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Chroma or ChromaDB is open-source data infrastructure tailored to applications with large language models. Its headquarters are in San Francisco. In April 2023, it raised 18 million US dollars as seed funding. ChromaDB has been used in academic studies on artificial intelligence, particularly as part of the tech stack for retrieval-augmented generation.
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Midjourney is a generative artificial intelligence program and service created and hosted by the San Francisco–based "independent research lab" Midjourney, Inc. Midjourney generates images from natural language descriptions, called prompts, similar to OpenAI's DALL-E and Stability AI's Stable Diffusion. It is one of the technologies of the AI boom. The tool was launched into open beta on July 12, 2022. The Midjourney team is led by David Holz, who co-founded Leap Motion. Holz told The Register in August 2022 that the company was already profitable. Users generate images with Midjourney using Discord bot commands or the official website. == History == Midjourney, Inc. was founded in San Francisco, California, by David Holz, previously a co-founder of Leap Motion. The Midjourney image generation platform entered open beta on July 12, 2022. On March 14, 2022, the Midjourney Discord server launched with a request to post high-quality photographs to Twitter and Reddit for systems training. === Model versions === The company has been working on improving its algorithms, releasing new model versions every few months. Version 2 of their algorithm was launched in April 2022, and version 3 on July 25. On November 5, 2022, the alpha iteration of version 4 was released to users. Starting from the 4th version, MJ models were trained on Google TPUs. On March 15, 2023, the alpha iteration of version 5 was released. The 5.1 model is more opinionated than version 5, applying more of its own stylization to images, while the 5.1 RAW model adds improvements while working better with more literal prompts. The version 5.2 included a new "aesthetics system", and the ability to "zoom out" by generating surroundings to an existing image. On December 21, 2023, the alpha iteration of version 6 was released. The model was trained from scratch over a nine month period. Support was added for better text rendition and a more literal interpretation of prompts. == Functionality == Midjourney is accessible through a Discord bot or by accessing their website. Users can use Midjourney through Discord either through their official Discord server, by directly messaging the bot, or by inviting the bot to a third-party server. To generate images, users use the /imagine command and type in a prompt; the bot then returns a set of four images, which users are given the option to upscale. To generate images on the website, users initially needed to have generated at least 1,000 images through the bot; this limitation has since been removed. === Vary (Region) + remix feature === Midjourney released a Vary (Region) feature on September 5, 2023, as part of MidJourney V5.2. This feature allows users to select a specific area of an image and apply variations only to that region while keeping the rest of the image unchanged. === Midjourney web interface === Midjourney introduced its web interface to make its tools more accessible, moving beyond its initial reliance on Discord. This web-based platform was launched in August 2024 alongside the release of Midjourney version 6.1. The web editor consolidates tools such as image editing, panning, zooming, region variation, and inpainting into a single interface. The introduction of the web interface also syncs conversations between Midjourney's Discord channels and web rooms, further enhancing collaboration across both platforms. This shift was in response to growing competition from other AI image generation platforms like Adobe Firefly and Google’s Imagen, which had already launched as native web apps with integration into popular design tools. === Image Weight === This feature lets users control how much influence an uploaded image has on the final output. By adjusting the "image weight" parameter, users can prioritize either the content of the prompt or the characteristics of the image. For instance, setting a higher weight will ensure that the generated result closely follows the image's structure and details, while a lower weight allows the text prompt to have more influence over the final output. === Style Reference === With Style Reference, users can upload an image to use as a stylistic guide for their creation. This tool enables MidJourney to extract the style—whether it is the color palette, texture, or overall atmosphere—from the reference image and apply it to a newly generated image. The feature allows users to fine-tune the aesthetics of their creations by integrating specific artistic styles or moods. === Character Reference === The Character Reference feature allows for a more targeted approach in defining characters. Users can upload an image of a character, and the system uses that image as a reference to generate similar characters in the output. This feature is particularly useful in maintaining consistency in appearance for characters across different images. == Uses == Midjourney's founder, David Holz, told The Register that artists use Midjourney for rapid prototyping of artistic concepts to show to clients before starting work themselves. The advertising industry quickly adopted AI tools such as Midjourney, DALL-E, and Stable Diffusion to create original content and brainstorm ideas. Architects have described using the software to generate mood boards for the early stages of projects, as an alternative to searching Google Images. === Notable usage and controversy === The program was used by the British magazine The Economist to create the front cover for an issue in June 2022. In Italy, the leading newspaper Corriere della Sera published a comic created with Midjourney by writer Vanni Santoni in August 2022. Charlie Warzel used Midjourney to generate two images of Alex Jones for Warzel's newsletter in The Atlantic. The use of an AI-generated cover was criticised by people who felt it was taking jobs from artists. Warzel called his action a mistake in an article about his decision to use generated images. Last Week Tonight with John Oliver included a 10-minute segment on Midjourney in an episode broadcast in August 2022. A Midjourney image called Théâtre D'opéra Spatial won first place in the digital art competition at the 2022 Colorado State Fair. Jason Allen, who wrote the prompt that led Midjourney to generate the image, printed the image onto a canvas and entered it into the competition using the name Jason M. Allen via Midjourney. Other digital artists were upset by the news. Allen was unapologetic, insisting that he followed the competition's rules. The two category judges were unaware that Midjourney used AI to generate images, although they later said that had they known this, they would have awarded Allen the top prize anyway. In December 2022, Midjourney was used to generate the images for an AI-generated children's book that was created over a weekend. Titled Alice and Sparkle, the book features a young girl who builds a robot that becomes self-aware. The creator, Ammaar Reeshi, used Midjourney to generate a large number of images, from which he chose 13 for the book. Both the product and process drew criticism. One artist wrote that "the main problem... is that it was trained off of artists' work. It's our creations, our distinct styles that we created, that we did not consent to being used." In 2023, the realism of AI-based text-to-image generators, such as Midjourney, DALL-E, or Stable Diffusion, reached such a high level that it led to a significant wave of viral AI-generated photos. Widespread attention was gained by a Midjourney-generated photo of Pope Francis wearing a white puffer coat, the fictional arrest of Donald Trump, and a hoax of an attack on the Pentagon, as well as the usage in professional creative arts. Research has suggested that the images Midjourney generates can be biased. For example, even neutral prompts in one study returned unequal results on the aspects of gender, skin color, and location. A study by researchers at the nonprofit group Center for Countering Digital Hate found the tool to be easy to use to generate racist and conspiratorial images. In October 2023, Rest of World reported that Midjourney tends to generate images based on national stereotypes. In 2024, a Frontiers journal published a paper which contained gibberish figures generated with Midjourney, one of which was a diagram of a rat with large testicles and a large penis towering over himself. The paper was retracted a day after the images went viral on Twitter. ==== Content moderation and censorship in Midjourney ==== Prior to May 2023, Midjourney implemented a moderation mechanism predicated on a banned word system. This method prohibited the use of language associated with explicit content, such as sexual or pornographic themes, as well as extreme violence. Moreover, the system also banned certain individual words, including those of religious and political figures, such as Allah or General Secretary of the Chinese Communist Party Xi Jinping. This practice occasionally stirred controversy due to perceiv
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Argüman is a free and open source software for collective structured argumentation and argument analysis via argumentation graphs or argument maps in which the type of connections can be specified. It allows users to create collaborative "semantic maps" of arguments in well structured tree formats and share them with an audience and potential participants. Arguman.org was an open structured social debate platform that implemented the software. It is down as of 2023. There also is a mobile version of the tool. The project was started, in 2014, and largely built by developers in Turkey. Some studies used or investigated excerpts of argumentations on the platform. Unlike the larger and functional alternative Kialo, which is structured using only 'Pro' and 'Con' relations, argüman arguments are structured by three types of premises – 'because', 'but', and 'however'. As of the latest version, debates are presented in their entirety as a large tree which may be harder to navigate than other formats – for instance, trees "can become extremely dense, and the interface does not make it obvious which arguments the user should pay attention to". Users can also flag arguments for fallacies. Arguman.org also had a Turkish-language subdomain. A researcher suggested the concept of the Semantic Web-interoperability could be useful for argumentative structures on the Web, going beyond the conventional flat structures of discussions and lack of characterizations of their components as implemented in argüman. There is research into how to automatically use these collaborative argumentation graphs, which is a "very active" topic in Artificial Intelligence. There also is research into applying conclusion-making methods to the debates or their data, such as bipolar weighted argumentation frameworks – this could be a way to find out what the current conclusion of debates like "Computer Science is not actually a science" is. A study suggests it could be useful for the development of critical thinking skills.
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Warframe is a free-to-play action role-playing third-person shooter multiplayer online game developed and published by Digital Extremes. First released for Windows in March 2013, it was later ported to PlayStation 4 in November 2013, Xbox One in September 2014, Nintendo Switch in November 2018, PlayStation 5 in November 2020, Xbox Series X/S in April 2021, iOS in February 2024, Android in Canada on February 11, 2026 followed by a global release on February 18, 2026, and was released on Nintendo Switch 2 on March 25, 2026. Support for cross-platform play was released in 2022. Cross-platform save began in December 2023, rolling out in waves to different groups of players before becoming fully available to all players in January 2024. In Warframe, a player controls a member of the Tenno, a caste of ancient warriors who have awoken from centuries of suspended animation far into Earth's future to find themselves at war with different factions in the Origin System. The Tenno use their powered Warframes, along with a variety of weapons and abilities, to complete missions. While many of the game's missions use procedurally generated levels, it also includes large open world areas similar to other massively multiplayer online games, as well as some story-specific missions with fixed level design. The game includes elements of shooting and melee games, parkour, and role-playing to allow players to advance their Tenno with improved gear. The game features both player versus environment and player versus player elements. It is supported by microtransactions, allowing players to purchase in-game items with money, while also offering the option to earn them at no cost through grinding. The concept for Warframe originated in 2000 when Digital Extremes began work on a new game titled Dark Sector. At the time, the company had been successful in supporting other developers and publishers but wanted to develop its own game in-house. Dark Sector suffered several delays and was eventually released in 2008, incorporating some of the initial framework but differing significantly from the original plan. By 2012, in the wake of the success of free-to-play games, the developers took their earlier Dark Sector ideas and art assets and incorporated them into a new project, their self-published Warframe. Initially, the growth of Warframe was slow, hindered by moderate critical reviews and low player counts. However, since its release, the game has experienced significant growth. It is one of Digital Extremes' most successful titles, reaching nearly 50 million registered players by 2019. == Plot == Warframe is set in a far future version of the Solar System, now known as the Origin System. At the start of the game players are given control of members of the Tenno, warriors who have awoken from a millennia-long cryosleep on Earth by the Lotus, who acts as a guide for the player. They join an interplanetary war between the Grineer, a violent war-driven matriarchal race of militarized human clones; the Corpus, a cult-like megacorporation dedicated to profit; the Infested, disfigured victims of the Technocyte virus; the Sentients, a race of self-replicating machines made by a long-dead transhuman race known as the Orokin; and the Corrupted, brainwashed variants of the previous three factions' units defending ancient Orokin towers. All of the factions encountered in the game, including the Tenno, were created by or are splinter groups of the old Orokin Empire, which the Tenno learns was an ancient fallen civilization and former reigning power in the Origin System. Although virtually all of them are long dead by the time of the Tenno's awakening, their lingering presence can still be felt throughout the Origin System. Before their fall, the Orokin had realized the Origin System was becoming dangerously depleted of resources, and their solution to keep their empire alive was to colonize new star systems. The Orokin sent out colony ships through the Void, a trans-dimensional space that enabled fast travel between stellar systems. They had also sent out the Sentients beforehand, to arrive in the Tau system first, and terraform it, so the colonists would arrive to garden worlds, capable of supporting human life. None of these residential ships returned, and those they had loaded with Sentients returned with the Sentients now deciding to wipe out the Orokin, leading to the Old War, the creation of the Tenno, and finally, the collapse of the Empire. In the game's "The Second Dream" quest, which was introduced in December 2015, the player discovers that the Lotus is a Sentient known as Natah, rebelling against the Sentients to protect the Tenno, desiring to have surrogate children after losing her ability to procreate. The Lotus' father, Hunhow, sends a vengeful assassin called the Stalker to Lua (the remains of Earth's Moon), which the Lotus had hidden in the Void, to find its secret. The Lotus dispatches the Tenno there to stop the Stalker, arriving too late as the Stalker unveils the entity that the Lotus had protected: a human child known as the Operator, who is the real Tenno controlling the Warframes through the course of the game. The Operator is one of several Tenno children that survived the passage of the Zariman Ten 0 colony ship through the Void; the adults have all gone mad from its travel. When the ship returned to the Orokin Empire, the children had all been put to sleep for thousands of years, outlasting the fall of the Empire, to be found by the Lotus and becoming the Tenno (Tenno short for the "Ten Zero" of the ship's name). The power of the Void gave these children the power of Transference, an ability that allows them to control Warframes. From this point forward, the player can then engage in missions both as the Warframe and the Operator. Throughout various updates, various quests have been released after the Second Dream that elaborates on the story. "The War Within" quest introduced the Grineer Queens, rulers of the Grineer, and their asteroid-based Kuva Fortress, also giving the Operator the ability to act fully on their own as another playable entity, rather than a single-use attack. Quests afterward would introduce figures such as "The Man In The Wall," a mysterious entity, presumably from the Void, who takes on the visage of whoever sees them, most often as the playable Operator, and Ballas, one of the last living Orokin, assumed to be responsible for creating the Warframes. == Gameplay == Warframe is an online action game that includes elements of shooters, RPG, and stealth games. The player starts with a silent pseudo-protagonist in the form of an anthropomorphous biomechanical combat unit called a 'Warframe', possessing supernatural agility and special abilities, a selection of weapons (primary, secondary, and melee) and a space ship called an 'Orbiter'. The Orbiter is supported by a Cephalon, a type of Artificial Intelligence created from the minds of living people. The Cephalon in the player's Orbiter is named Ordis, and refers to the player as 'Operator'. The player's primary goal from this point is to explore the Origin System. Later in the course of the game, the player unlocks the ability to gain direct control of the Operator, which is the true Tenno protagonist in physical form. The Operator can physically manifest themselves in the environment by projecting out of the Warframe, and disappear by resuming control of it through a telekinetic process called 'Transference'. The Operator also possesses weapons and abilities of their own. After that, the Operator can use Transference to control a larger, purely mechanical combat unit called a 'Necramech', which is the technological precursor to the Warframes. Players can engage in space-bound combat using an auxiliary combat platform called 'Archwing', mounted on a Warframe, which comes with a unique set of abilities. 'Archguns' are heavy weapons designed for Archwings and Necramechs, but can be adapted for Warframe use. Late in 2019, an update to the game allowed players to pilot and manage a spacefaring gunship called the 'Railjack', which is deployed in combat, unlike the Orbiter. Railjack was designed as a co-op experience with up to four people working together, performing different tasks to keep the ship operational while destroying enemy ships and completing objectives. A Railjack-focused update was released in 2021, which brought expanded content and a new skill tree system aimed at making solo play more accessible. Through the Orbiter's console, the player can select any of the missions available to them. To progress through the Solar System, players must complete mission 'nodes' on each planet to reach Junctions, and use these Junctions to travel to other planets. Other missions rotate over time as part of the game's living universe; these can include missions with special rewards and community challenges to allow all players to reap benefits if they are successfully met. High-di
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My Drama (also may be stylised as MyDrama) is a global streaming service specializing in vertical video series for Duanju. It is owned by the company Holywater Tech. The platform focuses on short-form, emotional storytelling optimized for smartphone viewing, offering content in over 30 languages across 190 countries. == History == My Drama was launched in 2024 by Holywater Tech, founded by Ukrainian entrepreneur Bogdan Nesvit and Anatolii Kasianov. The service gained international traction as part of a growing market for short-form vertical storytelling, influenced by mobile-first entertainment trends. My Drama primarily streams serialized vertical dramas, which are short-form episodes around 1-2 minutes in length designed for mobile consumption. Many series are adaptations of successful stories originally published on Holywater Tech's book platform My Passion. The platform employs AI technology in areas such as content recommendation and story generation, and is one of several Holywater apps focused on interactive entertainment. In 2024, My Drama won a People's Voice award at the 28th Annual Webby Awards. In 2025, My Drama received a Gold Award at the MUSE Creative Awards in the Mobile App: Video Streaming Services category. In 2025, the company received strategic investment from Fox Entertainment, aimed at expanding content creation capabilities and producing over 200 vertical video series. As of 2025, My Drama has produced over 56 titles and reached more than 40 million lifetime users, according to media reports. In January 2026, Holywater Tech raised $22 million in funding to expand its microdrama business in the United States. The investment round was led by Horizon Capital, with participation from U.S.-based investors including Endeavor Catalyst and Wheelhouse. The funding is intended to support the development of Holywater Tech's mobile-first vertical video platform, My Drama, as well as the company's AI-driven content initiatives, such as AI-assisted comics and anime. In February 2026, Holywater bought Jeynix, a studio that uses AI for special effects. This deal helps the company make better-quality shows and translate them into different languages much faster. == Partnerships == In 2024, Holywater Tech entered a partnership with Latin American studio Elefantec Global to distribute vertical dramas in Spanish-language markets. In early 2026, Fox Entertainment entered into a partnership with content creator Dhar Mann to produce a slate of 40 original vertical microdrama series. Under the agreement, the series debut exclusively on the My Drama platform, while global distribution is managed by Fox Entertainment Global. == Reception == My Drama has been highlighted in discussions of the global rise of vertical short drama platforms and has been compared with similar apps such as ReelShort and DramaBox.
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Deepfakes (a portmanteau of 'deep learning' and 'fake') are images, videos, or audio that have been edited or generated using artificial intelligence, AI-based tools or audio-video editing software. They may depict real or fictional people and are considered a form of synthetic media, that is media that is usually created by artificial intelligence systems by combining various media elements into a new media artifact. While the act of creating fake content is not new, deepfakes uniquely leverage machine learning and artificial intelligence techniques, including facial recognition algorithms and artificial neural networks such as variational autoencoders and generative adversarial networks (GANs). In turn, the field of image forensics has worked to develop techniques to detect manipulated images. Deepfakes have garnered widespread attention for their potential use in creating child sexual abuse material, celebrity pornographic videos, revenge porn, fake news, hoaxes, bullying, and financial fraud. Academics have raised concerns about the potential for deepfakes to promote disinformation and hate speech, as well as interfere with elections. In response, the information technology industry and governments have proposed recommendations and methods to detect and mitigate their use. Academic research has also delved deeper into the factors driving deepfake engagement online as well as potential countermeasures to malicious application of deepfakes. From traditional entertainment to gaming, deepfake technology has evolved to be increasingly convincing and available to the public, allowing for the disruption of the entertainment and media industries. == History == Photo manipulation was developed in the 19th century and soon applied to motion pictures. Technology steadily improved during the 20th century, and more quickly with the advent of digital video. Deepfake technology has been developed by researchers at academic institutions beginning in the 1990s, and later by amateurs in online communities. More recently, the methods have been adopted by industry. The development of generative adversarial networks (GANs) in the mid-2010s represented a key technical turning point in the evolution of deepfakes. GANs allowed for the creation of highly realistic fake images and videos by training competing neural networks, achieving a much improved visual fidelity over previous methods of creating the content using rules or by using autoencoders, and formed the basis for modern deepfake methods. === Academic research === Academic research related to deepfakes is split between the field of computer vision, a sub-field of computer science, which develops techniques for creating and identifying deepfakes, and humanities and social science approaches that study the social, ethical, aesthetic implications as well as journalistic and informational implications of deepfakes. As deepfakes have risen in prominence in popularity with innovations provided by AI tools, significant research has gone into detection methods and defining the factors driving engagement with deepfakes on the internet. Deepfakes have been shown to appear on social media platforms and other parts of the internet for purposes ranging from entertainment and education related to deepfakes to misinformation to elicit strong reactions. There are gaps in research related to the propagation of deepfakes on social media. Negativity and emotional response are the primary driving factors for users sharing deepfakes. === Social science and humanities approaches to deepfakes === In cinema studies, deepfakes illustrate how "the human face is emerging as a central object of ambivalence in the digital age". Video artists have used deepfakes to "playfully rewrite film history by retrofitting canonical cinema with new star performers". Film scholar Christopher Holliday analyses how altering the gender and race of performers in familiar movie scenes destabilizes gender classifications and categories. The concept of "queering" deepfakes is also discussed in Oliver M. Gingrich's discussion of media artworks that use deepfakes to reframe gender, including British artist Jake Elwes' Zizi: Queering the Dataset, an artwork that uses deepfakes of drag queens to intentionally play with gender. The aesthetic potentials of deepfakes are also beginning to be explored. Theatre historian John Fletcher notes that early demonstrations of deepfakes are presented as performances, and situates these in the context of theater, discussing "some of the more troubling paradigm shifts" that deepfakes represent as a performance genre. While most English-language academic studies of deepfakes focus on the Western anxieties about disinformation and pornography, digital anthropologist Gabriele de Seta has analyzed the Chinese reception of deepfakes, which are known as huanlian, which translates to "changing faces". The Chinese term does not contain the "fake" of the English deepfake, and de Seta argues that this cultural context may explain why the Chinese response has centered on practical regulatory measures to "fraud risks, image rights, economic profit, and ethical imbalances". === Computer science research on deepfakes === A landmark early project was the "Video Rewrite" program, published in 1997. The program modified existing video footage of a person speaking to depict that person mouthing the words from a different audio track. It was the first system to fully automate this kind of facial reanimation, and it did so using machine learning techniques to make connections between the sounds produced by a video's subject and the shape of the subject's face. Contemporary academic projects have focused on creating more realistic videos and improving deepfake techniques. The "Synthesizing Obama" program, published in 2017, modifies video footage of former president Barack Obama to depict him mouthing the words contained in a separate audio track. The project lists as a main research contribution to its photorealistic technique for synthesizing mouth shapes from audio. The "Face2Face" program, published in 2016, modifies video footage of a person's face to depict them mimicking another person's facial expressions. The project highlights its primary research contribution as the development of the first method for re-enacting facial expressions in real time using a camera that does not capture depth, enabling the technique to work with common consumer cameras. Researchers have also shown that deepfakes are expanding into other domains such as medical imagery. In this work, it was shown how an attacker can automatically inject or remove lung cancer in a patient's 3D CT scan. The result was so convincing that it fooled three radiologists and a state-of-the-art lung cancer detection AI. To demonstrate the threat, the authors successfully performed the attack on a hospital in a White hat penetration test. A survey of deepfakes, published in May 2020, provides a timeline of how the creation and detection of deepfakes have advanced over the last few years. The survey identifies that researchers have been focusing on resolving the following challenges of deepfake creation: Generalization. High-quality deepfakes are often achieved by training on hours of footage of the target. This challenge is to minimize the amount of training data and the time to train the model required to produce quality images and to enable the execution of trained models on new identities (unseen during training). Paired Training. Training a supervised model can produce high-quality results, but requires data pairing. This is the process of finding examples of inputs and their desired outputs for the model to learn from. Data pairing is laborious and impractical when training on multiple identities and facial behaviors. Some solutions include self-supervised training (using frames from the same video), the use of unpaired networks such as Cycle-GAN, or the manipulation of network embeddings. Identity leakage. This is where the identity of the driver (i.e., the actor controlling the face in a reenactment) is partially transferred to the generated face. Some solutions proposed include attention mechanisms, few-shot learning, disentanglement, boundary conversions, and skip connections. Occlusions. When part of the face is obstructed with a hand, hair, glasses, or any other item then artifacts can occur. A common occlusion is a closed mouth which hides the inside of the mouth and the teeth. Some solutions include image segmentation during training and in-painting. Temporal coherence. In videos containing deepfakes, artifacts such as flickering and jitter can occur because the network has no context of the preceding frames. Some researchers provide this context or use novel temporal coherence losses to help improve realism. As the technology improves, the interference is diminishing. Overall, deepfakes are expected to have several implications in media and society, med
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SCIgen is a paper generator that uses context-free grammar to randomly generate nonsense in the form of computer science research papers. Its original data source was a collection of computer science papers downloaded from CiteSeer. All elements of the papers are formed, including graphs, diagrams, and citations. Created by scientists at the Massachusetts Institute of Technology, its stated aim is "to maximize amusement, rather than coherence." Originally created in 2005 to expose the lack of scrutiny of submissions to conferences, the generator subsequently became used, primarily by Chinese academics, to create large numbers of fraudulent conference submissions, leading to the retraction of 122 SCIgen generated papers and the creation of detection software to combat its use. == Sample output == Opening abstract of Rooter: A Methodology for the Typical Unification of Access Points and Redundancy: Many physicists would agree that, had it not been for congestion control, the evaluation of web browsers might never have occurred. In fact, few hackers worldwide would disagree with the essential unification of voice-over-IP and public/private key pair. In order to solve this riddle, we confirm that SMPs can be made stochastic, cacheable, and interposable. == Prominent results == In 2005, a paper generated by SCIgen, Rooter: A Methodology for the Typical Unification of Access Points and Redundancy, was accepted as a non-reviewed paper to the 2005 World Multiconference on Systemics, Cybernetics and Informatics (WMSCI) and the authors were invited to speak. The authors of SCIgen described their hoax on their website, and it soon received great publicity when picked up by Slashdot. WMSCI withdrew their invitation, but the SCIgen team went anyway, renting space in the hotel separately from the conference and delivering a series of randomly generated talks on their own "track". The organizer of these WMSCI conferences is Professor Nagib Callaos. From 2000 until 2005, the WMSCI was also sponsored by the Institute of Electrical and Electronics Engineers. The IEEE stopped granting sponsorship to Callaos from 2006 to 2008. Submitting the paper was a deliberate attempt to embarrass WMSCI, which the authors claim accepts low-quality papers and sends unsolicited requests for submissions in bulk to academics. As the SCIgen website states: One useful purpose for such a program is to auto-generate submissions to conferences that you suspect might have very low submission standards. A prime example, which you may recognize from spam in your inbox, is SCI/IIIS and its dozens of co-located conferences (check out the very broad conference description on the WMSCI 2005 website). Computing writer Stan Kelly-Bootle noted in ACM Queue that many sentences in the "Rooter" paper were individually plausible, which he regarded as posing a problem for automated detection of hoax articles. He suggested that even human readers might be taken in by the effective use of jargon ("The pun on root/router is par for MIT-graduate humor, and at least one occurrence of methodology is mandatory") and attribute the paper's apparent incoherence to their own limited knowledge. His conclusion was that "a reliable gibberish filter requires a careful holistic review by several peer domain experts". === Schlangemann === The pseudonym "Herbert Schlangemann" was used to publish fake scientific articles in international conferences that claimed to practice peer review. The name is taken from the Swedish short film Der Schlangemann. In 2008, in response to a series of Call-for-Paper e-mails, SCIgen was used to generate a false scientific paper titled Towards the Simulation of E-Commerce, using "Herbert Schlangemann" as the author. The article was accepted at the 2008 International Conference on Computer Science and Software Engineering (CSSE 2008), co-sponsored by the IEEE, to be held in Wuhan, China, and the author was invited to be a session chair on grounds of his fictional Curriculum Vitae. The official review comment: "This paper presents cooperative technology and classical Communication. In conclusion, the result shows that though the much-touted amphibious algorithm for the refinement of randomized algorithms is impossible, the well-known client-server algorithm for the analysis of voice-over-IP by Kumar and Raman runs in _(n) time. The authors can clearly identify important features of visualization of DHTs and analyze them insightfully. It is recommended that the authors should develop ideas more cogently, organizes them more logically, and connects them with clear transitions." The paper was available for a short time in the IEEE Xplore Database, but was then removed. The entire story is described in the official "Herbert Schlangemann" blog, and it also received attention in Slashdot and the German-language technology-news site Heise Online. In 2009, the same incident happened and Herbert Schlangemann's latest fake paper PlusPug: A Methodology for the Improvement of Local-Area Networks was accepted for oral presentation at the 2009 International Conference on e-Business and Information System Security (EBISS 2009), also co-sponsored by IEEE, to be held again in Wuhan, China. In all cases, the published papers were withdrawn from the conferences' proceedings, and the conference organizing committee as well as the names of the keynote speakers were removed from their websites. === List of works with notable acceptance === ==== In conferences ==== Rob Thomas: Rooter: A Methodology for the Typical Unification of Access Points and Redundancy, 2005 for WMSCI (see above) Mathias Uslar's paper was accepted to the IPSI-BG conference. Professor Genco Gulan published a paper in the 3rd International Symposium of Interactive Media Design. A 2013 scientometrics paper demonstrated that at least 85 SCIgen papers have been published by IEEE and Springer. Over 120 SCIgen papers were removed according to this research. ==== In journals ==== Students at Iran's Sharif University of Technology published a paper in Elsevier's Journal of Applied Mathematics and Computation. The students wrote under the surname "MosallahNejad", which translates literally from Persian language (in spite of not being a traditional Persian name) as "from an Armed Breed". The paper was subsequently removed when the publishers were informed that it was a joke paper. Mikhail Gelfand published a translation of the "Rooter" article in the Russian-language Journal of Scientific Publications of Aspirants and Doctorants in August 2008. Gelfand was protesting against the journal, which was apparently not peer-reviewed and was being used by Russian PhD candidates to publish in an "accredited" scientific journal, charging them 4,000 Rubles to do so. The accreditation was revoked two weeks later. (See Dissernet for related information.) Springer Science+Business Media and IEEE were also the subject of similar pranks. === Spoofing Google Scholar and h-index calculators === Refereeing performed on behalf of the Institute of Electrical and Electronics Engineers has also been subject to criticism after fake papers were discovered in conference publications, most notably by Labbé and a researcher using the pseudonym of Schlangemann. Cyril Labbé from Grenoble University demonstrated the vulnerability of h-index calculations based on Google Scholar output by feeding it a large set of SCIgen-generated documents that were citing each other, effectively an academic link farm, in a 2010 paper. Using this method the author managed to rank "Ike Antkare" ahead of Albert Einstein for instance. === 2013 retractions === In 2013, over 122 published conference papers created by SCIgen were retracted by Springer and the IEEE. Unlike previous submissions that were intended to be pranks, this submission were largely made by Chinese academics, who were using SCIgen papers to boost their publication record. === SciDetect === In 2015, SciDetect was released by Springer. This software, developed by Cyril Labbé, is designed to automatically detect papers generated by SCIgen. === 2021 report === In 2021, a study was published on 243 SCIgen papers that had been published in the academic literature. They found that SCIgen papers made up 75 per million papers (< 0.01%) in information science, and that only a small fraction of the detected papers had been dealt with.
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The Pommerman Challenge is a multi-agent game to test autonomous artificial intelligence systems. == Game structure == Two-agent team compete against each other on an 11 x 11 board. Each agent can observe only part of the board, and the agents cannot communicate. The goal is to knock down the opponents. Agents place explosives to destroy walls and collect power-ups that appear from those walls, while avoiding death. Game objects can move unpredictably or be moved by an agent. == Play == The game involves real-time decision making. Agents must choose moves in about .1 seconds. == Algorithms == The real-time requirement limits the use of compute-heavy techniques such as Monte Carlo tree search. The branching factor at each move can be as large as 1,296, because all four agents act in each step, choosing among six possibilities. The agents choose by accounting for explosions, which have lifetimes of 10 steps. Explosions derail tree search techniques, as searches with less than 10 levels ignore explosions while deeper searches consider too many choices (given the branching factor). A hybrid approach uses a limited-depth tree search followed by exploring a deterministic/pessimistic scenario. Limiting the depth keeps the search tree small. The deterministic approach can predict far in the future, by omitting branching. "Good" actions are often those that perform well under pessimistic scenarios, particularly if safety is important. Identifying the worst sequence of positions for an object can suggest where to move it. After generating pessimistic scenarios, the agent quantifies the survivability of each move, notionally the number of positions in which the agent can then remain safely (without encountering other agents). == Competitions == 3 competitions were organized with slightly changing rules during 2018–2019. === Online - FFA === This round was a warm-up online event, where each competitor controlled only one agent. Results: 1st: Agent47Agent by Yichen Gong 2nd: aiKiller by Márton Görög === NeurIPS 2018 - Team === The first Pommerman competition with in-person finals. Results: 1st: hakozakijunctions by Toshihiro Takahashi 2nd: eisenach by Márton Görög 3rd: dypm by Takayuki Osogami The 3 best performing solutions used online tree search. === NeurIPS 2019 - Team Radio === The second competition with in-person finals improved communication between teammate agents. Results: 1st: Márton Görög 2nd: Paul Jasek 3rd: Yifan Zhang
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Collision detection is the computational problem of detecting an intersection of two or more objects in virtual space. More precisely, it deals with the questions of if, when, and where two or more objects intersect. Collision detection is a classic problem of computational geometry with applications in computer graphics, physical simulation, video games, robotics (including autonomous driving), and computational physics. Collision detection algorithms can be divided into operating on 2D or 3D spatial objects. == Overview == Collision detection is closely linked to calculating the distance between objects, as objects collide when the distance between them is less than or equal to zero. Negative distances indicate that one object has penetrated another. Performing collision detection requires more context than just the distance between the objects. Accurately identifying the points of contact on both objects' surfaces is also essential for computing a physically accurate collision response. The complexity of this task increases with the level of detail in the objects' representations: the more intricate the model, the greater the computational cost. Collision detection frequently involves dynamic objects, adding a temporal dimension to distance calculations. Instead of simply measuring distance between static objects, collision detection algorithms often aim to determine whether the objects' motion will bring them to a point in time when their distance is zero—an operation that adds significant computational overhead. In collision detection involving multiple objects, a naive approach would require detecting collisions for all pairwise combinations of objects. As the number of objects increases, the number of required comparisons grows rapidly: for n {\displaystyle n} objects, n ( n − 1 ) / 2 {n(n-1)}/{2} intersection tests are needed with a naive approach. This quadratic growth makes such an approach computationally expensive as n {\displaystyle n} increases. Due to the complexity mentioned above, collision detection is a computationally intensive process. Nevertheless, it is essential for interactive applications like video games, robotics, and real-time physics engines. To manage these computational demands, extensive efforts have gone into optimizing collision detection algorithms. A commonly used approach towards accelerating the required computations is to divide the process into two phases: the broad phase and the narrow phase. The broad phase aims to answer the question of whether objects might collide, using a conservative but efficient approach to rule out pairs that clearly do not intersect, thus avoiding unnecessary calculations. Objects that cannot be definitively separated in the broad phase are passed to the narrow phase. Here, more precise algorithms determine whether these objects actually intersect. If they do, the narrow phase often calculates the exact time and location of the intersection. == Broad phase == This phase aims at quickly finding objects or parts of objects for which it can be quickly determined that no further collision test is needed. A useful property of such approach is that it is output sensitive. In the context of collision detection this means that the time complexity of the collision detection is proportional to the number of objects that are close to each other. An early example of that is the I-COLLIDE where the number of required narrow phase collision tests was O ( n + m ) {\displaystyle O(n+m)} where n {\displaystyle n} is the number of objects and m {\displaystyle m} is the number of objects at close proximity. This is a significant improvement over the quadratic complexity of the naive approach. === Spatial partitioning === Several approaches can be grouped under the spatial partitioning umbrella, which includes octrees (for 3D), quadtrees (for 2D), binary space partitioning (or BSP trees) and other, similar approaches. If one splits space into a number of simple cells, and if two objects can be shown not to be in the same cell, then they need not be checked for intersection. Dynamic scenes and deformable objects require updating the partitioning which can add overhead. === Bounding volume hierarchy === Bounding Volume Hierarchy (BVH) is a tree structure over a set of bounding volumes. Collision is determined by doing a tree traversal starting from the root. If the bounding volume of the root doesn't intersect with the object of interest, the traversal can be stopped. If, however there is an intersection, the traversal proceeds and checks the branches for each there is an intersection. Branches for which there is no intersection with the bounding volume can be culled from further intersection test. Therefore, multiple objects can be determined to not intersect at once. BVH can be used with deformable objects such as cloth or soft-bodies but the volume hierarchy has to be adjusted as the shape deforms. For deformable objects we need to be concerned about self-collisions or self intersections. BVH can be used for that end as well. Collision between two objects is computed by computing intersection between the bounding volumes of the root of the tree as there are collision we dive into the sub-trees that intersect. Exact collisions between the actual objects, or its parts (often triangles of a triangle mesh) need to be computed only between intersecting leaves. The same approach works for pair wise collision and self-collisions. === Exploiting temporal coherence === During the broad-phase, when the objects in the world move or deform, the data-structures used to cull collisions have to be updated. In cases where the changes between two frames or time-steps are small and the objects can be approximated well with axis-aligned bounding boxes, the sweep and prune algorithm can be a suitable approach. Several key observation make the implementation efficient: Two bounding-boxes intersect if, and only if, there is overlap along all three axes; overlap can be determined, for each axis separately, by sorting the intervals for all the boxes; and lastly, between two frames updates are typically small (making sorting algorithms optimized for almost-sorted lists suitable for this application). The algorithm keeps track of currently intersecting boxes, and as objects move, re-sorting the intervals helps keep track of the status. === Pairwise pruning === Once a pair of physical bodies has been selected for further investigation, collisions need to be checked more carefully. However, in many applications, individual objects (if they are not too deformable) are described by a set of smaller primitives, mainly triangles. So there are two sets of triangles, S = S 1 , S 2 , … , S n {\displaystyle S={S_{1},S_{2},\dots ,S_{n}}} and T = T 1 , T 2 , … , T n {\displaystyle T={T_{1},T_{2},\dots ,T_{n}}} (for simplicity, each set has the same number of triangles.) The obvious thing to do is to check all triangles S j {\displaystyle S_{j}} against all triangles T k {\displaystyle T_{k}} for collisions, but this involves n 2 {\displaystyle n^{2}} comparisons, which is highly inefficient. If possible, it is desirable to use a pruning algorithm to reduce the number of pairs of triangles that need to be checked. The most widely used family of algorithms is known as the hierarchical bounding volumes method. As a preprocessing step, for each object (e.g., S {\displaystyle S} and T {\displaystyle T} ) calculates a hierarchy of bounding volumes. Then, at each time step, when collisions need to be checked between S {\displaystyle S} and T {\displaystyle T} , the hierarchical bounding volumes are used to reduce the number of pairs of triangles under consideration. For simplicity, provide an example using bounding spheres, although it has been noted that spheres are undesirable in many cases. If E {\displaystyle E} is a set of triangles, a bounding sphere is pre-calculated. B ( E ) {\displaystyle B(E)} . There are many ways of choosing B ( E ) {\displaystyle B(E)} , B ( E ) {\displaystyle B(E)} is a sphere that completely contains E {\displaystyle E} and is as small as possible. Ahead of time, B ( S ) {\displaystyle B(S)} and B ( T ) {\displaystyle B(T)} can be computed. Clearly, if these two spheres do not intersect (and that is very easy to test), then neither do S {\displaystyle S} and T {\displaystyle T} . This is not much better than an n-body pruning algorithm, however. If E = E 1 , E 2 , … , E m {\displaystyle E={E_{1},E_{2},\dots ,E_{m}}} is a set of triangles, then split it into two halves L ( E ) := E 1 , E 2 , … , E m / 2 {\displaystyle L(E):={E_{1},E_{2},\dots ,E_{m/2}}} and R ( E ) := E m / 2 + 1 , … , E m − 1 , E m {\displaystyle R(E):={E_{m/2+1},\dots ,E_{m-1},E_{m}}} . Apply this to S {\displaystyle S} and T {\displaystyle T} , and calculate (ahead of time) the bounding spheres B ( L ( S ) ) , B ( R ( S ) ) {\displaystyle B(L(S)),B(R(S))} and B ( L ( T ) ) , B ( R ( T ) ) {\displaystyle B(L(T)),B(R(T))} . T
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Plants vs. Zombies: Replanted is a 2025 tower defense video game developed by PopCap Seattle, The Lost Pixels, and published by Electronic Arts. It is a remaster of the 2009 game Plants vs. Zombies, introducing upscaled graphics and new additional content. Plants vs. Zombies: Replanted was released for video game consoles and personal computers on October 23, 2025. It received generally positive reviews from critics, but was criticized by the original game's development team for including fabricated concept art and for mishandling the soundtrack. == Gameplay == Plants vs. Zombies: Replanted follows the same gameplay of the original Plants vs. Zombies game with very minor changes. It is a lane-based tower defense game where the player has to defend their home from incoming zombies. The player can place various plants by spending "sun", the game's currency during levels. Sun icons can be collected from the sky during daytime and from sun-producing plants such as sunflowers. Some plants can attack zombies while some can act as defense. If all zombies are defeated in a level, the player wins. If a zombie reaches the left side of the line, a lawn mower—or other similar, relevant object—will activate and clear the row of any zombies, but if the lawn mower has already been used, and another zombie crosses, the game is over. === Replanted features === Plants vs. Zombies: Replanted contains up to 4K upscaled graphics and widescreen support, in comparison to the original game's static 800x600 resolution and 4:3 aspect ratio. Replanted now has full controller support and features local multiplayer modes ported from the original game's seventh generation console ports: co-op, where two players play together with assigned roles; and Versus, where one plays as the plants and the other as the zombies. No online multiplayer is planned, however support for Steam Remote Play was later added in a patch as an alternative for Windows users. Replanted also contains quality-of-life features. Gameplay can now be sped up by the player's will, with a max speed increase of 2.5x. Sun icons can now be mass collected using the "Sun Magnet." On Windows, players can quick-select plants from their seed bank using the number keys as hotkeys. Replanted also introduces two new additional game modes. "Cloudy Day" is a set of non-linear levels in the Adventure campaign. These levels only allow Sunflowers as sun-producing plants. During these levels, the amount of sun dropped from the sky and produced by plants are lowered. At certain times, rain clouds will move over the lawn. While these clouds are present, sun will stop appearing from the sky and from Sunflowers. However, all plants will cost around half their original price and have significantly faster recharge times. "R.I.P. Mode" is a harder difficulty of the Adventure campaign, but the player is forced back to the beginning if they lose a single level. Replanted additionally features "bonus levels" included as non-linear levels in the Adventure campaign. These include 10 new minigames that were previously unused in the original game. In a later update, Replanted added "Survival: Endless" levels to all five areas of the game instead of just the daytime pool. == Development == The existence of a Plants vs. Zombies remaster was revealed in an interview with Janet Robin from The String Revolution, who they did a vinyl collaboration with the franchise in 2025 with Iam8bit. Janet stated that EA commissioned them to record an acoustic composition of the track "Crazy Dave" to be used for an "anniversary edition" of the game. The song would be additionally be a tribute to the song "Bad Guy", which artist Billie Eilish has stated to be somewhat similar to the track. Plants vs. Zombies Replanted was officially announced in a Nintendo Direct presentation in late July 2025. As an incentive, people who pre-ordered the game are given an in-game retro-styled skin of the Peashooter. Replanted was showcased at PAX West on August 25, 2025. A dev diary for Plants vs. Zombies: Replanted was uploaded to YouTube on October 17, 2025. The video features Nick Reinhart, Jake Neri, and Matt Townsend. A developer panel for the game was available during TwitchCon 2025. == Release == Plants vs. Zombies: Replanted was released for Nintendo Switch, Nintendo Switch 2, PlayStation 4, PlayStation 5, Xbox One, Xbox Series X and Series S, and personal computers on October 23, 2025. It was leaked onto the internet on October 17, 2025. Players discovered multiple software bugs, and multiple assets alleged to be upscaled by generative artificial intelligence were found, leading to backlash. Numerous bugs were fixed in a day-one patch on October 23, 2025. == Reception == === Critical response === The versions of Plants vs. Zombies: Replanted for Windows, PlayStation 5, and Nintendo Switch 2 received "generally favorable" reviews from critics, according to review aggregator website Metacritic, while the Xbox Series X version received "mixed or average" reviews. According to OpenCritic, 57% of critics recommended it. IGN's Alessandro Fillari called it "a good way to get re-acquainted with one of the quirkiest puzzle-strategy games of the 2000s", while acknowledging its questionable decisions. Shacknews' David Craddock said it was his favorite version of Plants vs. Zombies, stating, "it packs everything fans loved about the original game, plus lots more" while justifying its US$20 price. The Verge described Replanted as "a time capsule from a simpler, happier time". Kyle Hilliard from Game Informer praised its faithfulness, complimenting the new animations and character designs that did not alter its memorability. Noah Hunter for Final Weapon described the remake as solid, though criticized the lack of certain features and containing bugs that gate it from being excellent. Ben Lyons from Gamereactor stated Replanted is the same as the original overall, despite believing the £18 price is not justified. === Original developers === Rich Werner, the original game's character designer, claims that some concept art contained in the game, speculated to be for Plants vs. Zombies: Garden Warfare (2014), did not originate from the original's development. Werner also stated that concept art for the Disco Zombie is fabricated; the design for the Disco Zombie was created after the estate of Michael Jackson requested the original Dancing Zombie, who resembles Michael Jackson from his Thriller music video, be removed from the game. On October 19, 2026, composer Laura Shigihara expressed her dissatisfaction with the lack of dynamic music in the game. Dynamic music would later be implemented in a later patch. In an interview featuring Rich Werner and user interface designer Matt Holmberg on April 29, 2026, Werner revealed that he and Shigihara were contacted by EA to make a music video to market Replanted. However, after the game was leaked, Werner's response on social media led EA to cancel the collaboration.
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Woken Furies (2005) is a science fiction novel by British writer Richard Morgan. It is the third novel featuring the anti-hero Takeshi Kovacs and is the sequel to Broken Angels. This addition to the series casts light upon Kovacs' early life providing information on his post-envoy activities. Morgan's official website and interviews suggest that Woken Furies could be the last Kovacs novel, although in 2018 (before Netflix cancelled the show) Morgan stated that the Netflix adaptation has "kind of woken it all up again" after all these years, making him possibly reconsider being done with Kovacs. == Plot == Takeshi Kovacs finds himself in a new "sleeve," or human body, back on his home planet of Harlan's World. He is on the run after making numerous attacks against the Knights of the New Revelation, an extremist religious order responsible for the death of his lost love and her daughter. Because she had violated tenets about resleeving, her executioners dropped her and her daughter's cortical stacks in the sea, effectively preventing them from being resleeved (into new bodies). While trying to secure passage after his most recent attack, Kovacs saves a woman named Sylvie from a group of religious zealots. In return, she allows him to take refuge with her mercenary "deCom" crew as they head out to decommission sentient military hardware that has run amok on the island of New Hokkaido (AKA New Hok). Sylvie is the "command head" of her crew, co-ordinating them during missions by using her biologically implanted circuitry and software. During one of these missions, Sylvie collapses, regains consciousness, and Kovacs realizes that her personality seems to have been replaced by that of long-dead revolutionary leader Quellcrist Falconer. Harlan's World is surrounded by automated "orbitals" which target flying objects, such as vehicles, with high-energy beam weapons known as "angelfire"; Falconer is believed to have died without a backup of her cortical stack when her getaway aircraft was destroyed by angelfire 300 years prior. When Sylvie's crew returns from New Hok, they discover a younger version of Kovacs has been illegally duplicated into a different body (AKA "double sleeved") and is hunting them on behalf of the Harlan family that rules the planet. Most of Sylvie's crew is killed and Sylvie/Quellcrist is captured. Kovacs schemes to rescue Sylvie by approaching old criminal associates of his, the Little Blue Bugs. The Little Blue Bugs mount a semi-successful attack on a Harlan fortress and rescue Sylvie/Quellcrist. Hiding from Harlan forces in a floating base, the neo-Quellists are sold out by its owner and recaptured. An assault by Kovacs and a single UN Envoy on the base ends badly when Kovacs is betrayed by the Envoy who was actually embedded with several colleagues. However, Sylvie/Quellcrist has established a connection with the orbitals and calls down angelfire, eliminating their captors. The younger Kovacs is killed in the aftermath. Sylvie explains that angelfire is a destructive recording device. Thus, in destroying Quellcrist and the helicopter carrying her, it copied her. When the technology of the deCom crews advanced far enough, her persona was able to insert itself into Sylvie's implants and co-exist in her body. The novel ends with Kovacs, Virginia Vidaura, and Sylvie/Quellcrist waiting to see if they can use Sylvie/Quellcrist's newfound connection to the orbitals and the expansion of a long-dormant genetic virus to turn the population against the ruling oligarchy.
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Split Up is an intelligent decision support system, which makes predictions about the distribution of marital property following divorce in Australia. It is designed to assist judges, registrars of the Family Court of Australia, mediators and lawyers. Split Up operates as a hybrid system, combining rule – based reasoning with neural network theory. Rule based reasoning operates within strict parameters, in the form: IF < condition(s) > then
Fantavision is an animation program by Scott Anderson for the Apple II and published by Broderbund in 1985. Versions were released for the Apple IIGS (1987), Amiga (1988), and MS-DOS (1988). Fantavision allows the creation of vector graphics animations using the mouse and keyboard. The user creates frames, and the software generates the frames between them. Because this is done in real-time, it allows for creative exploration and quick changes. The program uses a graphical user interface in the style of the Macintosh with pull-down menus and black text on a white background. Advertisements claimed Fantavision a revolutionary breakthrough that brings the animation features of "tweening" and "transforming" to home computers. == Reception == Compute! in 1989 called Fantavision the best animation program for the IBM PC, although it noted the inability to draw curves. == Reviews == Games #70
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Artificial intelligence in pharmacy refers to the application of artificial intelligence (AI) techniques across pharmaceutical research and practice, including drug discovery, drug delivery, safety monitoring, clinical decision support, and pharmacy operations. Machine learning, deep learning, and natural language processing have been applied to tasks ranging from molecular design to patient adherence monitoring, with the aim of reducing development costs, improving accuracy, and personalizing treatment. Adoption has been uneven. Barriers include limited AI training among pharmacists, high infrastructure costs, and the risk of harm from models trained on unrepresentative data. Regulatory frameworks for AI-based pharmaceutical tools remain in active development across most jurisdictions. == Applications == === Drug discovery and development === Drug development is resource-intensive: bringing a single drug to market typically costs around $2.6 billion and takes 12–14 years. Machine learning algorithms have been applied to analyze molecular datasets to identify potential drug candidates, predict drug–target interactions, and optimize formulations. Artificial neural networks and generative adversarial networks have been used in drug discovery tasks including virtual screening, structure-activity relationship modeling, and de novo molecule generation. Peptides designed using AI methods have shown activity against multidrug-resistant bacteria, and transcriptomic data from human cell lines has been used to train deep learning models to classify drugs by therapeutic properties. Results in drug discovery have been mixed. AI models depend on the quality and diversity of their training data; those trained on narrow chemical libraries can fail to generalize to novel molecular scaffolds. The gap between high virtual screening hit rates and success in preclinical or clinical testing remains a persistent challenge, and the translation of computationally predicted candidates into approved drugs has been slower than early projections suggested. === Drug delivery systems === AI methods including neural networks, principal component analysis, and neuro-fuzzy logic have been applied to identifying biological targets for pharmaceuticals and analyzing genetic information relevant to drug design. Computational models can predict how a formulation will behave in biological systems, helping narrow the field before laboratory synthesis begins. Systems have been proposed that monitor patient response and adjust doses in real time based on individual physiology, with potential applications in chronic disease management. Research has also explored AI applications in targeted cancer treatments and oral vaccine delivery, areas where precise control over drug release kinetics is a design priority. === Drug safety === AI has been applied to predicting and detecting adverse drug reactions using techniques including knowledge graphs, logistic regression classifiers, and neural networks. A 2023 study developed a machine learning algorithm using knowledge graph analysis to classify known causes of adverse reactions. Natural language processing and deep learning models including long short-term memory (LSTM) networks have shown better performance than conventional methods for detecting opioid misuse, drawing on both structured data from electronic health records and unstructured sources such as clinical notes. AI-based pharmacovigilance systems can scan large volumes of electronic health records and social media for drug safety signals at a scale not feasible with manual review. Limitations include difficulty distinguishing drug-related adverse events from unrelated conditions in free-text data, and the need for validated benchmarks to measure model performance against existing safety monitoring standards. === Clinical decision support and personalized medicine === Machine learning systems trained on patient datasets can predict individual risk profiles, including potential allergies and drug–drug interactions, reducing the risk of harm in complex polypharmacy cases where the number of possible interactions exceeds what a clinician can readily assess. Personalized dosing models have been developed for drugs with narrow therapeutic windows — including anticoagulants and immunosuppressants — using patient-specific variables such as weight, renal function, and relevant genetic markers. Prospective clinical validation of these systems has lagged behind their technical development. Most published evaluations report performance on retrospective datasets, and the regulatory pathway for AI-based clinical decision support tools in pharmacy varies by jurisdiction. === Pharmacy operations and automation === Robotic and AI-driven systems have been applied to dispensing accuracy and pharmacy logistics. At the UCSF Medical Center, robotic technology produced 350,000 medication doses with no dispensing errors recorded. Robots such as TUG assist with preparing and transporting medications and laboratory samples within hospital settings. AI has also been applied to inventory management, with demand-forecasting systems predicting medicine requirements to reduce shortages and minimize waste from expired stock. In community pharmacy settings, AI tools have been used to flag potential prescription errors and alert pharmacists to drug–drug interactions before dispensing. === Medication adherence === Confirming that patients take prescribed medications as directed is a persistent challenge in healthcare. AI-enabled tools including smart pillboxes, RFID tags, ingestible sensors, and video check-ins have been applied to this problem. Smart pillboxes record when they are opened, providing real-time adherence data that can be reviewed remotely by care teams. Ingestible sensors transmit a signal after dissolution, offering direct confirmation of ingestion rather than proxy measures such as pill count or self-report. == Adoption challenges == === Barriers === Several barriers limit AI adoption in pharmacy practice. Many published evaluations report model performance on retrospective datasets rather than prospective clinical outcomes, making it difficult to assess real-world benefit. Pharmacists have reported limited AI training and knowledge, and research facilities often lack the computational infrastructure required for model development and validation. Models trained on biased or unrepresentative datasets can produce misleading results with direct patient safety consequences. === Regulatory frameworks === Regulatory frameworks for AI-based pharmaceutical tools are in active development. In the United States, the Food and Drug Administration (FDA) has issued guidance on AI and machine learning-based software as a medical device, addressing requirements for pre-market review and post-market performance monitoring. The European Medicines Agency has published discussion papers on the use of AI across the medicines development lifecycle, with particular attention to transparency in model training and validation. The absence of harmonized international standards creates compliance complexity for developers operating across multiple jurisdictions. === Ethical challenges === AI adoption raises data privacy and security concerns, including the risk of exposing sensitive patient information through data breaches. Algorithmic bias presents a related hazard: a model trained on an unrepresentative patient population may generate unsuitable treatment recommendations for patients not reflected in its training data, with potential for disparate outcomes across demographic groups. The opacity of some machine learning models, particularly deep neural networks, limits clinicians' ability to interpret or contest a recommendation, raising questions of accountability when a model-assisted decision results in patient harm. === Proposed solutions === Responses proposed in the literature include AI-focused education programs for pharmacists, increased public funding for healthcare AI research, encryption and governance frameworks for patient data, and regulatory requirements to prevent the use of biased training datasets. Greater transparency about training data provenance, model architecture, and validation methodology has also been recommended, including disclosure requirements in regulatory submissions. === Future directions === Research groups have called for tighter integration between AI systems and electronic health records to reduce healthcare costs and improve continuity of care across settings. International collaboration through shared AI frameworks and federated learning approaches has been proposed to address data scarcity in underrepresented patient populations and accelerate validation across institutions.
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Orange is an open-source data visualization, machine learning and data mining toolkit. It features a visual programming front-end for exploratory qualitative data analysis and interactive data visualization. == Description == Orange is a component-based visual programming software package for data visualization, machine learning, data mining, and data analysis. Orange components are called widgets. They range from simple data visualization, subset selection, and preprocessing to empirical evaluation of learning algorithms and predictive modeling. Visual programming is implemented through an interface in which workflows are created by linking predefined or user-designed widgets, while advanced users can use Orange as a Python library for data manipulation and widget alteration. == Software == Orange is an open-source software package released under GPL and hosted on GitHub. Versions up to 3.0 include core components in C++ with wrappers in Python. From version 3.0 onwards, Orange uses common Python open-source libraries for scientific computing, such as numpy, scipy and scikit-learn, while its graphical user interface operates within the cross-platform Qt framework. The default installation includes a number of machine learning, preprocessing and data visualization algorithms in 6 widget sets (data, transform, visualize, model, evaluate and unsupervised). Additional functionalities are available as add-ons (text-mining, image analytics, bioinformatics, etc.). Orange is supported on macOS, Windows and Linux and can also be installed from the Python Package Index repository (pip install Orange3). == Features == Orange consists of a canvas interface onto which the user places widgets and creates a data analysis workflow. Widgets offer basic functionalities such as reading the data, showing a data table, selecting features, training predictors, comparing learning algorithms, visualizing data elements, etc. The user can interactively explore visualizations or feed the selected subset into other widgets. Canvas: graphical front-end for data analysis Widgets: Data: widgets for data input, data filtering, sampling, imputation, feature manipulation and feature selection Visualize: widgets for common visualization (box plot, histograms, scatter plot) and multivariate visualization (mosaic display, sieve diagram). Classify: a set of supervised machine learning algorithms for classification Regression: a set of supervised machine learning algorithms for regression Evaluate: cross-validation, sampling-based procedures, reliability estimation and scoring of prediction methods Unsupervised: unsupervised learning algorithms for clustering (k-means, hierarchical clustering) and data projection techniques (multidimensional scaling, principal component analysis, correspondence analysis). == Add-ons == Orange users can extend their core set of components with components in the add-ons. Supported add-ons include: Associate: components for mining frequent itemsets and association rule learning. Bioinformatics: components for gene expression analysis, enrichment, and access to expression databases (e.g., Gene Expression Omnibus) and pathway libraries. Data fusion: components for fusing different data sets, collective matrix factorization, and exploration of latent factors. Educational: components for teaching machine learning concepts, such as k-means clustering, polynomial regression, stochastic gradient descent, ... Explain: provides an extension with components for the model explanation, including Shapley value analysis Geo: components for working with geospatial data. Image analytics: components for working with images and ImageNet embeddings Network: components for graph and network analysis. Text mining: components for natural language processing and text mining. Time series: widget components for time series analysis and modeling. Single-cell: support for single-cell gene expression analysis, including components for loading single-cell data, filtering and batch effect removal, marker genes discovery, scoring of cells and genes, and cell type prediction. Spectroscopy: components for analyzing and visualization of (hyper)spectral datasets. Survival analysis: add-on for data analysis dealing with survival data. It includes widgets for standard survival analysis techniques, such as the Kaplan-Meier plot, the Cox regression model, and several derivative widgets. World Happiness: support for downloading socioeconomic data from a database, including OECD and World Development Indicators. Provides access to thousands of country indicators from various economic databases. Fairness: add-on for evaluation and creation of fair machine learning models without discrimination. Widgets range from computing fairness metrics like statistical parity to post-, pre-, in-processing methods to build fair models. == Objectives == The program provides a platform for experiment selection, recommendation systems, and predictive modelling and is used in biomedicine, bioinformatics, genomic research, and teaching. In science, it is used as a platform for testing new machine learning algorithms and for implementing new techniques in genetics and bioinformatics. In education, it was used for teaching machine learning and data mining methods to students of biology, biomedicine, and informatics. == Extensions == Various projects build on Orange either by extending the core components with add-ons or using only the Orange Canvas to exploit the implemented visual programming features and GUI. OASYS — ORange SYnchrotron Suite scOrange — single cell biostatistics Quasar — data analysis in natural sciences == History == In 1996, the University of Ljubljana and Jožef Stefan Institute started development of ML, a machine learning framework in C++, and Python bindings were developed for this framework in 1997, which, together with emerging Python modules, formed a joint framework called Orange. Over the following years, most contemporary major algorithms for data mining and machine learning were implemented in C++ (Orange's core) or Python modules. In 2002, first prototypes to create a flexible graphical user interface were designed using Pmw Python megawidgets. In 2003, the graphical user interface was redesigned and re-developed for Qt framework using PyQt Python bindings. The visual programming framework was defined, and the development of widgets (graphical components of the data analysis pipeline) began. In 2005, extensions for data analysis in bioinformatics was created. In 2008, Mac OS X DMG and Fink-based installation packages were developed. In 2009, over 100 widgets were created and maintained. In 2009, Orange 2.0 beta was released, offering installation packages on the website based on the daily compiling cycle. In 2012, a new object hierarchy was imposed, replacing the old module-based structure. In 2013, a significant redesign of the graphical user interface included a new toolbox and depiction of workflows. In 2015, Orange 3.0 was released. Orange stores the data in NumPy arrays; machine learning algorithms mostly use scikit-learn. In 2015, a text analysis add-on for Orange3 was released. In 2016, Orange released version 3.3. Development scheduled a monthly cycle for stable releases. In 2016, Orange began development and release of an Image Analytics add-on, with server-side deep neural networks for image embedding In 2017, a Spectroscopy add-on for the analysis of spectral data was introduced. In 2017, Geo, an add-on for dealing with geo-location data and visualisation of geo maps was introduced In 2018, Orange began development and release of an add-on for single-cell data analysis. In 2019, Orange separated its graphical interface for development as a separate project, orange-canvas-core In 2020, Orange introduced the Explain add-on with widgets for explaining classification models and regression models, highlighting the strength and contributions specific features make towards predicting a specific class. In 2022, World Happiness, an add-on for the Orange3 data mining suite, was introduced, providing widgets for accessing socioeconomic data from various databases such as World Happiness Report, World Development Indicators, OECD. In 2022, Orange extended the Explain add-on with an Individual Conditional Expectation plot and the Permutation Feature Importance technique. In 2023, Orange introduced the Fairness add-on, including widgets to calculate bias metrics, as well as widgets for pre-, post-, and in-processing methods, allowing the creation of models less susceptible to systematic error due to the vagaries of the data set.
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