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Sayre's paradox

Sayre's paradox is a dilemma encountered in the design of automated handwriting recognition systems. A standard statement of the paradox is that a cursively written word cannot be recognized without being segmented and cannot be segmented without being recognized. The paradox was first articulated in a 1973 publication by Kenneth M. Sayre, after whom it was named. == Nature of the problem == It is relatively easy to design automated systems capable of recognizing words inscribed in a printed format. Such words are segmented into letters by the very act of writing them on the page. Given templates matching typical letter shapes in a given language, individual letters can be identified with a high degree of probability. In cases of ambiguity, probable letter sequences can be compared with a selection of properly spelled words in that language (called a lexicon). If necessary, syntactic features of the language can be applied to render a generally accurate identification of the words in question. Printed-character recognition systems of this sort are commonly used in processing standardized government forms, in sorting mail by zip code, and so forth. In cursive writing, however, letters comprising a given word typically flow sequentially without gaps between them. Unlike a sequence of printed letters, cursively connected letters are not segmented in advance. Here is where Sayre's Paradox comes into play. Unless the word is already segmented into letters, template-matching techniques like those described above cannot be applied. That is, segmentation is a prerequisite for word recognition. But there are no reliable techniques for segmenting a word into letters unless the word itself has been identified. Word recognition requires letter segmentation, and letter segmentation requires word recognition. There is no way a cursive writing recognition system employing standard template-matching techniques can do both simultaneously. Advantages to be gained by use of automated cursive writing recognition systems include routing mail with handwritten addresses, reading handwritten bank checks, and automated digitalization of hand-written documents. These are practical incentives for finding ways of circumventing Sayre's Paradox. == Avoiding the paradox == One way of ameliorating the adverse effects of the paradox is to normalize the word inscriptions to be recognized. Normalization amounts to eliminating idiosyncrasies in the penmanship of the writer, such as unusual slope of the letters and unusual slant of the cursive line. This procedure can increase the probability of a correct match with a letter template, resulting in an incremental improvement in the success rate of the system. Since improvement of this sort still depends on accurate segmentation, however, it remains subject to the limitations of Sayre's Paradox. Researchers have come to realize that the only way to circumvent the paradox is by use of procedures that do not rely on accurate segmentation. == Directions of current research == Segmentation is accurate to the extent that it matches distinctions among letters in the actual inscriptions presented to the system for recognition (the input data). This is sometimes referred to as “explicit segmentation”. “Implicit segmentation,” by contrast, is division of the cursive line into more parts than the number of actual letters in the cursive line itself. Processing these “implicit parts” to achieve eventual word identification requires specific statistical procedures involving hidden Markov models (HMM). A Markov model is a statistical representation of a random process, which is to say a process in which future states are independent of states occurring before the present. In such a process, a given state is dependent only on the conditional probability of its following the state immediately before it. An example is a series of outcomes from successive casts of a die. An HMM is a Markov model, individual states of which are not fully known. Conditional probabilities between states are still determinate, but the identities of individual states are not fully disclosed. Recognition proceeds by matching HMMs of words to be recognized with previously prepared HMMs of words in the lexicon. The best match in a given case is taken to indicate the identity of the handwritten word in question. As with systems based on explicit segmentation, automated recognition systems based on implicit segmentation are judged more or less successful according to the percentage of correct identifications they accomplish. Instead of explicit segmentation techniques, most automated handwriting recognition systems today employ implicit segmentation in conjunction with HMM-based matching procedures. The constraints epitomized by Sayre's Paradox are largely responsible for this shift in approach.
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Markov blanket

In statistics and machine learning, a Markov blanket of a random variable is a set of variables that renders the variable conditionally independent of all other variables in the system. This concept is central in probabilistic graphical models and feature selection. If a Markov blanket is minimal—meaning that no variable in it can be removed without losing this conditional independence—it is called a Markov boundary. Identifying a Markov blanket or boundary allows for efficient inference and helps isolate relevant variables for prediction or causal reasoning. The terms Markov blanket and Markov boundary were coined by Judea Pearl in 1988. A Markov blanket may be derived from the structure of a probabilistic graphical model such as a Bayesian network or Markov random field. == Definition == A Markov blanket of a random variable Y {\displaystyle Y} in a random variable set S = { X 1 , … , X n } {\displaystyle {\mathcal {S}}=\{X_{1},\ldots ,X_{n}\}} is any subset S 1 {\displaystyle {\mathcal {S}}_{1}} of S {\displaystyle {\mathcal {S}}} , conditioned on which other variables are independent with Y {\displaystyle Y} : Y ⊥ ⊥ S ∖ S 1 ∣ S 1 {\displaystyle Y\perp \!\!\!\perp {\mathcal {S}}\smallsetminus {\mathcal {S}}_{1}\mid {\mathcal {S}}_{1}} It means that S 1 {\displaystyle {\mathcal {S}}_{1}} contains at least all the information one needs to infer Y {\displaystyle Y} , where the variables in S ∖ S 1 {\displaystyle {\mathcal {S}}\smallsetminus {\mathcal {S}}_{1}} are redundant. In general, a given Markov blanket is not unique. Any set in S {\displaystyle {\mathcal {S}}} that contains a Markov blanket is also a Markov blanket itself. Specifically, S {\displaystyle {\mathcal {S}}} is a Markov blanket of Y {\displaystyle Y} in S {\displaystyle {\mathcal {S}}} . === Example === In a Bayesian network, the Markov blanket of a node consists of its parents, its children, and its children's other parents (i.e., co-parents). Knowing the values of these nodes makes the target node conditionally independent of the rest of the network. In a Markov random field, the Markov blanket of a node is simply its immediate neighbors. == Markov condition == The concept of a Markov blanket is rooted in the Markov condition, which states that in a probabilistic graphical model, each variable is conditionally independent of its non-descendants given its parents. This condition implies the existence of a minimal separating set — the Markov blanket — that shields a variable from the rest of the network. For instance, when a person holds an object stationary against gravity, the object’s acceleration is fully determined by its direct causes—namely, the upward force from the hand and the downward gravitational pull. Other variables such as air pressure or temperature are causally irrelevant. == Markov boundary == A Markov boundary of Y {\displaystyle Y} in S {\displaystyle {\mathcal {S}}} is a subset S 2 {\displaystyle {\mathcal {S}}_{2}} of S {\displaystyle {\mathcal {S}}} , such that S 2 {\displaystyle {\mathcal {S}}_{2}} itself is a Markov blanket of Y {\displaystyle Y} , but any proper subset of S 2 {\displaystyle {\mathcal {S}}_{2}} is not a Markov blanket of Y {\displaystyle Y} . In other words, a Markov boundary is a minimal Markov blanket. The Markov boundary of a node A {\displaystyle A} in a Bayesian network is the set of nodes composed of A {\displaystyle A} 's parents, A {\displaystyle A} 's children, and A {\displaystyle A} 's children's other parents. In a Markov random field, the Markov boundary for a node is the set of its neighboring nodes. In a dependency network, the Markov boundary for a node is the set of its parents. === Uniqueness of Markov boundary === The Markov boundary always exists. Under some mild conditions, the Markov boundary is unique. However, for most practical and theoretical scenarios multiple Markov boundaries may provide alternative solutions. When there are multiple Markov boundaries, quantities measuring causal effect could fail. == In cognitive science == In the study of consciousness, brain function, and complex adaptive systems, Markov blankets are proposed as a mathematical mechanism which delimits the extent of cognitive entities, whether it be physical or causal.
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Physical neural network

A physical neural network is a type of artificial neural network in which an electrically adjustable material is used to emulate the function of a neural synapse or a higher-order (dendritic) neuron model. "Physical" neural network is used to emphasize the reliance on physical hardware used to emulate neurons as opposed to software-based approaches. More generally the term is applicable to other artificial neural networks in which a memristor or other electrically adjustable resistance material is used to emulate a neural synapse. == Types of physical neural networks == === ADALINE === In the 1960s Bernard Widrow and Ted Hoff developed ADALINE (Adaptive Linear Neuron) which used electrochemical cells called memistors (memory resistors) to emulate synapses of an artificial neuron. The memistors were implemented as 3-terminal devices operating based on the reversible electroplating of copper such that the resistance between two of the terminals is controlled by the integral of the current applied via the third terminal. The ADALINE circuitry was briefly commercialized by the Memistor Corporation in the 1960s enabling some applications in pattern recognition. However, since the memistors were not fabricated using integrated circuit fabrication techniques the technology was not scalable and was eventually abandoned as solid-state electronics became mature. === Analog VLSI === In 1989 Carver Mead published his book Analog VLSI and Neural Systems, which spun off perhaps the most common variant of analog neural networks. The physical realization is implemented in analog VLSI. This is often implemented as field effect transistors in low inversion. Such devices can be modelled as translinear circuits. This is a technique described by Barrie Gilbert in several papers around mid 1970th, and in particular his Translinear Circuits from 1981. With this method circuits can be analyzed as a set of well-defined functions in steady-state, and such circuits assembled into complex networks. === Physical Neural Network === Alex Nugent describes a physical neural network as one or more nonlinear neuron-like nodes used to sum signals and nanoconnections formed from nanoparticles, nanowires, or nanotubes which determine the signal strength input to the nodes. Alignment or self-assembly of the nanoconnections is determined by the history of the applied electric field performing a function analogous to neural synapses. Numerous applications for such physical neural networks are possible. For example, a temporal summation device can be composed of one or more nanoconnections having an input and an output thereof, wherein an input signal provided to the input causes one or more of the nanoconnection to experience an increase in connection strength thereof over time. Another example of a physical neural network is taught by U.S. Patent No. 7,039,619 entitled "Utilized nanotechnology apparatus using a neural network, a solution and a connection gap," which issued to Alex Nugent by the U.S. Patent & Trademark Office on May 2, 2006. A further application of physical neural network is shown in U.S. Patent No. 7,412,428 entitled "Application of hebbian and anti-hebbian learning to nanotechnology-based physical neural networks," which issued on August 12, 2008. Nugent and Molter have shown that universal computing and general-purpose machine learning are possible from operations available through simple memristive circuits operating the AHaH plasticity rule. More recently, it has been argued that also complex networks of purely memristive circuits can serve as neural networks. === Phase change neural network === In 2002, Stanford Ovshinsky described an analog neural computing medium in which phase-change material has the ability to cumulatively respond to multiple input signals. An electrical alteration of the resistance of the phase change material is used to control the weighting of the input signals. === Memristive neural network === Greg Snider of HP Labs describes a system of cortical computing with memristive nanodevices. The memristors (memory resistors) are implemented by thin film materials in which the resistance is electrically tuned via the transport of ions or oxygen vacancies within the film. DARPA's SyNAPSE project has funded IBM Research and HP Labs, in collaboration with the Boston University Department of Cognitive and Neural Systems (CNS), to develop neuromorphic architectures which may be based on memristive systems. === Protonic artificial synapses === In 2022, researchers reported the development of nanoscale brain-inspired artificial synapses, using the ion proton (H+), for 'analog deep learning'.
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Stochastic gradient descent

Stochastic gradient descent (often abbreviated SGD) is an iterative method for optimizing an objective function with suitable smoothness properties (e.g. differentiable or subdifferentiable). It can be regarded as a stochastic approximation of gradient descent optimization, since it replaces the actual gradient (calculated from the entire data set) by an estimate thereof (calculated from a randomly selected subset of the data). Especially in high-dimensional optimization problems this reduces the very high computational burden, achieving faster iterations in exchange for a lower convergence rate. The basic idea behind stochastic approximation can be traced back to the Robbins–Monro algorithm of the 1950s. Today, stochastic gradient descent has become an important optimization method in machine learning. == Background == Both statistical estimation and machine learning consider the problem of minimizing an objective function that has the form of a sum: Q ( w ) = 1 n ∑ i = 1 n Q i ( w ) , {\displaystyle Q(w)={\frac {1}{n}}\sum _{i=1}^{n}Q_{i}(w),} where the parameter w {\displaystyle w} that minimizes Q ( w ) {\displaystyle Q(w)} is to be estimated. Each summand function Q i {\displaystyle Q_{i}} is typically associated with the i {\displaystyle i} -th observation in the data set (used for training). In classical statistics, sum-minimization problems arise in least squares and in maximum-likelihood estimation (for independent observations). The general class of estimators that arise as minimizers of sums are called M-estimators. However, in statistics, it has been long recognized that requiring even local minimization is too restrictive for some problems of maximum-likelihood estimation. Therefore, contemporary statistical theorists often consider stationary points of the likelihood function (or zeros of its derivative, the score function, and other estimating equations). The sum-minimization problem also arises for empirical risk minimization. There, Q i ( w ) {\displaystyle Q_{i}(w)} is the value of the loss function at i {\displaystyle i} -th example, and Q ( w ) {\displaystyle Q(w)} is the empirical risk. When used to minimize the above function, a standard (or "batch") gradient descent method would perform the following iterations: w := w − η ∇ Q ( w ) = w − η n ∑ i = 1 n ∇ Q i ( w ) . {\displaystyle w:=w-\eta \,\nabla Q(w)=w-{\frac {\eta }{n}}\sum _{i=1}^{n}\nabla Q_{i}(w).} The step size is denoted by η {\displaystyle \eta } (sometimes called the learning rate in machine learning) and here " := {\displaystyle :=} " denotes the update of a variable in the algorithm. In many cases, the summand functions have a simple form that enables inexpensive evaluations of the sum-function and the sum gradient. For example, in statistics, one-parameter exponential families allow economical function-evaluations and gradient-evaluations. However, in other cases, evaluating the sum-gradient may require expensive evaluations of the gradients from all summand functions. When the training set is enormous and no simple formulas exist, evaluating the sums of gradients becomes very expensive, because evaluating the gradient requires evaluating all the summand functions' gradients. To economize on the computational cost at every iteration, stochastic gradient descent samples a subset of summand functions at every step. This is very effective in the case of large-scale machine learning problems. == Iterative method == In stochastic (or "on-line") gradient descent, the true gradient of Q ( w ) {\displaystyle Q(w)} is approximated by a gradient at a single sample: w := w − η ∇ Q i ( w ) . {\displaystyle w:=w-\eta \,\nabla Q_{i}(w).} As the algorithm sweeps through the training set, it performs the above update for each training sample. Several passes can be made over the training set until the algorithm converges. If this is done, the data can be shuffled for each pass to prevent cycles. Typical implementations may use an adaptive learning rate so that the algorithm converges. In pseudocode, stochastic gradient descent can be presented as : A compromise between computing the true gradient and the gradient at a single sample is to compute the gradient against more than one training sample (called a "mini-batch") at each step. This can perform significantly better than "true" stochastic gradient descent described, because the code can make use of vectorization libraries rather than computing each step separately as was first shown in where it was called "the bunch-mode back-propagation algorithm". It may also result in smoother convergence, as the gradient computed at each step is averaged over more training samples. The convergence of stochastic gradient descent has been analyzed using the theories of convex minimization and of stochastic approximation. Briefly, when the learning rates η {\displaystyle \eta } decrease with an appropriate rate, and subject to relatively mild assumptions, stochastic gradient descent converges almost surely to a global minimum when the objective function is convex or pseudoconvex, and otherwise converges almost surely to a local minimum. This is in fact a consequence of the Robbins–Siegmund theorem. == Linear regression == Suppose we want to fit a straight line y ^ = w 1 + w 2 x {\displaystyle {\hat {y}}=w_{1}+w_{2}x} to a training set with observations ( ( x 1 , y 1 ) , ( x 2 , y 2 ) … , ( x n , y n ) ) {\displaystyle ((x_{1},y_{1}),(x_{2},y_{2})\ldots ,(x_{n},y_{n}))} and corresponding estimated responses ( y ^ 1 , y ^ 2 , … , y ^ n ) {\displaystyle ({\hat {y}}_{1},{\hat {y}}_{2},\ldots ,{\hat {y}}_{n})} using least squares. The objective function to be minimized is Q ( w ) = ∑ i = 1 n Q i ( w ) = ∑ i = 1 n ( y ^ i − y i ) 2 = ∑ i = 1 n ( w 1 + w 2 x i − y i ) 2 . {\displaystyle Q(w)=\sum _{i=1}^{n}Q_{i}(w)=\sum _{i=1}^{n}\left({\hat {y}}_{i}-y_{i}\right)^{2}=\sum _{i=1}^{n}\left(w_{1}+w_{2}x_{i}-y_{i}\right)^{2}.} The last line in the above pseudocode for this specific problem will become: [ w 1 w 2 ] ← [ w 1 w 2 ] − η [ ∂ ∂ w 1 ( w 1 + w 2 x i − y i ) 2 ∂ ∂ w 2 ( w 1 + w 2 x i − y i ) 2 ] = [ w 1 w 2 ] − η [ 2 ( w 1 + w 2 x i − y i ) 2 x i ( w 1 + w 2 x i − y i ) ] . {\displaystyle {\begin{bmatrix}w_{1}\\w_{2}\end{bmatrix}}\leftarrow {\begin{bmatrix}w_{1}\\w_{2}\end{bmatrix}}-\eta {\begin{bmatrix}{\frac {\partial }{\partial w_{1}}}(w_{1}+w_{2}x_{i}-y_{i})^{2}\\{\frac {\partial }{\partial w_{2}}}(w_{1}+w_{2}x_{i}-y_{i})^{2}\end{bmatrix}}={\begin{bmatrix}w_{1}\\w_{2}\end{bmatrix}}-\eta {\begin{bmatrix}2(w_{1}+w_{2}x_{i}-y_{i})\\2x_{i}(w_{1}+w_{2}x_{i}-y_{i})\end{bmatrix}}.} Note that in each iteration or update step, the gradient is only evaluated at a single x i {\displaystyle x_{i}} . This is the key difference between stochastic gradient descent and batched gradient descent. In general, given a linear regression y ^ = ∑ k ∈ 1 : m w k x k {\displaystyle {\hat {y}}=\sum _{k\in 1:m}w_{k}x_{k}} problem, stochastic gradient descent behaves differently when m < n {\displaystyle m
Radek Maneuver

The Radek Maneuver is a scale-up-then-scale-down tactic used in the administration of web services, specifically those deployed under a cloud computing paradigm (by a provider e.g. Amazon Elastic Compute Cloud or Microsoft Azure). == History == Developed by Olivier "Radek" Dabrowski in the mid-2010s, the Radek Maneuver was originally conceived of in using and maintaining applications running on a PaaS system. == Execution == The Radek Maneuver consists of a series of steps, usually executed via the PaaS or web portal interface. The tactic should be used when a service is misbehaving or otherwise experiencing errors, and the suspected cause is the underlying cloud layer, rather than the application layer. This includes networking issues and other "bad box" problems. The steps are as follows: Identify the application or service which is misbehaving. Increase the compute resource (number of CPU cores, amount of ram) for the instance on which the application is running. This is also known as scaling up. Wait for the application to re-deploy and stabilize. Scale back down to the original instance size. == Principle of action == This scale-up-scale-down method is understood to shift the application to a different physical machine underlying the PaaS service or application virtual machine. While this layer of the cloud computing stack is generally out of the access of an application developer (instead in the hands of the cloud provider), the maneuver allows troubleshooting and dodging errors in that layer.
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Weighted majority algorithm (machine learning)

In machine learning, weighted majority algorithm (WMA) is a meta learning algorithm used to construct a compound algorithm from a pool of prediction algorithms, which could be any type of learning algorithms, classifiers, or even real human experts. The algorithm assumes that we have no prior knowledge about the accuracy of the algorithms in the pool, but there are sufficient reasons to believe that one or more will perform well. Assume that the problem is a binary decision problem. To construct the compound algorithm, a positive weight is given to each of the algorithms in the pool. The compound algorithm then collects weighted votes from all the algorithms in the pool, and gives the prediction that has a higher vote. If the compound algorithm makes a mistake, the algorithms in the pool that contributed to the wrong predicting will be discounted by a certain ratio β where 0<β<1. It can be shown that the upper bounds on the number of mistakes made in a given sequence of predictions from a pool of algorithms A {\displaystyle \mathbf {A} } is O ( l o g | A | + m ) {\displaystyle \mathbf {O(log|A|+m)} } if one algorithm in x i {\displaystyle \mathbf {x} _{i}} makes at most m {\displaystyle \mathbf {m} } mistakes. There are many variations of the weighted majority algorithm to handle different situations, like shifting targets, infinite pools, or randomized predictions. The core mechanism remains similar, with the final performances of the compound algorithm bounded by a function of the performance of the specialist (best performing algorithm) in the pool.
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Information Harvesting

Information Harvesting (IH) was an early data mining product from the 1990s. It was invented by Ralphe Wiggins and produced by the Ryan Corp, later Information Harvesting Inc., of Cambridge, Massachusetts. Wiggins had a background in genetic algorithms and fuzzy logic. IH sought to infer rules from sets of data. It did this first by classifying various input variables into one of a number of bins, thereby putting some structure on the continuous variables in the input. IH then proceeds to generate rules, trading off generalization against memorization, that will infer the value of the prediction variable, possibly creating many levels of rules in the process. It included strategies for checking if overfitting took place and, if so, correcting for it. Because of its strategies for correcting for overfitting by considering more data, and refining the rules based on that data, IH might also be considered to be a form of machine learning. The advantage of IH, as compared with other data mining products of its time and even later, was that it provided a mechanism for finding multiple rules that would classify the data and determining, according to set criteria, the best rules to use.
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Prescription monitoring program

In the United States, prescription monitoring programs (PMPs) or prescription drug monitoring programs (PDMPs) are state-run programs which collect and distribute data about the prescription and dispensation of federally controlled substances and, depending on state requirements, other potentially abusable prescription drugs. PMPs are meant to help prevent adverse drug-related events such as opioid overdoses, drug diversion, and substance abuse by decreasing the amount and/or frequency of opioid prescribing, and by identifying those patients who are obtaining prescriptions from multiple providers (i.e., "doctor shopping") or those physicians overprescribing opioids. Most US health care workers support the idea of PMPs, which intend to assist physicians, physician assistants, nurse practitioners, dentists and other prescribers, the pharmacists, chemists and support staff of dispensing establishments. The database, whose use is required by State law, typically requires prescribers and pharmacies dispensing controlled substances to register with their respective state PMPs and (for pharmacies and providers who dispense from their offices) to report the dispensation of such prescriptions to an electronic online database. The majority of PMPs are authorized to notify law enforcement agencies or licensing boards or physicians when a prescriber, or patients receiving prescriptions, exceed thresholds established by the state or prescription recipient exceeds thresholds established by the State. All states have implemented PDMPs, although evidence for the effectiveness of these programs is mixed. While prescription of opioids has decreased with PMP use, overdose deaths in many states have actually increased, with those states sharing data with neighboring jurisdictions or requiring reporting of more drugs experiencing highest increases in deaths. This may be because those declined opioid prescriptions turn to street drugs, whose potency and contaminants carry greater overdose risk. == History == Prescription drug monitoring programs, or PDMPs, are an example of one initiative proposed to alleviate effects of the opioid crisis. The programs are designed to restrict prescription drug abuse by limiting a patient's ability to obtain similar prescriptions from multiple providers (i.e. “doctor shopping”) and reducing diversion of controlled substances. This is meant to reduce risk of fatal overdose caused by high doses of opioids or interactions between opioids and benzodiazepenes, and to enable better decision making on the part of healthcare providers who may be unaware of a patient's prescription drug use, history or other prescriptions. PDMPs have been implemented in state legislations since 1939 in California, a time before electronic medical records, though implementation rose alongside increased awareness of overprescribing of opioids and overdose. A later New York state program was struck down by the U.S. Supreme Court in Whalen v. Roe. But, by 2019, 49 states, the District of Columbia, and Guam had enacted PDMP legislation. In 2021 Missouri, the last State to not use a PMP, adopted legislation to create one. PMPs are constantly being updated to increase speed of data collection, sharing of data across States, and ease of interpretation. This is being done by integrating PDMP reports with other health information technologies such as health information exchanges (HIE), electronic health record (EHR) systems, and/ or pharmacy dispensing software systems. One program that has been implemented in nine states is called the PDMP Electronic Health Records Integration and Interoperability Expansion, also known as PEHRIIE. Another software, marketed by Bamboo Health and integrated with PMPs in 43 states, uses an algorithm to track factors thought to increase risk of diversion, abuse or overdose, and assigns patients a three digit score based on presumed indicators of risk. While some studies have suggested that PDMP-HIT integration and sharing of interstate data brings benefits such as reduced opioid-related inpatient morbidity, others have found no or negative impact on mortality compared to states without PMP data sharing. Patient and media reports suggest need for testing and evaluation of algorithmic software used to score risk, with some patients reporting denial of prescriptions without c explanation or clarity of data. == Goals == Most health care workers support PMPs which intend to assist physicians, physician assistants, nurse practitioners, dentists and other prescribers, the pharmacists, chemists and support staff of dispensing establishments, as well as law-enforcement agencies. The collaboration supports the legitimate medical use of controlled substances while limiting their abuse and diversion. Pharmacies dispensing controlled substances and prescribers typically must register with their respective state PMPs and (for pharmacies and providers who dispense controlled substances from their offices) report the dispensation to an electronic online database. Some pharmacy software can submit these reports automatically to multiple states. == Usage == === List of programs by state === === Software systems === NarxCare is a prescription drug monitoring program (PDMP) run by Bamboo Health. Bamboo Health was formerly known as Appriss. It is widely used across the United States by pharmacies including Rite Aid as well as those at Walmart and Sam’s Club. The NarxCare software allows doctors to view data about a patient, combining data from the prescription registries of various U.S. states to make the registries interoperable nationally. It also uses machine learning to generate an "Overdose Risk Score" that potentially includes EMS and criminal justice data; these scores have been criticized by researchers and patient advocates for the lack of transparency in the process as well as the potential for disparate treatment of women and minority groups. Advertised as an "analytics tool and care management platform", the NarxCare software allows doctors to view data about a patient including how many pharmacies they have visited and the combinations of medication they are prescribed. It combines data from the prescription registries of various U.S. states, making the registries interoperable nationally. It additionally uses machine learning to generate various three-digit "risk scores" and an overall "Overdose Risk Score", collectively referred to as Narx Scores, in a process that potentially includes EMS and criminal justice data as well as court records. == Controversy == Many doctors and researchers support the idea of PDMPs as a tool in combatting the opioid epidemic. Opioid prescribing, opioid diversion and supply, opioid misuse, and opioid-related morbidity and mortality are common elements in data entered into PDMPs. Prescription Monitoring Programs are purported to offer economic benefits for the states who implement them by decreasing overall health care costs, lost productivity, and investigation times. However, there are many studies that conclude the impact of PDMPs is unclear. While use of PMPs has been accompanied by decrease in opioid prescribing, few analyses consider corresponding use of street opioids, extramedical use, or diversion, which might provide a more holistic method for evaluation of PMP intent and efficacy. Evidence for PDMP impact on fatal overdoses is decidedly mixed, with multiple studies finding increased overdose rates in some states, decreases in others, or no clear impact. Interestingly, an increase in heroin overdoses after PDMP implementation has been commonly reported, presumably as denial of prescription opioids sends patients in search of street drugs. Narx Scores have been criticized by researchers and patient advocates for the lack of transparency in the generation process as well as the potential for disparate treatment of women and minority groups. Writing in Duke Law Journal, Jennifer Oliva stated that "black-box algorithms" are used to generate the scores.
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Human-centered AI

Human-centered AI is the initiative at the intersection of the fields of artificial intelligence (AI) and human-computer interaction (HCI) to develop AI systems in a way that prioritizes human values, needs, and general flourishing. Emphasis is placed on the recognition that artificial intelligence systems are rapidly changing, and will continue to influence, many aspects of the human experience, in areas ranging from scientific inquiry, governance and policy, labor and the economy, and creative expression, with an aim set to adapt current developments and guide future developments on a trajectory which is most beneficial to the human population at large, with the goal of augmenting human intelligence and capacities across these areas, as opposed to replacing them. Particular attention is paid to mitigating negative effects of AI automation on the livelihoods of the labor force, the use of AI in healthcare fields, and imbuing AI systems with societal values. Human-centered AI is linked to related endeavors in AI alignment and AI safety, but while these fields primarily focus on mitigating risks posed by AI that is unaligned to human values and/or uncontrollable AI self-development, human-centered AI places significant focus in exploring how AI systems can augment human capacities and serve as collaborators. == Conceptual history == The importance of the alignment of artificial intelligence development towards human values in some sense predates artificial intelligence itself, as before the modern conception of artificial intelligence as coined at the 1956 Dartmouth Workshop, the conception of robots as constructed, autonomous agents entered the cultural consciousness as early as the 1920s, with Karel Capek's Rossum's Universal Robots. The imagined issues relating to robots' aims and values requiring intentional alignment and direction with those of humans followed soon after, most widely known from science fiction author Isaac Asimov’s Three Laws of Robotics, dating to his 1942 short story “Runaround”. Two of the three eponymous laws are directly concerned with robots’ interaction with and positioned deference towards humans, and have in recent times been reexamined in the face of modern AI. In 1985, after artificial intelligence research had taken off and its effects were more acutely conceptualized, Asimov added a Rule Zero, treating robots' relationship with humanity as a whole, distinct from individual humans. While modern artificial intelligence is largely distinct from robotics, the conceptualization of both robots and AI systems as autonomous agents positions this as a foundation for conceptions of human-centered AI. Aside from robots, artificially intelligent autonomous agents in interaction with humans have been conceived of for at least 75 years. In 1950, Alan Turing published his famous "Imitation Game", often also called the Turing Test, a thought experiment that uses human-machine interaction as an assessor for the intelligence of a system. In recent times, artificial intelligence researchers such as Stanford's Erik Brynjolfsson have conceived of rapid AI development leading to a so-called "Turing Trap". == Augmentation and automation == A major stated aim of human-centered AI is to promote the development of AI in ways that augment human capabilities, rather than replacing them. To this end, organizations and initiatives that take a human-centered approach to AI development focus on frameworks that encourage collaboration between humans and artificial intelligence systems to build towards even greater progress, rather than attempting to automate tasks currently handled by humans. Such avenues include everything from data visualization for big data, allowing human engineers to better understand extremely large datasets, allowing for the design of better machine learning models to handle them, to AI-powered sensors to monitor vitals, allowing for better responsiveness from healthcare providers. Many human-centered AI initiatives often position it as a better alternative to the apparent mainstream in AI development, which is primarily concerned with automation. Driven by the pressures of the market economy, AI development that does replace tasks currently performed by humans with automated processes is incentivized, as it allows for greater profit margins; this often comes at the detriment of the human whose performance is replaced, thus leading to an environment wherein human workers are outcompeted by AI systems across various service-sector and technology-based industries. At the same time, automation and augmentation are not always incompatible; a major aim of human-centered AI is towards the automation of rote tasks that would otherwise hinder a human’s productivity or creativity, freeing them to direct their energy and intelligence towards higher-level tasks, thus achieving augmentation through automation. Empirical research in pharmaceutical sales has shown that a human-centered implementation - where work procedures, training, and incentives are designed around individuals' cognitive needs - improves augmentation performance, while implementation without such adaptation can worsen outcomes relative to a legacy system. == Research == Much of the work done on human-centered AI comes from research institutes, within universities, companies, and as freestanding organizations. The Stanford Institute for Human-Centered AI (abbreviated to HAI) is one such group, engaging academics, industry professionals, and policymakers centered in Stanford University to conduct research and inform policy in various areas in human-centered AI, including on aspects of the intelligence itself, augmentation, and on measuring the impacts of AI systems on sociopolitcal and cultural institutions. Similar groups exist at other universities, including the Chicago Human + AI (CHAI) Lab at the University of Chicago, the HCAI@GU group at the University of Gothenburg, and the Human-Centered AI (HAI) Lab at the University of Oxford. Outside of the academy, companies such as IBM have research initiatives dedicated to advancements in human-centered AI. At Kenyon College, the Integrated Program for Humane Studies (IPHS) launched a human-centered AI program in 2016 integrating artificial intelligence research with humanities and social science inquiry. This approach treats computation and humanistic scholarship as a single unified field of research rather than as separate disciplines requiring collaboration. The program's researchers have published in both AI venues (such as the International Conference on Machine Learning and Frontiers of Computer Science) and humanities journals (such as PMLA and Poetics Today), and the lab was selected in December 2025 by Schmidt Sciences for its Humanities and AI Virtual Institute to apply AI methods to cultural heritage preservation.
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Rule-based machine learning

Rule-based machine learning (RBML) is a term in computer science intended to encompass any machine learning method that identifies, learns, or evolves 'rules' to store, manipulate or apply. The defining characteristic of a rule-based machine learner is the identification and utilization of a set of relational rules that collectively represent the knowledge captured by the system. Rule-based machine learning approaches include learning classifier systems, association rule learning, artificial immune systems, and any other method that relies on a set of rules, each covering contextual knowledge. While rule-based machine learning is conceptually a type of rule-based system, it is distinct from traditional rule-based systems, which are often hand-crafted, and other rule-based decision makers. This is because rule-based machine learning applies some form of learning algorithm such as Rough sets theory to identify and minimise the set of features and to automatically identify useful rules, rather than a human needing to apply prior domain knowledge to manually construct rules and curate a rule set. == Rules == Rules typically take the form of an '{IF:THEN} expression', (e.g. {IF 'condition' THEN 'result'}, or as a more specific example, {IF 'red' AND 'octagon' THEN 'stop-sign}). An individual rule is not in itself a model, since the rule is only applicable when its condition is satisfied. Therefore rule-based machine learning methods typically comprise a set of rules, or knowledge base, that collectively make up the prediction model usually known as decision algorithm. Rules can also be interpreted in various ways depending on the domain knowledge, data types(discrete or continuous) and in combinations. == RIPPER == Repeated incremental pruning to produce error reduction (RIPPER) is a propositional rule learner proposed by William W. Cohen as an optimized version of IREP.
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Sharpness aware minimization

Sharpness Aware Minimization (SAM) is an optimization algorithm used in machine learning that aims to improve model generalization. The method seeks to find model parameters that are located in regions of the loss landscape with uniformly low loss values, rather than parameters that only achieve a minimal loss value at a single point. This approach is described as finding "flat" minima instead of "sharp" ones. The rationale is that models trained this way are less sensitive to variations between training and test data, which can lead to better performance on unseen data. The algorithm was introduced in a 2020 paper by a team of researchers including Pierre Foret, Ariel Kleiner, Hossein Mobahi, and Behnam Neyshabur. == Underlying Principle == SAM modifies the standard training objective by minimizing a "sharpness-aware" loss. This is formulated as a minimax problem where the inner objective seeks to find the highest loss value in the immediate neighborhood of the current model weights, and the outer objective minimizes this value: min w max ‖ ϵ ‖ p ≤ ρ L train ( w + ϵ ) + λ ‖ w ‖ 2 2 {\displaystyle \min _{w}\max _{\|\epsilon \|_{p}\leq \rho }L_{\text{train}}(w+\epsilon )+\lambda \|w\|_{2}^{2}} In this formulation: w {\displaystyle w} represents the model's parameters (weights). L train {\displaystyle L_{\text{train}}} is the loss calculated on the training data. ϵ {\displaystyle \epsilon } is a perturbation applied to the weights. ρ {\displaystyle \rho } is a hyperparameter that defines the radius of the neighborhood (an L p {\displaystyle L_{p}} ball) to search for the highest loss. An optional L2 regularization term, scaled by λ {\displaystyle \lambda } , can be included. A direct solution to the inner maximization problem is computationally expensive. SAM approximates it by taking a single gradient ascent step to find the perturbation ϵ {\displaystyle \epsilon } . This is calculated as: ϵ ( w ) = ρ ∇ L train ( w ) ‖ ∇ L train ( w ) ‖ 2 {\displaystyle \epsilon (w)=\rho {\frac {\nabla L_{\text{train}}(w)}{\|\nabla L_{\text{train}}(w)\|_{2}}}} The optimization process for each training step involves two stages. First, an "ascent step" computes a perturbed set of weights, w adv = w + ϵ ( w ) {\displaystyle w_{\text{adv}}=w+\epsilon (w)} , by moving towards the direction of the highest local loss. Second, a "descent step" updates the original weights w {\displaystyle w} using the gradient calculated at these perturbed weights, ∇ L train ( w adv ) {\displaystyle \nabla L_{\text{train}}(w_{\text{adv}})} . This update is typically performed using a standard optimizer like SGD or Adam. == Application and Performance == SAM has been applied in various machine learning contexts, primarily in computer vision. Research has shown it can improve generalization performance in models such as Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs) on image datasets including ImageNet, CIFAR-10, and CIFAR-100. The algorithm has also been found to be effective in training models with noisy labels, where it performs comparably to methods designed specifically for this problem. Some studies indicate that SAM and its variants can improve out-of-distribution (OOD) generalization, which is a model's ability to perform well on data from distributions not seen during training. Other areas where it has been applied include gradual domain adaptation and mitigating overfitting in scenarios with repeated exposure to training examples. == Limitations == A primary limitation of SAM is its computational cost. By requiring two gradient computations (one for the ascent and one for the descent) per optimization step, it approximately doubles the training time compared to standard optimizers. The theoretical convergence properties of SAM are still under investigation. Some research suggests that with a constant step size, SAM may not converge to a stationary point. The accuracy of the single gradient step approximation for finding the worst-case perturbation may also decrease during the training process. The effectiveness of SAM can also be domain-dependent. While it has shown benefits for computer vision tasks, its impact on other areas, such as GPT-style language models where each training example is seen only once, has been reported as limited in some studies. Furthermore, while SAM seeks flat minima, some research suggests that not all flat minima necessarily lead to good generalization. The algorithm also introduces the neighborhood size ρ {\displaystyle \rho } as a new hyperparameter, which requires tuning. == Research, Variants, and Enhancements == Active research on SAM focuses on reducing its computational overhead and improving its performance. Several variants have been proposed to make the algorithm more efficient. These include methods that attempt to parallelize the two gradient computations, apply the perturbation to only a subset of parameters, or reduce the number of computation steps required. Other approaches use historical gradient information or apply SAM steps intermittently to lower the computational burden. To improve performance and robustness, variants have been developed that adapt the neighborhood size based on model parameter scales (Adaptive SAM or ASAM) or incorporate information about the curvature of the loss landscape (Curvature Regularized SAM or CR-SAM). Other research explores refining the perturbation step by focusing on specific components of the gradient or combining SAM with techniques like random smoothing. Theoretical work continues to analyze the algorithm's behavior, including its implicit bias towards flatter minima and the development of broader frameworks for sharpness-aware optimization that use different measures of sharpness.
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Mean squared error

In statistics, the mean squared error (MSE) or mean squared deviation (MSD) of an estimator (of a procedure for estimating an unobserved quantity) measures the average of the squares of the errors—that is, the average squared difference between the estimated values and the true value. MSE is a risk function, corresponding to the expected value of the squared error loss. The fact that MSE is almost always strictly positive (and not zero) is because of randomness or because the estimator does not account for information that could produce a more accurate estimate. In machine learning, specifically empirical risk minimization, MSE may refer to the empirical risk (the average loss on an observed data set), as an estimate of the true MSE (the true risk: the average loss on the actual population distribution). The MSE is a measure of the quality of an estimator. As it is derived from the square of Euclidean distance, it is always a positive value that decreases as the error approaches zero. The MSE is the second moment (about the origin) of the error, and thus incorporates both the variance of the estimator (how widely spread the estimates are from one data sample to another) and its bias (how far off the average estimated value is from the true value). For an unbiased estimator, the MSE is the variance of the estimator. Like the variance, MSE has the same units of measurement as the square of the quantity being estimated. In an analogy to standard deviation, taking the square root of MSE yields the root-mean-square error or root-mean-square deviation (RMSE or RMSD), which has the same units as the quantity being estimated; for an unbiased estimator, the RMSE is the square root of the variance, known as the standard error. == Definition and basic properties == The MSE either assesses the quality of a predictor (i.e., a function mapping arbitrary inputs to a sample of values of some random variable), or of an estimator (i.e., a mathematical function mapping a sample of data to an estimate of a parameter of the population from which the data is sampled). In the context of prediction, understanding the prediction interval can also be useful as it provides a range within which a future observation will fall, with a certain probability. The definition of an MSE differs according to whether one is describing a predictor or an estimator. === Predictor === If a vector of n {\displaystyle n} predictions is generated from a sample of n {\displaystyle n} data points on all variables, and Y {\displaystyle Y} is the vector of observed values of the variable being predicted, with Y ^ {\displaystyle {\hat {Y}}} being the predicted values (e.g. as from a least-squares fit), then the within-sample MSE of the predictor is computed as MSE = 1 n ∑ i = 1 n ( Y i − Y i ^ ) 2 {\displaystyle \operatorname {MSE} ={\frac {1}{n}}\sum _{i=1}^{n}\left(Y_{i}-{\hat {Y_{i}}}\right)^{2}} In other words, the MSE is the mean ( 1 n ∑ i = 1 n ) {\textstyle \left({\frac {1}{n}}\sum _{i=1}^{n}\right)} of the squares of the errors ( Y i − Y i ^ ) 2 {\textstyle \left(Y_{i}-{\hat {Y_{i}}}\right)^{2}} . This is an easily computable quantity for a particular sample (and hence is sample-dependent). In matrix notation, MSE = 1 n ∑ i = 1 n ( e i ) 2 = 1 n e T e {\displaystyle \operatorname {MSE} ={\frac {1}{n}}\sum _{i=1}^{n}(e_{i})^{2}={\frac {1}{n}}\mathbf {e} ^{\mathsf {T}}\mathbf {e} } where e i {\displaystyle e_{i}} is Y i − Y i ^ {\displaystyle Y_{i}-{\hat {Y_{i}}}} and e {\displaystyle \mathbf {e} } is a n × 1 {\displaystyle n\times 1} column vector. The MSE can also be computed on q data points that were not used in estimating the model, either because they were held back for this purpose, or because these data have been newly obtained. Within this process, known as cross-validation, the MSE is often called the test MSE, and is computed as MSE = 1 q ∑ i = n + 1 n + q ( Y i − Y i ^ ) 2 {\displaystyle \operatorname {MSE} ={\frac {1}{q}}\sum _{i=n+1}^{n+q}\left(Y_{i}-{\hat {Y_{i}}}\right)^{2}} === Estimator === The MSE of an estimator θ ^ {\displaystyle {\hat {\theta }}} with respect to an unknown parameter θ {\displaystyle \theta } is defined as MSE ⁡ ( θ ^ ) = E θ ⁡ [ ( θ ^ − θ ) 2 ] . {\displaystyle \operatorname {MSE} ({\hat {\theta }})=\operatorname {E} _{\theta }\left[({\hat {\theta }}-\theta )^{2}\right].} This definition depends on the unknown parameter, therefore the MSE is a priori property of an estimator. The MSE could be a function of unknown parameters, in which case any estimator of the MSE based on estimates of these parameters would be a function of the data (and thus a random variable). If the estimator θ ^ {\displaystyle {\hat {\theta }}} is derived as a sample statistic and is used to estimate some population parameter, then the expectation is with respect to the sampling distribution of the sample statistic. The MSE can be written as the sum of the variance of the estimator and the squared bias of the estimator, providing a useful way to calculate the MSE and implying that in the case of unbiased estimators, the MSE and variance are equivalent. MSE ⁡ ( θ ^ ) = Var θ ⁡ ( θ ^ ) + Bias ⁡ ( θ ^ , θ ) 2 . {\displaystyle \operatorname {MSE} ({\hat {\theta }})=\operatorname {Var} _{\theta }({\hat {\theta }})+\operatorname {Bias} ({\hat {\theta }},\theta )^{2}.} ==== Proof of variance and bias relationship ==== MSE ⁡ ( θ ^ ) = E θ ⁡ [ ( θ ^ − θ ) 2 ] = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] + E θ ⁡ [ θ ^ ] − θ ) 2 ] = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] ) 2 + 2 ( θ ^ − E θ ⁡ [ θ ^ ] ) ( E θ ⁡ [ θ ^ ] − θ ) + ( E θ ⁡ [ θ ^ ] − θ ) 2 ] = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] ) 2 ] + E θ ⁡ [ 2 ( θ ^ − E θ ⁡ [ θ ^ ] ) ( E θ ⁡ [ θ ^ ] − θ ) ] + E θ ⁡ [ ( E θ ⁡ [ θ ^ ] − θ ) 2 ] = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] ) 2 ] + 2 ( E θ ⁡ [ θ ^ ] − θ ) E θ ⁡ [ θ ^ − E θ ⁡ [ θ ^ ] ] + ( E θ ⁡ [ θ ^ ] − θ ) 2 E θ ⁡ [ θ ^ ] − θ = constant = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] ) 2 ] + 2 ( E θ ⁡ [ θ ^ ] − θ ) ( E θ ⁡ [ θ ^ ] − E θ ⁡ [ θ ^ ] ) + ( E θ ⁡ [ θ ^ ] − θ ) 2 E θ ⁡ [ θ ^ ] = constant = E θ ⁡ [ ( θ ^ − E θ ⁡ [ θ ^ ] ) 2 ] + ( E θ ⁡ [ θ ^ ] − θ ) 2 = Var θ ⁡ ( θ ^ ) + Bias θ ⁡ ( θ ^ , θ ) 2 {\displaystyle {\begin{aligned}\operatorname {MSE} ({\hat {\theta }})&=\operatorname {E} _{\theta }\left[({\hat {\theta }}-\theta )^{2}\right]\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]+\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}\right]\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)^{2}+2\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)+\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}\right]\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)^{2}\right]+\operatorname {E} _{\theta }\left[2\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)\right]+\operatorname {E} _{\theta }\left[\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}\right]\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)^{2}\right]+2\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)\operatorname {E} _{\theta }\left[{\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right]+\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}&&\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta ={\text{constant}}\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)^{2}\right]+2\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)+\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}&&\operatorname {E} _{\theta }[{\hat {\theta }}]={\text{constant}}\\&=\operatorname {E} _{\theta }\left[\left({\hat {\theta }}-\operatorname {E} _{\theta }[{\hat {\theta }}]\right)^{2}\right]+\left(\operatorname {E} _{\theta }[{\hat {\theta }}]-\theta \right)^{2}\\&=\operatorname {Var} _{\theta }({\hat {\theta }})+\operatorname {Bias} _{\theta }({\hat {\theta }},\theta )^{2}\end{aligned}}} An even shorter proof can be achieved using the well-known formula that for a random variable X {\textstyle X} , E ( X 2 ) = Var ⁡ ( X ) + ( E ( X ) ) 2 {\textstyle \mathbb {E} (X^{2})=\operatorname {Var} (X)+(\mathbb {E} (X))^{2}} . By substituting X {\textstyle X} with, θ ^ − θ {\textstyle {\hat {\theta }}-\theta } , we have MSE ⁡ ( θ ^ ) = E [ ( θ ^ − θ ) 2 ] = Var ⁡ ( θ ^ − θ ) + ( E [ θ ^ − θ ] ) 2 = Var ⁡ ( θ ^ ) + Bias 2 ⁡ ( θ ^ , θ ) {\displaystyle {\begin{aligned}\operatorname {MSE} ({\hat {\theta }})&=\mathbb {E} [({\hat {\theta }}-\theta )^{2}]\\&=\operator
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Electronic business

Electronic business (also known as online business or e-business) is any kind of business or commercial activity that includes sharing information across the internet. Commerce constitutes the exchange of products and services between businesses, groups, and individuals; and can be seen as one of the essential activities of any business. E-commerce focuses on the use of ICT to enable the external activities and relationships of the business with individuals, groups, and other organizations, while e-business does not only deal with online commercial operations of enterprises, but also deals with their other organizational matters such as human resource management and production. The term "e-business" was coined by IBM's marketing and Internet team in 1996. == Market participants == Electronic business can take place between a very large number of market participants; it can be between business and consumer, private individuals, public administrations, or any other organizations such as non-governmental organizations (NGOs). These various market participants can be divided into three main groups: Business (B) Consumer (C) Administration (A) All of them can be either buyers or service providers within the market. There are nine possible combinations for electronic business relationships. B2C and B2B belong to E-commerce, while A2B and A2A belong to the E-government sector which is also a part of the electronic business. == History == One of the founding pillars of electronic business was the development of the Electronic Data Interchange (EDI) electronic data interchange. This system replaced traditional mailing and faxing of documents with a digital transfer of data from one computer to another, without any human intervention. Michael Aldrich is considered the developer of the predecessor to online shopping. In 1979, the entrepreneur connected a television set to a transaction processing computer with a telephone line and called it "teleshopping", meaning shopping at distance. From the mid-nineties, major advancements were made in the commercial use of the Internet. Amazon, which launched in 1995, started as an online bookstore and grew to become nowadays the largest online retailer worldwide, selling food, toys, electronics, apparel and more. Other successful stories of online marketplaces include eBay or Etsy. In 1994, IBM, with its agency Ogilvy & Mather, began to use its foundation in IT solutions and expertise to market itself as a leader of conducting business on the Internet through the term "e-business." Then CEO Louis V. Gerstner, Jr. was prepared to invest $1 billion to market this new brand. After conducting worldwide market research in October 1997, IBM began with an eight-page piece in The Wall Street Journal that would introduce the concept of "e-business" and advertise IBM's expertise in the new field. IBM decided not to trademark the term "e-business" in the hopes that other companies would use the term and create an entirely new industry. However, this proved to be too successful and by 2000, to differentiate itself, IBM launched a $300 million campaign about its "e-business infrastructure" capabilities. Since that time, the terms, "e-business" and "e-commerce" have been loosely interchangeable and have become a part of the common vernacular. According to the U.S. Department Of Commerce, the estimated retail e-commerce sales in Q1 2020 were representing almost 12% of total U.S. retail sales, against 4% for Q1 2010. == Business model == The transformation toward e-business is complex and in order for it to succeed, there is a need to balance between strategy, an adapted business model (e-intermediary, marketplaces), right processes (sales, marketing) and technology (Supply Chain Management, Customer Relationship Management). When organizations go online, they have to decide which e-business models best suit their goals. A business model is defined as the organization of product, service and information flows, and the source of revenues and benefits for suppliers and customers. The concept of the e-business model is the same but used in online presence. === Revenue model === A key component of the business model is the revenue model or profit model, which is a framework for generating revenues. It identifies which revenue source to pursue, what value to offer, how to price the value, and who pays for the value. It is a key component of a company's business model. It primarily identifies what product or service will be created in order to generate revenues and the ways in which the product or service will be sold. Without a well-defined revenue model, that is, a clear plan of how to generate revenues, new businesses will more likely struggle due to costs that they will not be able to sustain. By having a revenue model, a business can focus on a target audience, fund development plans for a product or service, establish marketing plans, begin a line of credit and raise capital. ==== E-commerce ==== E-commerce (short for "electronic commerce") is trading in products or services using computer networks, such as the Internet. Electronic commerce draws on technologies such as mobile commerce, electronic funds transfer, supply chain management, Internet marketing, online transaction processing, electronic data interchange (EDI), inventory management systems, and automated data collection. Modern electronic commerce typically uses the World Wide Web for at least one part of the transaction's life cycle, although it may also use other technologies such as e-mail. == Concerns == While much has been written of the economic advantages of Internet-enabled commerce, there is also evidence that some aspects of the internet such as maps and location-aware services may serve to reinforce economic inequality and the digital divide. Electronic commerce may be responsible for consolidation and the decline of mom-and-pop, brick and mortar businesses resulting in increases in income inequality. === Security === E-business systems naturally have greater security risks than traditional business systems, therefore it is important for e-business systems to be fully protected against these risks. A far greater number of people have access to e-businesses through the internet than would have access to a traditional business. Customers, suppliers, employees, and numerous other people use any particular e-business system daily and expect their confidential information to stay secure. Hackers are one of the great threats to the security of e-businesses. Some common security concerns for e-Businesses include keeping business and customer information private and confidential, the authenticity of data, and data integrity. Some of the methods of protecting e-business security and keeping information secure include physical security measures as well as data storage, data transmission, anti-virus software, firewalls, and encryption to list a few. ==== Privacy and confidentiality ==== Confidentiality is the extent to which businesses makes personal information available to other businesses and individuals. With any business, confidential information must remain secure and only be accessible to the intended recipient. However, this becomes even more difficult when dealing with e-businesses specifically. To keep such information secure means protecting any electronic records and files from unauthorized access, as well as ensuring safe transmission and data storage of such information. Tools such as encryption and firewalls manage this specific concern within e-business. ==== Authenticity ==== E-business transactions pose greater challenges for establishing authenticity due to the ease with which electronic information may be altered and copied. Both parties in an e-business transaction want to have the assurance that the other party is who they claim to be, especially when a customer places an order and then submits a payment electronically. One common way to ensure this is to limit access to a network or trusted parties by using a virtual private network (VPN) technology. The establishment of authenticity is even greater when a combination of techniques are used, and such techniques involve checking "something you know" (i.e. password or PIN), "something you need" (i.e. credit card), or "something you are" (i.e. digital signatures or voice recognition methods). Many times in e-business, however, "something you are" is pretty strongly verified by checking the purchaser's "something you have" (i.e. credit card) and "something you know" (i.e. card number). ==== Data integrity ==== Data integrity answers the question "Can the information be changed or corrupted in any way?" This leads to the assurance that the message received is identical to the message sent. A business needs to be confident that data is not changed in transit, whether deliberately or by accident. To help with data integrity, firewalls protect stored data against unauthorized access, while
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Elastic map

Elastic maps provide a tool for nonlinear dimensionality reduction. By their construction, they are a system of elastic springs embedded in the data space. This system approximates a low-dimensional manifold. The elastic coefficients of this system allow the switch from completely unstructured k-means clustering (zero elasticity) to the estimators located closely to linear PCA manifolds (for high bending and low stretching modules). With some intermediate values of the elasticity coefficients, this system effectively approximates non-linear principal manifolds. This approach is based on a mechanical analogy between principal manifolds, that are passing through "the middle" of the data distribution, and elastic membranes and plates. The method was developed by A.N. Gorban, A.Y. Zinovyev and A.A. Pitenko in 1996–1998. == Energy of elastic map == Let S {\displaystyle {\mathcal {S}}} be a data set in a finite-dimensional Euclidean space. Elastic map is represented by a set of nodes w j {\displaystyle {\bf {w}}_{j}} in the same space. Each datapoint s ∈ S {\displaystyle s\in {\mathcal {S}}} has a host node, namely the closest node w j {\displaystyle {\bf {w}}_{j}} (if there are several closest nodes then one takes the node with the smallest number). The data set S {\displaystyle {\mathcal {S}}} is divided into classes K j = { s | w j is a host of s } {\displaystyle K_{j}=\{s\ |\ {\bf {w}}_{j}{\mbox{ is a host of }}s\}} . The approximation energy D is the distortion D = 1 2 ∑ j = 1 k ∑ s ∈ K j ‖ s − w j ‖ 2 {\displaystyle D={\frac {1}{2}}\sum _{j=1}^{k}\sum _{s\in K_{j}}\|s-{\bf {w}}_{j}\|^{2}} , which is the energy of the springs with unit elasticity which connect each data point with its host node. It is possible to apply weighting factors to the terms of this sum, for example to reflect the standard deviation of the probability density function of any subset of data points { s i } {\displaystyle \{s_{i}\}} . On the set of nodes an additional structure is defined. Some pairs of nodes, ( w i , w j ) {\displaystyle ({\bf {w}}_{i},{\bf {w}}_{j})} , are connected by elastic edges. Call this set of pairs E {\displaystyle E} . Some triplets of nodes, ( w i , w j , w k ) {\displaystyle ({\bf {w}}_{i},{\bf {w}}_{j},{\bf {w}}_{k})} , form bending ribs. Call this set of triplets G {\displaystyle G} . The stretching energy is U E = 1 2 λ ∑ ( w i , w j ) ∈ E ‖ w i − w j ‖ 2 {\displaystyle U_{E}={\frac {1}{2}}\lambda \sum _{({\bf {w}}_{i},{\bf {w}}_{j})\in E}\|{\bf {w}}_{i}-{\bf {w}}_{j}\|^{2}} , The bending energy is U G = 1 2 μ ∑ ( w i , w j , w k ) ∈ G ‖ w i − 2 w j + w k ‖ 2 {\displaystyle U_{G}={\frac {1}{2}}\mu \sum _{({\bf {w}}_{i},{\bf {w}}_{j},{\bf {w}}_{k})\in G}\|{\bf {w}}_{i}-2{\bf {w}}_{j}+{\bf {w}}_{k}\|^{2}} , where λ {\displaystyle \lambda } and μ {\displaystyle \mu } are the stretching and bending moduli respectively. The stretching energy is sometimes referred to as the membrane, while the bending energy is referred to as the thin plate term. For example, on the 2D rectangular grid the elastic edges are just vertical and horizontal edges (pairs of closest vertices) and the bending ribs are the vertical or horizontal triplets of consecutive (closest) vertices. The total energy of the elastic map is thus U = D + U E + U G . {\displaystyle U=D+U_{E}+U_{G}.} The position of the nodes { w j } {\displaystyle \{{\bf {w}}_{j}\}} is determined by the mechanical equilibrium of the elastic map, i.e. its location is such that it minimizes the total energy U {\displaystyle U} . == Expectation-maximization algorithm == For a given splitting of dataset S {\displaystyle {\mathcal {S}}} in classes K j {\displaystyle K_{j}} , minimization of the quadratic functional U {\displaystyle U} is a linear problem with the sparse matrix of coefficients. Therefore, similar to principal component analysis or k-means, a splitting method is used: For given { w j } {\displaystyle \{{\bf {w}}_{j}\}} find { K j } {\displaystyle \{K_{j}\}} ; For given { K j } {\displaystyle \{K_{j}\}} minimize U {\displaystyle U} and find { w j } {\displaystyle \{{\bf {w}}_{j}\}} ; If no change, terminate. This expectation-maximization algorithm guarantees a local minimum of U {\displaystyle U} . For improving the approximation various additional methods are proposed. For example, the softening strategy is used. This strategy starts with a rigid grids (small length, small bending and large elasticity modules λ {\displaystyle \lambda } and μ {\displaystyle \mu } coefficients) and finishes with soft grids (small λ {\displaystyle \lambda } and μ {\displaystyle \mu } ). The training goes in several epochs, each epoch with its own grid rigidness. Another adaptive strategy is growing net: one starts from a small number of nodes and gradually adds new nodes. Each epoch goes with its own number of nodes. == Applications == Most important applications of the method and free software are in bioinformatics for exploratory data analysis and visualisation of multidimensional data, for data visualisation in economics, social and political sciences, as an auxiliary tool for data mapping in geographic informational systems and for visualisation of data of various nature. The method is applied in quantitative biology for reconstructing the curved surface of a tree leaf from a stack of light microscopy images. This reconstruction is used for quantifying the geodesic distances between trichomes and their patterning, which is a marker of the capability of a plant to resist to pathogenes. Recently, the method is adapted as a support tool in the decision process underlying the selection, optimization, and management of financial portfolios. The method of elastic maps has been systematically tested and compared with several machine learning methods on the applied problem of identification of the flow regime of a gas-liquid flow in a pipe. There are various regimes: Single phase water or air flow, Bubbly flow, Bubbly-slug flow, Slug flow, Slug-churn flow, Churn flow, Churn-annular flow, and Annular flow. The simplest and most common method used to identify the flow regime is visual observation. This approach is, however, subjective and unsuitable for relatively high gas and liquid flow rates. Therefore, the machine learning methods are proposed by many authors. The methods are applied to differential pressure data collected during a calibration process. The method of elastic maps provided a 2D map, where the area of each regime is represented. The comparison with some other machine learning methods is presented in Table 1 for various pipe diameters and pressure. Here, ANN stands for the backpropagation artificial neural networks, SVM stands for the support vector machine, SOM for the self-organizing maps. The hybrid technology was developed for engineering applications. In this technology, elastic maps are used in combination with Principal Component Analysis (PCA), Independent Component Analysis (ICA) and backpropagation ANN. The textbook provides a systematic comparison of elastic maps and self-organizing maps (SOMs) in applications to economic and financial decision-making.
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Conference on Computer Vision and Pattern Recognition

The Conference on Computer Vision and Pattern Recognition is an annual conference on computer vision and pattern recognition. == Affiliations == The conference was first held in 1983 in Washington, DC, organized by Takeo Kanade and Dana H. Ballard. From 1985 to 2010 it was sponsored by the IEEE Computer Society. In 2011 it was also co-sponsored by University of Colorado Colorado Springs. Since 2012 it has been co-sponsored by the IEEE Computer Society and the Computer Vision Foundation, which provides open access to the conference papers. == Scope == The conference considers a wide range of topics related to computer vision and pattern recognition—basically any topic that is extracting structures or answers from images or video or applying mathematical methods to data to extract or recognize patterns. Common topics include object recognition, image segmentation, motion estimation, 3D reconstruction, and deep learning. The conference generally has less than 30% acceptance rates for all papers and less than 5% for oral presentations. It is managed by a rotating group of volunteers who are chosen in a public election at the Pattern Analysis and Machine Intelligence-Technical Community (PAMI-TC) meeting four years before the meeting. The conference uses a multi-tier double-blind peer review process. The program chairs, who cannot submit papers, select area chairs who manage the reviewers for their subset of submissions. == Location and time == The conference is usually held in June in North America. == Awards == === Best Paper Award === These awards are picked by committees delegated by the program chairs of the conference. === Longuet-Higgins Prize === The Longuet-Higgins Prize recognizes papers from ten years ago that have made a significant impact on computer vision research. === PAMI Young Researcher Award === The Pattern Analysis and Machine Intelligence Young Researcher Award is an award given by the Technical Committee on Pattern Analysis and Machine Intelligence of the IEEE Computer Society to a researcher within 7 years of completing their Ph.D. for outstanding early career research contributions. Candidates are nominated by the computer vision community, with winners selected by a committee of senior researchers in the field. This award was originally instituted in 2012 by the journal Image and Vision Computing, also presented at the conference, and the journal continues to sponsor the award. === PAMI Thomas S. Huang Memorial Prize === The Thomas Huang Memorial Prize was established at the 2020 conference and is awarded annually starting from 2021 to honor researchers who are recognized as examples in research, teaching/mentoring, and service to the computer vision community.
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