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  • Anthem medical data breach

    Anthem medical data breach

    The Anthem medical data breach was a medical data breach of information held by Elevance Health, known at that time as Anthem Inc. On February 4, 2015, Anthem, Inc. disclosed that criminal hackers had broken into its servers and had potentially stolen over 37.5 million records that contain personally identifiable information from its servers. On February 24, 2015 Anthem raised the number to 78.8 million people whose personal information had been affected. According to Anthem, Inc., the data breach extended into multiple brands Anthem, Inc. uses to market its healthcare plans, including, Anthem Blue Cross, Anthem Blue Cross and Blue Shield, Blue Cross and Blue Shield of Georgia, Empire Blue Cross and Blue Shield, Amerigroup, Caremore, and UniCare. Healthlink says that it was also a victim. Anthem says users' medical information and financial data were not compromised. Anthem has offered free credit monitoring in the wake of the breach. Michael Daniel, chief adviser on cybersecurity for President Barack Obama, said he would be changing his own password. According to The New York Times, about 80 million company records were hacked, and there is a fear that the stolen data will be used for identity theft. The compromised information contained names, birthdays, medical IDs, social security numbers, street addresses, e-mail addresses and employment information, including income data. == Theft of the data == The data was stolen over a period of weeks the month before the data breach was discovered. Because no medical information was compromised, Anthem was not required by law to encrypt the data. However, Anthem faced several civil class-action lawsuits, which were settled in 2017 at a cost of $115 million. Anthem did not admit any wrongdoing in the settlement. Data from the attack is expected to be sold on the black market. == Impact == Persons whose data was stolen could have resulting problems about identity theft for the rest of their lives. Anthem had a US$100 million insurance policy for cyber problems from American International Group. One report suggested that all of this money could be consumed by the process of notifying customers of the breach. == Responses == Anthem hired Mandiant, a cybersecurity firm, to review their security systems and advised people whose data was stolen to monitor their accounts and remain vigilant. The theft of the data raised fears generally about the theft of medical information. A writer from Harvard Law School suggested that this data breach might spark reform of security practices and government data safety regulation. An investigation conducted by several state insurance commissioners blames the breach on an attacker whose identity was withheld, and claims that the breach was likely ordered by a foreign government whose name was withheld. It also concluded that Anthem had taken reasonable measures to protect its data before the breach and that its remediation plan was effective at shutting down the breach once it was discovered. It also marks the starting date of the breach as February 18, 2014. The lead investigator was the Indiana Department of Insurance (DOI) -- Anthem's principal regulator, because Anthem is headquartered in Indiana. The Indiana DOI hired independent auditors to conduct a security assessment at Anthem, which concluded, "While deficiencies within Anthem’s cybersecurity posture were noted by the Examination Team, these deficiencies were not, in our experience, uncommon to companies comparable to Anthem in size and scope. While the pre-breach deficiencies impacted Anthem’s ability to reduce the likelihood of and quickly detect the Data Breach, the controls implemented subsequent to the Data Breach should improve Anthem’s ability to detect future breaches and enable Anthem to respond more effectively to a future attack than was the case in this instance." Federal regulators also conducted an investigation of the Anthem data breach, resulting in a $16 million settlement between Anthem and the Department of Health and Human Services (HHS) -- by far the largest HHS data breach settlement. An HHS Director overseeing the investigation said, "The largest health data breach in U.S. history fully merits the largest HIPAA settlement in history. Unfortunately, Anthem failed to implement appropriate measures for detecting hackers who had gained access to their system to harvest passwords and steal people's private information." The HHS settlement also required Anthem to perform a risk assessment and correct any identified deficiencies in its cybersecurity, with HHS oversight of Anthem's progress. Approximately 100 private class action lawsuits were filed against Anthem over the data breach and consolidated in California federal court, in front of Judge Koh, a respected authority in data breach litigation. After contested briefing over who should lead the litigation efforts, Judge Koh appoints Eve Cervantez of Altshuler Berzon and Andy Friedman of Cohen Milstein as co-lead counsel, and appointed Eric Gibbs of Gibbs Law Group and Michael Sobel of Lieff Cabraser to head a Plaintiffs' Steering Committee. In 2017, Anthem agreed to settle the litigation for $115 million, the largest ever data breach settlement at the time. The attorneys requested $38 million in fees for their work on the case, but Judge Koh slashed the fee request, finding that only $31 million in fees were merited.

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  • GNU Octave

    GNU Octave

    GNU Octave is a scientific programming language for scientific computing and numerical computation. Among other things, Octave can be used to solve linear and nonlinear problems numerically and to perform other numerical experiments using a language that is mostly compatible with MATLAB. It may also be used as a batch-oriented language. As part of the GNU Project, it is free software under the terms of the GNU General Public License. == History == The project was conceived around 1988. At first it was intended to be a companion to a chemical reactor design course. Full development was started by John W. Eaton in 1992. The first alpha release dates back to 4 January 1993 and on 17 February 1994 version 1.0 was released. Version 9.2.0 was released on 7 June 2024. The program is named after Octave Levenspiel, a former professor of the principal author. Levenspiel was known for his ability to perform quick back-of-the-envelope calculations. == Development history == == Developments == In addition to use on desktops for personal scientific computing, Octave is used in academia and industry. For example, Octave was used on a massive parallel computer at Pittsburgh Supercomputing Center to find vulnerabilities related to guessing social security numbers. Acceleration with OpenCL or CUDA is also possible with use of GPUs. == Technical details == Octave is written in C++ using the C++ standard library. Octave uses an interpreter to execute the Octave scripting language. Octave is extensible using dynamically loadable modules. Octave interpreter has an OpenGL-based graphics engine to create plots, graphs and charts and to save or print them. Alternatively, gnuplot can be used for the same purpose. Octave includes a graphical user interface (GUI) in addition to the traditional command-line interface (CLI); see #User interfaces for details. == Octave, the language == The Octave language is an interpreted programming language. It is a structured programming language (similar to C) and supports many common C standard library functions, and also certain UNIX system calls and functions. However, it does not support passing arguments by reference although function arguments are copy-on-write to avoid unnecessary duplication. Octave programs consist of a list of function calls or a script. The syntax is matrix-based and provides various functions for matrix operations. It supports various data structures and allows object-oriented programming. Its syntax is very similar to MATLAB, and careful programming of a script will allow it to run on both Octave and MATLAB. Because Octave is made available under the GNU General Public License, it may be freely changed, copied and used. The program runs on Microsoft Windows and most Unix and Unix-like operating systems, including Linux, Android, and macOS. == Notable features == === Command and variable name completion === Typing a TAB character on the command line causes Octave to attempt to complete variable, function, and file names (similar to Bash's tab completion). Octave uses the text before the cursor as the initial portion of the name to complete. === Command history === When running interactively, Octave saves the commands typed in an internal buffer so that they can be recalled and edited. === Data structures === Octave includes a limited amount of support for organizing data in structures. In this example, we see a structure x with elements a, b, and c, (an integer, an array, and a string, respectively): === Short-circuit Boolean operators === Octave's && and || logical operators are evaluated in a short-circuit fashion (like the corresponding operators in the C language), in contrast to the element-by-element operators & and |. === Increment and decrement operators === Octave includes the C-like increment and decrement operators ++ and -- in both their prefix and postfix forms. Octave also does augmented assignment, e.g. x += 5. === Unwind-protect === Octave supports a limited form of exception handling modelled after the unwind_protect of Lisp. The general form of an unwind_protect block looks like this: As a general rule, GNU Octave recognizes as termination of a given block either the keyword end (which is compatible with the MATLAB language) or a more specific keyword endblock or, in some cases, end_block. As a consequence, an unwind_protect block can be terminated either with the keyword end_unwind_protect as in the example, or with the more portable keyword end. The cleanup part of the block is always executed. In case an exception is raised by the body part, cleanup is executed immediately before propagating the exception outside the block unwind_protect. GNU Octave also supports another form of exception handling (compatible with the MATLAB language): This latter form differs from an unwind_protect block in two ways. First, exception_handling is only executed when an exception is raised by body. Second, after the execution of exception_handling the exception is not propagated outside the block (unless a rethrow( lasterror ) statement is explicitly inserted within the exception_handling code). === Variable-length argument lists === Octave has a mechanism for handling functions that take an unspecified number of arguments without explicit upper limit. To specify a list of zero or more arguments, use the special argument varargin as the last (or only) argument in the list. varargin is a cell array containing all the input arguments. === Variable-length return lists === A function can be set up to return any number of values by using the special return value varargout. For example: === C++ integration === It is also possible to execute Octave code directly in a C++ program. For example, here is a code snippet for calling rand([10,1]): C and C++ code can be integrated into GNU Octave by creating oct files, or using the MATLAB compatible MEX files. == MATLAB compatibility == Octave has been built with MATLAB compatibility in mind, and shares many features with MATLAB: % Script: myscript.m a = 5; b = a 2 % Function: myfunc.m function result = myfunc(x) result = x^2 + 3; end Matrices as fundamental data type. Built-in support for complex numbers. Powerful built-in math functions and extensive function libraries. Extensibility in the form of user-defined functions. Octave treats incompatibility with MATLAB as a bug; therefore, it could be considered a software clone, which does not infringe software copyright as per Lotus v. Borland court case. MATLAB scripts from the MathWorks' FileExchange repository in principle are compatible with Octave. However, while they are often provided and uploaded by users under an Octave compatible and proper open source BSD license, the FileExchange Terms of use prohibit any usage beside MathWorks' proprietary MATLAB. === Syntax compatibility === There are a few purposeful, albeit minor, syntax additions Archived 2012-04-26 at the Wayback Machine: Comment lines can be prefixed with the # character as well as the % character; Various C-based operators ++, --, +=, =, /= are supported; Elements can be referenced without creating a new variable by cascaded indexing, e.g. [1:10](3); Strings can be defined with the double-quote " character as well as the single-quote ' character; When the variable type is single (a single-precision floating-point number), Octave calculates the "mean" in the single-domain (MATLAB in double-domain) which is faster but gives less accurate results; Blocks can also be terminated with more specific Control structure keywords, i.e., endif, endfor, endwhile, etc.; Functions can be defined within scripts and at the Octave prompt; Presence of a do-until loop (similar to do-while in C). === Function compatibility === Many, but not all, of the numerous MATLAB functions are available in GNU Octave, some of them accessible through packages in Octave Forge. The functions available as part of either core Octave or Forge packages are listed online Archived 2024-03-14 at the Wayback Machine. A list of unavailable functions is included in the Octave function __unimplemented.m__. Unimplemented functions are also listed under many Octave Forge packages in the Octave Wiki. When an unimplemented function is called the following error message is shown: == User interfaces == Octave comes with an official graphical user interface (GUI) and an integrated development environment (IDE) based on Qt. It has been available since Octave 3.8, and has become the default interface (over the command-line interface) with the release of Octave 4.0. It was well-received by an EDN contributor, who wrote "[Octave] now has a very workable GUI" in reviewing the then-new GUI in 2014. Several 3rd-party graphical front-ends have also been developed, like ToolboX for coding education. == GUI applications == With Octave code, the user can create GUI applications. See GUI Development (GNU Octave (version 7.1.0)). Below are some examples: Button, edit control, checkboxTextboxListbox wit

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  • Robust principal component analysis

    Robust principal component analysis

    Robust Principal Component Analysis (RPCA) is a modification of the widely used statistical procedure of principal component analysis (PCA) which works well with respect to grossly corrupted observations. A number of different approaches exist for Robust PCA, including an idealized version of Robust PCA, which aims to recover a low-rank matrix L0 from highly corrupted measurements M = L0 +S0. This decomposition in low-rank and sparse matrices can be achieved by techniques such as Principal Component Pursuit method (PCP), Stable PCP, Quantized PCP, Block based PCP, and Local PCP. Then, optimization methods are used such as the Augmented Lagrange Multiplier Method (ALM), Alternating Direction Method (ADM), Fast Alternating Minimization (FAM), Iteratively Reweighted Least Squares (IRLS ) or alternating projections (AP). == Algorithms == === Non-convex method === The 2014 guaranteed algorithm for the robust PCA problem (with the input matrix being M = L + S {\displaystyle M=L+S} ) is an alternating minimization type algorithm. The computational complexity is O ( m n r 2 log ⁡ 1 ϵ ) {\displaystyle O\left(mnr^{2}\log {\frac {1}{\epsilon }}\right)} where the input is the superposition of a low-rank (of rank r {\displaystyle r} ) and a sparse matrix of dimension m × n {\displaystyle m\times n} and ϵ {\displaystyle \epsilon } is the desired accuracy of the recovered solution, i.e., ‖ L ^ − L ‖ F ≤ ϵ {\displaystyle \|{\widehat {L}}-L\|_{F}\leq \epsilon } where L {\displaystyle L} is the true low-rank component and L ^ {\displaystyle {\widehat {L}}} is the estimated or recovered low-rank component. Intuitively, this algorithm performs projections of the residual onto the set of low-rank matrices (via the SVD operation) and sparse matrices (via entry-wise hard thresholding) in an alternating manner - that is, low-rank projection of the difference the input matrix and the sparse matrix obtained at a given iteration followed by sparse projection of the difference of the input matrix and the low-rank matrix obtained in the previous step, and iterating the two steps until convergence. This alternating projections algorithm is later improved by an accelerated version, coined AccAltProj. The acceleration is achieved by applying a tangent space projection before projecting the residue onto the set of low-rank matrices. This trick improves the computational complexity to O ( m n r log ⁡ 1 ϵ ) {\displaystyle O\left(mnr\log {\frac {1}{\epsilon }}\right)} with a much smaller constant in front while it maintains the theoretically guaranteed linear convergence. Another fast version of accelerated alternating projections algorithm is IRCUR. It uses the structure of CUR decomposition in alternating projections framework to dramatically reduces the computational complexity of RPCA to O ( max { m , n } r 2 log ⁡ ( m ) log ⁡ ( n ) log ⁡ 1 ϵ ) {\displaystyle O\left(\max\{m,n\}r^{2}\log(m)\log(n)\log {\frac {1}{\epsilon }}\right)} === Convex relaxation === This method consists of relaxing the rank constraint r a n k ( L ) {\displaystyle rank(L)} in the optimization problem to the nuclear norm ‖ L ‖ ∗ {\displaystyle \|L\|_{}} and the sparsity constraint ‖ S ‖ 0 {\displaystyle \|S\|_{0}} to ℓ 1 {\displaystyle \ell _{1}} -norm ‖ S ‖ 1 {\displaystyle \|S\|_{1}} . The resulting program can be solved using methods such as the method of Augmented Lagrange Multipliers. === Deep-learning augmented method === Some recent works propose RPCA algorithms with learnable/training parameters. Such a learnable/trainable algorithm can be unfolded as a deep neural network whose parameters can be learned via machine learning techniques from a given dataset or problem distribution. The learned algorithm will have superior performance on the corresponding problem distribution. == Applications == RPCA has many real life important applications particularly when the data under study can naturally be modeled as a low-rank plus a sparse contribution. Following examples are inspired by contemporary challenges in computer science, and depending on the applications, either the low-rank component or the sparse component could be the object of interest: === Video surveillance === Given a sequence of surveillance video frames, it is often required to identify the activities that stand out from the background. If we stack the video frames as columns of a matrix M, then the low-rank component L0 naturally corresponds to the stationary background and the sparse component S0 captures the moving objects in the foreground. === Face recognition === Images of a convex, Lambertian surface under varying illuminations span a low-dimensional subspace. This is one of the reasons for effectiveness of low-dimensional models for imagery data. In particular, it is easy to approximate images of a human's face by a low-dimensional subspace. To be able to correctly retrieve this subspace is crucial in many applications such as face recognition and alignment. It turns out that RPCA can be applied successfully to this problem to exactly recover the face.

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  • UIMA

    UIMA

    UIMA ( yoo-EE-mə), short for Unstructured Information Management Architecture, is an OASIS standard for content analytics, originally developed at IBM. It provides a component software architecture for the development, discovery, composition, and deployment of multi-modal analytics for the analysis of unstructured information and integration with search technologies. == Structure == The UIMA architecture can be thought of in four dimensions: It specifies component interfaces in an analytics pipeline. It describes a set of design patterns. It suggests two data representations: an in-memory representation of annotations for high-performance analytics and an XML representation of annotations for integration with remote web services. It suggests development roles allowing tools to be used by users with diverse skills. == Implementations and uses == Apache UIMA, a reference implementation of UIMA, is maintained by the Apache Software Foundation. UIMA is used in a number of software projects: IBM Research's Watson uses UIMA for analyzing unstructured data. The Clinical Text Analysis and Knowledge Extraction System (Apache cTAKES) is a UIMA-based system for information extraction from medical records. DKPro Core is a collection of reusable UIMA components for general-purpose natural language processing.

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  • Aikuma

    Aikuma

    Aikuma is an Android app for collecting speech recordings with time-aligned translations. The app includes a text-free interface for consecutive interpretation, designed for users who are not literate. The Aikuma won Grand Prize in the Open Source Software World Challenge (2013). == Name == Aikuma means "meeting place" in Usarufa, a Papuan language where this software was first used in 2012. == History == Aikuma was developed with sponsorship from the National Science Foundation, including a $101,501 (US) project, "to use mobile telephones to collect larger amounts of data on undocumented endangered languages than would never be possible through usual fieldwork." Aikuma and its modified version (Lig-Aikuma) have been used for collecting substantial quantities of audio in remote indigenous villages. A modified version of the app, called Lig-Aikuma, has been developed at the Université Grenoble Alpes (LIG laboratory) and implements new features such as elicitation of speech from text, images and videos. == Similar Software == Lingua Libre is an online collaborative project and tool by the Wikimedia France association, which can be used as a tool for Language Preservation. Lingua Libre enables to record words, phrases, or sentences of any language, oral (audio recording) or signed (video recording). It is a highly efficient method to record endangered languages since up to 1000 words can be recorded per hour. All the content is under Free License, and speakers of minority languages are encouraged to record their own dialects.

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  • SqueezeNet

    SqueezeNet

    SqueezeNet is a deep neural network for image classification released in 2016. SqueezeNet was developed by researchers at DeepScale, University of California, Berkeley, and Stanford University. In designing SqueezeNet, the authors' goal was to create a smaller neural network with fewer parameters while achieving competitive accuracy. Their best-performing model achieved the same accuracy as AlexNet on ImageNet classification, but has a size 510x less than it. == Version history == SqueezeNet was originally released on February 22, 2016. This original version of SqueezeNet was implemented on top of the Caffe deep learning software framework. Shortly thereafter, the open-source research community ported SqueezeNet to a number of other deep learning frameworks. On February 26, 2016, Eddie Bell released a port of SqueezeNet for the Chainer deep learning framework. On March 2, 2016, Guo Haria released a port of SqueezeNet for the Apache MXNet framework. On June 3, 2016, Tammy Yang released a port of SqueezeNet for the Keras framework. In 2017, companies including Baidu, Xilinx, Imagination Technologies, and Synopsys demonstrated SqueezeNet running on low-power processing platforms such as smartphones, FPGAs, and custom processors. As of 2018, SqueezeNet ships "natively" as part of the source code of a number of deep learning frameworks such as PyTorch, Apache MXNet, and Apple CoreML. In addition, third party developers have created implementations of SqueezeNet that are compatible with frameworks such as TensorFlow. Below is a summary of frameworks that support SqueezeNet. == Relationship to other networks == === AlexNet === SqueezeNet was originally described in SqueezeNet: AlexNet-level accuracy with 50x fewer parameters and <0.5MB model size. AlexNet is a deep neural network that has 240 MB of parameters, and SqueezeNet has just 5 MB of parameters. This small model size can more easily fit into computer memory and can more easily be transmitted over a computer network. However, it's important to note that SqueezeNet is not a "squeezed version of AlexNet." Rather, SqueezeNet is an entirely different DNN architecture than AlexNet. What SqueezeNet and AlexNet have in common is that both of them achieve approximately the same level of accuracy when evaluated on the ImageNet image classification validation dataset. === Model compression === Model compression (e.g. quantization and pruning of model parameters) can be applied to a deep neural network after it has been trained. In the SqueezeNet paper, the authors demonstrated that a model compression technique called Deep Compression can be applied to SqueezeNet to further reduce the size of the parameter file from 5 MB to 500 KB. Deep Compression has also been applied to other DNNs, such as AlexNet and VGG. == Variants == Some of the members of the original SqueezeNet team have continued to develop resource-efficient deep neural networks for a variety of applications. A few of these works are noted in the following table. As with the original SqueezeNet model, the open-source research community has ported and adapted these newer "squeeze"-family models for compatibility with multiple deep learning frameworks. In addition, the open-source research community has extended SqueezeNet to other applications, including semantic segmentation of images and style transfer.

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  • Stochastic block model

    Stochastic block model

    The stochastic block model is a generative model for random graphs. This model tends to produce graphs containing communities, subsets of nodes characterized by being connected with one another with particular edge densities. For example, edges may be more common within communities than between communities. Its mathematical formulation was first introduced in 1983 in the field of social network analysis by Paul W. Holland et al. The stochastic block model is important in statistics, machine learning, and network science, where it serves as a useful benchmark for the task of recovering community structure in graph data. == Definition == The stochastic block model takes the following parameters: The number n {\displaystyle n} of vertices; a partition of the vertex set { 1 , … , n } {\displaystyle \{1,\ldots ,n\}} into disjoint subsets C 1 , … , C r {\displaystyle C_{1},\ldots ,C_{r}} , called communities; a symmetric r × r {\displaystyle r\times r} matrix P {\displaystyle P} of edge probabilities. The edge set is then sampled at random as follows: any two vertices u ∈ C i {\displaystyle u\in C_{i}} and v ∈ C j {\displaystyle v\in C_{j}} are connected by an edge with probability P i j {\displaystyle P_{ij}} . An example problem is: given a graph with n {\displaystyle n} vertices, where the edges are sampled as described, recover the groups C 1 , … , C r {\displaystyle C_{1},\ldots ,C_{r}} . == Special cases == If the probability matrix is a constant, in the sense that P i j = p {\displaystyle P_{ij}=p} for all i , j {\displaystyle i,j} , then the result is the Erdős–Rényi model G ( n , p ) {\displaystyle G(n,p)} . This case is degenerate—the partition into communities becomes irrelevant—but it illustrates a close relationship to the Erdős–Rényi model. The planted partition model is the special case that the values of the probability matrix P {\displaystyle P} are a constant p {\displaystyle p} on the diagonal and another constant q {\displaystyle q} off the diagonal. Thus two vertices within the same community share an edge with probability p {\displaystyle p} , while two vertices in different communities share an edge with probability q {\displaystyle q} . Sometimes it is this restricted model that is called the stochastic block model. The case where p > q {\displaystyle p>q} is called an assortative model, while the case p < q {\displaystyle p P j k {\displaystyle P_{ii}>P_{jk}} whenever j ≠ k {\displaystyle j\neq k} : all diagonal entries dominate all off-diagonal entries. A model is called weakly assortative if P i i > P i j {\displaystyle P_{ii}>P_{ij}} whenever i ≠ j {\displaystyle i\neq j} : each diagonal entry is only required to dominate the rest of its own row and column. Disassortative forms of this terminology exist, by reversing all inequalities. For some algorithms, recovery might be easier for block models with assortative or disassortative conditions of this form. == Typical statistical tasks == Much of the literature on algorithmic community detection addresses three statistical tasks: detection, partial recovery, and exact recovery. === Detection === The goal of detection algorithms is simply to determine, given a sampled graph, whether the graph has latent community structure. More precisely, a graph might be generated, with some known prior probability, from a known stochastic block model, and otherwise from a similar Erdos-Renyi model. The algorithmic task is to correctly identify which of these two underlying models generated the graph. === Partial recovery === In partial recovery, the goal is to approximately determine the latent partition into communities, in the sense of finding a partition that is correlated with the true partition significantly better than a random guess. === Exact recovery === In exact recovery, the goal is to recover the latent partition into communities exactly. The community sizes and probability matrix may be known or unknown. == Statistical lower bounds and threshold behavior == Stochastic block models exhibit a sharp threshold effect reminiscent of percolation thresholds. Suppose that we allow the size n {\displaystyle n} of the graph to grow, keeping the community sizes in fixed proportions. If the probability matrix remains fixed, tasks such as partial and exact recovery become feasible for all non-degenerate parameter settings. However, if we scale down the probability matrix at a suitable rate as n {\displaystyle n} increases, we observe a sharp phase transition: for certain settings of the parameters, it will become possible to achieve recovery with probability tending to 1, whereas on the opposite side of the parameter threshold, the probability of recovery tends to 0 no matter what algorithm is used. For partial recovery, the appropriate scaling is to take P i j = P ~ i j / n {\displaystyle P_{ij}={\tilde {P}}_{ij}/n} for fixed P ~ {\displaystyle {\tilde {P}}} , resulting in graphs of constant average degree. In the case of two equal-sized communities, in the assortative planted partition model with probability matrix P = ( p ~ / n q ~ / n q ~ / n p ~ / n ) , {\displaystyle P=\left({\begin{array}{cc}{\tilde {p}}/n&{\tilde {q}}/n\\{\tilde {q}}/n&{\tilde {p}}/n\end{array}}\right),} partial recovery is feasible with probability 1 − o ( 1 ) {\displaystyle 1-o(1)} whenever ( p ~ − q ~ ) 2 > 2 ( p ~ + q ~ ) {\displaystyle ({\tilde {p}}-{\tilde {q}})^{2}>2({\tilde {p}}+{\tilde {q}})} , whereas any estimator fails partial recovery with probability 1 − o ( 1 ) {\displaystyle 1-o(1)} whenever ( p ~ − q ~ ) 2 < 2 ( p ~ + q ~ ) {\displaystyle ({\tilde {p}}-{\tilde {q}})^{2}<2({\tilde {p}}+{\tilde {q}})} . For exact recovery, the appropriate scaling is to take P i j = P ~ i j log ⁡ n / n {\displaystyle P_{ij}={\tilde {P}}_{ij}\log n/n} , resulting in graphs of logarithmic average degree. Here a similar threshold exists: for the assortative planted partition model with r {\displaystyle r} equal-sized communities, the threshold lies at p ~ − q ~ = r {\displaystyle {\sqrt {\tilde {p}}}-{\sqrt {\tilde {q}}}={\sqrt {r}}} . In fact, the exact recovery threshold is known for the fully general stochastic block model. == Algorithms == In principle, exact recovery can be solved in its feasible range using maximum likelihood, but this amounts to solving a constrained or regularized cut problem such as minimum bisection that is typically NP-complete. Hence, no known efficient algorithms will correctly compute the maximum-likelihood estimate in the worst case. However, a wide variety of algorithms perform well in the average case, and many high-probability performance guarantees have been proven for algorithms in both the partial and exact recovery settings. Successful algorithms include spectral clustering of the vertices, semidefinite programming, forms of belief propagation, and community detection among others. == Variants == Several variants of the model exist. One minor tweak allocates vertices to communities randomly, according to a categorical distribution, rather than in a fixed partition. More significant variants include the degree-corrected stochastic block model, the hierarchical stochastic block model, the geometric block model, censored block model and the mixed-membership block model. == Topic models == Stochastic block model have been recognised to be a topic model on bipartite networks. In a network of documents and words, Stochastic block model can identify topics: group of words with a similar meaning. == Extensions to signed graphs == Signed graphs allow for both favorable and adverse relationships and serve as a common model choice for various data analysis applications, e.g., correlation clustering. The stochastic block model can be trivially extended to signed graphs by assigning both positive and negative edge weights or equivalently using a difference of adjacency matrices of two stochastic block models. == DARPA/MIT/AWS Graph Challenge: streaming stochastic block partition == GraphChallenge encourages community approaches to developing new solutions for analyzing graphs and sparse data derived from social media, sensor feeds, and scientific data to enable relationships between events to be discovered as they unfold in the field. Streaming stochastic block partition is one of the challenges since 2017. Spectral clustering has demonstrated outstanding performance compared to the original and even improved base algorithm, matching its quality of clusters while being multiple orders of magnitude faster.

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  • Distributional Soft Actor Critic

    Distributional Soft Actor Critic

    Distributional Soft Actor Critic (DSAC) is a suite of model-free off-policy reinforcement learning algorithms, tailored for learning decision-making or control policies in complex systems with continuous action spaces. Distinct from traditional methods that focus solely on expected returns, DSAC algorithms are designed to learn a Gaussian distribution over stochastic returns, called value distribution. This focus on Gaussian value distribution learning notably diminishes value overestimations, which in turn boosts policy performance. Additionally, the value distribution learned by DSAC can also be used for risk-aware policy learning. From a technical standpoint, DSAC is essentially a distributional adaptation of the well-established soft actor-critic (SAC) method. To date, the DSAC family comprises two iterations: the original DSAC-v1 and its successor, DSAC-T (also known as DSAC-v2), with the latter demonstrating superior capabilities over the Soft Actor-Critic (SAC) in Mujoco benchmark tasks. The source code for DSAC-T can be found at the following URL: Jingliang-Duan/DSAC-T. Both iterations have been integrated into an advanced, Pytorch-powered reinforcement learning toolkit named GOPS: GOPS (General Optimal control Problem Solver).

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  • Version space learning

    Version space learning

    Version space learning is a logical approach to machine learning, specifically binary classification. Version space learning algorithms search a predefined space of hypotheses, viewed as a set of logical sentences. Formally, the hypothesis space is a disjunction H 1 ∨ H 2 ∨ . . . ∨ H n {\displaystyle H_{1}\lor H_{2}\lor ...\lor H_{n}} (i.e., one or more of hypotheses 1 through n are true). A version space learning algorithm is presented with examples, which it will use to restrict its hypothesis space; for each example x, the hypotheses that are inconsistent with x are removed from the space. This iterative refining of the hypothesis space is called the candidate elimination algorithm, the hypothesis space maintained inside the algorithm, its version space. == The version space algorithm == In settings where there is a generality-ordering on hypotheses, it is possible to represent the version space by two sets of hypotheses: (1) the most specific consistent hypotheses, and (2) the most general consistent hypotheses, where "consistent" indicates agreement with observed data. The most specific hypotheses (i.e., the specific boundary SB) cover the observed positive training examples, and as little of the remaining feature space as possible. These hypotheses, if reduced any further, exclude a positive training example, and hence become inconsistent. These minimal hypotheses essentially constitute a (pessimistic) claim that the true concept is defined just by the positive data already observed: Thus, if a novel (never-before-seen) data point is observed, it should be assumed to be negative. (I.e., if data has not previously been ruled in, then it's ruled out.) The most general hypotheses (i.e., the general boundary GB) cover the observed positive training examples, but also cover as much of the remaining feature space without including any negative training examples. These, if enlarged any further, include a negative training example, and hence become inconsistent. These maximal hypotheses essentially constitute a (optimistic) claim that the true concept is defined just by the negative data already observed: Thus, if a novel (never-before-seen) data point is observed, it should be assumed to be positive. (I.e., if data has not previously been ruled out, then it's ruled in.) Thus, during learning, the version space (which itself is a set – possibly infinite – containing all consistent hypotheses) can be represented by just its lower and upper bounds (maximally general and maximally specific hypothesis sets), and learning operations can be performed just on these representative sets. After learning, classification can be performed on unseen examples by testing the hypothesis learned by the algorithm. If the example is consistent with multiple hypotheses, a majority vote rule can be applied. == Historical background == The notion of version spaces was introduced by Mitchell in the early 1980s as a framework for understanding the basic problem of supervised learning within the context of solution search. Although the basic "candidate elimination" search method that accompanies the version space framework is not a popular learning algorithm, there are some practical implementations that have been developed (e.g., Sverdlik & Reynolds 1992, Hong & Tsang 1997, Dubois & Quafafou 2002). A major drawback of version space learning is its inability to deal with noise: any pair of inconsistent examples can cause the version space to collapse, i.e., become empty, so that classification becomes impossible. One solution of this problem is proposed by Dubois and Quafafou that proposed the Rough Version Space, where rough sets based approximations are used to learn certain and possible hypothesis in the presence of inconsistent data.

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  • Gaussian adaptation

    Gaussian adaptation

    Gaussian adaptation (GA), also called normal or natural adaptation (NA) is an evolutionary algorithm designed for the maximization of manufacturing yield due to statistical deviation of component values of signal processing systems. In short, GA is a stochastic adaptive process where a number of samples of an n-dimensional vector x[xT = (x1, x2, ..., xn)] are taken from a multivariate Gaussian distribution, N(m, M), having mean m and moment matrix M. The samples are tested for fail or pass. The first- and second-order moments of the Gaussian restricted to the pass samples are m and M. The outcome of x as a pass sample is determined by a function s(x), 0 < s(x) < q ≤ 1, such that s(x) is the probability that x will be selected as a pass sample. The average probability of finding pass samples (yield) is P ( m ) = ∫ s ( x ) N ( x − m ) d x {\displaystyle P(m)=\int s(x)N(x-m)\,dx} Then the theorem of GA states: For any s(x) and for any value of P < q, there always exist a Gaussian p. d. f. [ probability density function ] that is adapted for maximum dispersion. The necessary conditions for a local optimum are m = m and M proportional to M. The dual problem is also solved: P is maximized while keeping the dispersion constant (Kjellström, 1991). Proofs of the theorem may be found in the papers by Kjellström, 1970, and Kjellström & Taxén, 1981. Since dispersion is defined as the exponential of entropy/disorder/average information it immediately follows that the theorem is valid also for those concepts. Altogether, this means that Gaussian adaptation may carry out a simultaneous maximisation of yield and average information (without any need for the yield or the average information to be defined as criterion functions). The theorem is valid for all regions of acceptability and all Gaussian distributions. It may be used by cyclic repetition of random variation and selection (like the natural evolution). In every cycle a sufficiently large number of Gaussian distributed points are sampled and tested for membership in the region of acceptability. The centre of gravity of the Gaussian, m, is then moved to the centre of gravity of the approved (selected) points, m. Thus, the process converges to a state of equilibrium fulfilling the theorem. A solution is always approximate because the centre of gravity is always determined for a limited number of points. It was used for the first time in 1969 as a pure optimization algorithm making the regions of acceptability smaller and smaller (in analogy to simulated annealing, Kirkpatrick 1983). Since 1970 it has been used for both ordinary optimization and yield maximization. == Natural evolution and Gaussian adaptation == It has also been compared to the natural evolution of populations of living organisms. In this case s(x) is the probability that the individual having an array x of phenotypes will survive by giving offspring to the next generation; a definition of individual fitness given by Hartl 1981. The yield, P, is replaced by the mean fitness determined as a mean over the set of individuals in a large population. Phenotypes are often Gaussian distributed in a large population and a necessary condition for the natural evolution to be able to fulfill the theorem of Gaussian adaptation, with respect to all Gaussian quantitative characters, is that it may push the centre of gravity of the Gaussian to the centre of gravity of the selected individuals. This may be accomplished by the Hardy–Weinberg law. This is possible because the theorem of Gaussian adaptation is valid for any region of acceptability independent of the structure (Kjellström, 1996). In this case the rules of genetic variation such as crossover, inversion, transposition etcetera may be seen as random number generators for the phenotypes. So, in this sense Gaussian adaptation may be seen as a genetic algorithm. == How to climb a mountain == Mean fitness may be calculated provided that the distribution of parameters and the structure of the landscape is known. The real landscape is not known, but figure below shows a fictitious profile (blue) of a landscape along a line (x) in a room spanned by such parameters. The red curve is the mean based on the red bell curve at the bottom of figure. It is obtained by letting the bell curve slide along the x-axis, calculating the mean at every location. As can be seen, small peaks and pits are smoothed out. Thus, if evolution is started at A with a relatively small variance (the red bell curve), then climbing will take place on the red curve. The process may get stuck for millions of years at B or C, as long as the hollows to the right of these points remain, and the mutation rate is too small. If the mutation rate is sufficiently high, the disorder or variance may increase and the parameter(s) may become distributed like the green bell curve. Then the climbing will take place on the green curve, which is even more smoothed out. Because the hollows to the right of B and C have now disappeared, the process may continue up to the peaks at D. But of course the landscape puts a limit on the disorder or variability. Besides — dependent on the landscape — the process may become very jerky, and if the ratio between the time spent by the process at a local peak and the time of transition to the next peak is very high, it may as well look like a punctuated equilibrium as suggested by Gould (see Ridley). == Computer simulation of Gaussian adaptation == Thus far the theory only considers mean values of continuous distributions corresponding to an infinite number of individuals. In reality however, the number of individuals is always limited, which gives rise to an uncertainty in the estimation of m and M (the moment matrix of the Gaussian). And this may also affect the efficiency of the process. Unfortunately very little is known about this, at least theoretically. The implementation of normal adaptation on a computer is a fairly simple task. The adaptation of m may be done by one sample (individual) at a time, for example m(i + 1) = (1 – a) m(i) + ax where x is a pass sample, and a < 1 a suitable constant so that the inverse of a represents the number of individuals in the population. M may in principle be updated after every step y leading to a feasible point x = m + y according to: M(i + 1) = (1 – 2b) M(i) + 2byyT, where yT is the transpose of y and b << 1 is another suitable constant. In order to guarantee a suitable increase of average information, y should be normally distributed with moment matrix μ2M, where the scalar μ > 1 is used to increase average information (information entropy, disorder, diversity) at a suitable rate. But M will never be used in the calculations. Instead we use the matrix W defined by WWT = M. Thus, we have y = Wg, where g is normally distributed with the moment matrix μU, and U is the unit matrix. W and WT may be updated by the formulas W = (1 – b)W + bygT and WT = (1 – b)WT + bgyT because multiplication gives M = (1 – 2b)M + 2byyT, where terms including b2 have been neglected. Thus, M will be indirectly adapted with good approximation. In practice it will suffice to update W only W(i + 1) = (1 – b)W(i) + bygT. This is the formula used in a simple 2-dimensional model of a brain satisfying the Hebbian rule of associative learning; see the next section (Kjellström, 1996 and 1999). The figure below illustrates the effect of increased average information in a Gaussian p.d.f. used to climb a mountain Crest (the two lines represent the contour line). Both the red and green cluster have equal mean fitness, about 65%, but the green cluster has a much higher average information making the green process much more efficient. The effect of this adaptation is not very salient in a 2-dimensional case, but in a high-dimensional case, the efficiency of the search process may be increased by many orders of magnitude. == The evolution in the brain == In the brain the evolution of DNA-messages is supposed to be replaced by an evolution of signal patterns and the phenotypic landscape is replaced by a mental landscape, the complexity of which will hardly be second to the former. The metaphor with the mental landscape is based on the assumption that certain signal patterns give rise to a better well-being or performance. For instance, the control of a group of muscles leads to a better pronunciation of a word or performance of a piece of music. In this simple model it is assumed that the brain consists of interconnected components that may add, multiply and delay signal values. A nerve cell kernel may add signal values, a synapse may multiply with a constant and An axon may delay values. This is a basis of the theory of digital filters and neural networks consisting of components that may add, multiply and delay signalvalues and also of many brain models, Levine 1991. In the figure below the brain stem is supposed to deliver Gaussian distributed signal patterns. This may be possible since certai

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  • IDistance

    IDistance

    In pattern recognition, iDistance is an indexing and query processing technique for k-nearest neighbor queries on point data in multi-dimensional metric spaces. The kNN query is one of the hardest problems on multi-dimensional data, especially when the dimensionality of the data is high. iDistance is designed to process kNN queries in high-dimensional spaces efficiently and performs extremely well for skewed data distributions, which usually occur in real-life data sets. iDistance employs a two-phase search strategy involving an initial filtering of candidate regions and a subsequent refinement of results, an approach aligned with the Filter and Refine Principle (FRP). This means that the index first prunes the search space to eliminate unlikely candidates, then verifies the true nearest neighbors in a refinement step, following the general FRP paradigm used in database search algorithms. The iDistance index can also be augmented with machine learning models to learn data distributions for improved searching and storage of multi-dimensional data. == Indexing == Building the iDistance index has two steps: A number of reference points in the data space are chosen. There are various ways of choosing reference points. Using cluster centers as reference points is the most efficient way. The data points are partitioned into Voronoi cells based on well-chosen reference points. The distance between a data point and its closest reference point is calculated. This distance plus a scaling value is called the point's iDistance. By this means, points in a multi-dimensional space are mapped to one-dimensional values, and then a B+-tree can be adopted to index the points using the iDistance as the key. The figure on the right shows an example where three reference points (O1, O2, O3) are chosen. The data points are then mapped to a one-dimensional space and indexed in a B+-tree. Various extensions have been proposed to make the selection of reference points for effective query performance, including employing machine learning to learn the identification of reference points. == Query processing == To process a kNN query, the query is mapped to a number of one-dimensional range queries, which can be processed efficiently on a B+-tree. In the above figure, the query Q is mapped to a value in the B+-tree while the kNN search ``sphere" is mapped to a range in the B+-tree. The search sphere expands gradually until the k NNs are found. This corresponds to gradually expanding range searches in the B+-tree. The iDistance technique can be viewed as a way of accelerating the sequential scan. Instead of scanning records from the beginning to the end of the data file, the iDistance starts the scan from spots where the nearest neighbors can be obtained early with a very high probability. == Applications == The iDistance has been used in many applications including Image retrieval Video indexing Similarity search in P2P systems Mobile computing Recommender system == Historical background == The iDistance was first proposed by Cui Yu, Beng Chin Ooi, Kian-Lee Tan and H. V. Jagadish in 2001. Later, together with Rui Zhang, they improved the technique and performed a more comprehensive study on it in 2005.

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  • Stochastic block model

    Stochastic block model

    The stochastic block model is a generative model for random graphs. This model tends to produce graphs containing communities, subsets of nodes characterized by being connected with one another with particular edge densities. For example, edges may be more common within communities than between communities. Its mathematical formulation was first introduced in 1983 in the field of social network analysis by Paul W. Holland et al. The stochastic block model is important in statistics, machine learning, and network science, where it serves as a useful benchmark for the task of recovering community structure in graph data. == Definition == The stochastic block model takes the following parameters: The number n {\displaystyle n} of vertices; a partition of the vertex set { 1 , … , n } {\displaystyle \{1,\ldots ,n\}} into disjoint subsets C 1 , … , C r {\displaystyle C_{1},\ldots ,C_{r}} , called communities; a symmetric r × r {\displaystyle r\times r} matrix P {\displaystyle P} of edge probabilities. The edge set is then sampled at random as follows: any two vertices u ∈ C i {\displaystyle u\in C_{i}} and v ∈ C j {\displaystyle v\in C_{j}} are connected by an edge with probability P i j {\displaystyle P_{ij}} . An example problem is: given a graph with n {\displaystyle n} vertices, where the edges are sampled as described, recover the groups C 1 , … , C r {\displaystyle C_{1},\ldots ,C_{r}} . == Special cases == If the probability matrix is a constant, in the sense that P i j = p {\displaystyle P_{ij}=p} for all i , j {\displaystyle i,j} , then the result is the Erdős–Rényi model G ( n , p ) {\displaystyle G(n,p)} . This case is degenerate—the partition into communities becomes irrelevant—but it illustrates a close relationship to the Erdős–Rényi model. The planted partition model is the special case that the values of the probability matrix P {\displaystyle P} are a constant p {\displaystyle p} on the diagonal and another constant q {\displaystyle q} off the diagonal. Thus two vertices within the same community share an edge with probability p {\displaystyle p} , while two vertices in different communities share an edge with probability q {\displaystyle q} . Sometimes it is this restricted model that is called the stochastic block model. The case where p > q {\displaystyle p>q} is called an assortative model, while the case p < q {\displaystyle p P j k {\displaystyle P_{ii}>P_{jk}} whenever j ≠ k {\displaystyle j\neq k} : all diagonal entries dominate all off-diagonal entries. A model is called weakly assortative if P i i > P i j {\displaystyle P_{ii}>P_{ij}} whenever i ≠ j {\displaystyle i\neq j} : each diagonal entry is only required to dominate the rest of its own row and column. Disassortative forms of this terminology exist, by reversing all inequalities. For some algorithms, recovery might be easier for block models with assortative or disassortative conditions of this form. == Typical statistical tasks == Much of the literature on algorithmic community detection addresses three statistical tasks: detection, partial recovery, and exact recovery. === Detection === The goal of detection algorithms is simply to determine, given a sampled graph, whether the graph has latent community structure. More precisely, a graph might be generated, with some known prior probability, from a known stochastic block model, and otherwise from a similar Erdos-Renyi model. The algorithmic task is to correctly identify which of these two underlying models generated the graph. === Partial recovery === In partial recovery, the goal is to approximately determine the latent partition into communities, in the sense of finding a partition that is correlated with the true partition significantly better than a random guess. === Exact recovery === In exact recovery, the goal is to recover the latent partition into communities exactly. The community sizes and probability matrix may be known or unknown. == Statistical lower bounds and threshold behavior == Stochastic block models exhibit a sharp threshold effect reminiscent of percolation thresholds. Suppose that we allow the size n {\displaystyle n} of the graph to grow, keeping the community sizes in fixed proportions. If the probability matrix remains fixed, tasks such as partial and exact recovery become feasible for all non-degenerate parameter settings. However, if we scale down the probability matrix at a suitable rate as n {\displaystyle n} increases, we observe a sharp phase transition: for certain settings of the parameters, it will become possible to achieve recovery with probability tending to 1, whereas on the opposite side of the parameter threshold, the probability of recovery tends to 0 no matter what algorithm is used. For partial recovery, the appropriate scaling is to take P i j = P ~ i j / n {\displaystyle P_{ij}={\tilde {P}}_{ij}/n} for fixed P ~ {\displaystyle {\tilde {P}}} , resulting in graphs of constant average degree. In the case of two equal-sized communities, in the assortative planted partition model with probability matrix P = ( p ~ / n q ~ / n q ~ / n p ~ / n ) , {\displaystyle P=\left({\begin{array}{cc}{\tilde {p}}/n&{\tilde {q}}/n\\{\tilde {q}}/n&{\tilde {p}}/n\end{array}}\right),} partial recovery is feasible with probability 1 − o ( 1 ) {\displaystyle 1-o(1)} whenever ( p ~ − q ~ ) 2 > 2 ( p ~ + q ~ ) {\displaystyle ({\tilde {p}}-{\tilde {q}})^{2}>2({\tilde {p}}+{\tilde {q}})} , whereas any estimator fails partial recovery with probability 1 − o ( 1 ) {\displaystyle 1-o(1)} whenever ( p ~ − q ~ ) 2 < 2 ( p ~ + q ~ ) {\displaystyle ({\tilde {p}}-{\tilde {q}})^{2}<2({\tilde {p}}+{\tilde {q}})} . For exact recovery, the appropriate scaling is to take P i j = P ~ i j log ⁡ n / n {\displaystyle P_{ij}={\tilde {P}}_{ij}\log n/n} , resulting in graphs of logarithmic average degree. Here a similar threshold exists: for the assortative planted partition model with r {\displaystyle r} equal-sized communities, the threshold lies at p ~ − q ~ = r {\displaystyle {\sqrt {\tilde {p}}}-{\sqrt {\tilde {q}}}={\sqrt {r}}} . In fact, the exact recovery threshold is known for the fully general stochastic block model. == Algorithms == In principle, exact recovery can be solved in its feasible range using maximum likelihood, but this amounts to solving a constrained or regularized cut problem such as minimum bisection that is typically NP-complete. Hence, no known efficient algorithms will correctly compute the maximum-likelihood estimate in the worst case. However, a wide variety of algorithms perform well in the average case, and many high-probability performance guarantees have been proven for algorithms in both the partial and exact recovery settings. Successful algorithms include spectral clustering of the vertices, semidefinite programming, forms of belief propagation, and community detection among others. == Variants == Several variants of the model exist. One minor tweak allocates vertices to communities randomly, according to a categorical distribution, rather than in a fixed partition. More significant variants include the degree-corrected stochastic block model, the hierarchical stochastic block model, the geometric block model, censored block model and the mixed-membership block model. == Topic models == Stochastic block model have been recognised to be a topic model on bipartite networks. In a network of documents and words, Stochastic block model can identify topics: group of words with a similar meaning. == Extensions to signed graphs == Signed graphs allow for both favorable and adverse relationships and serve as a common model choice for various data analysis applications, e.g., correlation clustering. The stochastic block model can be trivially extended to signed graphs by assigning both positive and negative edge weights or equivalently using a difference of adjacency matrices of two stochastic block models. == DARPA/MIT/AWS Graph Challenge: streaming stochastic block partition == GraphChallenge encourages community approaches to developing new solutions for analyzing graphs and sparse data derived from social media, sensor feeds, and scientific data to enable relationships between events to be discovered as they unfold in the field. Streaming stochastic block partition is one of the challenges since 2017. Spectral clustering has demonstrated outstanding performance compared to the original and even improved base algorithm, matching its quality of clusters while being multiple orders of magnitude faster.

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  • The Cancer Imaging Archive

    The Cancer Imaging Archive

    The Cancer Imaging Archive (TCIA) is an open-access database of medical images for cancer research. The site is funded by the National Cancer Institute's (NCI) Cancer Imaging Program, and the contract is operated by the University of Arkansas for Medical Sciences. Data within the archive is organized into collections which typically share a common cancer type and/or anatomical site. The majority of the data consists of CT, MRI, and nuclear medicine (e.g. PET) images stored in DICOM format, but many other types of supporting data are also provided or linked to, in order to enhance research utility. All data are de-identified in order to comply with the Health Insurance Portability and Accountability Act and National Institutes of Health data sharing policies. TCIA resources are intended to support: Development of computer aided diagnosis methods (quantitative imaging) Evaluation of unbiased science reproducibility by acceptable standard statistical methods Research on correlation of clinical diagnostic medical images with digital microscopic histological images Exploratory biomarker research for which imaging is a key element Collaboration between cross-disciplinary investigators where imaging is crucial to research on tumor heterogeneity, between patients and within the tumor; tissue temporal response tracking - objective measurements of tumor progression; imaging genomics and Big Data linkages and analysis (clinical, histo-pathology, genomics) TCIA is recognized as a recommended repository for the Scientific Data, PLOS One, and F1000Research journals. It is also listed in the Registry of Research Data Repositories. == History == Prior to the creation of TCIA, the NCI funded development of the National Biomedical Imaging Archive. NBIA is an open-source Web application which was designed to allow the storage and query of DICOM images. TCIA was subsequently initiated in December 2010 to expand data sharing activities by funding a service component which would help address the technical and policy challenges associated with medical imaging research. TCIA leverages open-source tools such as NBIA and Clinical Trials Processor in order to provide its services. == Organization of the archive == The site content is organized into five categories: About Us - Provides a general overview of the site the organizations responsible for operating it. Share Your Data - Provides an overview of how to apply to upload data to the archive. Access the Archive - Provides information about the available data, methods for accessing that data and system usage metrics. Research Activities - Provides information about major research initiatives being conducted using TCIA data as well as information about publication guidelines. Help - Provides information about how to get support using the archive as well as documentation and data usage policies. == Methods for accessing data == Most collections on the Cancer Imaging Archive can be accessed without an account, but a few are restricted to specific users and therefore require an account to access them. TCIA has several ways to browse, filter, and download data. They include: Downloading the entire contents of a collection in bulk Leveraging the NBIA application to filter or search within or across collections Utilizing the RESTful Application programming interface to filter or search within or across collections === Browsing, bulk downloading and access to supporting data === The home page includes a list of all available collections. Basic information about the data such as the cancer type, cancer location, modalities, and number of subjects are also provided. Clicking on a collection name presents a page which describes the data including its original research purpose, how the data were generated, and how it might be useful to other TCIA users. For example, doi:10.7937/K9/TCIA.2015.L4FRET6Z describes the NSCLC-Radiomics-Genomics Collection. In the lower section of the page there are links to search or download the images and any available supporting data in the Data Access tab. Additional tabs provide information about data versions and how to cite the data if used in publications. Many collections contain additional data types such as genomics, patient demographics, treatment details, and expert analyses of the images. This data is usually only found by browsing the collection pages as opposed to searching in NBIA or using the API. === Filtering or searching with NBIA === On each Collection page and also in the main menu of the site there are links to "Search TCIA". This will load the NBIA application which allows simple, advanced and free text searches. Search results follow the conventional DICOM hierarchy of patient -> study -> series. TCIA provides comprehensive documentation on the various features of the NBIA software. === RESTful API === A number of search and download commands are also available through the API. New iterations on the API are released as new versions, so that existing applications developed against older versions of the API continue to function. == Research activities == A list of known publications based on TCIA data is maintained as a convenience to researchers who might want to investigate how it has been used previously. In addition to peer-reviewed publications there are also several major research initiatives described in the Research Activities section of the site. === The CIP TCGA Radiology Initiative for Radiogenomics Research === A large number of collections contain subjects which were analyzed as part of the NIH/NHGRI database known as The Cancer Genome Atlas (TCGA). This offers researchers the ability to correlate clinical images using shared unique identifiers each study that has in TCGA extensive genomic analysis, digital pathology slides and bulk download of individual demographic data and clinical data. A multi-institutional network of investigators volunteering their time is using the data to develop methods to determine prognosis or predict the response to therapy. TCGA collections are designated by nomenclature shared by the TCGA Data Portal (e.g.: TCGA-BRCA, TCGA-GBM, etc). They are subject to a special publication policy which is unique from the other public data on TCIA. === Challenge competitions === TCIA also provides specific data sets used for "Challenge" competitions such as international digital image-focused professional societies like MICCAI, SPIE, or ISBI. A directory of previous and upcoming challenges is maintained on the site. === Digital object identifiers === To facilitate data sharing, many publications encourage authors to include data citations to the data that the authors used in creating the results described in their scholarly papers. In addition, new journals are now available for describing data collections outright (e.g., Nature Scientific Data). TCIA assigns digital object identifiers (DOIs) to all collections when they are submitted, and also has the ability to create persistent identifiers linked to subsets of data held within TCIA that authors may use for data citations in their scholarly papers.

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  • Markov blanket

    Markov blanket

    In statistics and machine learning, a Markov blanket of a random variable is a set of variables that renders the variable conditionally independent of all other variables in the system. This concept is central in probabilistic graphical models and feature selection. If a Markov blanket is minimal—meaning that no variable in it can be removed without losing this conditional independence—it is called a Markov boundary. Identifying a Markov blanket or boundary allows for efficient inference and helps isolate relevant variables for prediction or causal reasoning. The terms Markov blanket and Markov boundary were coined by Judea Pearl in 1988. A Markov blanket may be derived from the structure of a probabilistic graphical model such as a Bayesian network or Markov random field. == Definition == A Markov blanket of a random variable Y {\displaystyle Y} in a random variable set S = { X 1 , … , X n } {\displaystyle {\mathcal {S}}=\{X_{1},\ldots ,X_{n}\}} is any subset S 1 {\displaystyle {\mathcal {S}}_{1}} of S {\displaystyle {\mathcal {S}}} , conditioned on which other variables are independent with Y {\displaystyle Y} : Y ⊥ ⊥ S ∖ S 1 ∣ S 1 {\displaystyle Y\perp \!\!\!\perp {\mathcal {S}}\smallsetminus {\mathcal {S}}_{1}\mid {\mathcal {S}}_{1}} It means that S 1 {\displaystyle {\mathcal {S}}_{1}} contains at least all the information one needs to infer Y {\displaystyle Y} , where the variables in S ∖ S 1 {\displaystyle {\mathcal {S}}\smallsetminus {\mathcal {S}}_{1}} are redundant. In general, a given Markov blanket is not unique. Any set in S {\displaystyle {\mathcal {S}}} that contains a Markov blanket is also a Markov blanket itself. Specifically, S {\displaystyle {\mathcal {S}}} is a Markov blanket of Y {\displaystyle Y} in S {\displaystyle {\mathcal {S}}} . === Example === In a Bayesian network, the Markov blanket of a node consists of its parents, its children, and its children's other parents (i.e., co-parents). Knowing the values of these nodes makes the target node conditionally independent of the rest of the network. In a Markov random field, the Markov blanket of a node is simply its immediate neighbors. == Markov condition == The concept of a Markov blanket is rooted in the Markov condition, which states that in a probabilistic graphical model, each variable is conditionally independent of its non-descendants given its parents. This condition implies the existence of a minimal separating set — the Markov blanket — that shields a variable from the rest of the network. For instance, when a person holds an object stationary against gravity, the object’s acceleration is fully determined by its direct causes—namely, the upward force from the hand and the downward gravitational pull. Other variables such as air pressure or temperature are causally irrelevant. == Markov boundary == A Markov boundary of Y {\displaystyle Y} in S {\displaystyle {\mathcal {S}}} is a subset S 2 {\displaystyle {\mathcal {S}}_{2}} of S {\displaystyle {\mathcal {S}}} , such that S 2 {\displaystyle {\mathcal {S}}_{2}} itself is a Markov blanket of Y {\displaystyle Y} , but any proper subset of S 2 {\displaystyle {\mathcal {S}}_{2}} is not a Markov blanket of Y {\displaystyle Y} . In other words, a Markov boundary is a minimal Markov blanket. The Markov boundary of a node A {\displaystyle A} in a Bayesian network is the set of nodes composed of A {\displaystyle A} 's parents, A {\displaystyle A} 's children, and A {\displaystyle A} 's children's other parents. In a Markov random field, the Markov boundary for a node is the set of its neighboring nodes. In a dependency network, the Markov boundary for a node is the set of its parents. === Uniqueness of Markov boundary === The Markov boundary always exists. Under some mild conditions, the Markov boundary is unique. However, for most practical and theoretical scenarios multiple Markov boundaries may provide alternative solutions. When there are multiple Markov boundaries, quantities measuring causal effect could fail. == In cognitive science == In the study of consciousness, brain function, and complex adaptive systems, Markov blankets are proposed as a mathematical mechanism which delimits the extent of cognitive entities, whether it be physical or causal.

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  • Win–stay, lose–switch

    Win–stay, lose–switch

    In psychology, game theory, statistics, and machine learning, win–stay, lose–switch (also win–stay, lose–shift or Pavlov, named after Ivan Pavlov) is a heuristic learning strategy used to model learning in decision situations. It was first invented as an improvement over randomization in bandit problems. It was later applied to the prisoner's dilemma in order to model the evolution of altruism. In most versions, it starts either with a cooperate, then proceeds as always, or starts with a "probe" of cooperate-defect-cooperate to determine the other player's strategy. A mutual cooperation is regarded as a win. The learning rule bases its decision only on the outcome of the previous play. Outcomes are divided into successes (wins) and failures (losses). If the play on the previous round resulted in a success, then the agent plays the same strategy on the next round. Alternatively, if the play resulted in a failure the agent switches to another action. A large-scale empirical study of players of the game rock, paper, scissors shows that a variation of this strategy is adopted by real-world players of the game, instead of the Nash equilibrium strategy of choosing entirely at random between the three options.

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