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  System Service Descriptor Table

  The System Service Descriptor Table (SSDT) is an internal dispatch table within Microsoft Windows. == Function == The SSDT maps syscalls to kernel function addresses. When a syscall is issued by a user space application, it contains the service index as parameter to indicate which syscall is called. The SSDT is then used to resolve the address of the corresponding function within ntoskrnl.exe. In modern Windows kernels, two SSDTs are used: One for generic routines (KeServiceDescriptorTable) and a second (KeServiceDescriptorTableShadow) for graphical routines. A parameter passed by the calling userspace application determines which SSDT shall be used. == Hooking == Modification of the SSDT allows to redirect syscalls to routines outside the kernel. These routines can be either used to hide the presence of software or to act as a backdoor to allow attackers permanent code execution with kernel privileges. For both reasons, hooking SSDT calls is often used as a technique in both Windows kernel mode rootkits and antivirus software. In 2010, many computer security products which relied on hooking SSDT calls were shown to be vulnerable to exploits using race conditions to attack the products' security checks.

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  Philosophy of information

  The philosophy of information (PI) is a branch of philosophy that studies topics relevant to information processing, representational system and consciousness, cognitive science, computer science, information science and information technology. It includes: the critical investigation of the conceptual nature and basic principles of information, including its dynamics, utilisation and sciences the elaboration and application of information-theoretic and computational methodologies to philosophical problems. == History == The philosophy of information (PI) has evolved from the philosophy of artificial intelligence, logic of information, cybernetics, social theory, ethics and the study of language and information. === Logic of information === The logic of information, also known as the logical theory of information, considers the information content of logical signs and expressions along the lines initially developed by Charles Sanders Peirce. === Study of language and information === Later contributions to the field were made by Fred Dretske, Jon Barwise, Brian Cantwell Smith, and others. The Center for the Study of Language and Information (CSLI) was founded at Stanford University in 1983 by philosophers, computer scientists, linguists, and psychologists, under the direction of John Perry and Jon Barwise. === P.I. === More recently this field has become known as the philosophy of information. The expression was coined in the 1990s by Luciano Floridi, who has published prolifically in this area with the intention of elaborating a unified and coherent, conceptual frame for the whole subject. == Definitions of "information" == The concept information has been defined by several theorists. Charles S. Peirce's theory of information was embedded in his wider theory of symbolic communication he called the semiotic, now a major part of semiotics. For Peirce, information integrates the aspects of signs and expressions separately covered by the concepts of denotation and extension, on the one hand, and by connotation and comprehension on the other. Donald M. MacKay says that information is a distinction that makes a difference. According to Luciano Floridi, four kinds of mutually compatible phenomena are commonly referred to as "information": Information about something (e.g. a train timetable) Information as something (e.g. DNA, or fingerprints) Information for something (e.g. algorithms or instructions) Information in something (e.g. a pattern or a constraint). == Philosophical directions == === Computing and philosophy === Recent creative advances and efforts in computing, such as semantic web, ontology engineering, knowledge engineering, and modern artificial intelligence provide philosophy with fertile ideas, new and evolving subject matters, methodologies, and models for philosophical inquiry. While computer science brings new opportunities and challenges to traditional philosophical studies, and changes the ways philosophers understand foundational concepts in philosophy, further major progress in computer science would only be feasible when philosophy provides sound foundations for areas such as bioinformatics, software engineering, knowledge engineering, and ontologies. Classical topics in philosophy, namely, mind, consciousness, experience, reasoning, knowledge, truth, morality and creativity are rapidly becoming common concerns and foci of investigation in computer science, e.g., in areas such as agent computing, software agents, and intelligent mobile agent technologies. According to Luciano Floridi " one can think of several ways for applying computational methods towards philosophical matters: Conceptual experiments in silico: As an innovative extension of an ancient tradition of thought experiment, a trend has begun in philosophy to apply computational modeling schemes to questions in logic, epistemology, philosophy of science, philosophy of biology, philosophy of mind, and so on. Pancomputationalism: On this view, computational and informational concepts are considered to be so powerful that given the right level of abstraction, anything in the world could be modeled and represented as a computational system, and any process could be simulated computationally. Then, however, pancomputationalists have the hard task of providing credible answers to the following two questions: how can one avoid blurring all differences among systems? what would it mean for the system under investigation not to be an informational system (or a computational system, if computation is the same as information processing)?

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  Semantic similarity network

  A semantic similarity network (SSN) is a special form of semantic network. designed to represent concepts and their semantic similarity. Its main contribution is reducing the complexity of calculating semantic distances. Bendeck (2004, 2008) introduced the concept of semantic similarity networks (SSN) as the specialization of a semantic network to measure semantic similarity from ontological representations. Implementations include genetic information handling. The concept is formally defined (Bendeck 2008) as a directed graph, with concepts represented as nodes and semantic similarity relations as edges. The relationships are grouped into relation types. The concepts and relations contain attribute values to evaluate the semantic similarity between concepts. The semantic similarity relationships of the SSN represent several of the general relationship types of the standard Semantic network, reducing the complexity of the (normally, very large) network for calculations of semantics. SSNs define relation types as templates (and taxonomy of relations) for semantic similarity attributes that are common to relations of the same type. SSN representation allows propagation algorithms to faster calculate semantic similarities, including stop conditions within a specified threshold. This reduces the computation time and power required for calculation. A more recent publications on Semantic Matching and Semantic Similarity Networks could be found in (Bendeck 2019). Specific Semantic Similarity Network application on healthcare was presented at the Healthcare information exchange Format (FHIR European Conference) 2019. The latest evolution in Artificial Intelligence (like ChatGPT, based on Large language model), relay strongly on evolutionary computation, the next level will be to include semantic unification (like in the Semantic Networks and this Semantic similarity network) to extend the current models with more powerful understanding tools.

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  Tabnine

  Tabnine is a code completion tool which uses generative artificial intelligence to assist users by autocompleting code. It was created in 2018 by Jacob Jackson, a student at the University of Waterloo. It is now developed by Tabnine, a software company founded under the name Codota by Dror Weiss and Eran Yahav in Tel Aviv, Israel, in 2013, and renamed to Tabnine in 2021. Initially established under the name Codota, the company underwent a rebranding in May 2021 following the release of the company’s first large language model based AI coding assistant, adopting the name Tabnine. == History == Tabnine was established as Codota in 2013 by Dror Weiss and Eran Yahav in Tel Aviv, Israel. Tabnine, initially founded under the name Codota, was created to develop tools based on over a decade of academic research at the Technion. Codota, the predecessor of Tabnine, secured $2 million in seed investment in June 2017. Following this, in June 2018, the company introduced the first AI-based code completion for Java IDE. In 2019, Codota acquired a product called Tabnine, which used the newly available large-language model technology to provide generative AI for software code across a broader range of programming languages across five IDEs. Codota replaced its earlier approach to code generation with this new approach to generative AI. The company secured a Series A round of funding in April 2020, raising $12 million. On May 26, 2021, Codota changed its name to Tabnine and underwent a corresponding rebranding. By April 2022, Tabnine reached over one million users. In June of the same year, Tabnine launched models that could predict full lines and snippets of code. The same year it raised $15.5 mln in a funding round led co-led by Qualcomm Ventures. In June 2023, Tabnine introduced an AI-powered chat agent, enabling developers to use natural language to generate code, to explain code, to generate tests and documentation, and to propose fixes to code. In November 2023, Tabnine closed a Series B round of funding, raising $25 million to scale the company’s operations. == Operations == Tabnine's headquarters is located in Tel Aviv, Israel, with an additional corporate entity in the United States. As of November 2023, Tabnine generative AI for software development is used by a million developers. It has 10 million installations across VS Code and JetBrains. Since its founding, Dror Weiss has served as CEO, with Eran Yahav as CTO.

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  Commonsense knowledge (artificial intelligence)

  In artificial intelligence research, commonsense knowledge consists of facts about the everyday world, such as "Lemons are sour" or "Cows say moo", that all humans are expected to know. It is currently an unsolved problem in artificial general intelligence. The first AI program to address common sense knowledge was Advice Taker in 1959 by John McCarthy. Commonsense knowledge can underpin a commonsense reasoning process, to attempt inferences such as "You might bake a cake because you want people to eat the cake." A natural language processing process can be attached to the commonsense knowledge base to allow the knowledge base to attempt to answer questions about the world. Common sense knowledge also helps to solve problems in the face of incomplete information. Using widely held beliefs about everyday objects, or common sense knowledge, AI systems make common sense assumptions or default assumptions about the unknown similar to the way people do. In an AI system or in English, this is expressed as "Normally P holds", "Usually P" or "Typically P so Assume P". For example, if we know the fact "Tweety is a bird", because we know the commonly held belief about birds, "typically birds fly," without knowing anything else about Tweety, we may reasonably assume the fact that "Tweety can fly." As more knowledge of the world is discovered or learned over time, the AI system can revise its assumptions about Tweety using a truth maintenance process. If we later learn that "Tweety is a penguin" then truth maintenance revises this assumption because we also know "penguins do not fly". == Commonsense reasoning == Commonsense reasoning simulates the human ability to use commonsense knowledge to make presumptions about the type and essence of ordinary situations they encounter every day, and to change their "minds" should new information come to light. This includes time, missing or incomplete information and cause and effect. The ability to explain cause and effect is an important aspect of explainable AI. Truth maintenance algorithms automatically provide an explanation facility because they create elaborate records of presumptions. Compared with humans, all existing computer programs that attempt human-level AI perform extremely poorly on modern "commonsense reasoning" benchmark tests such as the Winograd Schema Challenge. The problem of attaining human-level competency at "commonsense knowledge" tasks is considered to probably be "AI complete" (that is, solving it would require the ability to synthesize a fully human-level intelligence), although some oppose this notion and believe compassionate intelligence is also required for human-level AI. Common sense reasoning has been applied successfully in more limited domains such as natural language processing and automated diagnosis or analysis. == Commonsense knowledge base construction == Compiling comprehensive knowledge bases of commonsense assertions (CSKBs) is a long-standing challenge in AI research. From early expert-driven efforts like CYC and WordNet, significant advances were achieved via the crowdsourced OpenMind Commonsense project, which led to the crowdsourced ConceptNet KB. Several approaches have attempted to automate CSKB construction, most notably, via text mining (WebChild, Quasimodo, TransOMCS, Ascent), as well as harvesting these directly from pre-trained language models (AutoTOMIC). These resources are significantly larger than ConceptNet, though the automated construction mostly makes them of moderately lower quality. Challenges also remain on the representation of commonsense knowledge: Most CSKB projects follow a triple data model, which is not necessarily best suited for breaking more complex natural language assertions. A notable exception here is GenericsKB, which applies no further normalization to sentences, but retains them in full. == Applications == Around 2013, MIT researchers developed BullySpace, an extension of the commonsense knowledgebase ConceptNet, to catch taunting social media comments. BullySpace included over 200 semantic assertions based around stereotypes, to help the system infer that comments like "Put on a wig and lipstick and be who you really are" are more likely to be an insult if directed at a boy than a girl. ConceptNet has also been used by chatbots and by computers that compose original fiction. At Lawrence Livermore National Laboratory, common sense knowledge was used in an intelligent software agent to detect violations of a comprehensive nuclear test ban treaty. == Data == As an example, as of 2012 ConceptNet includes these 21 language-independent relations: IsA (An "RV" is a "vehicle" | X is an instance of a Y) UsedFor (a "cake tin" is used for "making cakes" | X is used for the purpose Y) HasA (A "rabbit" has a "tail" | X possesses Y element or feature) CapableOf (a "cook" is capable of "making baked goods" | X is capable of doing Y) Desires (a "child" desires "the aroma of baking" | X has a desire for Y) CreatedBy ("cake" is created by a "baker" | X is created by Y) PartOf (a "knife" is be part of a "knife set" | X is a part of Y) Causes ("Heat" causes "cooking"| X is what causes Y) LocatedNear (the "oven" is located near the "refrigerator" | X is located near Y) AtLocation (Somewhere a "Cook" can be at a "restaurant" | X is at the location of Y) DefinedAs (a "Cupcake" is defined as a "cake" that also has the qualities of being "small", "baked within a wrapper", and "containing only one area of frosting or icing" | X is defined as Y that also has the properties A, B & C) SymbolOf (a "heart" is a symbol of "affection" | X is a symbolic representation of Y) ReceivesAction ("cake" can receive the action of being "eaten" | X is capable of receiving action Y) HasPrerequisite ("baking" has the prerequisite of obtaining the "ingredients" | X cannot do Y unless A does B) MotivatedByGoal ("baking" is motivated by the goal of "consumption"/"eating" | X has the motivation of Y goal) CausesDesire ("baking" makesYou want to "follow recipe" | X causes the desire to do Y) MadeOf ("Cake" is made of "flour"/"eggs"/"sugar"/"oil"/etc | X is made of Y) HasFirstSubevent ("baking" has first subevent "make batter" | To do X the first thing that needs to be done is Y) HasSubevent ("eat" has subevent "swallow" | Doing X will lead to Y event following) HasLastSubevent ("sleeping" has last subevent of "waking" | Doing X ends with the event Y) == Commonsense knowledge bases == Cyc Open Mind Common Sense (data source) and ConceptNet (datastore and NLP engine) Evi Graphiq

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  National Security Commission on Artificial Intelligence

  The National Security Commission on Artificial Intelligence (NSCAI) was an independent commission of the United States of America from 2018 to 2021. Its mission was to make recommendations to the President and Congress to "advance the development of artificial intelligence, machine learning, and associated technologies to comprehensively address the national security and defense needs of the United States". The commission's 15 members were nominated by the United States Congress. The NSCAI was dissolved on 1 October 2021. == History and reporting == The NSCAI began working in March 2019 and by November 2019 it had received more than 200 classified and unclassified briefings to help with the creation of its final report due in 2021.On 4 November 2019, the NSCAI shared its interim report with Congress, where it explained the 27 initial judgements to base its ongoing work. In the interim report the commission also agreed on seven principles: Global leadership in AI technology is a national security priority AI adoption is an urgent imperative for national security A shared sense of responsibility for the American peoples security must be created from government officials and private sector leaders. It needs to find local AI talent and use it to attract the world’s best minds Actions used for the protection of America’s AI leadership against foreign threats needs to follow the principles of free enterprise, free inquiry and free flow of ideas. The technical limitations of AI are universally known, however, a strong desire remains for powerful, dependable, and secure AI systems. United States used AI must follow American values including the rule of law Fundamental areas of effort for the preservation of U.S. advantages were also agreed upon in the interim report of 2019. The NSCAI released its first report of recommendations in March 2020, most of which were included in the 2021 National Defense Authorization Act. In July 2020, the commission published the second report to Congress. It identified 35 actions for both Executive and Legislative branches, which were focused on six fundamental areas. This report was available to the public. In January 2021, a draft of the final report was presented at a panel led by Schmidt. The report recommended the US to use AI technology for military use and development. It issued its final report in March 2021, saying that the U.S. is not sufficiently prepared to defend or compete against China in the AI era. It was broken up into two parts, the first titled “Defending America in the AI Era”, and the second “Winning the Technology Competition”. The report spoke about China’s efforts and investments into integration and that it could very well take the lead in AI in the next few years. Additional suggestions were made to concentrate on AI in everything we do and to implement it into US national security on multiple levels, as well as focus on bringing in new talent to develop AI and to introduce it to the working force on both civilian and military levels. Another recommendation of the NSCAI report was to develop and provide China and Russia with alternative models that are based on norms and democratic values. The final report also included a proposed $40 billion budget for government spending. On 14 April 2021, NSCAI executive director Ylli Bajraktari and director of Research and Analysis Justin Lynch participated in an event held by the Center for Security and Emerging Technology (CSET) to discuss the final report findings. In October 2021, NSCAI chair Eric Schmidt founded the bipartisan, non-profit Special Competitive Studies Project (SCSP) through his family led non-profit Eric & Wendy Schmidt Fund for Strategic Innovation in order to carry on the NSCAI’s efforts and expand beyond national security. The Foundation for Defense of Democracies held an event in June 2023, called “Thinking Forward After the NSCAI and CSC: A Discussion on AI and Cyber Policy”, with former members of NSCAI on the moderation panel, including Eric Schmidt and Ylli Bajraktari. == Members == Members of the National Security Commission on Artificial Intelligence: Eric Schmidt (chair), former CEO of Google Robert Work (Vice Chair), former Deputy Secretary of Defense Mignon Clyburn, former Commissioner of the Federal Communications Commission Chris Darby, CEO of In-Q-Tel Kenneth M. Ford, CEO of the Florida Institute for Human and Machine Cognition Jose-Marie Griffiths, President of Dakota State University Eric Horvitz, Technical Fellow at Microsoft Katrina G. McFarland, former Assistant Secretary of Defense for Acquisition Jason Matheny, Director of the Center for Security and Emerging Technology at Georgetown University Gilman Louie, partner at Alsop Louie Partners William Mark, vice president at SRI International Andy Jassy, CEO of Amazon Web Services (AWS) Safra Catz, CEO of Oracle Steve Chien, Technical Fellow at Jet Propulsion Laboratory (JPL) Andrew Moore, Google/Alphabet == Recommendations == The report's recommendations include: Dramatically increasing non-defense federal spending on AI research and development, doubling every year from $2 billion in 2022, to $32 billion in 2026. That would bring it up to a level similar to spending on biomedical research A dramatic increase in undergraduate scholarship and graduate studies fellowships in AI Creation of a Digital Corps to bring skilled tech workers into government Founding of a Digital Service Academy: an accredited university providing subsidized education in exchange for a commitment to work for a time in government Include civil rights and civil liberty reports for new AI systems or major updates to existing systems Expanding allocations of employment-based green cards, and giving them to every AI PhD graduate from an accredited U.S. university Reforming the acquisition management system Department of Defense to make it faster and easier to introduce new technologies == Transparency == In December 2019, a ruling was made under the Freedom of Information Act (FOIA) that the NSCAI must also provide historical documents upon request. The Electronic Privacy Information Center (EPIC) filed the lawsuit against the NSCAI in September 2019 after being refused information about the upcoming meetings and prepared records of the commission under FOIA and the Federal Advisory Committee Act (FACA). The U.S. District Court for the District of Columbia ruled in June 2020 that the NSCAI must comply with FACA and therefore hold open meetings and provide records to the public. The lawsuit was also filed by EPIC.

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  Global Partnership on Artificial Intelligence

  The Global Partnership on Artificial Intelligence (GPAI, pronounced "gee-pay") is an international initiative established to guide the responsible development and use of artificial intelligence (AI) in a manner that respects human rights and the shared democratic values of its members. The partnership was first proposed by Canada and France at the 2018 44th G7 summit, and officially launched in June 2020. GPAI is hosted by the Organisation for Economic Co-operation and Development (OECD). GPAI seeks to bridge the gap between theory and practice by supporting research and applied activities in areas that are directly relevant to policymakers in the realm of AI. It brings together experts from industry, civil society, governments, and academia to collaborate on the challenges and opportunities presented by artificial intelligence. == History == The Global Partnership on Artificial Intelligence was announced on the margins of the 2018 G7 Summit by Canadian Prime Minister Justin Trudeau and French President Emmanuel Macron. It officially launched on June 15, 2020 with fifteen founding members: Australia, Canada, France, Germany, India, Italy, Japan, Mexico, New Zealand, the Republic of Korea, Singapore, Slovenia, the United Kingdom, the United States, and the European Union. The Organisation for Economic Co-operation and Development (OECD) hosts a dedicated secretariat to support GPAI's governing bodies and activities. UNESCO joined the partnership in December 2020 as an observer. On November 11, 2021, Czechia, Israel and few more EU countries also joined the GPAI, bringing the total membership to 25 countries. Since the November 2022 summit, the list of members stands at 29. Austria, Chile, Finland, Malaysia, Norway, Slovakia and Switzerland were invited. The seven, however, are pending membership approval. == Membership == The following 29 members of the GPAI are: Argentina Australia Belgium Brazil Canada Czech Republic Denmark France Germany India Ireland Israel Italy Japan Mexico Netherlands New Zealand Poland Republic of Korea Senegal Serbia Singapore Slovenia Spain Sweden Turkey United Kingdom United States European Union Invited members: Austria (pending membership approval) Chile (pending membership approval) Finland (pending membership approval) Malaysia (pending membership approval) Norway (pending membership approval) Slovakia (pending membership approval) Switzerland (pending membership approval) == Organization == GPAI's experts collaborate across several Working Groups themes: Responsible AI (including an ad-hoc subgroup on AI and Pandemic Response), Data Governance, Future of Work, and Innovation & Commercialization. GPAI's Working Groups are supported by two Centres of Expertise: one in Montreal that supports the first two Working Groups, and one in Paris that supports the latter two. It also has a Steering Committee, the elected chair of which has also been to date elected chair of the Multi Stakeholder Group (MEG). These chairs have been: Jordan Zed and Baroness Joanna Shields (Shields, MEG chair; 2020-2021), Joanna Shields and Renaud Vedel (Shields, MEG chair; 2021-2022), Yoichi Iida and Inma Martinez (Martinez, MEG chair; 2023-2024) GPAI has a rotating presidency and host (much like the G7). The presidencies to date have been: Canada (2020) France (2021) Japan (2022) India (2023)

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  Eimear Kenny

  Eimear E. Kenny is a researcher in population genetics and translation genomics, and is the Founding Director of the Institute for Genomic Health, and Endowed Chair and Professor of Genomic Health at the Icahn School of Medicine at Mount Sinai. She is known for novel approaches in computational genomics, advancing the study of human genetic variation and its connection to disease risk and diagnosis. Her research has laid the foundation for integrating artificial intelligence (AI) and genomics into precision medicine and routine clinical care. By combining genomics, computer science, and medicine, her work leverages genomic sequencing technologies and machine learning algorithms to uncover insights that improve patient care, accelerate genomic data analysis, and enable the future of AI-driven healthcare. She has led multiple genomics-based clinical trials, applying computational biology and AI in clinical settings to advance genomic medicine and precision healthcare. == Research == A recipient of the Early-Career Award from the American Society of Human Genetics (USA), Kenny, as of 2024, leads a team in genetics, computer science, and medicine, focusing on genetic ancestry, large-scale genomics, clinical trials, and genomic medicine at the Institute for Genomic Health. The lab works to advance understanding of genetic ancestry and its impact on health in order to inform better clinical medicine models. She is recognized for her work to leverage biobanks for translational genomics and her development of new genetic tests an strategies for health care management. In one study, she and her colleagues investigated genetic disorders that might be under-diagnosed due to insufficient data, and found a variant in a collagen gene associated with Steel syndrome. This syndrome caused short stature and bone and joint issues and was thought to be rare. However, the study revealed it is common in individuals with Puerto Rican ancestry. Three of Kenny's genomic medicine clinical trials assessed how to bring new technology, such as digital apps, or information, such as polygenic risk scores, into routine clinical care. In the 2010s, Kenny was instrumental in several large-scale sequencing studies, including the 1000 Genomes Project, the Exome Sequencing Project, the Genome Sequencing Project, and the Trans-Omics for Precision Medicine. In 2012, she led work that discovered the variant responsible for blond hair in Melanesia, work that was featured in the Smithsonian NHGRI Human Genome Exhibit in Washington, D.C. In 2017, her group was one of the first to demonstrate that polygenic risk scores derived in predominantly European populations have reduced accuracy when applied in populations now widely acknowledged as a major challenge in the field of genomic risk prediction. As of 2024, she is Principal Investigator in many NIH-funded international consortium focused on computational genomics and genomic medicine, including Electronic Medical Records and Genomics, Polygenic Risk Methods in Diverse Populations, and the Human Pangenome Reference Consortium. In 2023, Kenny played a key role in a groundbreaking advancement in genomics research by helping to map a diverse human pangenome—a major shift from reliance on a single reference genome. Unlike the earlier genetic map, based on one man of mixed European and African ancestry in Buffalo, this new pangenome project captures far greater human genetic diversity. As reported by The Washington Post, Kenny's work demonstrates how a more inclusive human genome can drive discoveries in rare genetic diseases, improve genomic medicine, and accelerate the future of precision healthcare. Kenny was co-developer and current license holder for Random Forest adMIXture (RFMix), a patented software for inferring continental and sub-continental ancestry at genomic loci. == Education and career == Kenny graduated from Trinity College Dublin with a BA in Biochemistry in 1999 and did a masters in Bioinformatics at Leeds University. She received her PhD in Computational Genomics at Rockefeller University, and did her post-doctoral work in the lab of Dr. Carlos D. Bustamante at Stanford University. === Academic appointments === As of 2024, at Mount Sinai, she serves as the Endowed Chair and Professor of Genomic Health, Professor at the Department of Medicine and Professor at the Department of Genetics and Genomic Sciences. Since 2018 she has served as the Founding Director of the Institute for Genomic Health, and since 2022, she also serves as the Founding Director of the Center for Translational Genomics. She is also the Director of Translational Research, Division for Genomic Medicine. Former appointments include Assistant Professor at the Department of Genetics and Genomic Sciences and Member at The Charles Bronfman Institute of Personalized Medicine, both at Mount Sinai. She was also Bioinformatics Programmer at the California Institute of Technology, and research assistant at the Massachusetts Institute of Technology. == Publications == As of 2024, Kenny is an advisor to Cell Genomics. Google Scholar reports 50,623 citations, an h-index of 66 and an i10-index of 130. The five most-cited articles she contributed to are: Auton, A; Brooks, LD; Durbin, RM; Garrison, EP; Kang, HM; Korbel, JO; Marchini, JL; McCarthy, S; McVean, GA; Abecasis, GR (2015). "A global reference for human genetic variation". Nature. 526 (7571): 68–74. Bibcode:2015Natur.526...68T. doi:10.1038/nature15393. PMC 4750478. PMID 26432245.. Cited by 14847 Abecasis, GR; Auton, A; Brooks, LD; DePristo, MA; Durbin, RM; Handsaker, RE; Kang, HM; Marth, GT; McVean, GA (2012). "An integrated map of genetic variation from 1,092 human genomes". Nature. 491 (7422): 56–65. Bibcode:2012Natur.491...56T. doi:10.1038/nature11632. PMC 3498066. PMID 23128226.. Cited by 8287 Jacob A. Tennessen et al. Evolution and Functional Impact of Rare Coding Variation from Deep Sequencing of Human Exomes.Science337,64–69(2012).DOI:10.1126/science.1219240 Cited by 1886 Taliun, D.; Harris, D.N.; Kessler, M.D.; et al. (2021). "Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program". Nature. 590 (7845): 290–299. Bibcode:2021Natur.590..290T. doi:10.1038/s41586-021-03205-y. PMC 7875770. PMID 33568819.. Cited by 1369 Vilhjálmsson, BJ; et al. (2015). "Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores". Am J Hum Genet. 97 (4): 576–92. doi:10.1016/j.ajhg.2015.09.001. PMC 4596916. PMID 26430803.. Cited by 1327

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  Czekanowski distance

  The Czekanowski distance (sometimes shortened as CZD) is a per-pixel quality metric that estimates quality or similarity by measuring differences between pixels. Because it compares vectors with strictly non-negative elements, it is often used to compare colored images, as color values cannot be negative. This different approach has a better correlation with subjective quality assessment than PSNR. == Definition == Androutsos et al. give the Czekanowski coefficient as follows: d z ( i , j ) = 1 − 2 ∑ k = 1 p min ( x i k , x j k ) ∑ k = 1 p ( x i k + x j k ) {\displaystyle d_{z}(i,j)=1-{\frac {2\sum _{k=1}^{p}{\text{min}}(x_{ik},\ x_{jk})}{\sum _{k=1}^{p}(x_{ik}+x_{jk})}}} Where a pixel x i {\displaystyle x_{i}} is being compared to a pixel x j {\displaystyle x_{j}} on the k-th band of color – usually one for each of red, green and blue. For a pixel matrix of size M × N {\displaystyle M\times N} , the Czekanowski coefficient can be used in an arithmetic mean spanning all pixels to calculate the Czekanowski distance as follows: 1 M N ∑ i = 0 M − 1 ∑ j = 0 N − 1 ( 1 − 2 ∑ k = 1 3 min ( A k ( i , j ) , B k ( i , j ) ) ∑ k = 1 3 ( A k ( i , j ) + B k ( i , j ) ) ) {\displaystyle {\frac {1}{MN}}\sum _{i=0}^{M-1}\sum _{j=0}^{N-1}{\begin{pmatrix}1-{\frac {2\sum _{k=1}^{3}{\text{min}}(A_{k}(i,j),\ B_{k}(i,j))}{\sum _{k=1}^{3}(A_{k}(i,j)+B_{k}(i,j))}}\end{pmatrix}}} Where A k ( i , j ) {\displaystyle A_{k}(i,j)} is the (i, j)-th pixel of the k-th band of a color image and, similarly, B k ( i , j ) {\displaystyle B_{k}(i,j)} is the pixel that it is being compared to. == Uses == In the context of image forensics – for example, detecting if an image has been manipulated –, Rocha et al. report the Czekanowski distance is a popular choice for Color Filter Array (CFA) identification.

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  Artificial intelligence systems integration

  The core idea of artificial intelligence systems integration is making individual software components, such as speech synthesizers, interoperable with other components, such as common sense knowledgebases, in order to create larger, broader and more capable A.I. systems. The main methods that have been proposed for integration are message routing, or communication protocols that the software components use to communicate with each other, often through a middleware blackboard system. Most artificial intelligence systems involve some sort of integrated technologies, for example, the integration of speech synthesis technologies with that of speech recognition. However, in recent years, there has been an increasing discussion on the importance of systems integration as a field in its own right. Proponents of this approach are researchers such as Marvin Minsky, Aaron Sloman, Deb Roy, Kristinn R. Thórisson and Michael A. Arbib. A reason for the recent attention A.I. integration is attracting is that there have already been created a number of (relatively) simple A.I. systems for specific problem domains (such as computer vision, speech synthesis, etc.), and that integrating what's already available is a more logical approach to broader A.I. than building monolithic systems from scratch. == Integration focus == The focus on systems' integration, especially with regard to modular approaches, derive from the fact that most intelligences of significant scales are composed of a multitude of processes and/or utilize multi-modal input and output. For example, a humanoid-type of intelligence would preferably have to be able to talk using speech synthesis, hear using speech recognition, understand using a logical (or some other undefined) mechanism, and so forth. In order to produce artificially intelligent software of broader intelligence, integration of these modalities is necessary. == Challenges and solutions == Collaboration is an integral part of software development as evidenced by the size of software companies and the size of their software departments. Among the tools to ease software collaboration are various procedures and standards that developers can follow to ensure quality, reliability and that their software is compatible with software created by others (such as W3C standards for webpage development). However, collaboration in fields of A.I. has been lacking, for the most part not seen outside the respected schools, departments or research institutes (and sometimes not within them either). This presents practitioners of A.I. systems integration with a substantial problem and often causes A.I. researchers to have to 're-invent the wheel' each time they want a specific functionality to work with their software. Even more damaging is the "not invented here" syndrome, which manifests itself in a strong reluctance of A.I. researchers to build on the work of others. The outcome of this in A.I. is a large set of "solution islands": A.I. research has produced numerous isolated software components and mechanisms that deal with various parts of intelligence separately. To take some examples: Speech synthesis FreeTTS from CMU Speech recognition Sphinx from CMU Logical reasoning OpenCyc from Cycorp Open Mind Common Sense Net from MIT With the increased popularity of the free software movement, a lot of the software being created, including A.I. systems, is available for public exploit. The next natural step is to merge these individual software components into coherent, intelligent systems of a broader nature. As a multitude of components (that often serve the same purpose) have already been created by the community, the most accessible way of integration is giving each of these components an easy way to communicate with each other. By doing so, each component by itself becomes a module, which can then be tried in various settings and configurations of larger architectures. Some challenging and limitations of using A.I. software is the uncontrolled fatal errors. For example, serious and fatal errors have been discovered in very precise fields such as human oncology, as in an article published in the journal Oral Oncology Reports entitled "When AI goes wrong: Fatal errors in oncological research reviewing assistance". The article pointed out a grave error in artificial intelligence based on GBT in the field of biophysics. Many online communities for A.I. developers exist where tutorials, examples, and forums aim at helping both beginners and experts build intelligent systems. However, few communities have succeeded in making a certain standard, or a code of conduct popular to allow the large collection of miscellaneous systems to be integrated with ease. == Methodologies == === Constructionist design methodology === The constructionist design methodology (CDM, or 'Constructionist A.I.') is a formal methodology proposed in 2004, for use in the development of cognitive robotics, communicative humanoids and broad AI systems. The creation of such systems requires the integration of a large number of functionalities that must be carefully coordinated to achieve coherent system behavior. CDM is based on iterative design steps that lead to the creation of a network of named interacting modules, communicating via explicitly typed streams and discrete messages. The OpenAIR message protocol (see below) was inspired by the CDM and has frequently been used to aid in the development of intelligent systems using CDM. == Examples == ASIMO, Honda's humanoid robot, and QRIO, Sony's version of a humanoid robot. Cog, M.I.T. humanoid robot project under the direction of Rodney Brooks. AIBO, Sony's robot dog, integrates vision, hearing and motorskills. TOPIO, TOSY's humanoid robot can play ping-pong with human

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  JaCoP (solver)

  JaCoP is a constraint solver for constraint satisfaction problems. It is written in Java and it is provided as a Java library. JaCoP has an interface to the MiniZinc and AMPL modeling languages. Its main focus is on ease of use, modeling power, as well as efficiency. It has a large collection of global constraints implemented to facilitate problem modeling. JaCoP is actively developed since year 2001. Krzysztof Kuchcinski and Radoslaw Szymanek are the core developers of this Java library. There are number of people who have contributed to JaCoP development in addition to core developers. JaCoP development has been influenced by more than 20 research articles from Constraint Programming community. It has been used as a tool in more than 30 research articles. There are many different examples provided so it is easier to learn how to use JaCoP. The JaCoP project contains a wrapper for the Scala programming language, and a wrapper for Clojure is maintained as a separate project CloCoP.

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  Is-a

  In knowledge representation, ontology components and ontology engineering, including for object-oriented programming and design, is-a (also written as is_a or is a) is a subsumptive relationship between abstractions (e.g., types, classes), wherein one class A is a subclass of another class B (and so B is a superclass of A). In other words, type A is a subtype of type B when A's specification implies B's specification. That is, any object (or class) that satisfies A's specification also satisfies B's specification, because B's specification is weaker. For example, a cat 'is a[n]' animal, but not vice versa. All cats are animals, but not all animals are cats. Behaviour that is relevant to all animals is defined on an animal class, whereas behaviour that is relevant only for cats is defined in a cat class. By defining the cat class as 'extending' the animal class, all cats 'inherit' the behaviour defined for animals, without the need to explicitly code that behaviour for cats. == Related concepts == The is-a relationship is to be contrasted with the has-a (has_a or has a) relationship between types (classes); confusing the relations has-a and is-a is a common error when designing a model (e.g., a computer program) of the real-world relationship between an object and its subordinate. The is-a relationship may also be contrasted with the instance-of relationship between objects (instances) and types (classes): see Type–token distinction. To summarize the relations, there are: hyperonym–hyponym (supertype/superclass–subtype/subclass) relations between types (classes) defining a taxonomic hierarchy, where for a subsumption relation: a hyponym (subtype, subclass) has a type-of (is-a) relationship with its hyperonym (supertype, superclass); holonym–meronym (whole/entity/container–part/constituent/member) relations between types (classes) defining a possessive hierarchy, where for an aggregation (i.e. without ownership) relation: a holonym (whole) has a has-a relationship with its meronym (part), for a composition (i.e. with ownership) relation: a meronym (constituent) has a part-of relationship with its holonym (entity), for a containment relation: a meronym (member) has a member-of relationship with its holonym (container); concept–object (type–token) relations between types (classes) and objects (instances), where a token (object) has an instance-of relationship with its type (class).

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  List of large language models

  A large language model (LLM) is a type of machine learning model designed for natural language processing tasks such as language generation. LLMs are language models with many parameters, and are trained with self-supervised learning on a vast amount of text. == List == For the training cost column, 1 petaFLOP-day equals 1 petaFLOP/sec × 1 day, or 8.64×1019 FLOP (floating point operations). Only the cost of the largest model is shown. The number of parameters is measured in billions, and the training cost is measured in petaFLOP-days. === 2018 === === 2019 === === 2020 === === 2021 === === 2022 === === 2023 === === 2024 === === 2025 === === 2026 ===

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  Jailbreak (computer science)

  In computer security, jailbreaking is defined as the act of removing limitations that a vendor attempted to hard-code or hard-wire into its hardware and/or software. It is a form of privilege escalation. The term may have originated with the use of toolsets to break out of a chroot or jail in UNIX-like operating systems. This allowed the user to see files outside of the file system that the administrator intended to make available to the application or user in question. The term was first used in its modern meaning in the iPhone/iOS jailbreaking community and has also been used as a term for PlayStation Portable hacking; these devices have repeatedly been subject to jailbreaks, allowing the execution of arbitrary code, and sometimes have had those jailbreaks disabled by vendor updates, especially in the case of iOS devices. == iOS jailbreaking == iOS systems including the iPhone, iPad, and iPod Touch have been subject to iOS jailbreaking efforts since they were released, and continuing with each firmware update. iOS jailbreaking tools have included the option to install package frontends such as Cydia and Installer.app, third-party alternatives to the App Store, as a way to find and install system tweaks and binaries. To prevent iOS jailbreaking, Apple has made the device boot ROM execute checks for SHSH blobs in order to disallow uploads of custom kernels and prevent software downgrades to earlier, jailbreakable firmware. In an "untethered" jailbreak, the iBoot environment is changed to execute a boot ROM exploit and allow submission of a patched low level bootloader or hack the kernel to submit the jailbroken kernel after the SHSH check. == Other phones == A similar method of jailbreaking exists for S60 Platform smartphones, where utilities such as HelloOX allow the execution of unsigned code and full access to system files. or edited firmware (similar to the M33 hacked firmware used for the PlayStation Portable) to circumvent restrictions on unsigned code. Nokia has since issued updates to curb unauthorized jailbreaking, in a manner similar to Apple. Rooting is the equivalent concept for Android phones and other devices. == Console jailbreaking == In the case of gaming consoles, jailbreaking is often used to execute homebrew games. In 2011, Sony, with assistance from law firm Kilpatrick Stockton, sued 21-year-old George Hotz and associates of the group fail0verflow for jailbreaking the PlayStation 3 (see Sony Computer Entertainment America v. George Hotz and PlayStation Jailbreak). == AI jailbreaks == Jailbreaking can also occur in systems and software that use generative artificial intelligence models, such as ChatGPT. In jailbreaking attacks on artificial intelligence systems, users are able to manipulate the system to behave differently than it was intended, making it possible to reveal information about how the model was instructed by the vendor (the "system prompt") or to induce it to respond in an anomalous or harmful way. These attacks typically simply require prompting the AIs with specific phrasal templates - no software is typically required, although software could theoretically be used to "industrialise" such exploits, and some research has been done in this direction. In 2024, a consortium of AI firms founded HackAPrompt.com, a competition to encourage users to find new and effective AI jailbreaking techniques. These and other findings from "ethical hackers" have been used by AI model providers to try to improve AI safety.

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  Demis Hassabis

  Sir Demis Hassabis (/ˈdɛ.mɪs/ DE-mis /hɑːˈsɑː.bis/ hah-SAH-bees; born Dimitrios Hassapis, Greek: Δημήτριος Χασάπης, 27 July 1976) is a British artificial intelligence (AI) researcher and entrepreneur. He is the chief executive officer and co-founder of Google DeepMind and Isomorphic Labs, and a UK Government AI Adviser. In 2024, Hassabis and John M. Jumper were jointly awarded the Nobel Prize in Chemistry for their AI research contributions to protein structure prediction. Hassabis is a Fellow of the Royal Society and has won awards for his research efforts, including the Breakthrough Prize, the Canada Gairdner International Award and the Lasker Award. He was appointed a CBE in 2017, and knighted in 2024 for his work on AI. He was also listed among the Time 100 most influential people in the world in 2017 and 2025, and was one of the "Architects of AI" collectively chosen as Time's 2025 Person of the Year. == Early life and education == Hassabis was born to Costas and Angela Hassapis. His father is a Greek Cypriot and his mother is a Chinese Singaporean. Demis grew up in North London. His original surname was "Hassapis" (Greek: Χασάπης), meaning "butcher" in Greek, but he later, according to Ingo Althöfer, "executed a point mutation by changing ‘p’ to ‘b’". One of his younger brothers still carries the original surname. In his early career, he was a video game AI programmer and designer, and an expert board games player. A child prodigy in chess from the age of four, when he first learnt chess by watching his father playing against his uncle, Hassabis reached master standard at the age of 13 with an Elo rating of 2300 and captained many of the England junior chess teams. He represented the University of Cambridge in the Oxford–Cambridge varsity chess matches of 1995, 1996 and 1997, winning a half blue. He first got interested in technology after buying his first computer in 1984, a ZX Spectrum 48K, funded from chess winnings. He taught himself how to program from books. He subsequently wrote his first AI program on a Commodore Amiga to play the reversi board game. Between 1988 and 1990, Hassabis was educated at Queen Elizabeth's School, Barnet, a boys' grammar school in North London. He was subsequently home-schooled by his parents for a year, before studying at the comprehensive school of Christ's College in East Finchley. He completed his A-level exams two years early at 16. === Bullfrog Productions === Asked by Cambridge University to take a gap year owing to his young age, Hassabis began his computer games career at Bullfrog Productions after entering an Amiga Power "Win-a-job-at-Bullfrog" competition. He began by playtesting on Syndicate and then at 17 co-designing and lead-programming on the 1994 game Theme Park, with the game's designer Peter Molyneux. Theme Park, a simulation video game, sold several million copies and inspired a whole genre of simulation sandbox games. Despite being offered a seven-figure sum to remain in the games industry, he turned it down. He earned enough from his gap year to pay his own way through university. === University of Cambridge === Hassabis left Bullfrog to study at Queens' College of the University of Cambridge, where he completed the Computer Science Tripos and graduated in 1997 with a double first. == Career and research == === Lionhead === After graduating from Cambridge, Hassabis worked at Lionhead Studios. Games designer Peter Molyneux, with whom Hassabis had worked at Bullfrog Productions, had recently founded the company. At Lionhead, Hassabis worked as lead AI programmer on the 2001 god game Black & White. === Elixir Studios === Hassabis left Lionhead in 1998 to found Elixir Studios, a London-based independent games developer, signing publishing deals with Eidos Interactive, Vivendi Universal and Microsoft. In addition to managing the company, Hassabis served as executive designer of the games Republic: The Revolution and Evil Genius. Each received BAFTA nominations for their interactive music scores, created by James Hannigan. The release of Elixir's first game, Republic: The Revolution, a highly ambitious and unusual political simulation game, was delayed due to its huge scope, which involved an AI simulation of the workings of an entire fictional country. The final game was reduced from its original vision and greeted with lukewarm reviews, receiving a Metacritic score of 62/100. Evil Genius, a tongue-in-cheek Austin Powers parody, fared much better with a score of 75/100. In April 2005 the intellectual property and technology rights were sold to various publishers and the studio was closed. === Neuroscience research === Following Elixir Studios, Hassabis returned to academia to obtain his PhD in cognitive neuroscience from UCL Queen Square Institute of Neurology in 2009 supervised by Eleanor Maguire. He sought to find inspiration in the human brain for new AI algorithms. He continued his neuroscience and artificial intelligence research as a visiting scientist jointly at Massachusetts Institute of Technology (MIT), in the lab of Tomaso Poggio, and Harvard University, before earning a Henry Wellcome postdoctoral research fellowship to the Gatsby Computational Neuroscience Unit at UCL in 2009 working with Peter Dayan. Working in the field of imagination, memory, and amnesia, he co-authored several influential papers published in Nature, Science, Neuron, and PNAS. His very first academic work, published in PNAS, was a landmark paper that showed systematically for the first time that patients with damage to their hippocampus, known to cause amnesia, were also unable to imagine themselves in new experiences. The finding established a link between the constructive process of imagination and the reconstructive process of episodic memory recall. Based on this work and a follow-up functional magnetic resonance imaging (fMRI) study, Hassabis developed a new theoretical account of the episodic memory system identifying scene construction, the generation and online maintenance of a complex and coherent scene, as a key process underlying both memory recall and imagination. This work received widespread coverage in the mainstream media and was listed in the top 10 scientific breakthroughs of the year by the journal Science. He later generalised these ideas to advance the notion of a 'simulation engine of the mind' whose role it was to imagine events and scenarios to aid with better planning. === DeepMind === Hassabis is the CEO and co-founder of DeepMind, a machine learning AI startup, founded in London in 2010 with Shane Legg and Mustafa Suleyman. Hassabis met Legg when both were postdocs at the Gatsby Computational Neuroscience Unit, and he and Suleyman had been friends through family. Hassabis also recruited his university friend and Elixir partner David Silver. DeepMind's mission is to "solve intelligence" and then use intelligence "to solve everything else". More concretely, DeepMind aims to combine insights from systems neuroscience with new developments in machine learning and computing hardware to unlock increasingly powerful general-purpose learning algorithms that will work towards the creation of an artificial general intelligence (AGI). The company has focused on training learning algorithms to master games, and in December 2013 it announced that it had made a pioneering breakthrough by training an algorithm called a Deep Q-Network (DQN) to play Atari games at a superhuman level by using only the raw pixels on the screen as inputs. DeepMind's early investors included several high-profile tech entrepreneurs. In 2014, Google purchased DeepMind for £400 million. Although most of the company has remained an independent entity based in London, DeepMind Health has since been directly incorporated into Google Health. Since the Google acquisition, the company has notched up a number of significant achievements, perhaps the most notable being the creation of AlphaGo, a program that defeated world champion Lee Sedol at the complex game of Go. Go had been considered a holy grail of AI, for its high number of possible board positions and resistance to existing programming techniques. However, AlphaGo beat European champion Fan Hui 5–0 in October 2015 before winning 4–1 against former world champion Lee Sedol in March 2016 and winning 3–0 against the world's top-ranked player Ke Jie in 2017. Additional DeepMind accomplishments include creating a neural Turing machine, reducing the energy used by the cooling systems in Google's data centres by 40%, and advancing research on AI safety. DeepMind has also been responsible for technical advances in machine learning, having produced a number of award-winning papers. In particular, the company has made significant advances in deep learning and reinforcement learning, and pioneered the field of deep reinforcement learning which combines these two methods. Hassabis has predicted that artificial intelligence will be "one of the most beneficial techn

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