A recursive neural network is a kind of deep neural network created by applying the same set of weights recursively over a structured input, to produce a structured prediction over variable-size input structures, or a scalar prediction on it, by traversing a given structure in topological order. These networks were first introduced to learn distributed representations of structure (such as logical terms), but have been successful in multiple applications, for instance in learning sequence and tree structures in natural language processing (mainly continuous representations of phrases and sentences based on word embeddings). == Architectures == === Basic === In the simplest architecture, nodes are combined into parents using a weight matrix (which is shared across the whole network) and a non-linearity such as the tanh {\displaystyle \tanh } hyperbolic function. If c 1 {\displaystyle c_{1}} and c 2 {\displaystyle c_{2}} are n {\displaystyle n} -dimensional vector representations of nodes, their parent will also be an n {\displaystyle n} -dimensional vector, defined as: p 1 , 2 = tanh ( W [ c 1 ; c 2 ] ) {\displaystyle p_{1,2}=\tanh(W[c_{1};c_{2}])} where W {\displaystyle W} is a learned n × 2 n {\displaystyle n\times 2n} weight matrix. This architecture, with a few improvements, has been used for successfully parsing natural scenes, syntactic parsing of natural language sentences, and recursive autoencoding and generative modeling of 3D shape structures in the form of cuboid abstractions. === Recursive cascade correlation (RecCC) === RecCC is a constructive neural network approach to deal with tree domains with pioneering applications to chemistry and extension to directed acyclic graphs. === Unsupervised RNN === A framework for unsupervised RNN has been introduced in 2004. === Tensor === Recursive neural tensor networks use a single tensor-based composition function for all nodes in the tree. == Training == === Stochastic gradient descent === Typically, stochastic gradient descent (SGD) is used to train the network. The gradient is computed using backpropagation through structure (BPTS), a variant of backpropagation through time used for recurrent neural networks. == Properties == The universal approximation capability of RNNs over trees has been proved in literature. == Related models == === Recurrent neural networks === Recurrent neural networks are recursive artificial neural networks with a certain structure: that of a linear chain. Whereas recursive neural networks operate on any hierarchical structure, combining child representations into parent representations, recurrent neural networks operate on the linear progression of time, combining the previous time step and a hidden representation into the representation for the current time step. === Tree Echo State Networks === An efficient approach to implement recursive neural networks is given by the Tree Echo State Network within the reservoir computing paradigm. === Extension to graphs === Extensions to graphs include graph neural network (GNN), Neural Network for Graphs (NN4G), and more recently convolutional neural networks for graphs.
Actionstep
Actionstep is a cloud-based legal practice management software for law firms and compliance-focused businesses. Actionstep is built to be a comprehensive practice management software with features for workflow automation as well as automatic document generation == History == Actionstep was created by Ted Jordan, CEO of Actionstep, in 2004. It was first used commercially in 2005 by a New Zealand construction franchise as well as a law firm. Actionstep soon expanded into central government and a wider range of small business users (mainly in New Zealand and Australia). After a few years the expanse of their legal client base prompted the company to add key legal specific features to the product with the aim of further expanding their legal market. Through Actionstep's tenure as a practice management software they have gradually expanded from their headquarters in New Zealand and offices located in the United Kingdom and the United States of America. In October 2020, private equity firm Serent Capital Partners purchased 84.25% stake in Actionstep. In April 2022, the company announced unlimited annual leave to its staff == Product == The premise of Actionstep is that it saves companies from having to purchase software tailored to their work flow and instead allows companies to modify the program without additional coding.{{Citation needed}} The founder and CEO Ted Jordan used cloud technology to allow the software to be continuously updated without the need to purchase or redesign new software. This theoretically allows businesses to remain current all the time and cut external I.T. costs.{{Citation needed}} Actionstep also integrates with software from other companies, such as Xero accounting, Microsoft Office & Office 365, Gmail, Google Drive, Dropbox, NetDocuments, QuickBooks, LawPay, BundleDocs, Box, HotDocs, Infotrack, GlobalX, PEXA, JOSEF and Zapier. Actionstep contains workflow automation features aimed at increasing office efficiency. These automated processes include automatic task assignment, information collection, document generation & automation, cataloguing, and matter generation. == Awards == Actionstep was named First International Best of SaaS Showplace Award Winner in 2009. Actionstep has also been a finalist in the ComputerWorld Excellence Awards (2007), and the Vero Excellence in Business Support (2010).
GeWorkbench
geWorkbench (genomics Workbench) is an open-source software platform for integrated genomic data analysis. It is a desktop application written in the programming language Java. geWorkbench uses a component architecture. As of 2016, there are more than 70 plug-ins available, providing for the visualization and analysis of gene expression, sequence, and structure data. geWorkbench is the Bioinformatics platform of MAGNet, the National Center for the Multi-scale Analysis of Genomic and Cellular Networks, one of the 8 National Centers for Biomedical Computing funded through the NIH Roadmap (NIH Common Fund). Many systems and structure biology tools developed by MAGNet investigators are available as geWorkbench plugins. == Features == Computational analysis tools such as t-test, hierarchical clustering, self-organizing maps, regulatory network reconstruction, BLAST searches, pattern-motif discovery, protein structure prediction, structure-based protein annotation, etc. Visualization of gene expression (heatmaps, volcano plot), molecular interaction networks (through Cytoscape), protein sequence and protein structure data (e.g., MarkUs). Integration of gene and pathway annotation information from curated sources as well as through Gene Ontology enrichment analysis. Component integration through platform management of inputs and outputs. Among data that can be shared between components are expression datasets, interaction networks, sample and marker (gene) sets and sequences. Dataset history tracking - complete record of data sets used and input settings. Integration with 3rd party tools such as GenePattern, Cytoscape, and Genomespace. Demonstrations of each feature described can be found at GeWorkbench-web Tutorials. == Versions == geWorkbench is open-source software that can be downloaded and installed locally. A zip file of the released version Java source is also available. Prepackaged installer versions also exist for Windows, Macintosh, and Linux.
Variational autoencoder
In machine learning, a variational autoencoder (VAE) is an artificial neural network architecture introduced by Diederik P. Kingma and Max Welling in 2013. It is part of the families of probabilistic graphical models and variational Bayesian methods. In addition to being seen as an autoencoder neural network architecture, variational autoencoders can also be studied within the mathematical formulation of variational Bayesian methods, connecting a neural encoder network to its decoder through a probabilistic latent space (for example, as a multivariate Gaussian distribution) that corresponds to the parameters of a variational distribution. Thus, the encoder maps each point (such as an image) from a large complex dataset into a distribution within the latent space, rather than to a single point in that space. The decoder has the opposite function, which is to map from the latent space to the input space, again according to a distribution (although in practice, noise is rarely added during the decoding stage). By mapping a point to a distribution instead of a single point, the network can avoid overfitting the training data. Both networks are typically trained together with the usage of the reparameterization trick, although the variance of the noise model can be learned separately. Although this type of model was initially designed for unsupervised learning, its effectiveness has been proven for semi-supervised learning and supervised learning. == Overview of architecture and operation == A variational autoencoder is a generative model with a prior and noise distribution respectively. Usually such models are trained using the expectation-maximization meta-algorithm (e.g. probabilistic PCA, (spike & slab) sparse coding). Such a scheme optimizes a lower bound of the data likelihood, which is usually computationally intractable, and in doing so requires the discovery of q-distributions, or variational posteriors. These q-distributions are normally parameterized for each individual data point in a separate optimization process. However, variational autoencoders use a neural network as an amortized approach to jointly optimize across data points. In that way, the same parameters are reused for multiple data points, which can result in massive memory savings. The first neural network takes as input the data points themselves, and outputs parameters for the variational distribution. As it maps from a known input space to the low-dimensional latent space, it is called the encoder. The decoder is the second neural network of this model. It is a function that maps from the latent space to the input space, e.g. as the means of the noise distribution. It is possible to use another neural network that maps to the variance, however this can be omitted for simplicity. In such a case, the variance can be optimized with gradient descent. To optimize this model, one needs to know two terms: the "reconstruction error", and the Kullback–Leibler divergence (KL-D). Both terms are derived from the free energy expression of the probabilistic model, and therefore differ depending on the noise distribution and the assumed prior of the data, here referred to as p-distribution. For example, a standard VAE task such as IMAGENET is typically assumed to have a gaussianly distributed noise; however, tasks such as binarized MNIST require a Bernoulli noise. The KL-D from the free energy expression maximizes the probability mass of the q-distribution that overlaps with the p-distribution, which unfortunately can result in mode-seeking behaviour. The "reconstruction" term is the remainder of the free energy expression, and requires a sampling approximation to compute its expectation value. More recent approaches replace Kullback–Leibler divergence (KL-D) with various statistical distances, see "Statistical distance VAE variants" below. == Formulation == From the point of view of probabilistic modeling, one wants to maximize the likelihood of the data x {\displaystyle x} by their chosen parameterized probability distribution p θ ( x ) = p ( x | θ ) {\displaystyle p_{\theta }(x)=p(x|\theta )} . This distribution is usually chosen to be a Gaussian N ( x | μ , σ ) {\displaystyle N(x|\mu ,\sigma )} which is parameterized by μ {\displaystyle \mu } and σ {\displaystyle \sigma } respectively, and as a member of the exponential family it is easy to work with as a noise distribution. Simple distributions are easy enough to maximize, however distributions where a prior is assumed over the latents z {\displaystyle z} results in intractable integrals. Let us find p θ ( x ) {\displaystyle p_{\theta }(x)} via marginalizing over z {\displaystyle z} . p θ ( x ) = ∫ z p θ ( x , z ) d z , {\displaystyle p_{\theta }(x)=\int _{z}p_{\theta }({x,z})\,dz,} where p θ ( x , z ) {\displaystyle p_{\theta }({x,z})} represents the joint distribution under p θ {\displaystyle p_{\theta }} of the observable data x {\displaystyle x} and its latent representation or encoding z {\displaystyle z} . According to the chain rule, the equation can be rewritten as p θ ( x ) = ∫ z p θ ( x | z ) p θ ( z ) d z {\displaystyle p_{\theta }(x)=\int _{z}p_{\theta }({x|z})p_{\theta }(z)\,dz} In the vanilla variational autoencoder, z {\displaystyle z} is usually taken to be a finite-dimensional vector of real numbers, and p θ ( x | z ) {\displaystyle p_{\theta }({x|z})} to be a Gaussian distribution. Then p θ ( x ) {\displaystyle p_{\theta }(x)} is a mixture of Gaussian distributions. It is now possible to define the set of the relationships between the input data and its latent representation as Prior p θ ( z ) {\displaystyle p_{\theta }(z)} Likelihood p θ ( x | z ) {\displaystyle p_{\theta }(x|z)} Posterior p θ ( z | x ) {\displaystyle p_{\theta }(z|x)} Unfortunately, the computation of p θ ( z | x ) {\displaystyle p_{\theta }(z|x)} is expensive and in most cases intractable. To speed up the calculus to make it feasible, it is necessary to introduce a further function to approximate the posterior distribution as q ϕ ( z | x ) ≈ p θ ( z | x ) {\displaystyle q_{\phi }({z|x})\approx p_{\theta }({z|x})} with ϕ {\displaystyle \phi } defined as the set of real values that parametrize q {\displaystyle q} . This is sometimes called amortized inference, since by "investing" in finding a good q ϕ {\displaystyle q_{\phi }} , one can later infer z {\displaystyle z} from x {\displaystyle x} quickly without doing any integrals. In this way, the problem is to find a good probabilistic autoencoder, in which the conditional likelihood distribution p θ ( x | z ) {\displaystyle p_{\theta }(x|z)} is computed by the probabilistic decoder, and the approximated posterior distribution q ϕ ( z | x ) {\displaystyle q_{\phi }(z|x)} is computed by the probabilistic encoder. Parametrize the encoder as E ϕ {\displaystyle E_{\phi }} , and the decoder as D θ {\displaystyle D_{\theta }} . == Evidence lower bound (ELBO) == Like many deep learning approaches that use gradient-based optimization, VAEs require a differentiable loss function to update the network weights through backpropagation. For variational autoencoders, the idea is to jointly optimize the generative model parameters θ {\displaystyle \theta } to reduce the reconstruction error between the input and the output, and ϕ {\displaystyle \phi } to make q ϕ ( z | x ) {\displaystyle q_{\phi }({z|x})} as close as possible to p θ ( z | x ) {\displaystyle p_{\theta }(z|x)} . As reconstruction loss, mean squared error and cross entropy are often used. The Kullback–Leibler divergence D K L ( q ϕ ( z | x ) ∥ p θ ( z | x ) ) {\displaystyle D_{KL}(q_{\phi }({z|x})\parallel p_{\theta }({z|x}))} can be used as a loss function to squeeze q ϕ ( z | x ) {\displaystyle q_{\phi }({z|x})} under p θ ( z | x ) {\displaystyle p_{\theta }(z|x)} . This divergence loss expands to D K L ( q ϕ ( z | x ) ∥ p θ ( z | x ) ) = E z ∼ q ϕ ( ⋅ | x ) [ ln q ϕ ( z | x ) p θ ( z | x ) ] = E z ∼ q ϕ ( ⋅ | x ) [ ln q ϕ ( z | x ) p θ ( x ) p θ ( x , z ) ] = ln p θ ( x ) + E z ∼ q ϕ ( ⋅ | x ) [ ln q ϕ ( z | x ) p θ ( x , z ) ] . {\displaystyle {\begin{aligned}D_{KL}(q_{\phi }({z|x})\parallel p_{\theta }({z|x}))&=\mathbb {E} _{z\sim q_{\phi }(\cdot |x)}\left[\ln {\frac {q_{\phi }(z|x)}{p_{\theta }(z|x)}}\right]\\&=\mathbb {E} _{z\sim q_{\phi }(\cdot |x)}\left[\ln {\frac {q_{\phi }({z|x})p_{\theta }(x)}{p_{\theta }(x,z)}}\right]\\&=\ln p_{\theta }(x)+\mathbb {E} _{z\sim q_{\phi }(\cdot |x)}\left[\ln {\frac {q_{\phi }({z|x})}{p_{\theta }(x,z)}}\right].\end{aligned}}} Now, define the evidence lower bound (ELBO): L θ , ϕ ( x ) := E z ∼ q ϕ ( ⋅ | x ) [ ln p θ ( x , z ) q ϕ ( z | x ) ] = ln p θ ( x ) − D K L ( q ϕ ( ⋅ | x ) ∥ p θ ( ⋅ | x ) ) {\displaystyle L_{\theta ,\phi }(x):=\mathbb {E} _{z\sim q_{\phi }(\cdot |x)}\left[\ln {\frac {p_{\theta }(x,z)}{q_{\phi }({z|x})}}\right]=\ln p_{\theta }(x)-D_{KL}(q_{\phi }({\cdot |x})\parallel p_{\theta }({\cdot |x}))} Maximizing the ELBO θ ∗ , ϕ ∗ = argmax θ , ϕ L θ , ϕ ( x ) {\dis
Variable kernel density estimation
In statistics, adaptive or "variable-bandwidth" kernel density estimation is a form of kernel density estimation in which the size of the kernels used in the estimate are varied depending upon either the location of the samples or the location of the test point. It is a particularly effective technique when the sample space is multi-dimensional. == Rationale == Given a set of samples, { x → i } {\displaystyle \lbrace {\vec {x}}_{i}\rbrace } , we wish to estimate the density, P ( x → ) {\displaystyle P({\vec {x}})} , at a test point, x → {\displaystyle {\vec {x}}} : P ( x → ) ≈ W n h D {\displaystyle P({\vec {x}})\approx {\frac {W}{nh^{D}}}} W = ∑ i = 1 n w i {\displaystyle W=\sum _{i=1}^{n}w_{i}} w i = K ( x → − x → i h ) {\displaystyle w_{i}=K\left({\frac {{\vec {x}}-{\vec {x}}_{i}}{h}}\right)} where n is the number of samples, K is the "kernel", h is its width and D is the number of dimensions in x → {\displaystyle {\vec {x}}} . The kernel can be thought of as a simple, linear filter. Using a fixed filter width may mean that in regions of low density, all samples will fall in the tails of the filter with very low weighting, while regions of high density will find an excessive number of samples in the central region with weighting close to unity. To fix this problem, we vary the width of the kernel in different regions of the sample space. There are two methods of doing this: balloon and pointwise estimation. In a balloon estimator, the kernel width is varied depending on the location of the test point. In a pointwise estimator, the kernel width is varied depending on the location of the sample. For multivariate estimators, the parameter, h, can be generalized to vary not just the size, but also the shape of the kernel. This more complicated approach will not be covered here. == Balloon estimators == A common method of varying the kernel width is to make it inversely proportional to the density at the test point: h = k [ n P ( x → ) ] 1 / D {\displaystyle h={\frac {k}{\left[nP({\vec {x}})\right]^{1/D}}}} where k is a constant. If we back-substitute the estimated PDF, and assuming a Gaussian kernel function, we can show that W is a constant: W = k D ( 2 π ) D / 2 {\displaystyle W=k^{D}(2\pi )^{D/2}} A similar derivation holds for any kernel whose normalising function is of the order hD, although with a different constant factor in place of the (2 π)D/2 term. This produces a generalization of the k-nearest neighbour algorithm. That is, a uniform kernel function will return the KNN technique. There are two components to the error: a variance term and a bias term. The variance term is given as: e 1 = P ∫ K 2 n h D {\displaystyle e_{1}={\frac {P\int K^{2}}{nh^{D}}}} . The bias term is found by evaluating the approximated function in the limit as the kernel width becomes much larger than the sample spacing. By using a Taylor expansion for the real function, the bias term drops out: e 2 = h 2 n ∇ 2 P {\displaystyle e_{2}={\frac {h^{2}}{n}}\nabla ^{2}P} An optimal kernel width that minimizes the error of each estimate can thus be derived. == Use for statistical classification == The method is particularly effective when applied to statistical classification. There are two ways we can proceed: the first is to compute the PDFs of each class separately, using different bandwidth parameters, and then compare them as in Taylor. Alternatively, we can divide up the sum based on the class of each sample: P ( j , x → ) ≈ 1 n ∑ i = 1 , c i = j n w i {\displaystyle P(j,{\vec {x}})\approx {\frac {1}{n}}\sum _{i=1,c_{i}=j}^{n}w_{i}} where ci is the class of the ith sample. The class of the test point may be estimated through maximum likelihood.
Digital Michelangelo Project
The Digital Michelangelo Project was a pioneering initiative undertaken during the 1998–1999 academic year to digitize the sculptures and architecture of Michelangelo using advanced laser scanning technology. The project was led by a team of 30 faculty, staff, and students from Stanford University and the University of Washington, with the aim of creating high-resolution 3D models of Michelangelo's works for scholarly, educational, and preservation purposes. == Objectives == The primary goals of the Digital Michelangelo Project were: To apply recent advancements in laser rangefinder technology for digitizing large cultural artifacts. To create detailed digital archives of Michelangelo's sculptures and architectural spaces for future study and analysis. To explore potential educational and curatorial applications for 3D scanned data. === Artworks digitized === The project involved scanning several iconic works by Michelangelo, including: David The Unfinished Slaves (Atlas, Awakening, Bearded, and Youthful) St. Matthew The allegorical statues from the Medici tombs (Night, Day, Dawn, and Dusk) The architectural interiors of the Tribuna del David at the Galleria dell'Accademia and the New Sacristy in the Medici Chapels. == Technology and methodology == === 3D scanning === The project's primary scanner was a laser triangulation rangefinder mounted on a motorized gantry, custom-built by Cyberware Inc. The scanner used a laser sheet to project onto an object, capturing its shape through triangulation. Multiple scans were taken from various angles and combined into a single, detailed 3D mesh. The resolution achieved was fine enough to capture even Michelangelo's chisel marks, with triangles approximately 0.25 mm on each side. In addition to shape data, color data was captured using a spotlight and a secondary camera, enabling the creation of textured 3D models. === Data processing === The project developed a software suite for processing the scanned data. This included: Aligning and merging multiple scans into a seamless 3D model. Filling holes in the geometry caused by inaccessible areas. Correcting color data for lighting inconsistencies and shadowing. Non-photorealistic rendering techniques were also applied, highlighting surface features such as Michelangelo’s chisel marks for enhanced visualization. == Logistical challenges == The scale and complexity of the project presented several challenges: Data size: The dataset for David alone comprised 2 billion polygons and 7,000 color images, occupying 60 GB of storage. Artifact safety: Ensuring the safety of the statues during scanning required extensive crew training, foam-encased equipment, and collision-prevention mechanisms. == Applications and impact == The digitized models have numerous potential applications: Art history: Allowing precise measurements and geometric analysis, such as determining chisel types or evaluating structural balance. Education: Providing new ways to study art, including interactive viewing from unconventional angles and with custom lighting. Museum curation: Enhancing visitor experiences through interactive kiosks and virtual models. The project demonstrated the potential for 3D technology to preserve and disseminate cultural heritage. == Data distribution == The project's models are available through Stanford University for scholarly purposes, under strict licensing due to Italian intellectual property laws. === ScanView === To provide public access to the 3D models while respecting usage restrictions, the project developed ScanView, a client/server rendering system. ScanView allows users to view and interact with high-resolution 3D models without downloading the data. The client component consists of a freely available viewer program and simplified 3D models. Users can navigate these models locally, adjusting position, orientation, lighting, and surface appearance. When a user finalizes a view, the client queries a remote server for a high-resolution rendering of the model, which is sent back to overwrite the simplified version on the user’s screen. A typical query-response cycle takes 1–2 seconds, depending on network conditions. To protect the models from unauthorized reconstruction, the system employs several security measures, including: Encrypting queries Perturbing viewpoint and lighting parameters Adding noise and warping rendered images Compressing images before transmission ScanView operates on Windows-based PCs and provides access to selected models, including David and St. Matthew, as well as other artifacts such as fragments of the Forma Urbis Romae and items from the Stanford 3D Scanning Repository. == Sponsors == The Digital Michelangelo Project was supported by Stanford University, Interval Research Corporation, and the Paul G. Allen Foundation for the Arts.
Genotypic and phenotypic repair
Genotypic and phenotypic repair are optional components of an evolutionary algorithm (EA). An EA reproduces essential elements of biological evolution as a computer algorithm in order to solve demanding optimization or planning tasks, at least approximately. A candidate solution is represented by a - usually linear - data structure that plays the role of an individual's chromosome. New solution candidates are generated by mutation and crossover operators following the example of biology. These offspring may be defective, which is corrected or compensated for by genotypic or phenotypic repair. == Description == Genotypic repair, also known as genetic repair, is the removal or correction of impermissible entries in the chromosome that violate restrictions. In phenotypic repair, the corrections are only made in the genotype-phenotype mapping and the chromosome remains unchanged. Michalewicz wrote about the importance of restrictions in real-world applications: "In general, constraints are an integral part of the formulation of any problem". Restriction violations are application-specific and therefore it depends on the current problem whether and which type of repair is useful. They can usually also be treated by a correspondingly extended evaluation and it depends on the problem which measures are possible and which is the most suitable. If a phenotypic repair is feasible, then it is usually the most efficient compared to the other measures. A survey on repair methods used as constraint handling techniques can be found in. Violations of the range limits of genes should be avoided as far as possible by the formulation of the genome. If this is not possible or if restrictions within the search space defined by the genome are involved, their violations are usually handled by the evaluation. This can be done, for example, by penalty functions that lower the fitness. Repair is often also required for combinatorial tasks. The application of a 1- or n-point crossover operator can, for example, lead to genes being missing in one of the child genomes that are present in duplicate in the other. In this case, a suitable genotypic repair measure is to move the surplus genes to the other genome in a positional manner. The use of the aforementioned operators in combinatorial tasks has also proven to be useful in combination with crossover types specially developed for permutations, at least for certain problems. Particularly in combinatorial problems, it has been observed that genotypic repair can promote premature convergence to a suboptimum, but can also significantly accelerate a successful search. Studies on various tasks have shown that this is application-dependent. An effective measure to avoid premature convergence is generally the use of structured populations instead of the usual panmictic ones. Sequence restrictions play a role in many scheduling tasks, for example when it comes to planning workflows. If, for example, it is specified that step A must be carried out before step B and the gene of step B is located before the gene of A in the chromosome, then there is an impermissible gene sequence. This is because the scheduling operation of step B requires the planned end of step A for correct scheduling, but this is not yet scheduled at the time gene B is processed. The problem can be solved in two ways: The scheduling operation of step B is postponed until the gene from step A has been processed. The genome remains unchanged and the repair only influences the genotype-phenotype mapping. Since only the phenotype is changed, this is referred to as phenotypic repair. If, on the other hand, the gene of step B is moved behind the gene of step A, this is a genotypic repair. The same applies to the alternative shift of gene A in front of gene B. In this case, genotypic repair has the disadvantage that it prevents a meaningful restructuring of the gene sequence in the chromosome if this requires several intermediate steps (mutations) that at least partially violate restrictions.