Embodied cognitive science is an interdisciplinary field of research, the aim of which is to explain the mechanisms underlying intelligent behavior. It comprises three main methodologies: the modeling of psychological and biological systems in a holistic manner that considers the mind and body as a single entity; the formation of a common set of general principles of intelligent behavior; and the experimental use of robotic agents in controlled environments. == Contributors == Embodied cognitive science borrows heavily from embodied philosophy and the related research fields of cognitive science, psychology, neuroscience and artificial intelligence. Contributors to the field include: From the perspective of neuroscience, Gerald Edelman of the Neurosciences Institute at La Jolla, Francisco Varela of CNRS in France, and J. A. Scott Kelso of Florida Atlantic University From the perspective of psychology, Lawrence Barsalou, Michael Turvey, Vittorio Guidano and Eleanor Rosch From the perspective of linguistics, Gilles Fauconnier, George Lakoff, Mark Johnson, Leonard Talmy and Mark Turner From the perspective of language acquisition, Eric Lenneberg and Philip Rubin at Haskins Laboratories From the perspective of anthropology, Edwin Hutchins, Bradd Shore, James Wertsch and Merlin Donald. From the perspective of autonomous agent design, early work is sometimes attributed to Rodney Brooks or Valentino Braitenberg From the perspective of artificial intelligence, Understanding Intelligence by Rolf Pfeifer and Christian Scheier or How the Body Shapes the Way We Think, by Rolf Pfeifer and Josh C. Bongard From the perspective of philosophy, Andy Clark, Dan Zahavi, Shaun Gallagher, and Evan Thompson In 1950, Alan Turing proposed that a machine may need a human-like body to think and speak: It can also be maintained that it is best to provide the machine with the best sense organs that money can buy, and then teach it to understand and speak English. That process could follow the normal teaching of a child. Things would be pointed out and named, etc. Again, I do not know what the right answer is, but I think both approaches should be tried. == Traditional cognitive theory == Embodied cognitive science is an alternative theory to cognition in which it minimizes appeals to computational theory of mind in favor of greater emphasis on how an organism's body determines how and what it thinks. Traditional cognitive theory is based mainly around symbol manipulation, in which certain inputs are fed into a processing unit that produces an output. These inputs follow certain rules of syntax, from which the processing unit finds semantic meaning. Thus, an appropriate output is produced. For example, a human's sensory organs are its input devices, and the stimuli obtained from the external environment are fed into the nervous system which serves as the processing unit. From here, the nervous system is able to read the sensory information because it follows a syntactic structure, thus an output is created. This output then creates bodily motions and brings forth behavior and cognition. Of particular note is that cognition is sealed away in the brain, meaning that mental cognition is cut off from the external world and is only possible by the input of sensory information. == The embodied cognitive approach == Embodied cognitive science differs from the traditionalist approach in that it denies the input-output system. This is chiefly due to the problems presented by the Homunculus argument, which concluded that semantic meaning could not be derived from symbols without some kind of inner interpretation. If some little man in a person's head interpreted incoming symbols, then who would interpret the little man's inputs? Because of the specter of an infinite regress, the traditionalist model began to seem less plausible. Thus, embodied cognitive science aims to avoid this problem by defining cognition in three ways. === Physical attributes of the body === The first aspect of embodied cognition examines the role of the physical body, particularly how its properties affect its ability to think. This part attempts to overcome the symbol manipulation component that is a feature of the traditionalist model. Depth perception, for instance, can be better explained under the embodied approach due to the sheer complexity of the action. Depth perception requires that the brain detect the disparate retinal images obtained by the distance of the two eyes. In addition, body and head cues complicate this further. When the head is turned in a given direction, objects in the foreground will appear to move against objects in the background. From this, it is said that some kind of visual processing is occurring without the need of any kind of symbol manipulation. This is because the objects appearing to move the foreground are simply appearing to move. This observation concludes then that depth can be perceived with no intermediate symbol manipulation necessary. A more poignant example exists through examining auditory perception. Generally speaking the greater the distance between the ears, the greater the possible auditory acuity. Also relevant is the amount of density in between the ears, for the strength of the frequency wave alters as it passes through a given medium. The brain's auditory system takes these factors into account as it process information, but again without any need for a symbolic manipulation system. This is because the distance between the ears for example does not need symbols to represent it. The distance itself creates the necessary opportunity for greater auditory acuity. The amount of density between the ears is similar, in that it is the actual amount itself that simply forms the opportunity for frequency alteration. Thus under consideration of the physical properties of the body, a symbolic system is unnecessary and an unhelpful metaphor. === The body's role in the cognitive process === The second aspect draws heavily from George Lakoff's and Mark Johnson's work on concepts. They argued that humans use metaphors whenever possible to better explain their external world. Humans also have a basic stock of concepts in which other concepts can be derived from. These basic concepts include spatial orientations such as up, down, front, and back. Humans can understand what these concepts mean because they can directly experience them from their own bodies. For example, because human movement revolves around standing erect and moving the body in an up-down motion, humans innately have these concepts of up and down. Lakoff and Johnson contend this is similar with other spatial orientations such as front and back too. As mentioned earlier, these basic stocks of spatial concepts are the basis in which other concepts are constructed. Happy and sad for instance are seen now as being up or down respectively. When someone says they are feeling down, what they are really saying is that they feel sad for example. Thus the point here is that true understanding of these concepts is contingent on whether one can have an understanding of the human body. So the argument goes that if one lacked a human body, they could not possibly know what up or down could mean, or how it could relate to emotional states. [I]magine a spherical being living outside of any gravitational field, with no knowledge or imagination of any other kind of experience. What could UP possibly mean to such a being? While this does not mean that such beings would be incapable of expressing emotions in other words, it does mean that they would express emotions differently from humans. Human concepts of happiness and sadness would be different because human would have different bodies. So then an organism's body directly affects how it can think, because it uses metaphors related to its body as the basis of concepts. === Interaction of local environment === A third component of the embodied approach looks at how agents use their immediate environment in cognitive processing. Meaning, the local environment is seen as an actual extension of the body's cognitive process. The example of a personal digital assistant (PDA) is used to better imagine this. Echoing functionalism (philosophy of mind), this point claims that mental states are individuated by their role in a much larger system. So under this premise, the information on a PDA is similar to the information stored in the brain. So then if one thinks information in the brain constitutes mental states, then it must follow that information in the PDA is a cognitive state too. Consider also the role of pen and paper in a complex multiplication problem. The pen and paper are so involved in the cognitive process of solving the problem that it seems ridiculous to say they are somehow different from the process, in very much the same way the PDA is used for information like the brain. Another example examines how humans control and manipulate their environment
Free boundary condition
In image processing, the free boundary condition is the convention used when applying a convolution kernel to a digital image in which pixel locations that lie outside the image boundaries are interpreted as having a value of zero.[1] The question of what value to assign out-of-bounds pixels may arise, for instance, when applying a 3×3 kernel to the corner pixel in an image.
Artificial intelligence in India
The artificial intelligence (AI) market in India is projected to reach $8 billion by 2025, growing at 40% CAGR from 2020 to 2025. This growth is part of the broader AI boom, a global period of rapid technological advancements with India being pioneer starting in the early 2010s with NLP based Chatbots from Haptik, Corover.ai, Niki.ai and then gaining prominence in the early 2020s based on reinforcement learning, marked by breakthroughs such as generative AI models from Krutrim, Sarvam, CoRover, OpenAI and Alphafold by Google DeepMind. In India, the development of AI has been similarly transformative, with applications in healthcare, finance, and education, bolstered by government initiatives like NITI Aayog's 2018 National Strategy for Artificial Intelligence. Institutions such as the Indian Statistical Institute and the Indian Institute of Science published breakthrough AI research papers and patents. India's transformation to AI is primarily being driven by startups and government initiatives & policies like Digital India. By fostering technological trust through digital public infrastructure, India is tackling socioeconomic issues by taking a bottom-up approach to AI. NASSCOM and Boston Consulting Group estimate that by 2027, India's AI services might be valued at $17 billion. According to 2025 Technology and Innovation Report, by UN Trade and Development, India ranks 10th globally for private sector investments in AI. According to Mary Meeker, India has emerged as a key market for AI platforms, accounting for the largest share of ChatGPT's mobile app users and having the third-largest user base for DeepSeek in 2025. While AI presents significant opportunities for economic growth and social development in India, challenges such as data privacy concerns, skill shortages, and ethical considerations need to be addressed for responsible AI deployment. The growth of AI in India has also led to an increase in the number of cyberattacks that use AI to target organizations. == History == === Early days (1960s-1980s) === The TIFRAC (Tata Institute of Fundamental Research Automatic Calculator) was designed and developed by a team led by Rangaswamy Narasimhan between 1954 and 1960. He worked on pattern recognition from 1961 to 1964 at the University of Illinois Urbana-Champaign's Digital Computer Laboratory. In order to conduct research on database technology, computer networking, computer graphics, and systems software, he and M. G. K. Menon founded the National Centre for Software Development and Computing Techniques. In 1965, he established the Computer Society of India and supervised the initial research work on AI at Tata Institute of Fundamental Research. Jagdish Lal launched the first computer science program in 1976 at Motilal Nehru Regional Engineering College. H. K. Kesavan from the University of Waterloo and Vaidyeswaran Rajaraman from the University of Wisconsin–Madison joined the IIT Kanpur Electrical Engineering Department in 1963–1964 as Assistant Professor and Head of Department, respectively. H.N. Mahabala, who was employed at Bendix Corporation's Computer Division, joined the department in 1965. He previously worked with Marvin Minsky. The IIT Kanpur Computer Center was led by H. K. Kesavan, with Vaidyeswaran Rajaraman serving as his deputy. Kesavan informally permitted Rajaraman and Mahabala to introduce artificial intelligence into computer science classes. The computer science program was approved by IIT Kanpur in 1971 and split out from the electrical engineering department. In 1973, an IBM System/370 Model 155 was installed at IIT Madras. John McCarthy, head of the Artificial Intelligence Laboratory at Stanford University visited IIT Kanpur in 1971. He donated PDP-1 with a time-sharing operating system. During the 1970s, the balance of payments deficit in India restricted import of computers. The Department of Computer Science and Automation at the Indian Institute of Science established in 1969, played an important role in nurturing the development of data science and artificial intelligence in India. First course on AI was introduced in the 1970s by G. Krishna. B. L. Deekshatulu introduced the first course on pattern recognition in the early 1970s. === Foundation phase === ==== 1980s ==== In the 1980s, the Indian Statistical Institute's Optical Character Recognition Project was one of the country's first attempts at studying artificial intelligence and machine learning. OCR technology has benefited greatly from the work of ISI's Computer Vision and Pattern Recognition Unit, which is headed by Bidyut Baran Chaudhuri. He also contributed in the development of computer vision and digital image processing. As part of the Indian Fifth Generation Computer Systems Research Programme, the Department of Electronics, with support from the United Nations Development Programme, initiated the Knowledge Based Computer Systems Project in 1986, marking the beginning of India's first major AI research program. Prime Minister Rajiv Gandhi requested that the Department of Electronics and IISc to initiate the Parallel Processing Project in 1986–1987. The Center for Development of Advanced Computing eventually joined those efforts. IIT Madras was selected to develop system diagnosis, ISI for image processing, National Centre for Software Technology for natural language processing and TIFR for speech processing. In 1987, the proposal of N. Seshagiri, Director General of the National Informatics Centre for the prototype development of supercomputer was cleared. Negotiations for a Cray supercomputer were underway between the Reagan administration and the Rajiv Gandhi government. US Defense Secretaries Frank Carlucci and Caspar Weinberger visited New Delhi after the US approved the transfer in 1988. The sale of a lower-end XMP-14 supercomputer was permitted in lieu of the Cray XMP-24 supercomputer due to security concerns. The Center for Development of Advanced Computing was formally established in March 1988 by the Ministry of Communications and Information Technology (previously the Ministry of IT) within the Department of Information Technology (formerly the Department of Electronics) in response to a recommendation made to the Prime Minister by the Scientific Advisory Council. The National Initiative in Supercomputing, which produced the PARAM series, was led by Vijay P. Bhatkar. For the first ten years, supercomputing and Indian language computing were the two main focus areas. C-DAC has expanded its operations in order to meet the needs in a number of domains, including network and internet software, real-time systems, artificial intelligence, and NLP. Under the direction of Professor KV Ramakrishnamacharyulu from National Sanskrit University and Professor Rajeev Sangal from the International Institute of Information Technology, Hyderabad, the Akshar Bharati Research Group was established in 1984 with support from IIT Kanpur and the University of Hyderabad for computational processing of Indian languages. They focused on computational linguistics, NLP with ontological database systems, and Indian language/translation theories with linguistic tradition. ==== 1990s ==== From IIT Kanpur, Mohan Tambe joined C-DAC in the 1990s to work on Graphics and Intelligence based Script Technology (GIST), which addressed the challenge of adapting personal computer software based on Latin script to Devanagiri and a number of other Indian language scripts. He was previously working on the Machine Translation for Indian languages Project. Within C-DAC, he established the GIST group. The technology was expanded to encompass NLP, artificial intelligence-based machine-aided language learning and translation, multimedia and multilingual computing solutions, and more. GIST resulted in the creation of G-CLASS (GIST cross language search plug-ins suite), a cross-language search engine. The Applied Artificial Intelligence Group at C-DAC has developed some basic and novel applications in the field of NLP, including machine translation, information extraction/retrieval, automatic summarization, speech recognition, text-to-speech synthesis, intelligent language teaching, and natural language-based document management with Decision Support Systems. These applications are the result of the foundation laid by previous language technology activities. Software firms in the Indian private sector began looking into AI applications, mostly in the area of business process automation. In order to allow machines to read, comprehend, and interpret human languages, the Language Technologies Research Center was founded in October 1999 at the International Institute of Information Technology, Hyderabad. It focused on the advancements in semantic parsing, information extraction, natural language generation, sentiment analysis, and dialogue systems. Some of the early AI research in India was driven by societal needs. For example; Eklavya, a knowledge-based program created by I
Irish logarithm
The Irish logarithm was a system of number manipulation invented by Percy Ludgate for machine multiplication. The system used a combination of mechanical cams as lookup tables and mechanical addition to sum pseudo-logarithmic indices to produce partial products, which were then added to produce results. The technique is similar to Zech logarithms (also known as Jacobi logarithms), but uses a system of indices original to Ludgate. == Concept == Ludgate's algorithm compresses the multiplication of two single decimal numbers into two table lookups (to convert the digits into indices), the addition of the two indices to create a new index which is input to a second lookup table that generates the output product. Because both lookup tables are one-dimensional, and the addition of linear movements is simple to implement mechanically, this allows a less complex mechanism than would be needed to implement a two-dimensional 10×10 multiplication lookup table. Ludgate stated that he deliberately chose the values in his tables to be as small as he could make them; given this, Ludgate's tables can be simply constructed from first principles, either via pen-and-paper methods, or a systematic search using only a few tens of lines of program code. They do not correspond to either Zech logarithms, Remak indexes or Korn indexes. == Pseudocode == The following is an implementation of Ludgate's Irish logarithm algorithm in the Python programming language: Table 1 is taken from Ludgate's original paper; given the first table, the contents of Table 2 can be trivially derived from Table 1 and the definition of the algorithm. Note since that the last third of the second table is entirely zeros, this could be exploited to further simplify a mechanical implementation of the algorithm.
Manufacture Modules Technologies
Manufacture Modules Technologies Sarl (MMT) is a Swiss company established in Geneva in 2015 which originally specialised in the development and commercialization of "Horological Smartwatch modules", firmware, apps and cloud. Located at Geneva's Skylab high-tech hub, it expanded into the development and manufacturing of "E-Straps" operated with a mobile application. Philippe Fraboulet is the CEO. == History == In June 2015, Fullpower Technologies and Union Horlogère Suisse (Swiss Watchmakers Corporation) formed MMT as a joint venture, which then launched the MotionX Horological Smartwatch Open Platform for the Swiss watch industry. The initial licensees were Frederique Constant, Alpina and Mondaine, brands owned by Union Horlogère Suisse. Fullpower created and managed the circuit design, firmware, smartphone applications (including sleep activity), as well as the cloud Infrastructure. MMT managed the Swiss watch movement development and production as well as licensing and support. In July 2016, Union Horlogere Holding and MMT were spun-out of the Frédérique Constant Group. Fullpower Technologies' 19.99% share was acquired by Union Horlogere Holding BV, giving it 100% of MMT's shares. == Business == The company offers firmware, a cloud, manufacturing, service and over-the-air facilities for upgrades. The company also offers its own apps, which bear the label “Swiss Made software”.
Feature (machine learning)
In machine learning and pattern recognition, a feature is an individual measurable property or characteristic of a data set. Choosing informative, discriminating, and independent features is crucial to producing effective algorithms for pattern recognition, classification, and regression tasks. Features are usually numeric, but other types such as strings and graphs are used in syntactic pattern recognition, after some pre-processing step such as one-hot encoding. The concept of "features" is related to that of explanatory variables used in statistical techniques such as linear regression. == Feature types == In feature engineering, two types of features are commonly used: numerical and categorical. Numerical features are continuous values that can be measured on a scale. Examples of numerical features include age, height, weight, and income. Numerical features can be used in machine learning algorithms directly. Categorical features are discrete values that can be grouped into categories. Examples of categorical features include gender, color, and zip code. Categorical features typically need to be converted to numerical features before they can be used in machine learning algorithms. This can be done using a variety of techniques, such as one-hot encoding, label encoding, and ordinal encoding. The type of feature that is used in feature engineering depends on the specific machine learning algorithm that is being used. Some machine learning algorithms, such as decision trees, can handle both numerical and categorical features. Other machine learning algorithms, such as linear regression, can only handle numerical features. == Classification == A numeric feature can be conveniently described by a feature vector. One way to achieve binary classification is using a linear predictor function (related to the perceptron) with a feature vector as input. The method consists of calculating the scalar product between the feature vector and a vector of weights, qualifying those observations whose result exceeds a threshold. Algorithms for classification from a feature vector include nearest neighbor classification, neural networks, and statistical techniques such as Bayesian approaches. == Examples == In character recognition, features may include histograms counting the number of black pixels along horizontal and vertical directions, number of internal holes, stroke detection and many others. In speech recognition, features for recognizing phonemes can include noise ratios, length of sounds, relative power, filter matches, logarithmic Mel-scale spectral vectors and Mel-frequency cepstral coefficients, which represent the frequency characteristics of audio signals. In spam detection algorithms, features may include the presence or absence of certain email headers, the email structure, the language, the frequency of specific terms, the grammatical correctness of the text. In computer vision, there are a large number of possible features, such as edges and objects. == Feature vectors == In pattern recognition and machine learning, a feature vector is an n-dimensional vector of numerical features that represent some object. Many algorithms in machine learning require a numerical representation of objects, since such representations facilitate processing and statistical analysis. When representing images, the feature values might correspond to the pixels of an image, while when representing texts the features might be the frequencies of occurrence of textual terms. Feature vectors are equivalent to the vectors of explanatory variables used in statistical procedures such as linear regression. Feature vectors are often combined with weights using a dot product in order to construct a linear predictor function that is used to determine a score for making a prediction. The vector space associated with these vectors is often called the feature space. In order to reduce the dimensionality of the feature space, a number of dimensionality reduction techniques can be employed. Higher-level features can be obtained from already available features and added to the feature vector; for example, for the study of diseases the feature 'Age' is useful and is defined as Age = 'Year of death' minus 'Year of birth' . This process is referred to as feature construction. Feature construction is the application of a set of constructive operators to a set of existing features resulting in construction of new features. Examples of such constructive operators include checking for the equality conditions {=, ≠}, the arithmetic operators {+,−,×, /}, the array operators {max(S), min(S), average(S)} as well as other more sophisticated operators, for example count(S, C) that counts the number of features in the feature vector S satisfying some condition C or, for example, distances to other recognition classes generalized by some accepting device. Feature construction has long been considered a powerful tool for increasing both accuracy and understanding of structure, particularly in high-dimensional problems. Applications include studies of disease and emotion recognition from speech. == Selection and extraction == The initial set of raw features can be redundant and large enough that estimation and optimization is made difficult or ineffective. Therefore, a preliminary step in many applications of machine learning and pattern recognition consists of selecting a subset of features, or constructing a new and reduced set of features to facilitate learning, and to improve generalization and interpretability. Extracting or selecting features is a combination of art and science; developing systems to do so is known as feature engineering. It requires the experimentation of multiple possibilities and the combination of automated techniques with the intuition and knowledge of the domain expert. Automating this process is feature learning, where a machine not only uses features for learning, but learns the features itself.
Shapiro–Senapathy algorithm
The Shapiro—Senapathy algorithm (S&S) is a computational method for identifying splice sites in eukaryotic genes. The algorithm employs a Position Weight Matrix (PWM) scoring formula to predict donor and acceptor splice sites in any given gene. This methodology has been used to discover splice sites and disease-causing splice site mutations in the human genome, and has become a standard tool in clinical genomics. The S&S algorithm has been cited in thousands of clinical studies, according to Google Scholar. It has also formed the basis of widely used software, including Human Splicing Finder, SROOGLE, and Alamut, which identify splice sites and splice site mutations that cause disease. The algorithm has uncovered splicing mutations in diseases ranging from cancers to inherited disorders, and predicted the deleterious effects of these mutations including exon skipping, intron retention, and cryptic splice site activation. == The algorithm == A splice site defines the boundary between a coding exon and a non-coding intron in eukaryotic genes. The S&S algorithm employs a sliding window, corresponding to the length of the splice site motif, to scan a gene sequence and detect potential splice sites. For each sliding window, the algorithm calculates a score by comparing the nucleotide sequence to a Position Weight Matrix (PWM) derived from known splice sites. This formula generates a percentile score, indicating the likelihood that a given sequence functions as a donor or acceptor splice site. The majority of disease-causing mutations in the human genome are located in splice sites. Clinical genomics studies analyze the splice site scores generated by the S&S algorithm to predict the consequences of splice site mutations including exon skipping and intron retention. The algorithm's sensitivity to single-nucleotide changes allows it to determine mutations that may impact RNA splicing and contribute to disease. In addition to identifying real splice sites, the S&S algorithm has been used to discover cryptic splice sites — alternative splice sites activated by mutations — which may disrupt normal splicing. The algorithm detects mutations that lead to the activation of cryptic splice sites, which may be located proximal to real splice sites or deep within non-coding introns. It has thus been used to determine the causes of numerous diseases that are due to cryptic splicing. == Cancer gene discovery using S&S == The S&S algorithm has been used to identify splice-site mutations in genes associated with several cancers. For example, genes causing commonly occurring cancers including breast cancer, ovarian cancer, colorectal cancer, leukemia, head and neck cancers, prostate cancer, retinoblastoma, squamous cell carcinoma, gastrointestinal cancer, melanoma, liver cancer, Lynch syndrome, skin cancer, and neurofibromatosis have been found. In addition, splicing mutations in genes causing less commonly known cancers including gastric cancer, gangliogliomas, Li-Fraumeni syndrome, Loeys–Dietz syndrome, Osteochondromas (bone tumor), Nevoid basal cell carcinoma syndrome, and Pheochromocytomas have been identified. Specific mutations in different splice sites in various genes causing breast cancer (e.g., BRCA1, PALB2), ovarian cancer (e.g., SLC9A3R1, COL7A1, HSD17B7), colon cancer (e.g., APC, MLH1, DPYD), colorectal cancer (e.g., COL3A1, APC, HLA-A), skin cancer (e.g., COL17A1, XPA, POLH), and Fanconi anemia (e.g., FANC, FANA) have been uncovered. The mutations in the donor and acceptor splice sites in different genes causing a variety of cancers that have been identified by S&S are shown in Table 1. == Discovery of genes causing inherited disorders using S&S == Specific mutations in different splice sites in various genes that cause inherited disorders, including, for example, Type 1 diabetes (e.g., PTPN22, TCF1 (HCF-1A)), hypertension (e.g., LDL, LDLR, LPL), Marfan syndrome (e.g., FBN1, TGFBR2, FBN2), cardiac diseases (e.g., COL1A2, MYBPC3, ACTC1), eye disorders (e.g., EVC, VSX1) have been uncovered. A few example mutations in the donor and acceptor splice sites in different genes causing a variety of inherited disorders identified using S&S are shown in Table 2. == Genes causing immune system disorders == More than 100 immune system disorders affect humans, including inflammatory bowel diseases, multiple sclerosis, systemic lupus erythematosus, bloom syndrome, familial cold autoinflammatory syndrome, and dyskeratosis congenita. The Shapiro–Senapathy algorithm has been used to discover genes and mutations involved in many immune disorder diseases, including Ataxia telangiectasia, B-cell defects, epidermolysis bullosa, and X-linked agammaglobulinemia. Xeroderma pigmentosum, an autosomal recessive disorder is caused by faulty proteins formed due to new preferred splice donor site identified using S&S algorithm and resulted in defective nucleotide excision repair. Type I Bartter syndrome (BS) is caused by mutations in the gene SLC12A1. S&S algorithm helped in disclosing the presence of two novel heterozygous mutations c.724 + 4A > G in intron 5 and c.2095delG in intron 16 leading to complete exon 5 skipping. Mutations in the MYH gene, which is responsible for removing the oxidatively damaged DNA lesion are cancer-susceptible in the individuals. The IVS1+5C plays a causative role in the activation of a cryptic splice donor site and the alternative splicing in intron 1, S&S algorithm shows, guanine (G) at the position of IVS+5 is well conserved (at the frequency of 84%) among primates. This also supported the fact that the G/C SNP in the conserved splice junction of the MYH gene causes the alternative splicing of intron 1 of the β type transcript. Splice site scores were calculated according to S&S to find EBV infection in X-linked lymphoproliferative disease. Identification of Familial tumoral calcinosis (FTC) is an autosomal recessive disorder characterized by ectopic calcifications and elevated serum phosphate levels and it is because of aberrant splicing. == Application of S&S in hospitals for clinical practice and research == The Shapiro–Senapathy (S&S) algorithm has played a significant role in advancing the diagnosis and treatment of human diseases through its application in modern clinical genomics. With the widespread adoption of next-generation sequencing (NGS) technologies, the S&S algorithm is now routinely integrated into clinical practice by geneticists and diagnostic laboratories. It is implemented in various computational tools such as Human Splicing Finder (HSF), Splice Site Finder (SSF), and Alamut Visual, which assist in interpreting the functional impact of genetic variants on RNA splicing. The algorithm is particularly useful in identifying pathogenic splice site mutations in cases where the clinical presentation is unclear or where conventional diagnostic methods have failed to identify a causative gene. Its utility has been demonstrated across diverse patient cohorts, including individuals from different ethnic backgrounds with various cancers and inherited genetic disorders. The following are selected examples illustrating its application in clinical research. === Cancers === === Inherited disorders === == S&S - Algorithm for identifying splice sites, exons and split genes == The Shapiro–Senapathy algorithm (SSA) was developed to identify splice sites in uncharacterized genomic sequences, with early applications in the Human Genome Project. The method introduced a Position Weight Matrix (PWM)-based approach to analyze splicing sequences across eukaryotic organisms, marking the first computational framework to systematically define splice sites using probabilistic scoring. Key innovations of the algorithm included: Exon Detection – Exons were defined as sequences bounded by acceptor and donor splice sites with S&S scores above a threshold, requiring an open reading frame (ORF) for validation. Gene Prediction – The method enabled the identification of complete genes by assembling predicted exons, forming a basis for later gene-finding tools. Mutation Analysis – The algorithm distinguishes deleterious splice-site mutations (which disrupt protein function by lowering S&S scores) from neutral variations. This capability allowed researchers to study disease-linked cryptic splice sites in humans, animals, and plants. SSA's PWM-based framework influenced subsequent computational methods, including machine learning and neural network approaches, for splice-site prediction and alternative splicing research. It remains a foundational tool in genomics and disease studies. == Discovering the mechanisms of aberrant splicing in diseases == The Shapiro–Senapathy algorithm has been used to determine the various aberrant splicing mechanisms in genes due to deleterious mutations in the splice sites, which cause numerous diseases. Deleterious splice site mutations impair the normal splicing of the gene transcripts, and thereby make the encoded protei