzy control Neuro-fuzzy control Expert Systems Genetic control New control techniques are created continuously as new models of intelligent behavior are created and computational methods developed to support them. === Neural network controller === Neural networks have been used to solve problems in almost all spheres of science and technology. Neural network control basically involves two steps: System identification Control It has been shown that a feedforward network with nonlinear, continuous and differentiable activation functions have universal approximation capability. Recurrent networks have also been used for system identification. Given, a set of input-output data pairs, system identification aims to form a mapping among these data pairs. Such a network is supposed to capture the dynamics of a system. For the control part, deep reinforcement learning has shown its ability to control complex systems. === Bayesian controllers === Bayesian probability has produced a number of algorithms that are in common use in many advanced control systems, serving as state space estimators of some variables that are used in the controller. The Kalman filter and the Particle filter are two examples of popular Bayesian control components. The Bayesian approach to controller design often requires an important effort in deriving the so-called system model and measurement model, which are the mathematical relationships linking the state variables to the sensor measurements available in the controlled system. In this respect, it is very closely linked to the system-theoretic approach to control design.
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Teleradiology

Teleradiology is the transmission of radiological patient images from procedures such as x-rays, Computed tomography (CT), and MRI imaging, from one location to another for the purposes of sharing studies with other radiologists and physicians. Teleradiology allows radiologists to provide services without actually having to be at the location of the patient. This is particularly important when a sub-specialist such as an MRI radiologist, neuroradiologist, pediatric radiologist, or musculoskeletal radiologist is needed, since these professionals are generally only located in large metropolitan areas working during daytime hours. Teleradiology allows for specialists to be available at all times. Teleradiology utilizes standard network technologies such as the Internet, telephone lines, wide area networks, local area networks (LAN) and the latest advanced technologies such as medical cloud computing. Specialized software is used to transmit the images and enable the radiologist to effectively analyze potentially hundreds of images of a given study. Technologies such as advanced graphics processing, voice recognition, artificial intelligence, and image compression are often used in teleradiology. Through teleradiology and mobile DICOM viewers, images can be sent to another part of the hospital or to other locations around the world with equal effort. Teleradiology is a growth technology given that imaging procedures are growing approximately 15% annually against an increase of only 2% in the radiologist population. == Reports == Teleradiology services commonly provide either preliminary or final interpretations of medical imaging studies. Preliminary reads are frequently used in emergency settings to support immediate clinical decisions and may include direct communication of critical findings to the referring physician. Some providers report turnaround times of approximately 30 minutes for emergency cases, with faster processing for time-sensitive conditions such as stroke. Final reads are definitive and used in official patient records and billing. These reports typically include all relevant findings and may require access to prior imaging and clinical data. Teleradiology is also employed to provide off-hour or overflow coverage for healthcare institutions lacking continuous on-site radiology staffing. == Subspecialties == Some teleradiologists are fellowship trained and have a wide variety of subspecialty expertise including such difficult-to-find areas as neuroradiology, pediatric neuroradiology, thoracic imaging, musculoskeletal radiology, mammography, and nuclear cardiology. There are also various medical practitioners who are not radiologists that take on studies in radiology to become sub specialists in their respected fields, an example of this is dentistry where oral and maxillofacial radiology allows those in dentistry to specialize in the acquisition and interpretation of radiographic imaging studies performed for diagnosis of treatment guidance for conditions affecting the maxillofacial region. == Teleultrasound == Teleradiology infrastructure has also been adapted to support point-of-care ultrasound (POCUS) in remote and austere environments. In teleultrasound—also known as telementored ultrasound—a remote expert guides a non-specialist in real time during image acquisition. This technique has been successfully demonstrated in extreme settings, including aboard the International Space Station, on Mount Everest, and during helicopter flight. == Regulations == In the United States, Medicare and Medicaid laws require the teleradiologist to be on U.S. soil in order to qualify for reimbursement of the Final Read. In addition, advanced teleradiology systems must also be HIPAA compliant, which helps to ensure patients' privacy. HIPAA (Health Insurance Portability and Accountability Act of 1996) is a uniform, federal floor of privacy protections for consumers. It limits the ways that entities can use patients' personal information and protects the privacy of all medical information no matter what form it is in. Quality teleradiology must abide by important HIPAA rules to ensure patients' privacy is protected. Also State laws governing the licensing requirements and medical malpractice insurance coverage required for physicians vary from state to state. Ensuring compliance with these laws is a significant overhead expense for larger multi-state teleradiology groups. Medicare (Australia) has identical requirements to that of the United States, where the guidelines are provided by the Department of Health and Ageing, and government based payments fall under the Health Insurance Act. The regulations in Australia are also conducted at both federal and state levels, ensuring that strict guidelines are adhered to at all times, with regular yearly updates and amendments are introduced (usually around March and November of every year), ensuring that the legislation is kept up to date with changes in the industry. One of the most recent changes to Medicare and radiology / teleradiology in Australia was the introduction of the Diagnostic Imaging Accreditation Scheme (DIAS) on 1 July 2008. DIAS was introduced to further improve the quality of Diagnostic Imaging and to amend the Health Insurance Act. == Industry growth == Until the late 1990s teleradiology was primarily used by individual radiologists to interpret occasional emergency studies from offsite locations, often in the radiologists home. The connections were made through standard analog phone lines. Teleradiology expanded rapidly as the growth of the internet and broad band combined with new CT scanner technology to become an essential tool in trauma cases in emergency rooms throughout the country. The occasional 2–3 x-ray studies a week soon became 3–10 CT scans, or more, a night. Because ER physicians are not trained to read CT scans or MRIs, radiologists went from working 8–10 hours a day, five and half days a week to a schedule of 24 hours a day, 7 days a week coverage. This became a particularly acute challenge in smaller rural facilities that only had one solo radiologist with no other to share call. These circumstances spawned a post-dot.com boom of firms and groups that provided medical outsourcing, off-site teleradiology on-call services to hospitals and Radiology Groups around the country. As an example, a teleradiology firm might cover trauma at a hospital in Indiana with doctors based in Texas. Some firms even used overseas doctors in locations like Australia and India. Nighthawk, founded by Paul Berger, was the first to station U.S. licensed radiologists overseas (initially Australia and later Switzerland) to maximize the time zone difference to provide nightcall in U.S. hospitals. Currently, teleradiology firms are facing pricing pressures. Industry consolidation is likely as there are more than 500 of these firms, large and small, throughout the United States.
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RagTime

RagTime is a frame-oriented business publishing software which combines word processing, spreadsheets, simple drawings, image processing, and charts, in a single document/program, integrated software. It is often used to create forms, reports, documentation, desktop publishing, and in office environments. Typical users are business clients, educational institutions, administrations, architects, and also private users. Ragtime includes the following modules: Page layout (forms, templates etc.) Word processing Image processing Spreadsheets, similar to Microsoft Excel Formulas and functions which can be used throughout, in text, graphics, and spreadsheets Charts in different types of diagrams Drawings in vector graphics including lines, polygons, Bézier curves and more Slide show (presentation of RagTime documents) Audio/video Buttons (pop-up menus, switches, and more) that can be used within RagTime documents Import/export of various file formats Support of the AppleScript scripting language available system-wide under macOS == Principle == RagTime differs from most other comparable programs or software packages in its strict frame-oriented design: all content is contained within frames on each page. The content can have a fixed position within its frame or, if it is text or a spreadsheet, flow into another frame that is connected to the first frame via a so-called “pipeline”. RagTime has no different document types for different types of data; all content is stored in a single compound document type. Thus, a RagTime document not only can contain multiple pages, but also multiple layouts within the same document; e.g. spreadsheets in addition to text and images. The RagTime filename extension is .rtd (RagTime document); for templates the extension is .rtt (RagTime template). The current version is RagTime 6.6.5. It is available for OS X (10.6-10.14) and Windows (XP/Vista/7/8/10). == Extensions == FileTime – allows accessing “FileMaker Pro” databases from RagTime documents under OS X RagTime Connect – ODBC database connection for RagTime 6 (Mac and Windows) Johannes – print extension for the simple creation of stapled or folded brochures, booklets etc. PowerFunctions – additional functions for a more effective creation of intelligent documents for exchanging data and for use in mixed Mac/Windows environments MetaFormula – SYLK-based extension that allows calculating text as formula == History == RagTime has been developed since 1985 for the Macintosh – originally named MacFrame – and was published in 1986. When released, it already had the present name, which was chosen following the then-available software package Lotus Jazz. In the European Macintosh market, RagTime quickly gained a prominent position that continues to this day, even though the market share has decreased. Despite repeated attempts, the program could not gain acceptance in the North American market due to its high cost ($395 in 1990). The North American sales office closed in 1991, shortly after Claris Corporation released ClarisWorks which duplicated much of the functionality of RagTime for a lower price. After the manufacturer – first Brüning & Everth, followed by B&E Software and today RagTime.de Development – had focused on the Macintosh only for a very long time, it also released a Windows version, RagTime 5.0, in 1999. However, the program could not assume great significance against established competitors, especially Microsoft Office. Until mid-2006 RagTime was, in addition to the commercial version, also available as a free version (RagTime Solo) for personal use. RagTime Solo included the same features and performance (except for spelling and Syllabification) dictionaries), but was not allowed for use in commercial environments. In other languages RagTime Solo was distributed as RagTime Privat. In a press release from July 5, 2006, RagTime announced the discontinuation of RagTime Solo: “… the RagTime Solo license conditions were often misinterpreted or deliberately flouted. Therefore we discontinued RagTime Solo, there will be no private version of RagTime 6 anymore.” After a successful start of the RagTime 6.0 software, sales edged significantly lower in the following years. Disagreements arose among the shareholders about the continuation of the company, which filed for bankruptcy in July 2007. As a result, the rights to RagTime were taken over by the newly established company RagTime.de Development GmbH, which was responsible for the development. The sales partner RagTime.de Sales GmbH distributed the RagTime products until October 2015. Today RagTime.de Development GmbH is also responsible for sales. The last level of development is the extensively revamped version RagTime 6.6 of 8 October 2015, which also includes new OS X features (e.g. high-resolution “Retina” displays) and supports Windows 10. == Programming == RagTime 1-3 were developed in Pascal, since version 4 the development is completely coded in C++. External programming and automation can be implemented via AppleScript on a Mac, and via OLE/COM-API (e.g. Visual Basic) under Windows. On a Mac, RagTime provides a comprehensive AppleScript library, for the automation of almost any task, from automatic document creation to the export of PDF documents. RagTime also supports “recordings” by use of the “AppleScript Editor”, which allows recording the interactive RagTime operation as an AppleScript program sequence. AppleScripts can be saved in the RagTime document and called via menu or shortcut keys. On Windows, RagTime (since version 6) disposes over an OLE/COM API, which allows automating many RagTime components via external programming. For that purpose there is a type library that installs the available RagTime OLE/COM object catalogue. Programming can be realized in all programming languages supported by Microsoft.
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VueScan

VueScan is a computer program for image scanning, especially of photographs, including negatives. It supports optical character recognition (OCR) of text documents. The software can be downloaded and used free of charge, but adds a watermark on scans until a license is purchased. == Purpose == VueScan is intended to work with a large number of image scanners, excluding specialised professional scanners such as drum scanners, on many computer operating systems (OS), even if drivers for the scanner are not available for the OS. These scanners are supplied with device drivers and software to operate them, included in their price. A 2014 review considered that the reasons to purchase VueScan are to allow older scanners not supported by drivers for newer operating systems to be used in more up-to-date systems and for better scanning and processing of photographs (prints; also slides and negatives when supported by scanners) than is afforded by manufacturers' software. The review did not report any advantages to VueScan's processing of documents over other software. The reviewer considered VueScan comparable to SilverFast, a similar program, with support for some specific scanners better in one or the other. Vuescan supports more scanners, with a single purchase giving access to the full range of both film and flatbed scanners, and costs less. The VueScan program can be used with its own drivers or with drivers supplied by the scanner manufacturer, if supported by the operating system. VueScan drivers can also be used without the VueScan program by application software that supports scanning directly, such as Adobe Photoshop, again enabling the use of scanners without current manufacturers' drivers. In 2019 when Apple released macOS Catalina, they removed support for running 32-bit programs, including 32-bit drivers for scanning equipment. In response, Hamrick released VueScan 9.7, effectively saving thousands of scanners from being rendered obsolete. == Overview == VueScan enables the user to modify and fine-tune the scanning parameters. The program uses its own independent method to interface with scanner hardware, and can support many older scanners under computer operating systems for which drivers are not available, allowing old scanners to be used with newer platforms that do not otherwise support them. VueScan supports an increasing number of scanners and digital cameras; 2,400 on Windows, 2,100 on Mac OS X and 1,900 on Linux in 2018. VueScan is supplied as one downloadable file for each operating system, which supports the full range of scanners. Without the purchase of a license, the program runs in fully functional demonstration mode, identical to Professional mode, except that watermarks are superimposed on saved and printed images. Purchase of a license removes the watermark. A standard license allows updates for one year; a professional license allows unlimited updates and provides some additional features. VueScan supports optical character recognition (OCR), with English included, and 32 additional language packages available on its website. In September 2011, VueScan co-developer Ed Hamrick said that he was selling US$3 million per year of VueScan licenses.
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Open Cloud Computing Interface

The Open Cloud Computing Interface (OCCI) is a set of specifications delivered through the Open Grid Forum, for cloud computing service providers. OCCI has a set of implementations that act as proofs of concept. It builds upon World Wide Web fundamentals by using the Representational State Transfer (REST) approach for interacting with services. == Scope == The aim of the Open Cloud Computing Interface is the development of an open specification and API for cloud offerings. The focus was on Infrastructure-as-a-Service (IaaS) based offerings but the interface can be extended to support Platform and Software as a Service offerings as well. IaaS is one of three primary segments of the cloud computing industry in which compute, storage and network resources are provided as services. The API is based on a review of existing service-provider functionality and a set of use cases contributed by the working group. OCCI is a boundary API that acts as a service front-end to an IaaS provider’s internal infrastructure management framework. OCCI provides commonly understood semantics, syntax and a means of management in the domain of consumer-to-provider IaaS. It covers management of the entire life-cycle of OCCI-defined model entities and is compatible with existing standards such as the Open Virtualization Format (OVF) and the Cloud Data Management Interface (CDMI). Notably, it serves as an integration point for standardization efforts including Distributed Management Task Force, Internet Engineering Task Force and the Storage Networking Industry Association. == Context == OCCI began in March 2009 and was initially led by RabbitMQ and the Complutense University of Madrid. Today, the working group has over 250 members and includes numerous individuals, industry and academic parties. The OCCI operates under the umbrella of the Open Grid Forum (OGF), using a wiki and a mailing list for collaboration. == Goals == Interoperability: allow different Cloud providers to work together without data schema/format translation, facade/proxying between APIs and understanding and/or dependency on multiple APIs Portability: no technical/vendor lock-in and enable services to move between providers allows clients to easily switch between providers based on business objectives (e.g., cost) with minimal technical costs, thus enabling and fostering competition. Integration: the specification can be implemented with both the latest infrastructures or legacy ones. Extensibility: thanks to the use of a meta-model and capabilities discovery features, an OCCI client is able to interact with any OCCI server using provider-specific OCCI extensions. == Specific Implementations == They implement specific extensions of OCCI for a particular service: IaaS, PaaS, brokering, etc. Several implementations have been announced or released. == Generic Implementations (frameworks) == Here are frameworks to build OCCI APIs. Complementing these are a variety of developer tools. == Alternatives == Alternative approaches include the use of the Cloud Infrastructure Management Interface (CIMI) and related standards set from DMTF and the Amazon Web Services interfaces from Amazon. (The latter have not been endorsed by any known Standards organization). OpenNebula conducted a survey of their users in which the results showed, 38% do not expose cloud APIs, their users only interface through the Sunstone GUI, 36% mostly use the Amazon Web Services API, and 26% mostly use the OpenNebula’s OCCI API or the OCCI API offered by rOCCI.
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Non-separable wavelet

Non-separable wavelets are multi-dimensional wavelets that are not directly implemented as tensor products of wavelets on some lower-dimensional space. They have been studied since 1992. They offer a few important advantages. Notably, using non-separable filters leads to more parameters in design, and consequently better filters. The main difference, when compared to the one-dimensional wavelets, is that multi-dimensional sampling requires the use of lattices (e.g., the quincunx lattice). The wavelet filters themselves can be separable or non-separable regardless of the sampling lattice. Thus, in some cases, the non-separable wavelets can be implemented in a separable fashion. Unlike separable wavelet, the non-separable wavelets are capable of detecting structures that are not only horizontal, vertical or diagonal (show less anisotropy). == Examples == Red-black wavelets Contourlets Shearlets Directionlets Steerable pyramids Non-separable schemes for tensor-product wavelets
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Elowan

Elowan is a plant-robot cyborg. Using its own internal bioelectrical signals, The plant has a robotic extension that makes it move towards light sources. Electrodes are inserted into the leaves, stem, and ground to detect the faint bioelectrical signals the plant produces. Then they are amplified so the robot can read them. So when the plant "wants" to go to light, the cyborg automatically goes to the nearest light source. Future extensions of the robot could provide: Protection, growth frameworks, and nutrients. Other factors that could make the cyborg move are temperature, soil, and gravity conditions Elowan is one in a series of plant-electronic hybrid experiments.
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