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Absher (application)

Absher (Arabic: أبشر ‘Absher, roughly meaning "good tidings" or "yes, done") is a smartphone application and web portal which allows citizens and residents of Saudi Arabia to use a variety of governmental services. Amongst several other services with the Absher app, it can be used to apply for jobs and Hajj permits, passport info can be updated, and electronic crimes can be reported. The application provides around 280 services for residents of Saudi Arabia including but not limited to making appointments, renewing passports, residents' cards, IDs, driver's licenses and others, and, controversially, enables Saudi men to track the whereabouts of women they control as part of the country's male guardianship system. The app can be downloaded from the Google Play Store and Apple App Store and is supplied by the Saudi Interior Ministry. According to the Ministry of the Interior, Absher has more than 20 million users. As of February 2019, Absher has been downloaded 4.2 million times from the App Store. Some services provided through Absher can also be accessed through the website absher.sa. In March 2021, Saudi Arabia launched the digital version of the Absher for individuals app through which the users can download a copy of their digital ID. Then, new services were added to the platform such as online birth and death registration services, requesting amendments to academic credentials, correcting names in English and marital status and requesting civil records of children. == Impact on women's rights == The app has been criticized by various human rights activists, human rights organisations and international communities. The US and European countries have also condemned the app and urged the kingdom to end its male guardianship system. Absher gained media attention in 2019 for its functions supporting the Saudi policy of male guardianship following an investigation by Business Insider. The app allows for designated guardians to receive notifications if a woman under their guardianship passes through an airport and subsequently gives them the option to withdraw her right to travel. In a few cases, this system has been circumvented by women who have been able to gain control over its settings and use it to allow themselves to travel. US Senator Ron Wyden of Oregon wrote a letter to the CEO's of Apple and Google, criticizing the app and demanding for its removal immediately. Wyden said "American companies should not enable or facilitate the Saudi government's patriarchy," and called the Saudi system of control over women "abhorrent". According to the EU lawmakers, current rules imposed over the women by the Saudi government make women “second-class citizens”. The lawmakers also asked the EU states to continue to build pressure on Riyadh so as to improve the conditions of women and human rights. Amnesty International and Human Rights Watch accused Apple and Google of helping "enforce gender apartheid" by hosting the app. US congresswomen Rep. Katherine Clark and Rep. Carolyn B. Maloney condemned the kingdom's male guardianship system that reflected from the app, calling Absher a "patriarchal weapon" and asking for its removal. In response to the criticism received by Absher, Apple chief executive officer Tim Cook stated in February 2019 that he intended to investigate the situation. Similarly, Google announced that it would also review the application. After a prompt review, Google declined to remove the app from Google Play, citing that it did not violate the agreed upon terms and conditions of the store. Saudi doctor Khawla Al-Kuraya supported this app an editorial in Bloomberg News. Kuraya wrote that Absher helped Saudi women avoid governmental bureaucracy as it allows their male guardians to process their travel permits anywhere and anytime through Absher. Although she believes that the guardianship system needs to be reconsidered, she thinks that Absher is an important step towards facilitating women-guardians related issues in Saudi Arabia. Absher manager Atiyah Al-Anazy announced in 2019 that two million women were using the application in Saudi Arabia to facilitate their transactions. Some female users stated that the application has made their movement and travel-related issues easier. New measures were introduced that year to allow Saudi women above the age of 18 to travel without their male guardians, which ultimately released male authoritative rights on women. A law was subsequently passed allowing women over the age of 21 to receive a passport and travel without prior male permission.
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AI Clip Makers: Free vs Paid (2026)

Shopping for the best AI clip maker? An AI clip maker is software that uses machine learning to help you get more done — it keeps getting smarter as the underlying models improve. Pricing, accuracy, and the size of the model behind the tool are the three factors that most affect daily usefulness. Whether you are a beginner or a pro, the right AI clip maker slots into your workflow and pays for itself fast. Below we compare features, pricing, and real output so you can choose with confidence.
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How to Choose an AI Paragraph Rewriter

Comparing the best AI paragraph rewriter? An AI paragraph rewriter is software that uses machine learning to help you get more done — it lowers the barrier so anyone can produce professional output. Privacy matters too: check whether your data trains the model and whether a no-log or enterprise tier is available. Whether you are a beginner or a pro, the right AI paragraph rewriter slots into your workflow and pays for itself fast. Below we compare features, pricing, and real output so you can choose with confidence.
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Hartmut Neven

Hartmut Neven (born 1964) is a German American scientist working in quantum computing, computer vision, robotics and computational neuroscience. He is best known for his work in face and object recognition and his contributions to quantum machine learning. He is currently Vice President of Engineering at Google where he leads the Quantum Artificial Intelligence Lab, which he founded in 2012. == Education == Hartmut Neven studied Physics and Economics in Brazil, Köln, Paris, Tübingen and Jerusalem. He wrote his Master thesis on a neuronal model of object recognition at the Max Planck Institute for Biological Cybernetics under Valentino Braitenberg. In 1996 he received his Ph.D. in Physics from the Institute for Neuroinformatics at the Ruhr University in Bochum, Germany, for a thesis on "Dynamics for vision-guided autonomous mobile robots" written under the tutelage of Christoph von der Malsburg. He received a scholarship from the Studienstiftung des Deutschen Volkes, Germany's most prestigious scholarship foundation. == Work == In 1998 Neven became research professor of computer science at the University of Southern California at the Laboratory for Biological and Computational Vision. In 2003 he returned as the head of the Laboratory for Human-Machine Interfaces at USC's Information Sciences Institute. === Face recognition, avatars and face filters === Neven co-founded two companies, Eyematic for which he served as CTO and Neven Vision which he initially led as CEO. At Eyematic he developed face recognition technology and real-time facial feature analysis for avatar animation. Teams led by Neven have repeatedly won top scores in government sponsored tests designed to determine the most accurate face recognition software. Face filters, now ubiquitous on mobile phones, were launched for the first time by Neven Vision on the networks of NTT DoCoMo and Vodafone Japan in 2003. Neven Vision also pioneered mobile visual search for camera phones. Neven Vision was acquired by Google in 2006. === Object recognition and adversarial images === At Google he managed teams responsible for advancing Google's visual search technologies. His team launched Google Goggles now Google Lens. The concept of adversarial patterns originated in his group when he tasked Christian Szegedy with a project to modify the pixel inputs of a deep neural network to lower the activity of select output nodes. The motivation was to use this technique for object localization which did not work out. But the idea gave rise to the fields of adversarial learning and DeepDream art. In 2013 his optical character recognition team won the ICDAR Robust Reading Competition by a wide margin and in 2014 the object recognition team won the ImageNet challenge. === Google Glass === Neven was a co-founder of the Google Glass project. His team completed the first prototype, codenamed Ant, in 2011. === Quantum Artificial Intelligence === In 2006 Neven started to explore the application of quantum computing to hard combinatorial problems arising in machine learning. In collaboration with D-Wave Systems he developed the first image recognition system based on quantum algorithms. It was demonstrated at SuperComputing07. At NIPS 2009 his team demonstrated the first binary classifier trained on a quantum processor. In 2012 together with Pete Worden at NASA Ames he founded the Quantum Artificial Intelligence Laboratory. In 2014 he invited John M. Martinis and his group at UC Santa Barbara to join the lab to start a fabrication facility for superconducting quantum processors. The Quantum Artificial Intelligence team performed the first experimental demonstration of a scalable simulation of a molecule. In 2016 the team formulated an experiment to demonstrate quantum supremacy. Quantum supremacy was then declared by Google in October 2019. In 2023 Quantum AI researchers demonstrated that quantum error correction works in practice by showing for the first time that the error of a logical qubit decreases when increasing the number of physical qubits it is composed of. Google's quantum processors have been used to study the physics of quantum many body states that otherwise are challenging to prepare in a laboratory such as time crystals, traversable wormholes and non-Abelian anyons. ==== Neven's law ==== Neven's law states that the performance of quantum computers improves at a doubly exponential rate.
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Deep learning in photoacoustic imaging

Photoacoustic imaging (PA) is based on the photoacoustic effect, in which optical absorption causes a rise in temperature, which causes a subsequent rise in pressure via thermo-elastic expansion. This pressure rise propagates through the tissue and is sensed via ultrasonic transducers. Due to the proportionality between the optical absorption, the rise in temperature, and the rise in pressure, the ultrasound pressure wave signal can be used to quantify the original optical energy deposition within the tissue. Photoacoustic imaging has applications of deep learning in both photoacoustic computed tomography (PACT) and photoacoustic microscopy (PAM). PACT utilizes wide-field optical excitation and an array of unfocused ultrasound transducers. Similar to other computed tomography methods, the sample is imaged at multiple view angles, which are then used to perform an inverse reconstruction algorithm based on the detection geometry (typically through universal backprojection, modified delay-and-sum, or time reversal ) to elicit the initial pressure distribution within the tissue. PAM on the other hand uses focused ultrasound detection combined with weakly focused optical excitation (acoustic resolution PAM or AR-PAM) or tightly focused optical excitation (optical resolution PAM or OR-PAM). PAM typically captures images point-by-point via a mechanical raster scanning pattern. At each scanned point, the acoustic time-of-flight provides axial resolution while the acoustic focusing yields lateral resolution. == Applications of deep learning in PACT == The first application of deep learning in PACT was by Reiter et al. in which a deep neural network was trained to learn spatial impulse responses and locate photoacoustic point sources. The resulting mean axial and lateral point location errors on 2,412 of their randomly selected test images were 0.28 mm and 0.37 mm respectively. After this initial implementation, the applications of deep learning in PACT have branched out primarily into removing artifacts from acoustic reflections, sparse sampling, limited-view, and limited-bandwidth. There has also been some recent work in PACT toward using deep learning for wavefront localization. There have been networks based on fusion of information from two different reconstructions to improve the reconstruction using deep learning fusion based networks. === Using deep learning to locate photoacoustic point sources === Traditional photoacoustic beamforming techniques modeled photoacoustic wave propagation by using detector array geometry and the time-of-flight to account for differences in the PA signal arrival time. However, this technique failed to account for reverberant acoustic signals caused by acoustic reflection, resulting in acoustic reflection artifacts that corrupt the true photoacoustic point source location information. In Reiter et al., a convolutional neural network (similar to a simple VGG-16 style architecture) was used that took pre-beamformed photoacoustic data as input and outputted a classification result specifying the 2-D point source location. ==== Deep learning for PA wavefront localization ==== Johnstonbaugh et al. was able to localize the source of photoacoustic wavefronts with a deep neural network. The network used was an encoder-decoder style convolutional neural network. The encoder-decoder network was made of residual convolution, upsampling, and high field-of-view convolution modules. A Nyquist convolution layer and differentiable spatial-to-numerical transform layer were also used within the architecture. Simulated PA wavefronts served as the input for training the model. To create the wavefronts, the forward simulation of light propagation was done with the NIRFast toolbox and the light-diffusion approximation, while the forward simulation of sound propagation was done with the K-Wave toolbox. The simulated wavefronts were subjected to different scattering mediums and Gaussian noise. The output for the network was an artifact free heat map of the targets axial and lateral position. The network had a mean error rate of less than 30 microns when localizing target below 40 mm and had a mean error rate of 1.06 mm for localizing targets between 40 mm and 60 mm. With a slight modification to the network, the model was able to accommodate multi target localization. A validation experiment was performed in which pencil lead was submerged into an intralipid solution at a depth of 32 mm. The network was able to localize the lead's position when the solution had a reduced scattering coefficient of 0, 5, 10, and 15 cm−1. The results of the network show improvements over standard delay-and-sum or frequency-domain beamforming algorithms and Johnstonbaugh proposes that this technology could be used for optical wavefront shaping, circulating melanoma cell detection, and real-time vascular surgeries. === Removing acoustic reflection artifacts (in the presence of multiple sources and channel noise) === Building on the work of Reiter et al., Allman et al. utilized a full VGG-16 architecture to locate point sources and remove reflection artifacts within raw photoacoustic channel data (in the presence of multiple sources and channel noise). This utilization of deep learning trained on simulated data produced in the MATLAB k-wave library, and then later reaffirmed their results on experimental data. === Ill-posed PACT reconstruction === In PACT, tomographic reconstruction is performed, in which the projections from multiple solid angles are combined to form an image. When reconstruction methods like filtered backprojection or time reversal, are ill-posed inverse problems due to sampling under the Nyquist-Shannon's sampling requirement or with limited-bandwidth/view, the resulting reconstruction contains image artifacts. Traditionally these artifacts were removed with slow iterative methods like total variation minimization, but the advent of deep learning approaches has opened a new avenue that utilizes a priori knowledge from network training to remove artifacts. In the deep learning methods that seek to remove these sparse sampling, limited-bandwidth, and limited-view artifacts, the typical workflow involves first performing the ill-posed reconstruction technique to transform the pre-beamformed data into a 2-D representation of the initial pressure distribution that contains artifacts. Then, a convolutional neural network (CNN) is trained to remove the artifacts, in order to produce an artifact-free representation of the ground truth initial pressure distribution. ==== Using deep learning to remove sparse sampling artifacts ==== When the density of uniform tomographic view angles is under what is prescribed by the Nyquist-Shannon's sampling theorem, it is said that the imaging system is performing sparse sampling. Sparse sampling typically occurs as a way of keeping production costs low and improving image acquisition speed. The typical network architectures used to remove these sparse sampling artifacts are U-net and Fully Dense (FD) U-net. Both of these architectures contain a compression and decompression phase. The compression phase learns to compress the image to a latent representation that lacks the imaging artifacts and other details. The decompression phase then combines with information passed by the residual connections in order to add back image details without adding in the details associated with the artifacts. FD U-net modifies the original U-net architecture by including dense blocks that allow layers to utilize information learned by previous layers within the dense block. Another technique was proposed using a simple CNN based architecture for removal of artifacts and improving the k-wave image reconstruction. ==== Removing limited-view artifacts with deep learning ==== When a region of partial solid angles are not captured, generally due to geometric limitations, the image acquisition is said to have limited-view. As illustrated by the experiments of Davoudi et al., limited-view corruptions can be directly observed as missing information in the frequency domain of the reconstructed image. Limited-view, similar to sparse sampling, makes the initial reconstruction algorithm ill-posed. Prior to deep learning, the limited-view problem was addressed with complex hardware such as acoustic deflectors and full ring-shaped transducer arrays, as well as solutions like compressed sensing, weighted factor, and iterative filtered backprojection. The result of this ill-posed reconstruction is imaging artifacts that can be removed by CNNs. The deep learning algorithms used to remove limited-view artifacts include U-net and FD U-net, as well as generative adversarial networks (GANs) and volumetric versions of U-net. One GAN implementation of note improved upon U-net by using U-net as a generator and VGG as a discriminator, with the Wasserstein metric and gradient penalty to stabilize training (WGAN-GP). ==== Pixel-wise interpolation
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Andrew McCallum

Andrew McCallum is an American professor in the computer science department at University of Massachusetts Amherst. His primary specialties are in machine learning, natural language processing, information extraction, information integration, and social network analysis. == Career == McCallum graduated summa cum laude from Dartmouth College in 1989. He completed his Ph.D. at the University of Rochester in 1995 under the supervision of Dana H. Ballard. McCallum was then a postdoctoral fellow, working with Sebastian Thrun and Tom M. Mitchell at Carnegie Mellon University. From 1998 to 2000, he was a Research Scientist and Research Coordinator at Justsystem Pittsburgh Research Center. From 2000 to 2002, he was Vice President of Research and Development at WhizBang Labs, and Director of its Pittsburgh office. Since 2002, he has worked as a professor of computer science at the University of Massachusetts Amherst. In 2020, he also joined Google as a part-time research scientist. He was elected as a fellow of the Association for the Advancement of Artificial Intelligence in 2009, and as an Association for Computing Machinery in 2017. From 2014 to 2017, he was the President of International Machine Learning Society (IMLS), which organizes the International Conference on Machine Learning. He is also the director of the Center for Data Science at UMass, leading a new partnership with the Chan and Zuckerberg Initiative. In 2018, the initiative made an initial grant of 5.5 million to the center, supporting research to facilitate new ways for scientists to explore and discover research articles. == Main contributions == In collaboration with John D. Lafferty and Fernando Pereira, McCallum developed conditional random fields, first described in a paper presented at the International Conference on Machine Learning (ICML). In 2011 this research paper won the ICML "Test of Time" (10-year best paper) award. McCallum has written several widely used open-source software toolkits for machine learning, natural language processing and other text processing, including Rainbow, Mallet (software project), and FACTORIE. In addition, he was instrumental in publishing the Enron Corpus, a large collection of emails that has been used as a basis for a number of academic studies of social networking and language. McCallum instigated and directs the nonprofit project OpenReview.net, an online platform that aims to promote openness in scientific communication, particularly the peer review process, by providing a flexible cloud-based web interface and underlying database API.
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Top 10 AI Text-to-image Tools Compared (2026)

Comparing the best AI text-to-image tool? An AI text-to-image tool is software that uses machine learning to help you get more done — it lowers the barrier so anyone can produce professional output. Privacy matters too: check whether your data trains the model and whether a no-log or enterprise tier is available. Whether you are a beginner or a pro, the right AI text-to-image tool slots into your workflow and pays for itself fast. Below we compare features, pricing, and real output so you can choose with confidence.
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Candace Sidner

Candace Lee (Candy) Sidner is an American computer scientist whose research has applied artificial intelligence and natural language processing to problems in personal information management, intelligent user interfaces, and human–robot interaction. She is a research professor of computer science at the Worcester Polytechnic Institute, and a former president of the Association for Computational Linguistics. == Education and career == Sidner majored in mathematics at Kalamazoo College, graduating in 1971. She earned a master's degree in computer science at the University of Pittsburgh in 1975, and completed a Ph.D. in computer science in 1979 at the Massachusetts Institute of Technology. Her dissertation, Towards A Computational Theory of Definite Anaphora Comprehension in English Discourse, was supervised by Jonathan Allen. She worked as a researcher for Bolt Beranek and Newman from 1979 to 1989, and continued to work in industry for the Digital Equipment Corporation (1989 to 1993), the Lotus Development Corporation (1993 to 2000), Mitsubishi Electric Research Laboratories (2000 to 2007), and BAE Systems (2007 to 2010). She took her present position as a research professor at the Worcester Polytechnic Institute in 2009. She served as president of the Association for Computational Linguistics in 1989. == Recognition == Sidner was named a Fellow of the Association for the Advancement of Artificial Intelligence in 1991. In 2013, she was named a Fellow of the Association for Computational Linguistics, "for seminal contributions to discourse focus and collaborative dialog".
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Coalition for App Fairness

The Coalition for App Fairness (CAF) is a coalition comprised by companies, who aim to reach a fairer deal for the inclusion of their apps into the Apple App Store or the Google Play Store. The organization's executive director is Meghan DiMuzio and its headquarters are located in Washington, D.C. == Background == In July 2015, Spotify launched an email campaign to urge its App Store subscribers to cancel their subscriptions and start new ones through its website, bypassing the 30% transaction fee for in-app purchases required for iOS applications by technology company Apple Inc. A later update to the Spotify app on iOS was rejected by Apple, prompting Spotify's general counsel Horacio Gutierrez to write a letter to Apple's then-general counsel Bruce Sewell, stating: "This latest episode raises serious concerns under both U.S. and EU competition law. It continues a troubling pattern of behavior by Apple to exclude and diminish the competitiveness of Spotify on iOS and as a rival to Apple Music, particularly when seen against the backdrop of Apple's previous anticompetitive conduct aimed at Spotify … we cannot stand by as Apple uses the App Store approval process as a weapon to harm competitors." In August 2020, Epic Games updated their Fortnite Battle Royale game app on both Apple's App Store and Google's Google Play to include its own storefront that offered a 20% discount on V-Bucks, the in-game currency, if players bought through there rather than through the app stores' storefront, both which take a 30% revenue cut of the sale. Both Apple and Google removed the Fortnite app within hours, as this alternate storefront violated their terms of use that required all in-app purchases to be made through their storefronts. Epic immediately filed lawsuits against both companies challenging their storefront policies on antitrust principles, arguing that their non-negotiable 30% revenue cut is too high and the restrictions against alternate storefronts anticompetitive. Apple countersued Epic over its behavior, leading to a highly publicized 2021 bench trial. Ultimately, Epic largely lost its lawsuit against Apple, though the court did order Apple to allow developers to point users to alternative payment methods. Conversely, Epic won its antitrust lawsuit against Google in late 2023. == Foundation == On 24 September 2020, Epic Games joined forces with thirteen other prominent companies—including the music streaming platform Spotify, Tinder owner Match Group, the encrypted mail service Proton Mail, and the crypto currency website Blockchain.com—to establish the Coalition for App Fairness. It also includes Basecamp. The coalition criticizes the fact that for now the app stores of both Apple and Google charge their clients a 30% fee on any purchases made over their stores. Apple and Google defended themselves by arguing that the 30% transaction fee is a standard in the industry while the Coalition for App Fairness states that there is no other transaction fee which is even close to the 30%. In October 2020, it was reported that the coalition grew from 13 to 40 members since its foundation and received more than 400 applications for membership. In October 2025, X (formerly Twitter) joined CAF. This was seen as a larger pushback in the industry against Apple and Google, and a step towards hopefully passing the Bipartisan Open App Markets Act. == Aims == The group has broadened their demands for the app stores and now also aim for a better treatment for the apps available in the App Store. They claim that Apple favors its own services before other services available on the market and unjustifiably excludes other apps from their App Store. The group has also been viewing other transaction fees like the 5% fee which is charged by credit card companies, and states that Apple charges up to 600% more and would like the 30% fee, which was only included in 2011 by Apple, adapted to a comparable percentage that charge other providers of payment solutions. Its demands are mainly directed at Apple's strict control over its App Store, but to a lesser extent are also directed towards Google. Google allows apps to be downloaded over an independent web link or also another App Store, such as the Epic Game App Store. The organization emphasizes that no app developer should come into the position in which they are discriminated and are not granted the same rights as to the developers of the owner of the app store. == Reactions == In October 2020, Microsoft presented a new framework concerning the access to its Windows 10 operating system by app stores other than the one offered by Microsoft. The new framework is based on the demands of the Coalition for App Fairness. Microsoft emphasized though, that these principles would not apply to the Xbox. In December 2020, Apple announced that they would be lowering the revenue cut Apple takes for app developers making $1M or less from 30% to 15% if app developers fill out an application for the lowered revenue cut. In March 2021, Google followed suit by also lowering the revenue cut from the Play Store from 30% to 15% for the first million in revenue earned by a developer each year. == Notable members == Members listed are notable companies listed as members the groups website: Blockchain.com Deezer Epic Games European Digital SME Alliance Fanfix Life360 Masimo Nium Proton Mail Spotify TapTap Threema Vipps
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The Best Free AI Bug Finder for Beginners

Shopping for the best AI bug finder? An AI bug finder is software that uses machine learning to help you get more done — it keeps getting smarter as the underlying models improve. Pricing, accuracy, and the size of the model behind the tool are the three factors that most affect daily usefulness. Whether you are a beginner or a pro, the right AI bug finder slots into your workflow and pays for itself fast. We tested the leading options and ranked them by quality, value, and ease of use.
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The Best Free AI Coding Assistant for Beginners

Trying to pick the best AI coding assistant? An AI coding assistant is software that uses machine learning to help you get more done — it scales effortlessly from a single task to thousands. The best picks balance beginner-friendly simplicity with the depth power users need, and they ship updates often. Whether you are a beginner or a pro, the right AI coding assistant slots into your workflow and pays for itself fast. Read on for hands-on impressions, pricing tiers, and the standout features that matter.
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AI Analytics Tools: Free vs Paid (2026)

In search of the best AI analytics tool? An AI analytics tool is software that uses machine learning to help you get more done — it turns a rough idea into a polished result in seconds. When choosing one, weigh output quality, pricing, export formats, and how well it fits the tools you already use. Whether you are a beginner or a pro, the right AI analytics tool slots into your workflow and pays for itself fast. We tested the leading options and ranked them by quality, value, and ease of use.
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Super-resolution optical fluctuation imaging

Super-resolution optical fluctuation imaging (SOFI) is a post-processing method for the calculation of super-resolved images from recorded image time series that is based on the temporal correlations of independently fluctuating fluorescent emitters. SOFI has been developed for super-resolution of biological specimen that are labelled with independently fluctuating fluorescent emitters (organic dyes, fluorescent proteins). In comparison to other super-resolution microscopy techniques such as STORM or PALM that rely on single-molecule localization and hence only allow one active molecule per diffraction-limited area (DLA) and timepoint, SOFI does not necessitate a controlled photoswitching and/ or photoactivation as well as long imaging times. Nevertheless, it still requires fluorophores that are cycling through two distinguishable states, either real on-/off-states or states with different fluorescence intensities. In mathematical terms SOFI-imaging relies on the calculation of cumulants, for what two distinguishable ways exist. For one thing an image can be calculated via auto-cumulants that by definition only rely on the information of each pixel itself, and for another thing an improved method utilizes the information of different pixels via the calculation of cross-cumulants. Both methods can increase the final image resolution significantly although the cumulant calculation has its limitations. Actually SOFI is able to increase the resolution in all three dimensions. == Principle == Likewise to other super-resolution methods SOFI is based on recording an image time series on a CCD- or CMOS camera. In contrary to other methods the recorded time series can be substantially shorter, since a precise localization of emitters is not required and therefore a larger quantity of activated fluorophores per diffraction-limited area is allowed. The pixel values of a SOFI-image of the n-th order are calculated from the values of the pixel time series in the form of a n-th order cumulant, whereas the final value assigned to a pixel can be imagined as the integral over a correlation function. The finally assigned pixel value intensities are a measure of the brightness and correlation of the fluorescence signal. Mathematically, the n-th order cumulant is related to the n-th order correlation function, but exhibits some advantages concerning the resulting resolution of the image. Since in SOFI several emitters per DLA are allowed, the photon count at each pixel results from the superposition of the signals of all activated nearby emitters. The cumulant calculation now filters the signal and leaves only highly correlated fluctuations. This provides a contrast enhancement and therefore a background reduction for good measure. As it is implied in the figure on the left the fluorescence source distribution: ∑ k = 1 N δ ( r → − r → k ) ⋅ ε k ⋅ s k ( t ) {\displaystyle \sum _{k=1}^{N}\delta ({\vec {r}}-{\vec {r}}_{k})\cdot \varepsilon _{k}\cdot s_{k}(t)} is convolved with the system's point spread function (PSF) U(r). Hence the fluorescence signal at time t and position r → {\displaystyle {\vec {r}}} is given by F ( r → , t ) = ∑ k = 1 N U ( r → − r → k ) ⋅ ε k ⋅ s k ( t ) . {\displaystyle F({\vec {r}},t)=\sum _{k=1}^{N}U({\vec {r}}-{\vec {r}}_{k})\cdot \varepsilon _{k}\cdot s_{k}(t).} Within the above equations N is the amount of emitters, located at the positions r → k {\displaystyle {\vec {r}}_{k}} with a time-dependent molecular brightness ε k ⋅ s k {\displaystyle \varepsilon _{k}\cdot s_{k}} where ε k {\displaystyle \varepsilon _{k}} is a variable for the constant molecular brightness and s k ( t ) {\displaystyle s_{k}(t)} is a time-dependent fluctuation function. The molecular brightness is just the average fluorescence count-rate divided by the number of molecules within a specific region. For simplification it has to be assumed that the sample is in a stationary equilibrium and therefore the fluorescence signal can be expressed as a zero-mean fluctuation: δ F ( r → , t ) = F ( r → , t ) − ⟨ F ( r → , t ) ⟩ t {\displaystyle \delta F({\vec {r}},t)=F({\vec {r}},t)-\langle F({\vec {r}},t)\rangle _{t}} where ⟨ ⋯ ⟩ t {\displaystyle \langle \cdots \rangle _{t}} denotes time-averaging. The auto-correlation here e.g. the second-order can then be described deductively as follows for a certain time-lag τ {\displaystyle \tau } : δ F ( r → , t ) = ⟨ δ F ( r → , t + τ ) ⋅ δ F ( r → , t ) ⟩ t {\displaystyle \delta F({\vec {r}},t)=\langle \delta F({\vec {r}},t+\tau )\cdot \delta F({\vec {r}},t)\rangle _{t}} From these equations it follows that the PSF of the optical system has to be taken to the power of the order of the correlation. Thus in a second-order correlation the PSF would be reduced along all dimensions by a factor of 2 {\displaystyle {\sqrt {2}}} . As a result, the resolution of the SOFI-images increases according to this factor. === Cumulants versus correlations === Using only the simple correlation function for a reassignment of pixel values, would ascribe to the independency of fluctuations of the emitters in time in a way that no cross-correlation terms would contribute to the new pixel value. Calculations of higher-order correlation functions would suffer from lower-order correlations for what reason it is superior to calculate cumulants, since all lower-order correlation terms vanish. == Cumulant-calculation == === Auto-cumulants === For computational reasons it is convenient to set all time-lags in higher-order cumulants to zero so that a general expression for the n-th order auto-cumulant can be found: A C n ( r → , τ 1 … n − 1 = 0 ) = ∑ k = 1 N U n ( r → − r → k ) ε k n w k ( 0 ) {\displaystyle AC_{n}({\vec {r}},\tau _{1\ldots n-1}=0)=\sum _{k=1}^{N}U^{n}({\vec {r}}-{\vec {r}}_{k})\varepsilon _{k}^{n}w_{k}(0)} w k {\displaystyle w_{k}} is a specific correlation based weighting function influenced by the order of the cumulant and mainly depending on the fluctuation properties of the emitters. Albeit there is no fundamental limitation in calculating very high orders of cumulants and thereby shrinking the FWHM of the PSF there are practical limitations according to the weighting of the values assigned to the final image. Emitters with a higher molecular brightness will show a strong increase in terms of the pixel cumulant value assigned at higher-orders as well as this performance can be expected from a diverse appearance of fluctuations of different emitters. A wide intensity range of the resulting image can therefore be expected and as a result dim emitters can get masked by bright emitters in higher-order images:. The calculation of auto-cumulants can be realized in a very attractive way in a mathematical sense. The n-th order cumulant can be calculated with a basic recursion from moments K n ( r → ) = μ n ( r → ) − ∑ i = 1 n − 1 ( n − 1 i ) K n − i ( r → ) μ i ( r → ) {\displaystyle K_{n}({\vec {r}})=\mu _{n}({\vec {r}})-\sum _{i=1}^{n-1}{\begin{pmatrix}n-1\\i\end{pmatrix}}K_{n-i}({\vec {r}})\mu _{i}({\vec {r}})} where K is a cumulant of the index's order, likewise μ {\displaystyle \mu } represents the moments. The term within the brackets indicates a binomial coefficient. This way of computation is straightforward in comparison with calculating cumulants with standard formulas. It allows for the calculation of cumulants with only little time of computing and is, as it is well implemented, even suitable for the calculation of high-order cumulants on large images. === Cross-cumulants === In a more advanced approach cross-cumulants are calculated by taking the information of several pixels into account. Cross-cumulants can be described as follows: C C n ( r → , τ 1 … n − 1 = 0 ) = ∏ j < l n U ( r → j − r → l n ) ⋅ ∑ i = 1 N U n ( r → i − ∑ k n r → k n ) ε i n w i ( 0 ) {\displaystyle CC_{n}({\vec {r}},\tau _{1\ldots n-1}=0)=\prod _{j Read more →
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