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Israeli cybersecurity industry

The Israeli cybersecurity industry is a rapidly growing sector within Israel's technology and innovation ecosystem. Israel is internationally recognized as a powerhouse in the cybersecurity domain, with numerous cybersecurity startups, established companies, research institutions, and government initiatives. Tel Aviv itself is being ranked 7th in annual list of best global tech ecosystems, as reported by the Jerusalem Post. == History == The roots of Israel's cybersecurity industry can be traced back to the country's strong focus on national security and intelligence. The establishment of elite military units such as Unit 8200, the Israeli Intelligence Corps unit responsible for signals intelligence and code decryption, played a significant role in the development of cybersecurity expertise in the country. Many former members of Unit 8200 have gone on to establish successful cybersecurity companies or join existing organizations, bringing their unique skill sets and experience to the private sector. == Market overview == As of 2024, Israel housed more than 450 cybersecurity startups and companies. In 2023, the value of exits by Israeli tech companies reached $7.5 billion. Israel's cybersecurity industry is characterized by a high concentration of startups develop new technologies in areas such as network security, endpoint protection, data security, cloud security, and threat intelligence. In recent years, the sector has attracted significant investment from both local and international venture capital firms, as well as major technology companies such as Microsoft, Google, and IBM. Several Israeli cybersecurity companies have gained global recognition and success, with some being acquired by major corporations or conducting successful initial public offerings (IPOs). === Key Israeli cybersecurity companies === Some key Israeli cybersecurity companies include: Check Point Software Technologies CyberArk Cato Networks Radware Wiz === Financial activity === Israel’s cybersecurity sector has seen significant financial activity. As of 2023, mergers and acquisitions in the cybersecurity sector totaled $2.8 billion. In the first quarter of 2024, the sector secured $846 million in private funding. == Background == The military experience helped much. Israel's mandatory military service, combined with the expertise developed within elite units such as Unit 8200, has fostered a strong talent pool with practical experience in cybersecurity. Israel's thriving startup ecosystem, often referred to as the "Startup Nation," has fostered an environment of innovation and collaboration that has contributed to the growth of the cybersecurity industry. Israeli cybersecurity companies often collaborate with international partners, both in the private and public sectors, to share knowledge and develop joint solutions. === Government Initiatives and Support === The government also supported well through various initiatives, such as the Israel National Cyber Directorate (INCD), which works to strengthen cybersecurity defenses and promote the development of the sector. === Academic institutions === Israeli universities and research centers are involved in cybersecurity research and education, contributing to the development of new technologies and training the next generation of cybersecurity professionals. Academic Tech transfer offices in Israel also facilitate the commercialization of cybersecurity technologies. Some academic institutions with cybersecurity laboratories include: Tel Aviv University Technion Ben-Gurion University
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Common Voice

Common Voice is a crowdsourcing project started by Mozilla to create a free and open speech corpus. The project is supported by volunteers who record sample sentences with a microphone and review recordings of other users. The transcribed sentences are collected in a voice database available under the public domain license CC0. This license ensures that developers can use the database for voice-to-text and text-to-voice applications without restrictions or costs. == Aims == Common Voice aims to provide diverse voice samples. According to Mozilla's Katharina Borchert, many existing projects took datasets from public radio or otherwise had datasets that underrepresented both women and people with pronounced accents. == Voice database == The first dataset was released in November 2017. More than 20,000 users worldwide had recorded 500 hours of English sentences. In February 2019, the first batch of languages was released for use. This included 18 languages such as English, French, German and Mandarin Chinese, but also less prevalent languages like Welsh and Kabyle. In total, this included almost 1,400 hours of recorded voice data from more than 42,000 contributors. By July 2020 the database had amassed 7,226 hours of voice recordings in 54 languages, 5,591 hours of which had been verified by volunteers. In May 2021, following the work to add Kinyarwanda, the project received a grant to add Kiswahili. At the beginning of 2022, Bengali.AI partnered with Common Voice to launch the "Bangla Speech Recognition" project that aims to make machines understand the Bangla language. 2000 hours of voice was collected. In September 2022, it was announced that the Twi language of Ghana was the 100th language to be added to the database. As of December 2025, Mozilla Common Voice collects voice data for over 250 languages, with the most hours having been collected in English, Catalan, Kinyarwanda, Belarusian and Esperanto.
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Almeida–Pineda recurrent backpropagation

Almeida–Pineda recurrent backpropagation is an extension to the backpropagation algorithm that is applicable to recurrent neural networks. It is a type of supervised learning. It was described somewhat cryptically in Richard Feynman's senior thesis, and rediscovered independently in the context of artificial neural networks by both Fernando Pineda and Luis B. Almeida. A recurrent neural network for this algorithm consists of some input units, some output units and eventually some hidden units. For a given set of (input, target) states, the network is trained to settle into a stable activation state with the output units in the target state, based on a given input state clamped on the input units.
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Nearest centroid classifier

In machine learning, a nearest centroid classifier or nearest prototype classifier is a classification model that assigns to observations the label of the class of training samples whose mean (centroid) is closest to the observation. When applied to text classification using word vectors containing tfidf weights to represent documents, the nearest centroid classifier is known as the Rocchio classifier because of its similarity to the Rocchio algorithm for relevance feedback. An extended version of the nearest centroid classifier has found applications in the medical domain, specifically classification of tumors. == Algorithm == === Training === Given labeled training samples { ( x → 1 , y 1 ) , … , ( x → n , y n ) } {\displaystyle \textstyle \{({\vec {x}}_{1},y_{1}),\dots ,({\vec {x}}_{n},y_{n})\}} with class labels y i ∈ Y {\displaystyle y_{i}\in \mathbf {Y} } , compute the per-class centroids μ → ℓ = 1 | C ℓ | ∑ i ∈ C ℓ x → i {\displaystyle \textstyle {\vec {\mu }}_{\ell }={\frac {1}{|C_{\ell }|}}{\underset {i\in C_{\ell }}{\sum }}{\vec {x}}_{i}} where C ℓ {\displaystyle C_{\ell }} is the set of indices of samples belonging to class ℓ ∈ Y {\displaystyle \ell \in \mathbf {Y} } . === Prediction === The class assigned to an observation x → {\displaystyle {\vec {x}}} is y ^ = arg ⁡ min ℓ ∈ Y ‖ μ → ℓ − x → ‖ {\displaystyle {\hat {y}}={\arg \min }_{\ell \in \mathbf {Y} }\|{\vec {\mu }}_{\ell }-{\vec {x}}\|} .
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Scenery generator

A scenery generator (or terrain generator) is a software used to create landscape images, 3D models, and animations. These programs often use procedural generation to generate the landscapes, or sometimes created and rendered by a 3D artist. These programs are often used in video games or movies. Basic elements of landscapes created by scenery generators include terrain, water, foliage, and clouds. The process for basic random generation uses a diamond square algorithm. == Common features == Most scenery generators can create basic heightmaps to simulate the variation of elevation in basic terrain. Common techniques include Simplex noise, fractals, or the diamond-square algorithm, which can generate 2-dimensional heightmaps. A version of scenery generator can be very simplistic. Using a diamond-square algorithm with some extra steps involving fractals, an algorithm for random generation of terrain can be made with only 120 lines of code. The program in example takes a grid and then divides the grid repeatedly. Each smaller grid is then split into squares and diamonds and the algorithm then makes the randomized terrain for each square and diamond. Most programs for creating landscapes also allow for adjustment and editing of the landscape. For example, World Creator allows for terrain sculpting, which uses a similar brush system as Photoshop, and allows for additional terrain enhancement with its procedural techniques such as erosion, sediments, and more. Other tools in the World Creator program include terrain stamping, which allows you to import elevation maps and use them as a base. The programs tend to also allow for additional placement of rocks, trees, etc. These can be done procedurally or by hand depending on the program. Typically the models used for the placement objects are the same as to lessen the amount of work that would be done if the user was to create a multitude of different trees. The terrain generated the computer does a generation of multifractals then integrates them until finally rendering them onto the screen. These techniques are typically done “on-the-fly” which typically for a 128 × 128 resolution terrain would mean 1.5 seconds on a CPU from the early 1990s. == Applications == Scenery generators are commonly used in movies, animations, 3D rendering, and video games. For example, Industrial Light & Magic used E-on Vue to create the fictional environments for Pirates of the Caribbean: Dead Man's Chest. In such live-action cases, a 3D model of the generated environment is rendered and blended with live-action footage. Scenery generated by the software may also be used to create completely computer-generated scenes. In the case of animated movies such as Kung Fu Panda, the raw generation is assisted by hand-painting to accentuate subtle details. Environmental elements not commonly associated with landscapes, such as ocean waves, have also been handled by the software. Scenery generation is used in most 3D based video-games. These typically use either custom or purchased engines that contain their own scenery generators. For some games they tend to use a procedurally generated terrain. These typically use a form of height mapping and use of Perlin noise. This will create a grid that with one point in a 2D coordinate will create the same heightmap as it is pseudorandom, meaning it will result in the same output with the same input. This can then easily be translated into the product 3D image. These can then be changed from the editor tools in most engines if the terrain will be custom built. With recent developments neural networks can be built to create or texture the terrain based on previously suggested artwork or heightmap data. These would be generated using algorithms that have been able to identify images and similarities between them. With the info the machine can take other heightmaps and render a very similar looking image to the style image. This can be used to create similar images in example a Studio Ghibli or Van Gogh art-style. == Software == Most game engines, whether custom or proprietary, will have terrain generation built in. Some terrain generator programs include, Terragen, which can create terrain, water, atmosphere and lighting; L3DT, which provides similar functions to Terragen, and has a 2048 × 2048 resolution limit; and World Creator, which can create terrain, and is fully GPU powered. === List of 3D terrain generation software ===
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Evolutionary attractor

An evolutionary attractor is a point in an evolutionary space where a selection process will always drive trait values towards that point from the region around it. Because of the importance of evolution through natural selection, often such an evolutionary space will be defined by genetic or phenotypic traits, or possibly both. In this case the selection process will be a form of natural selection. The existence of an evolutionary attractor in a biological evolutionary space does not always imply that it can be reached from all points in that evolutionary space, nor does it identify what will happen when the evolutionary attractor is reached. While an evolutionary attractor may represent a point in evolutionary space that is resistant to further selection, such as an evolutionarily stable strategy, other possibilities are available. Because identification of an evolutionary attractor on its own does not describe everything about the evolutionary space in which it lies, this has led to interest in the evolutionary dynamics surrounding evolutionary attractors and in evolutionary spaces in general. (Theoretical biologists and mathematicians working in the area may prefer the terms adaptive dynamics or evolutionary invasion analysis to evolutionary dynamics.) These fields use differential equations which allows a more complete understanding of the dynamics in evolutionary spaces including the existence or otherwise of evolutionary attractors. Advances in the study of molecular evolution have also led to the identification of evolutionary attractors at a molecular level. Because biological evolutionary processes have been studied using evolutionary game theory, a technique inspired by game theory originally derived to address economic problems, not only can evolutionary attractors be found in biology but economists studying evolutionary economic models have also identified evolutionary attractors. Evolution in biology has also inspired evolutionary computation in computer science. Many algorithms in this field use a form of selection inspired by natural selection to generate results through evolutionary algorithms. This is therefore another area in which evolutionary attractors have been identified. == Evolutionary attractors in biology == It is not probably not surprising that biology is the field where most examples of evolutionary attractors have been identified, given the importance of evolution through natural selection. === Evolutionary attractors in adaptive landscapes === An evolutionary attractor is a point in genetic and/or phenotypic trait space, that evolution will always drive trait values towards via a selection process. The concept of an evolutionary attractor arose in population genetics following the origin of the adaptive landscape originally proposed by Sewall Wright in 1932. The height of a point in an adaptive landscape is a measure of evolutionary fitness. If a point in an adaptive landscape is a peak, then selection will always drive traits towards it and it will be an evolutionary attractor. While population genetics deals with discrete genetic traits, quantitative genetics extended such concepts to deal with continuous genetic traits, where the concept of evolutionary attractor is also valid. === Evolutionary attractors in evolutionary game models === Evolutionary game theory introduced into evolutionary biology concepts originally used in economics, with the advantage that evolution could be studied in relation to strategic choices made in animal conflicts. This is of particular interest because of the concept of the evolutionarily stable strategy or ESS, a strategy that once established is resistant to invasion by other strategies. ESSs will not always be evolutionary attractors, but if they are they will persist over evolutionary time. === Dynamics around evolutionary attractors in biology === Evolutionary attractors in biology do not exist in isolation. By definition they must exist in an evolutionary trait space where selection drives all traits towards them from a region immediately around them. That is, they must be convergence stable. Eshel (1983) modified the definition of an ESS by considering individually advantageous reduction from a majority deviation: he created the term continuous stability. A continuously stable ESS can be shown to be convergence stable, therefore it will act as an evolutionary attractor. But the nature of evolutionary trait spaces in biology means that it is not possible to guarantee that the region of convergence to the evolutionary attractor covers the whole of the trait space, nor that there is only one evolutionary attractor in a particular trait space. These issues have led to the emergence of the related fields of evolutionary dynamics, adaptive dynamics and evolutionary invasion analysis, all of which use differential equations to understand the dynamics in evolutionary trait spaces. Hence, if one or more evolutionary attractor exists in an evolutionary trait space, they provide techniques to understand the dynamics in that trait space around the evolutionary attractor. === Evolutionary attractors in an ecological context === Evolution in biology does not take place in single species in isolation. Ecological interaction of species leads to coevolution. Important examples of this are host-parasite or host-pathogen interaction, which can make both the dynamics around evolutionary attractors more complex, and the occurrence and number of evolutionary attractors more diverse. Evolutionary attractors have been identified in the analysis of evolutionary epidemiology of plant pathogens. In the above study working on plant populations the authors were able to identify evolutionary attractors using methods from adaptive dynamics. A model applied to the analysis of a maize (Zea mays L.) virus identified convergence stable equilibria through simulation modelling. A related model identified evolutionary attractors in the interaction of plants with fungal pathogens. === Evolutionary attractors in molecular genetics === As mentioned above much of the consideration of evolutionary attractors in biology has been through investigation of selection at a genetic or phenotypic level or both, in a single species or in coevolving species. Advances in the study of molecular genetics now allow the study of evolutionary attractors to be taken to a molecular genetic level. Wilson et. al (2019) studied the evolution of gene regulatory networks and identified the emergence of evolutionary attractors. == Evolutionary attractors in economics == Evolutionary game theory as applied in biology was inspired by game theory originally devised for applications in economics. Game theory remains an active field of research outside of biology, and thus it is not surprising that researchers in evolutionary economics use evolutionary game theory. Evolutionary attractors have been demonstrated by economists studying the evolutionary dynamics of market entry with market dynamics based on the replicator dynamics of biological evolutionary games. == Evolutionary attractors in computing == Evolutionary computation is a branch of computer science inspired by biological evolution. Many algorithms in evolutionary computation use a form of selection. Thus evolutionary attractors have been identified in computer science as well as in biology and economics. Evolutionary algorithms have generated evolutionary attractors, probably because of the similarity between adaptive hill-climbing in evolutionary heuristics and the adaptive landscape originated to explain evolution through natural selection.
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Quickprop

Quickprop is an iterative method for determining the minimum of the loss function of an artificial neural network, following an algorithm inspired by the Newton's method. Sometimes, the algorithm is classified to the group of the second order learning methods. It follows a quadratic approximation of the previous gradient step and the current gradient, which is expected to be close to the minimum of the loss function, under the assumption that the loss function is locally approximately square, trying to describe it by means of an upwardly open parabola. The minimum is sought in the vertex of the parabola. The procedure requires only local information of the artificial neuron to which it is applied. The k {\displaystyle k} -th approximation step is given by: Δ ( k ) w i j = Δ ( k − 1 ) w i j ( ∇ i j E ( k ) ∇ i j E ( k − 1 ) − ∇ i j E ( k ) ) {\displaystyle \Delta ^{(k)}\,w_{ij}=\Delta ^{(k-1)}\,w_{ij}\left({\frac {\nabla _{ij}\,E^{(k)}}{\nabla _{ij}\,E^{(k-1)}-\nabla _{ij}\,E^{(k)}}}\right)} Where w i j {\displaystyle w_{ij}} is the weight of input i {\displaystyle i} of neuron j {\displaystyle j} , and E {\displaystyle E} is the loss function. The Quickprop algorithm is an implementation of the error backpropagation algorithm, but the network can behave chaotically during the learning phase due to large step sizes.
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Types of artificial neural networks

Types of neural networks (NN) include a family of techniques. The simplest types have static components, including number of units, number of layers, unit weights and topology. Dynamic NNs evolve via learning. Some types allow/require learning to be "supervised" by the operator, while others operate independently. Some types operate purely in hardware, while others are purely software and run on general purpose computers. The main types are: Transformers: these use attention to analyze every token in the input stream against every other token in the stream. That technique has enabled neural networks to reach the general public via chatbots, code generators and many other forms. Convolutional neural networks (CNN): a FNN that uses kernels and regularization to evade problems in prior generations of NNs. They are typically used to analyze visual and other two-dimensional data. Generative adversarial networks set networks (of varying structure) against each other, each trying to push the other(s) to produce better results such as winning a game or to deceive the opponent about the authenticity of an input. == Feedforward == In feedforward neural networks the information moves from the input to output directly in every layer. There can be hidden layers with or without cycles/loops to sequence inputs. Feedforward networks can be constructed with various types of units, such as binary McCulloch–Pitts neurons, the simplest of which is the perceptron. Continuous neurons, frequently with sigmoidal activation, are used in the context of backpropagation. == Group method of data handling == The Group Method of Data Handling (GMDH) features fully automatic structural and parametric model optimization. The node activation functions are Kolmogorov–Gabor polynomials that permit additions and multiplications. It uses a deep multilayer perceptron with eight layers. It is a supervised learning network that grows layer by layer, where each layer is trained by regression analysis. Useless items are detected using a validation set, and pruned through regularization. The size and depth of the resulting network depends on the task. == Autoencoder == An autoencoder, autoassociator or Diabolo network is similar to the multilayer perceptron (MLP) – with an input layer, an output layer and one or more hidden layers connecting them. However, the output layer has the same number of units as the input layer. Its purpose is to reconstruct its own inputs (instead of emitting a target value). Therefore, autoencoders are unsupervised learning models. An autoencoder is used for unsupervised learning of efficient codings, typically for the purpose of dimensionality reduction and for learning generative models of data. == Probabilistic == A probabilistic neural network (PNN) is a four-layer feedforward neural network. The layers are Input, hidden pattern, hidden summation, and output. In the PNN algorithm, the parent probability distribution function (PDF) of each class is approximated by a Parzen window and a non-parametric function. Then, using PDF of each class, the class probability of a new input is estimated and Bayes’ rule is employed to allocate it to the class with the highest posterior probability. It was derived from the Bayesian network and a statistical algorithm called Kernel Fisher discriminant analysis. It is used for classification and pattern recognition. == Time delay == A time delay neural network (TDNN) is a feedforward architecture for sequential data that recognizes features independent of sequence position. In order to achieve time-shift invariance, delays are added to the input so that multiple data points (points in time) are analyzed together. It usually forms part of a larger pattern recognition system. It has been implemented using a perceptron network whose connection weights were trained with back propagation (supervised learning). == Convolutional == A convolutional neural network (CNN, or ConvNet or shift invariant or space invariant) is a class of deep network, composed of one or more convolutional layers with fully connected layers (matching those in typical ANNs) on top. It uses tied weights and pooling layers. In particular, max-pooling. It is often structured via Fukushima's convolutional architecture. They are variations of multilayer perceptrons that use minimal preprocessing. This architecture allows CNNs to take advantage of the 2D structure of input data. Its unit connectivity pattern is inspired by the organization of the visual cortex. Units respond to stimuli in a restricted region of space known as the receptive field. Receptive fields partially overlap, over-covering the entire visual field. Unit response can be approximated mathematically by a convolution operation. CNNs are suitable for processing visual and other two-dimensional data. They have shown superior results in both image and speech applications. They can be trained with standard backpropagation. CNNs are easier to train than other regular, deep, feed-forward neural networks and have many fewer parameters to estimate. Capsule Neural Networks (CapsNet) add structures called capsules to a CNN and reuse output from several capsules to form more stable (with respect to various perturbations) representations. Examples of applications in computer vision include DeepDream and robot navigation. They have wide applications in image and video recognition, recommender systems and natural language processing. == Deep stacking network == A deep stacking network (DSN) (deep convex network) is based on a hierarchy of blocks of simplified neural network modules. It was introduced in 2011 by Deng and Yu. It formulates the learning as a convex optimization problem with a closed-form solution, emphasizing the mechanism's similarity to stacked generalization. Each DSN block is a simple module that is easy to train by itself in a supervised fashion without backpropagation for the entire blocks. Each block consists of a simplified multi-layer perceptron (MLP) with a single hidden layer. The hidden layer h has logistic sigmoidal units, and the output layer has linear units. Connections between these layers are represented by weight matrix U; input-to-hidden-layer connections have weight matrix W. Target vectors t form the columns of matrix T, and the input data vectors x form the columns of matrix X. The matrix of hidden units is H = σ ( W T X ) {\displaystyle {\boldsymbol {H}}=\sigma ({\boldsymbol {W}}^{T}{\boldsymbol {X}})} . Modules are trained in order, so lower-layer weights W are known at each stage. The function performs the element-wise logistic sigmoid operation. Each block estimates the same final label class y, and its estimate is concatenated with original input X to form the expanded input for the next block. Thus, the input to the first block contains the original data only, while downstream blocks' input adds the output of preceding blocks. Then learning the upper-layer weight matrix U given other weights in the network can be formulated as a convex optimization problem: min U T f = ‖ U T H − T ‖ F 2 , {\displaystyle \min _{U^{T}}f=\|{\boldsymbol {U}}^{T}{\boldsymbol {H}}-{\boldsymbol {T}}\|_{F}^{2},} which has a closed-form solution. Unlike other deep architectures, such as DBNs, the goal is not to discover the transformed feature representation. The structure of the hierarchy of this kind of architecture makes parallel learning straightforward, as a batch-mode optimization problem. In purely discriminative tasks, DSNs outperform conventional DBNs. === Tensor deep stacking networks === This architecture is a DSN extension. It offers two important improvements: it uses higher-order information from covariance statistics, and it transforms the non-convex problem of a lower-layer to a convex sub-problem of an upper-layer. TDSNs use covariance statistics in a bilinear mapping from each of two distinct sets of hidden units in the same layer to predictions, via a third-order tensor. While parallelization and scalability are not considered seriously in conventional DNNs, all learning for DSNs and TDSNs is done in batch mode, to allow parallelization. Parallelization allows scaling the design to larger (deeper) architectures and data sets. The basic architecture is suitable for diverse tasks such as classification and regression. == Physics-informed == Such a neural network is designed for the numerical solution of mathematical equations, such as differential, integral, delay, fractional and others. As input parameters, PINN accepts variables (spatial, temporal, and others), transmits them through the network block. At the output, it produces an approximate solution and substitutes it into the mathematical model, considering the initial and boundary conditions. If the solution does not satisfy the required accuracy, one uses the backpropagation and rectify the solution. Besides PINN, other architectures have been developed to produce surrogate models for scientific comput
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Ampere Computing

Ampere Computing LLC is an American fabless semiconductor company that designs ARM-based central processing units (CPUs) with high core counts for use in cloud computing and data center environments. Founded in 2017 by former Intel president Renée James, the company is headquartered in Santa Clara, California, and operates as an independent subsidiary of SoftBank Group since November 2025. == History == Ampere Computing was founded in fall 2017 by Renée James, ex-President of Intel, with funding from The Carlyle Group. James acquired a team from MACOM Technology Solutions (formerly AppliedMicro) in addition to several industry hires to start the company. Ampere Computing is an ARM architecture licensee and develops its own server microprocessors. Ampere fabricates its products at TSMC. In April 2019, Ampere announced its second major investment round, including investment from Arm Holdings and Oracle Corporation. In June 2019, Nvidia announced a partnership with Ampere to bring support for Compute Unified Device Architecture (CUDA). In November 2019, Nvidia announced a reference design platform for graphics processing unit (GPU)-accelerated ARM-based servers including Ampere. In the first half of 2020, Ampere announced Ampere Altra, an 80-core processor, and Ampere Altra Max, a 128-core processor, without the use of simultaneous multithreading. In March 2020, the company announced a partnership with Oracle. In September 2020, Oracle said it would launch bare-metal and virtual machine instances in early 2021 based on Ampere Altra. In November 2020, Ampere was named one of the top 10 hottest semiconductor startups by CRN. In May 2021, the company announced a partnership with Microsoft. In April 2022, Ampere said that it had filed a confidential prospectus with the U.S. Securities and Exchange Commission, signaling its intent to go public. In June 2022, HPE announced their Gen11 ProLiant system would use Ampere Altra and Ampere Altra Max Cloud Native Processors. In July 2022, Google announced T2A instances using Ampere Altra in the Google cloud and in August 2022 Microsoft announced their instances of Ampere running in Azure. On March 19, 2025, investment holding company SoftBank Group announced it will acquire Ampere Computing for $6.5 billion. The deal finalized in November 2025, with Ampere remaining as an independent subsidiary with its headquarters in Santa Clara, California. == Products == Ampere develops ARM-based computer processors and CPU cores under their Altra brands. These are used in databases, media encoding, web services, network acceleration, mobile gaming, AI inference processing, and other applications and programs that need to scale. On February 5, 2018, Ampere announced the eMAG 8180 featuring 32x Skylark cores fabricated on TSMC's 16FF+ process. It supports a turbo of up to 3.3 GHz with a TDP of 125 W, 8ch 64-bit DDR4, up to 1 TB DDR4 per socket, and 42x PCIe 3.0 Lanes. The Skylark cores were based on AppliedMicro's X-Gene 3. Packet offers servers with the eMAG 8180 and 128 GB DRAM, 480 GB SSD, and 2x 10 Gbit/s networking. On September 19, 2018, Ampere announced the availability of a version featuring 16x Skylark cores. === 2020 === On March 3, 2020, Ampere announced the Ampere Altra featuring 80 cores fabricated on TSMC's N7 process for hyperscale computing. It was the first server-grade processor to include 80 cores and the Q80-30 conserves power by running at 161 W in use. The cores are semi-custom Arm Neoverse N1 cores with Ampere modifications. It supports a frequency of up to 3.3 GHz with TDP of 250 W, 8ch 72-bit DDR4, up to 4 TB DDR4-3200 per socket, 128x PCIe 4.0 Lanes, 1 MB L2 per core and 32 MB SLC. Ampere also announced their roadmap with Ampere Altra Max (2021) in development and AmpereOne (2022) defined. === 2021 === The 128-core Altra Max was released in 2021 and targeted hyperscale cloud providers. It uses the same server socket and platforms as Ampere Altra, and both products have one thread per core. The Altra Max CPUs provide 128 Arm v8.2+ cores per chip and run up to 3.0 GHz. They also support eight channels of DDR4-3200 memory and 128 lanes of PCIe Gen4. Also in 2021, Oracle launched its Oracle Cloud Infrastructure (OCI) using Ampere Altra processors. === 2022 === In February 2022, Ampere and Rigetti Computing announced a strategic partnership to create hybrid quantum-classical computers. The companies will combine Ampere's Altra Max CPUs with Rigetti's Quantum Processing Units (QPU) in cloud-based High-Performance Computing (HPC) environments. In April, Microsoft previewed its Azure Virtual Machines running on the Ampere Altra. The VMs run scale-out workloads, web servers, application servers, open source databases, cloud native .NET applications, Java applications, gaming servers, media servers, and other processes. In May, Ampere announced the sampling of AmpereOne CPUs, 5 nanometer chips based on its in-house Ampere-developed core. AmpereOne will add support for DDR5 main memory and PCIe Gen5 peripherals. On June 28, 2022, HPE became first tier-one server provider to offer compute with optimized cloud-native silicon for service providers and enterprises embracing cloud-native development with new line of HPE ProLiant RL Gen11 servers, using Ampere® Altra® and Ampere® Altra® Max processors, delivering high performance and power efficiency. === 2023 === During April 2023, Ampere released the Altra developer's kit, an IoT Prototype Kit based on Ampere Altra, aimed at cloud developers, available in 32-core, 64-core, and 80-core formats. === 2024 === In May 2024, Ampere updated its AmpereOne roadmap to 256 cores and announced a joint effort with Qualcomm on CPUs and accelerators. == Customers == Ampere's customers include Microsoft Azure, Tencent Cloud, Oracle, ByteDance, Hewlett Packard Enterprise (HPE), Cloudflare, Equinix, Kingsoft Cloud, Meituan, Scaleway, UCloud, Foxconn Industrial Internet, Gigabyte, Inspur, Cruise, Hetzner, Project Ronin, Wiwynn and Google Cloud Platform Cruise uses an Ampere Altra variant for its autonomous driving unit. The CPU was selected because of its throughput and low power consumption. In 2021, Oracle, Microsoft, Tencent, and ByteDance committed to using Ampere's customized chips, first announced in May. In April 2022, Microsoft previewed Ampere Altra processors in its new Azure D-and E- series virtual machines. The Dpsv5 series is built for Linux enterprise application types, and the Epsv5 series is for memory-intensive Linux workloads. They provide up to 64 vCPUs, include VM sizes with 2GiB, 4GiB, and 8GiB per vCPU memory configurations, up to 40 Gbit/s networking, and high-performance local SSD storage. In 2022, Microsoft's Ampere Altra-based Azure servers became the first cloud solution provider server to be Arm SystemReady SR certified. The Azure VMs, powered by Altra processors, were also the first to be SystemReady Virtual Environment standard certified. SystemReady defines a set of firmware and hardware standards as a baseline for system development for software developers, original equipment vendors, and chipmakers.
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U-matrix

The U-matrix (unified distance matrix) is a representation of a self-organizing map (SOM) where the Euclidean distance between the codebook vectors of neighboring neurons is depicted in a grayscale image. This image is used to visualize the data in a high-dimensional space using a 2D image. == Construction procedure == Once the SOM is trained using the input data, the final map is not expected to have any twists. If the map is twist-free, the distance between the codebook vectors of neighboring neurons gives an approximation of the distance between different parts of the underlying data. When such distances are depicted in a grayscale image, light colors depict closely spaced node codebook vectors and darker colors indicate more widely separated node codebook vectors. Thus, groups of light colors can be considered as clusters, and the dark parts as the boundaries between the clusters. This representation can help to visualize the clusters in the high-dimensional spaces, or to automatically recognize them using relatively simple image processing techniques.
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Feature selection

In machine learning, feature selection is the process of selecting a subset of relevant features (variables, predictors) for use in model construction. Feature selection techniques are used for several reasons: simplification of models to make them easier to interpret, shorter training times, to avoid the curse of dimensionality, improve the compatibility of the data with a certain learning model class, to encode inherent symmetries present in the input space. The central premise when using feature selection is that data sometimes contains features that are redundant or irrelevant, and can thus be removed without incurring much loss of information. Redundancy and irrelevance are two distinct notions, since one relevant feature may be redundant in the presence of another relevant feature with which it is strongly correlated. Feature extraction creates new features from functions of the original features, whereas feature selection finds a subset of the features. Feature selection techniques are often used in domains where there are many features and comparatively few samples (data points). == Introduction == A feature selection algorithm can be seen as the combination of a search technique for proposing new feature subsets, along with an evaluation measure which scores the different feature subsets. The simplest algorithm is to test each possible subset of features finding the one which minimizes the error rate. This is an exhaustive search of the space, and is computationally intractable for all but the smallest of feature sets. The choice of evaluation metric heavily influences the algorithm, and it is these evaluation metrics which distinguish between the three main categories of feature selection algorithms: wrappers, filters and embedded methods. Wrapper methods use a predictive model to score feature subsets. Each new subset is used to train a model, which is tested on a hold-out set. Counting the number of mistakes made on that hold-out set (the error rate of the model) gives the score for that subset. As wrapper methods train a new model for each subset, they are very computationally intensive, but usually provide the best performing feature set for that particular type of model or typical problem. Filter methods use a proxy measure instead of the error rate to score a feature subset. This measure is chosen to be fast to compute, while still capturing the usefulness of the feature set. Common measures include the mutual information, the pointwise mutual information, Pearson product-moment correlation coefficient, Relief-based algorithms, and inter/intra class distance or the scores of significance tests for each class/feature combinations. Filters are usually less computationally intensive than wrappers, but they produce a feature set which is not tuned to a specific type of predictive model. This lack of tuning means a feature set from a filter is more general than the set from a wrapper, usually giving lower prediction performance than a wrapper. However the feature set doesn't contain the assumptions of a prediction model, and so is more useful for exposing the relationships between the features. Many filters provide a feature ranking rather than an explicit best feature subset, and the cut off point in the ranking is chosen via cross-validation. Filter methods have also been used as a preprocessing step for wrapper methods, allowing a wrapper to be used on larger problems. One other popular approach is the Recursive Feature Elimination algorithm, commonly used with Support Vector Machines to repeatedly construct a model and remove features with low weights. Embedded methods are a catch-all group of techniques which perform feature selection as part of the model construction process. The exemplar of this approach is the LASSO method for constructing a linear model, which penalizes the regression coefficients with an L1 penalty, shrinking many of them to zero. Any features which have non-zero regression coefficients are 'selected' by the LASSO algorithm. Improvements to the LASSO include Bolasso which bootstraps samples; Elastic net regularization, which combines the L1 penalty of LASSO with the L2 penalty of ridge regression; and FeaLect which scores all the features based on combinatorial analysis of regression coefficients. AEFS further extends LASSO to nonlinear scenario with autoencoders. These approaches tend to be between filters and wrappers in terms of computational complexity. In traditional regression analysis, the most popular form of feature selection is stepwise regression, which is a wrapper technique. It is a greedy algorithm that adds the best feature (or deletes the worst feature) at each round. The main control issue is deciding when to stop the algorithm. In machine learning, this is typically done by cross-validation. In statistics, some criteria are optimized. This leads to the inherent problem of nesting. More robust methods have been explored, such as branch and bound and piecewise linear network. == Subset selection == Subset selection evaluates a subset of features as a group for suitability. Subset selection algorithms can be broken up into wrappers, filters, and embedded methods. Wrappers use a search algorithm to search through the space of possible features and evaluate each subset by running a model on the subset. Wrappers can be computationally expensive and have a risk of over fitting to the model. Filters are similar to wrappers in the search approach, but instead of evaluating against a model, a simpler filter is evaluated. Embedded techniques are embedded in, and specific to, a model. Many popular search approaches use greedy hill climbing, which iteratively evaluates a candidate subset of features, then modifies the subset and evaluates if the new subset is an improvement over the old. Evaluation of the subsets requires a scoring metric that grades a subset of features. Exhaustive search is generally impractical, so at some implementor (or operator) defined stopping point, the subset of features with the highest score discovered up to that point is selected as the satisfactory feature subset. The stopping criterion varies by algorithm; possible criteria include: a subset score exceeds a threshold, a program's maximum allowed run time has been surpassed, etc. Alternative search-based techniques are based on targeted projection pursuit which finds low-dimensional projections of the data that score highly: the features that have the largest projections in the lower-dimensional space are then selected. Search approaches include: Exhaustive Best first Simulated annealing Genetic algorithm Greedy forward selection Greedy backward elimination Particle swarm optimization Targeted projection pursuit Scatter search Variable neighborhood search Two popular filter metrics for classification problems are correlation and mutual information, although neither are true metrics or 'distance measures' in the mathematical sense, since they fail to obey the triangle inequality and thus do not compute any actual 'distance' – they should rather be regarded as 'scores'. These scores are computed between a candidate feature (or set of features) and the desired output category. There are, however, true metrics that are a simple function of the mutual information; see here. Other available filter metrics include: Class separability Error probability Inter-class distance Probabilistic distance Entropy Consistency-based feature selection Correlation-based feature selection == Optimality criteria == The choice of optimality criteria is difficult as there are multiple objectives in a feature selection task. Many common criteria incorporate a measure of accuracy, penalised by the number of features selected. Examples include Akaike information criterion (AIC) and Mallows's Cp, which have a penalty of 2 for each added feature. AIC is based on information theory, and is effectively derived via the maximum entropy principle. Other criteria are Bayesian information criterion (BIC), which uses a penalty of log ⁡ n {\displaystyle {\sqrt {\log {n}}}} for each added feature, minimum description length (MDL) which asymptotically uses log ⁡ n {\displaystyle {\sqrt {\log {n}}}} , Bonferroni / RIC which use 2 log ⁡ p {\displaystyle {\sqrt {2\log {p}}}} , maximum dependency feature selection, and a variety of new criteria that are motivated by false discovery rate (FDR), which use something close to 2 log ⁡ p q {\displaystyle {\sqrt {2\log {\frac {p}{q}}}}} . A maximum entropy rate criterion may also be used to select the most relevant subset of features. == Structure learning == Filter feature selection is a specific case of a more general paradigm called structure learning. Feature selection finds the relevant feature set for a specific target variable whereas structure learning finds the relationships between all the variables, usually by expressing these relationships as a graph. The most common structure learning algorithms
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Spatial Analysis of Principal Components

Spatial Principal Component Analysis (sPCA) is a multivariate statistical technique that complements the traditional Principal Component Analysis (PCA) by incorporating spatial information into the analysis of genetic variation. While traditional PCA can be used to find spatial patterns, it focuses on reducing data dimensionality by identifying uncorrelated principal components that capture maximum variance, thus often lacking power to identify non-trivial spatial genetic patterns. By accounting for spatial autocorrelation, sPCA is able to uncover spatial patterns in the data and find the spatial structure of datasets where observations are either geographically or topologically linked. This statistical power improvement allows the investigation of cryptic spatial patterns of genetic variability otherwise overlooked. sPCA has been applied in various fields, including geography, ecology and genetics. == History == sPCA was introduced in 2008 by Thibaut Jombart, Sébastien Devillard, Anne-Béatrice Dufour, and D. Pontier as a spatially explicit method to investigate the spatial pattern of genetic variation among individuals or populations. In 2017, Valeria Montano and Thibaut Jombart published an alternative non-parametric test to evaluate the significance of global and local spatial genetic patterns with improved statistical power. == Details == sPCA modifies the PCA framework by integrating spatial weights, typically in the form of connectivity matrices or spatial adjacency graphs. It identifies principal components (PCs) that maximize both genentic variance and spatial autocorreation, as measured by Moran's I. These weights represent relationships between observations based on geographic distance or other spatial criteria. The method decomposes variance into two components: Global structures, correspond to positive autocorrelation, that is, reflect broad-scale spatial patterns where similar values cluster over large regions. Local structures, correspond to negative autocorrelation, that is, capture fine-scale spatial variations or localized patterns. The core of sPCA relies on the eigenanalysis of a spatially weighted covariance or correlation matrix. The spatial weight matrix can be constructed using techniques such as Delaunay triangulation, nearest-neighbor graphs, or distance-based criteria. Applications of sPCA should be used only as an explorative tool. == Applications == sPCA has been widely used in many fields, including: Ecology: To find spatial patterns in species distributions and environmental gradients. Genetics: Population structure and gene flow analysis while allowing for spatial autocorrelation considerations. Biogeography: To identify historical dispersal routes, and barriers to gene flow, providing insights into species distribution patterns and evolutionary history. == Software/Source Code == sPCA implementations are available in R in adegenet and ntbox . These tools facilitate the application of sPCA by providing functions for constructing spatial weight matrices, performing eigenanalysis, and obtaining spatial principal components in an easy-to-read form.
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Corona-Warn-App

Corona-Warn-App was the official and open-source COVID-19 contact tracing app used for digital contact tracing in Germany made by SAP and Deutsche Telekom subsidiary T-Systems. It had been downloaded 22.8 million times as of 19 November 2020 and 26.2 million times as of 18 March 2021. The app has been promoted by billboard and broadcast advertisements, e.g. in cooperation with the German Football Association (DFB) and other prominent companies. The German government has announced that the app would no longer exchange tracing information as of April 30, 2023 & would enter hibernation as of June 1, 2023. == Effectiveness == Experts believe that time saved by using the app can be critical for improving the effectiveness contact tracing efforts. Some virologists say when at least 60% of people in Germany use it, it would be very effective. == Functioning == The app works with the Exposure Notification Framework (what is implemented in Google Play Services for Android and in iOS) by using Bluetooth to exchange codes with app users that are within 1.5 meters of each other for a period of at least 10 minutes. Anyone who tests positive for COVID-19 can share this information voluntarily with the app. Other app users are then notified about when, how long and at what distance they had contact with the infected person within a 14-day period. Testing is available for persons on a voluntary basis. === Server architecture === Based on the Client–server model five servers are operated within the app backend: the Corona-Warn-App server. It stores the authorized keys of infected users, referred to as diagnosis keys, from the past 14 days in its database. Stored diagnosis keys are grouped into regularly updated blocks which are transmitted to the Content Delivery Network. This interface supplies the keys for the app clients to download and locally compute a potential exposure risk. the Verification server. It is responsible for documenting the approval of the user to share their positive test result with the app and also to verify the test result. the Portal Server. It generates a so-called teleTAN token if the user did not give their consent to share their test result with the app at first but then changed their mind or if the local public health authority or test laboratory is not connected to the app system yet. the Test Result Server. It saves the test results provided by the local public health authorities or test laboratories for further use within the backend. the Federation Gateway Server. It connects to the national Corona-Warn-App servers of participating EU countries to enable transnational key exchange. By the distribution of the data on different servers the decoupling of the data becomes possible and results in an obstructed tracing of the app users. ==== Report of a positive COVID-19 test ==== The app provides a function to warn other app users by uploading their positive test result on a voluntarily and anonymous basis to the Corona-Warn-App server. In case the local public health authority or test laboratory is already connected to the app system, the user receives a QR-Code when the swab specimen is taken that can be scanned in the app. After scanning the QR-Code und the user getting authorized by the Verification server, the app receives an individual Registration token which gets stored locally and with which the status and the result of the test can be checked manually as well as automatically. If the local public health authority or test laboratory is not connected to the app system yet and the user wants to share their positive test result with other app users, it is required to request a teleTAN token by calling the verification hotline of the app. In both cases, the user can upload their diagnosis keys of the last 14 days to the Corona-Warn-App server in case their consent to share the information is given. The Corona-Warn-App server then verifies the uploaded keys by asking the Verification server if the keys are valid and if they are, the Corona-Warn-App server stores them in its database. == Privacy == The use of the app is voluntary. The app implements decentralized data storage to ensure data privacy. Employers can require that Corona-Warn be installed on company phones, but can not compel its use on private phones. == Funding == The open source app, which costs €20 million to develop is intended to supplement human contact tracing efforts, which Germany put in place during the early stages of the COVID-19 pandemic in Germany. In August 2022, a spokesperson for the German ministry of health announced that the total costs including all additional developments are now estimated to be closer to €150m. == Interoperability == At its start the app only worked in Germany, and Jens Spahn, than Federal Minister of Health (CDU), has said the development of a Europe-wide system is a future goal. With the update published on 19 October 2020 the app supports key-exchanges with the EU Interoperability Gateway and is therefore able to communicate with contact tracing apps from Ireland and Italy. Austria, Belgium, Czech Republic, Croatia, Cyprus, Denmark, Finland, Ireland, Italy, Latvia, Malta, Netherlands, Norway, Poland, Slovenia, Spain and Switzerland had joined the gateway as well and are also able to exchange keys with Corona-Warn-App. The app can be downloaded in many App stores outside of Germany. However, as of August 2021, the app is still unavailable for those of notable national German minorities like Turks, Russians or Ukrainians, who use App stores of their home countries. == Software variants == An unofficial Corona-Warn-App has been released on F-Droid, making the app available without proprietary components on Android phones. == Literature == Thomas Köllmann: Die Corona-Warn-App – Schnittstelle zwischen Datenschutz- und Arbeitsrecht. In: Neue Zeitschrift für Arbeitsrecht. Nr. 13, 10. Juli 2020, S. 831–836.
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Blockmodeling

Blockmodeling is a set or a coherent framework, that is used for analyzing social structure and also for setting procedure(s) for partitioning (clustering) social network's units (nodes, vertices, actors), based on specific patterns, which form a distinctive structure through interconnectivity. It is primarily used in statistics, machine learning and network science. As an empirical procedure, blockmodeling assumes that all the units in a specific network can be grouped together to such extent to which they are equivalent. Regarding equivalency, it can be structural, regular or generalized. Using blockmodeling, a network can be analyzed using newly created blockmodels, which transforms large and complex network into a smaller and more comprehensible one. At the same time, the blockmodeling is used to operationalize social roles. While some contend that the blockmodeling is just clustering methods, Bonacich and McConaghy state that "it is a theoretically grounded and algebraic approach to the analysis of the structure of relations". Blockmodeling's unique ability lies in the fact that it considers the structure not just as a set of direct relations, but also takes into account all other possible compound relations that are based on the direct ones. The principles of blockmodeling were first introduced by Francois Lorrain and Harrison C. White in 1971. Blockmodeling is considered as "an important set of network analytic tools" as it deals with delineation of role structures (the well-defined places in social structures, also known as positions) and the discerning the fundamental structure of social networks. According to Batagelj, the primary "goal of blockmodeling is to reduce a large, potentially incoherent network to a smaller comprehensible structure that can be interpreted more readily". Blockmodeling was at first used for analysis in sociometry and psychometrics, but has now spread also to other sciences. == Definition == A network as a system is composed of (or defined by) two different sets: one set of units (nodes, vertices, actors) and one set of links between the units. Using both sets, it is possible to create a graph, describing the structure of the network. During blockmodeling, the researcher is faced with two problems: how to partition the units (e.g., how to determine the clusters (or classes), that then form vertices in a blockmodel) and then how to determine the links in the blockmodel (and at the same time the values of these links). In the social sciences, the networks are usually social networks, composed of several individuals (units) and selected social relationships among them (links). Real-world networks can be large and complex; blockmodeling is used to simplify them into smaller structures that can be easier to interpret. Specifically, blockmodeling partitions the units into clusters and then determines the ties among the clusters. At the same time, blockmodeling can be used to explain the social roles existing in the network, as it is assumed that the created cluster of units mimics (or is closely associated with) the units' social roles. Blockmodeling can thus be defined as a set of approaches for partitioning units into clusters (also known as positions) and links into blocks, which are further defined by the newly obtained clusters. A block (also blockmodel) is defined as a submatrix, that shows interconnectivity (links) between nodes, present in the same or different clusters. Each of these positions in the cluster is defined by a set of (in)direct ties to and from other social positions. These links (connections) can be directed or undirected; there can be multiple links between the same pair of objects or they can have weights on them. If there are not any multiple links in a network, it is called a simple network. A matrix representation of a graph is composed of ordered units, in rows and columns, based on their names. The ordered units with similar patterns of links are partitioned together in the same clusters. Clusters are then arranged together so that units from the same clusters are placed next to each other, thus preserving interconnectivity. In the next step, the units (from the same clusters) are transformed into a blockmodel. With this, several blockmodels are usually formed, one being core cluster and others being cohesive; a core cluster is always connected to cohesive ones, while cohesive ones cannot be linked together. Clustering of nodes is based on the equivalence, such as structural and regular. The primary objective of the matrix form is to visually present relations between the persons included in the cluster. These ties are coded dichotomously (as present or absent), and the rows in the matrix form indicate the source of the ties, while the columns represent the destination of the ties. Equivalence can have two basic approaches: the equivalent units have the same connection pattern to the same neighbors or these units have same or similar connection pattern to different neighbors. If the units are connected to the rest of network in identical ways, then they are structurally equivalent. Units can also be regularly equivalent, when they are equivalently connected to equivalent others. With blockmodeling, it is necessary to consider the issue of results being affected by measurement errors in the initial stage of acquiring the data. == Different approaches == Regarding what kind of network is undergoing blockmodeling, a different approach is necessary. Networks can be one–mode or two–mode. In the former all units can be connected to any other unit and where units are of the same type, while in the latter the units are connected only to the unit(s) of a different type. Regarding relationships between units, they can be single–relational or multi–relational networks. Further more, the networks can be temporal or multilevel and also binary (only 0 and 1) or signed (allowing negative ties)/values (other values are possible) networks. Different approaches to blockmodeling can be grouped into two main classes: deterministic blockmodeling and stochastic blockmodeling approaches. Deterministic blockmodeling is then further divided into direct and indirect blockmodeling approaches. Among direct blockmodeling approaches are: structural equivalence and regular equivalence. Structural equivalence is a state, when units are connected to the rest of the network in an identical way(s), while regular equivalence occurs when units are equally related to equivalent others (units are not necessarily sharing neighbors, but have neighbour that are themselves similar). Indirect blockmodeling approaches, where partitioning is dealt with as a traditional cluster analysis problem (measuring (dis)similarity results in a (dis)similarity matrix), are: conventional blockmodeling, generalized blockmodeling: generalized blockmodeling of binary networks, generalized blockmodeling of valued networks and generalized homogeneity blockmodeling, prespecified blockmodeling. According to Brusco and Steinley (2011), the blockmodeling can be categorized (using a number of dimensions): deterministic or stochastic blockmodeling, one–mode or two–mode networks, signed or unsigned networks, exploratory or confirmatory blockmodeling. == Blockmodels == Blockmodels (sometimes also block models) are structures in which: vertices (e.g., units, nodes) are assembled within a cluster, with each cluster identified as a vertex; from such vertices a graph can be constructed; combinations of all the links (ties), represented in a block as a single link between positions, while at the same time constructing one tie for each block. In a case, when there are no ties in a block, there will be no ties between the two positions that define the block. Computer programs can partition the social network according to pre-set conditions. When empirical blocks can be reasonably approximated in terms of ideal blocks, such blockmodels can be reduced to a blockimage, which is a representation of the original network, capturing its underlying 'functional anatomy'. Thus, blockmodels can "permit the data to characterize their own structure", and at the same time not seek to manifest a preconceived structure imposed by the researcher. Blockmodels can be created indirectly or directly, based on the construction of the criterion function. Indirect construction refers to a function, based on "compatible (dis)similarity measure between paris of units", while the direct construction is "a function measuring the fit of real blocks induced by a given clustering to the corresponding ideal blocks with perfect relations within each cluster and between clusters according to the considered types of connections (equivalence)". === Types === Blockmodels can be specified regarding the intuition, substance or the insight into the nature of the studied network; this can result in such models as follows: parent-child role systems, organizational hierarchies, systems of
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Prescription monitoring program

In the United States, prescription monitoring programs (PMPs) or prescription drug monitoring programs (PDMPs) are state-run programs which collect and distribute data about the prescription and dispensation of federally controlled substances and, depending on state requirements, other potentially abusable prescription drugs. PMPs are meant to help prevent adverse drug-related events such as opioid overdoses, drug diversion, and substance abuse by decreasing the amount and/or frequency of opioid prescribing, and by identifying those patients who are obtaining prescriptions from multiple providers (i.e., "doctor shopping") or those physicians overprescribing opioids. Most US health care workers support the idea of PMPs, which intend to assist physicians, physician assistants, nurse practitioners, dentists and other prescribers, the pharmacists, chemists and support staff of dispensing establishments. The database, whose use is required by State law, typically requires prescribers and pharmacies dispensing controlled substances to register with their respective state PMPs and (for pharmacies and providers who dispense from their offices) to report the dispensation of such prescriptions to an electronic online database. The majority of PMPs are authorized to notify law enforcement agencies or licensing boards or physicians when a prescriber, or patients receiving prescriptions, exceed thresholds established by the state or prescription recipient exceeds thresholds established by the State. All states have implemented PDMPs, although evidence for the effectiveness of these programs is mixed. While prescription of opioids has decreased with PMP use, overdose deaths in many states have actually increased, with those states sharing data with neighboring jurisdictions or requiring reporting of more drugs experiencing highest increases in deaths. This may be because those declined opioid prescriptions turn to street drugs, whose potency and contaminants carry greater overdose risk. == History == Prescription drug monitoring programs, or PDMPs, are an example of one initiative proposed to alleviate effects of the opioid crisis. The programs are designed to restrict prescription drug abuse by limiting a patient's ability to obtain similar prescriptions from multiple providers (i.e. “doctor shopping”) and reducing diversion of controlled substances. This is meant to reduce risk of fatal overdose caused by high doses of opioids or interactions between opioids and benzodiazepenes, and to enable better decision making on the part of healthcare providers who may be unaware of a patient's prescription drug use, history or other prescriptions. PDMPs have been implemented in state legislations since 1939 in California, a time before electronic medical records, though implementation rose alongside increased awareness of overprescribing of opioids and overdose. A later New York state program was struck down by the U.S. Supreme Court in Whalen v. Roe. But, by 2019, 49 states, the District of Columbia, and Guam had enacted PDMP legislation. In 2021 Missouri, the last State to not use a PMP, adopted legislation to create one. PMPs are constantly being updated to increase speed of data collection, sharing of data across States, and ease of interpretation. This is being done by integrating PDMP reports with other health information technologies such as health information exchanges (HIE), electronic health record (EHR) systems, and/ or pharmacy dispensing software systems. One program that has been implemented in nine states is called the PDMP Electronic Health Records Integration and Interoperability Expansion, also known as PEHRIIE. Another software, marketed by Bamboo Health and integrated with PMPs in 43 states, uses an algorithm to track factors thought to increase risk of diversion, abuse or overdose, and assigns patients a three digit score based on presumed indicators of risk. While some studies have suggested that PDMP-HIT integration and sharing of interstate data brings benefits such as reduced opioid-related inpatient morbidity, others have found no or negative impact on mortality compared to states without PMP data sharing. Patient and media reports suggest need for testing and evaluation of algorithmic software used to score risk, with some patients reporting denial of prescriptions without c explanation or clarity of data. == Goals == Most health care workers support PMPs which intend to assist physicians, physician assistants, nurse practitioners, dentists and other prescribers, the pharmacists, chemists and support staff of dispensing establishments, as well as law-enforcement agencies. The collaboration supports the legitimate medical use of controlled substances while limiting their abuse and diversion. Pharmacies dispensing controlled substances and prescribers typically must register with their respective state PMPs and (for pharmacies and providers who dispense controlled substances from their offices) report the dispensation to an electronic online database. Some pharmacy software can submit these reports automatically to multiple states. == Usage == === List of programs by state === === Software systems === NarxCare is a prescription drug monitoring program (PDMP) run by Bamboo Health. Bamboo Health was formerly known as Appriss. It is widely used across the United States by pharmacies including Rite Aid as well as those at Walmart and Sam’s Club. The NarxCare software allows doctors to view data about a patient, combining data from the prescription registries of various U.S. states to make the registries interoperable nationally. It also uses machine learning to generate an "Overdose Risk Score" that potentially includes EMS and criminal justice data; these scores have been criticized by researchers and patient advocates for the lack of transparency in the process as well as the potential for disparate treatment of women and minority groups. Advertised as an "analytics tool and care management platform", the NarxCare software allows doctors to view data about a patient including how many pharmacies they have visited and the combinations of medication they are prescribed. It combines data from the prescription registries of various U.S. states, making the registries interoperable nationally. It additionally uses machine learning to generate various three-digit "risk scores" and an overall "Overdose Risk Score", collectively referred to as Narx Scores, in a process that potentially includes EMS and criminal justice data as well as court records. == Controversy == Many doctors and researchers support the idea of PDMPs as a tool in combatting the opioid epidemic. Opioid prescribing, opioid diversion and supply, opioid misuse, and opioid-related morbidity and mortality are common elements in data entered into PDMPs. Prescription Monitoring Programs are purported to offer economic benefits for the states who implement them by decreasing overall health care costs, lost productivity, and investigation times. However, there are many studies that conclude the impact of PDMPs is unclear. While use of PMPs has been accompanied by decrease in opioid prescribing, few analyses consider corresponding use of street opioids, extramedical use, or diversion, which might provide a more holistic method for evaluation of PMP intent and efficacy. Evidence for PDMP impact on fatal overdoses is decidedly mixed, with multiple studies finding increased overdose rates in some states, decreases in others, or no clear impact. Interestingly, an increase in heroin overdoses after PDMP implementation has been commonly reported, presumably as denial of prescription opioids sends patients in search of street drugs. Narx Scores have been criticized by researchers and patient advocates for the lack of transparency in the generation process as well as the potential for disparate treatment of women and minority groups. Writing in Duke Law Journal, Jennifer Oliva stated that "black-box algorithms" are used to generate the scores.
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