AlphaEvolve is an evolutionary coding agent for designing advanced algorithms based on large language models such as Gemini. It was developed by Google DeepMind and unveiled in May 2025. == Design == AlphaEvolve aims to autonomously discover and refine algorithms through a combination of large language models (LLMs) and evolutionary computation. AlphaEvolve needs an evaluation function with metrics to optimize, and an initial algorithm. At each step, AlphaEvolve uses the LLM to produce variants of the existing algorithms, and then selects the most effective ones. Unlike domain-specific predecessors like AlphaFold or AlphaTensor, AlphaEvolve is designed as a general-purpose system. It can operate across a wide array of scientific and engineering tasks by automatically modifying code and optimizing for multiple objectives. Its architecture allows it to evaluate code programmatically, reducing reliance on human input and mitigating risks such as hallucinations common in standard LLM outputs. == Achievements == According to Google, across a selection of 50 open mathematical problems, the model was able to rediscover state-of-the-art solutions 75% of the time and discovered improved solutions 20% of the time, for example advancing the kissing number problem. AlphaEvolve was also used to optimize Google's computing ecosystem. Improved data center scheduling heuristics, enabled the recovery of 0.7% of stranded resources. It was also used to optimize TPU circuit design and Gemini's training matrix multiplication kernel. == Open source implementations == Following the publication of AlphaEvolve, several open source implementations have been developed by the research community. One such implementation is OpenEvolve, which implements distributed evolutionary algorithms, multi-language support, integration with various large language model providers, and automated discovery of high-performance GPU kernels that outperform expert-engineered baselines.
Normalization (image processing)
In image processing, normalization is a process that changes the range of pixel intensity values, a kind of intensity mapping. Applications include photographs with poor contrast due to glare, for example. A typical case is contrast stretching. In more general fields of data processing, such as digital signal processing, it is referred to as dynamic range expansion. The purpose of dynamic range expansion in the various applications is usually to bring the image, or other type of signal, into a range that is more familiar or normal to the senses, hence the term normalization. Often, the motivation is to achieve consistency in dynamic range for a set of data, signals, or images to avoid mental distraction or fatigue. For example, a newspaper will strive to make all of the images in an issue share a similar range of grayscale. Auto-normalization in image processing software typically normalizes to the full dynamic range of the number system specified in the image file format. == Definition == Normalization transforms an n-dimensional grayscale image I : { X ⊆ R n } → { Min , . . , Max } {\displaystyle I:\{\mathbb {X} \subseteq \mathbb {R} ^{n}\}\rightarrow \{{\text{Min}},..,{\text{Max}}\}} with intensity values in the range ( Min , Max ) {\displaystyle ({\text{Min}},{\text{Max}})} , into a new image I N : { X ⊆ R n } → { newMin , . . , newMax } {\displaystyle I_{N}:\{\mathbb {X} \subseteq \mathbb {R} ^{n}\}\rightarrow \{{\text{newMin}},..,{\text{newMax}}\}} with intensity values in the range ( newMin , newMax ) {\displaystyle ({\text{newMin}},{\text{newMax}})} . The linear normalization of a grayscale digital image is performed according to the formula I N = ( I − Min ) newMax − newMin Max − Min + newMin {\displaystyle I_{N}=(I-{\text{Min}}){\frac {{\text{newMax}}-{\text{newMin}}}{{\text{Max}}-{\text{Min}}}}+{\text{newMin}}} For example, if the intensity range of the image is 50 to 180 and the desired range is 0 to 255 the process entails subtracting 50 from each of pixel intensity, making the range 0 to 130. Then each pixel intensity is multiplied by 255/130, making the range 0 to 255. Normalization might also be non-linear, as the relationship between I {\displaystyle I} and I N {\displaystyle I_{N}} may not be linear. An example of non-linear normalization is when the normalization follows a sigmoid function, in which case the normalized image is computed according to the formula I N = ( newMax − newMin ) 1 1 + e − I − β α + newMin {\displaystyle I_{N}=({\text{newMax}}-{\text{newMin}}){\frac {1}{1+e^{-{\frac {I-\beta }{\alpha }}}}}+{\text{newMin}}} Where α {\displaystyle \alpha } defines the width of the input intensity range, and β {\displaystyle \beta } defines the intensity around which the range is centered. Gamma correction (log/inverse log) is also a common transformation function. === Colorspace === Intensity operations generally operate on a colorspace that maps to the human perception of lightness without intentionally changing the other properties. This can be done, for example, by operating on the L component of the CIELAB color space, or approximately by operating on the Y component of YCbCr. It is also possible to operate on each of the RGB color channels, though the result will not always make sense. == Contrast stretching == This is the most significant and essential technique of spatial-based image enhancement. The basic intent of this contrast enhancement technique is to adjust the local contrast in the image so as to bring out the clear regions or objects in the image. Low-contrast images often result from poor or non-uniform lighting conditions, a limited dynamic range of the imaging sensor, or improper settings of the lens aperture. This operation tries to change the intensity of the pixel in the image, particularly in the input image, to obtain an enhanced image. It is based on the number of techniques, namely local, global, dark and bright levels of contrast. The contrast enhancement is considered as the amount of color or gray differentiation that lies among the different features in an image. The contrast enhancement improves the quality of image by increasing the luminance difference between the foreground and background. A contrast stretching transformation can be achieved by: Stretching the dark range of input values into a wider range of output values: This involves increasing the brightness of the darker areas in the image to enhance details and improve visibility. Shifting the mid-range of input values: This involves adjusting the brightness levels of the mid-tones in the image to improve overall contrast and clarity. Compressing the bright range of input values: This process involves reducing the brightness of the brighter areas in the image to prevent overexposure resulting in a more balanced and visually appealing image. It can be described as the following piecewise funciton: I N = { s 1 r 1 I if I < r 1 s 2 − s 1 r 1 − r 2 ( I − r 1 ) if r 1 ≤ I ≤ r 2 1 − s 2 1 − r 2 ( I − r 2 ) if I > r 2 {\displaystyle I_{N}={\begin{cases}{\frac {s_{1}}{r_{1}}}I&{\text{if }}I
Government Secure Intranet
Government Secure Intranet (GSi) was a United Kingdom government wide area network, whose main purpose was to enable connected organisations to communicate electronically and securely at low protective marking levels. It was known for the '.gsi.gov.uk' family of domains for government email. Migration away from these domains began in 2019 and was completed in 2023. == History == === Use === Many UK government organisations used the GSi to transfer files on a peer-to-peer (P2P) basis between similarly accredited networks. The network itself was open within the context of its accreditation – it imposed no restrictions on traffic types carried across the network, restrictions and policy control were left to the connecting departments. Email traffic in and out of the network was filtered by an external provider. === Origin === The concept of GSi was defined by the Cabinet Office, and was turned into practical reality by the Internet Special Products group of Cable & Wireless (then known as Mercury Communications) at their Brentford premises. GSi development started late 1996, and can be roughly dated by checking the registration date of its first domain name, 'gsi.net', registered 30 May 1997. The formal go-live date was several months later (according to the Central Computer and Telecommunications Agency (CCTA) this was February 1998). The main drivers behind the development of GSi was the plethora of inter-agency connections in UK government which made managing security and connectivity budgets problematic. GSi not only provided better oversight, it also normalised connectivity. GSi was designed as an accredited, dual link connected Internet Protocol backbone, it imposed no restrictions on what type of traffic it carried; any restrictions were considered a policy decision for each connecting department. The design of GSi partly supported the then developing eGIF interoperability standards. This was a direct consequence of the two key technical people driving the project, one from Cable & Wireless, one from the UK government in the form of the CCTA. GSi used SMTP as mail transport protocol, and the conversion from the then prevalent X.400 email facilities to SMTP proved for many departments an improvement in reliability and speed. In the case of X.400, this conversion also cut email costs substantially as X.400 message conversions were still chargeable even if the conversion failed due to message size. In some cases, the ROI of such an email conversion was as short as two months. The creation of GSi handed Cable & Wireless a monopoly on UK government data connectivity. GSi can be considered one of the more successful UK government IT projects from the point of view of take up - even when still in pilot phase, demand increased to a point where service windows had to be imposed to continue building the platform to full strength. The development of GSi was also the root of the creation of the CESG Listed Adviser Scheme (CLAS). During the build of GSi, the need for accredited advisers became clear as advice on connectivity invariably involved discussing government confidential matters. CESG eventually responded with the above CLAS scheme. === Operations contract === GSi was operated on a five-year renewable contract basis. Energis won this contract from Cable & Wireless in August 2003. Cable & Wireless then bought Energis in 2005, thus regaining control over the platform. Cable and Wireless Worldwide won the GSi Convergence Framework (GCF) contract in 2011. The GSi and Managed Telecommunications Service (MTS) framework agreements finished in August 2011 with contracts running on to 12 February 2012. GCF is intended to facilitate the migration to the Public Services Network. === Previous developments === Government Connect went live across local authorities in England and Wales. Government Connect is a pan-government programme providing an accredited and secure network between central government and every local authority in England and Wales and allows exchange of RESTRICTED information between authorities. The GCSX network is part of the wider GSi and provides connectivity to nearly all central departments. Scottish local authorities have already established a similar network known as the Government Secure Extranet (GSX). Local authorities with a GCSX connection can now use a GCSX email account to exchange sensitive data, including DWP benefits data, patient identifiable data, with health sector staff who have a NHS.net email address, e.g. PCT staff and GPs. As both GCSX and the Police National Network (PNN) are both connected to the wider Government Secure Intranet (GSi), data can be transferred securely between local authorities and the Police. GC Mail can be used now to replace the existing less efficient and less secure methods of exchanging data between local authorities and the Police. Local authorities that deliver Housing and Council Tax benefits are taking part in the e-Transfers programme, which is e-enabling the process for delivery of Local Authority Input Documents (LAIDs) and Local Authority Claim Information (LACIs). Version 4.1 of the Code of Connection for compliance was introduced in 2010. Compared with version 3.2 the main Code of Connection version 4.1 areas of are: Mobile working - full implementation of compliant service Firewall specification (EAL 4) Execution of unauthorised software Requirement for IT Healthchecks (CHECK / CREST / TigerScheme) Labelling e-mails with protective markings. == Public Services Network == The Public Services Network is a UK Government programme that unified the provision of network infrastructure across the United Kingdom public sector into an interconnected "network of networks". This included large elements of GSi. It is now a legacy network. Centrally procured public sector networks migrated across to the PSN framework as they reached the end of their contract terms, either through an interim framework or directly. The Government Secure Intranet (GSi) contracts expired in September 2011, running on to 12 February 2012 and were replaced by the transitional Government Secure Intranet Convergence Framework (GCF).
Online Safety Amendment (Social Media Minimum Age) Act 2024
The Online Safety Amendment (Social Media Minimum Age) Act 2024 is an Australian act of parliament that prohibits minors under the age of 16 from holding an account on certain social media platforms. It is an amendment to the Online Safety Act 2021 and was passed by the Parliament of Australia on 29 November 2024. It imposes monetary penalties on social media companies that fail to take reasonable steps to prevent minors under 16 that are located in Australia from having accounts on their services. The legislation allows the government to determine which social media platforms must ban age‑restricted users and proclaim a date for the commencement of the ban, with those provisions taking effect on 10 December 2025. Facebook, Instagram, Reddit, Snapchat, TikTok, Twitter, Threads, Twitch, Kick, and YouTube were age‑restricted on 10 December 2025, with the possibility that more platforms may be added. The act is being challenged in the High Court by the Digital Freedom Project. == Background == The ban on access to social media by young people by the federal government originated in November 2023, when shadow communications minister David Coleman introduced a private member's bill requiring the government to conduct a trial for age-verification technology on pornography and social media platforms. While the bill did not succeed, the Albanese government funded the trial in the 2024 Australian federal budget. In June 2024, opposition leader Peter Dutton pledged that a Coalition government would implement a ban on social media for under-16s within 100 days of taking office. The following month, prime minister Anthony Albanese announced the government would introduce legislation banning under-16s from social media. The Online Safety Amendment (Social Media Minimum Age) Bill 2024 was introduced into parliament by minister for communications Michelle Rowland on 21 November 2024, passing both houses on 28 November 2024. The ban on access to social media by young people by the federal government also gained momentum following an entreaty by the wife of the premier of South Australia, Peter Malinauskas, to her husband. She requested that he read The Anxious Generation by Jonathan Haidt and take action to address the impact of social media on the mental health of children. The couple have four young children, and, thinking of them, the premier thought that government should play a part in helping parents to regulate use of social media by their children at home. Malinauskas contacted former High Court chief justice Robert French, who agreed to look at the issue, and in September 2024 handed the premier a 267 page proposal, which he dubbed a "Swiss Army knife" rather than a machete, to adjust to social media's "changing landscape and its complexity". The leaders of other states and territories gave their support to Malinauskas's idea, and he took the French report to National Cabinet to collaborate with chief ministers, premiers, and the prime minister. Community support swelled after stories of parents who had lost their children to suicide after being bullied on social media were published. Albanese himself was moved by a personal letter received from Kelly O'Brien, whose 12-year-old daughter Charlotte had taken her own life due to bullying at school. An event took place at the sidelines of the United Nations General Assembly session in September 2025 at which a mother spoke of her daughter's suicide as "death by bullying ... enabled by social media". The speech won support from world leaders in Greece, Fiji, Tonga and the president of the European Commission Ursula von der Leyen. In early September 2024, South Australia proposed legislation similar to the federal law now in place. The state-based version was intended to ban users under the age of 14, unlike the federal law, which bans those under 16. The state-based law also proposed to require parental consent for 14 and 15‑year‑olds. Later in September, prime minister Anthony Albanese announced that his government intended to introduce legislation to set a minimum age requirement for social media. In November 2024, the federal government indicated their intention to engage the Age Check Certification Scheme following a tender process for an age assurance technology trial. The Albanese government's proposed ban was supported by the governments of every state and territory. Albanese described social media as a "scourge", and said "I want people to spend more time on the footy field or the netball court than they're spending on their phones", that family members are "worried sick about the safety of our kids online", and that social media "is having a negative impact on young people's mental health and on anxiety". Albanese's statements followed an earlier pledge by Liberal opposition leader Peter Dutton who was pushed by the early advocacy of shadow communications minister David Coleman to implement a ban on social media for under 16s within 100 days of being elected. The opposition organised an open letter signed by 140 experts who specialise in child welfare and technology. The opposition was concerned about the invasion of privacy that will occur with the introduction of identification-based age checks. An advocacy group for digital companies in Australia called the plans a "20th Century response to 21st Century challenges". A director of a mental health service voiced concerns, stating that "73% of young people across Australia who accessed mental health support did so through social media". == Implementation == Social media companies will receive a transition period of one year after the legislation is enacted to introduce reasonable controls preventing minors under the age of 16 from holding accounts on their services while physically located in Australia. Enforcement will involve fines of up to A$49.5 million for companies failing to take such steps, with no consequences for parents and children who violate the restrictions. There are no parental consent exceptions to the ban, and while the use of virtual private networks (VPNs) to access these services remains legal in Australia, the services are expected to try to stop under 16s from using VPNs to pretend to be outside Australia. The expectation is to make best-efforts to implement the ban on platforms including Facebook, Instagram, Reddit, Snapchat, TikTok, Twitter, Threads, Twitch, Kick and YouTube. Some social media companies are now obligated to become good enough at profiling Australian children under 16 to satisfy the Australian government they tried to implement the ban to avoid being fined. Consequently, social media companies said they will try to identify restricted users using various methods including behavioural inferencing. On 5 November 2025, it was announced that online gaming platform Roblox will not be banned, but Reddit and live-streaming platform Kick will be added to the list of platforms to be banned. A report by Age Check Certification Scheme, a UK company recruited by the government to consult on the technology used to implement the restrictions, was issued in June 2025, ahead of the December deadline to implement the ban. In June 2025, the preliminary report was released, which stated that "there are no significant technological barriers" to implementing the ban. In late July 2025, Google warned that it would sue the Australian government if YouTube was included in the ban. On 30 July, the government announced that it would extend its social media age limit to include YouTube, following advice from Grant. On 30 July 2025, the minister for communications, Anika Wells, published the Online Safety (Age-Restricted Social Media Platforms) Rules 2025, which specify exactly which types of social media platforms will be banned for certain users. On 31 August 2025, the full report was released, which stated that it would technically be possible to implement the ban; however, coordination among different services is required to successfully implement it. It also highlighted the benefits and flaws of different methods of age verification. On 16 September 2025, it was announced that the eSafety Commissioner will be able to take legal action against social media companies that have not pursued reasonable steps to bar users under the age of 16, and that fines can range up to A$49.5 million against these companies in court. On 19 November 2025, Meta announced that from 4 December their platforms (Instagram, Facebook, and Threads) would be removing users under the age of 16 ahead of the 10 December deadline. Users will be able to scan a face or provide an identity document to prove their age. On 21 November 2025, the eSafety Commissioner announced that the live-streaming platform Twitch will be included in the ban, but that Pinterest would not be. In December 2025, eSafety Commissioner Julie Inman Grant suggested efforts to block users include use by social media companies of various "signals" to identify children that are
Hike Messenger
Hike Messenger, aka Hike Sticker Chat, is a multifunctional Indian social media and social networking service offering instant messaging (IM) and Voice over IP (VoIP) services that was launched on December 11, 2012, by Kavin Bharti Mittal. Hike functioned through SMS. The app registration used a standard, one-time password (OTP) based authentication process. It was estimated to be worth $1.4 billion and had more than 100 million registered users. It went defunct on January 6, 2021, as they were unable to compete with global messaging platforms. The app re-appeared on google play store and apple app store on 19 September 2025. == History == Hike Messenger was launched on December 12, 2012, by its founder, Kavin Bharti Mittal. The majority of users were from India, with 80% under the age of 25. The company purchased startups like TinyMogul and Hoppr in 2015. After buying US-based free voice calling company Zip Phones, Hike provided VoIP calling services. On March 5, 2015, Hike launched the 'Great Indian Sticker Challenge' to create more stickers. In February 2017, Hike acquired the social networking app Pulse. From version 5.0, it became the first social messaging app to start a mobile payment service in India. The timeline feature came back after multiple user requests and the introduction of a personalized digital envelope called Blue Packets for sending monetary gifts through a built-in wallet. In 2017, the acquisition of Bengaluru-based startup Creo was announced to enable third-party developers to build services on top of the Hike platform. In 2018, Hike provided 1 billion users with internet access by targeting smaller cities. In January 2019, the company discarded the previous super-app approach, and began launching specialized apps for specific use-cases. In May 2019, Hike announced a collaboration with Indraprastha Institute of Information Technology, Delhi (IIIT-D) to develop a variety of machine learning models. In April 2019, the company launched its first standalone app, Hike Sticker Chat. A separate content app Hike News & Content was also launched. In 2021, Hike shut down its messaging service and shifted focus to gaming and community platforms. It launched Rush, a real-money gaming app featuring casual titles like ludo and carrom, which scaled to over 10 million users and generated more than US$500 million in gross revenue over four years. The company also introduced Vibe, an approval-only community app, as part of its pivot away from the super-app and messaging model. In September 2025, following the passage of the Promotion and Regulation of Online Gaming Act, which banned real-money gaming in India, Hike announced its complete closure. Founder Kavin Bharti Mittal stated that while the company had begun international expansion, scaling globally under the new regulatory regime would require a full reset that was not a viable use of capital or resources. On 19 September 2025, hike was relaunched on play store and app store by the name hike messenger. == Application == === Timeline of Features === On 15 April 2014, Hike introduced unlimited free SMS via a service called Hike Offline, through credits earned by users from regular chatting, as connectivity is still a major issue in many parts of India. In an attempt to appeal to its younger users, Hike introduced features that find resonance with the local market, such as Last Seen Privacy and localized sticker packs. It also introduced a two-way chat theme, allowing users to change the chat background for themselves and for their friends simultaneously. The app also started showing live Cricket scores in collaboration with Cricbuzz, as well as news, casual games, and social media feeds. Hike also added a file transfer service, allowing files less than 100MB of all formats, with a view on further increasing the size limit to 1 GB. With the launch of version 2.9.2.0 in January 2015, Hike implemented support for sending uncompressed images and a "quick upload" feature optimized for 2G speed. Later that month, Hike introduced a voice calling feature for its users. In September 2015, Hike launched free group call support with up to 100 people in a simultaneous conference call environment. In November 2016, Hike announced the launch of a feature called Stories that allows people to share real-life moments using fun live filters which automatically get deleted after 48 hours, and a new camera design with localized filters. Hike 4.0 launched on 26 August 2015 with the tagline 'Got a Gang? Get on Hike'. Hike 4.0 was an optimization-focused update, increasing the performance of the app on poor networks. It supported photo filters, doodles, and bite-sized news updates in under 100 characters. Hike launched News Feed with Hindi language support on 29 September 2015 to cater for the needs of the non-English population. Hike launched version 3.5 as the biggest update for Windows Phone 8.1 during December 2015 which changed the user interface for more simpler navigation, supported sending unlimited non-media files and documents of any format and better group admin settings. It also included ten brand new chat themes. Hike launched a microapp feature which was live for two days on 8 May 2016, as a Mother's Day special in which users could add images, quotes or messages as a token of love with customized e-cards and stickers on their timeline not only on Hike, but also on other platforms. On 26 October 2016, Hike Messenger rolled out the beta version of a video calling feature ahead of WhatsApp starting with the Android users which also lets recipients preview a video call before deciding to take it and is optimized to even work under 2G conditions. On 24 December 2016, Hike rolled out a short 20-second Video Stories feature that can be directly shared with friends or posted on a public timeline with different filters in collaboration with content creators with the same 48-hour time limit before being automatically deleted. The Stories feature continues to receive constant future updates to include and enable content, public story option, private user messaging and geo-tagging. In September 2017, Hike launched personalized sticker packs with 20,000+ graphical stickers for over 500 colleges that covered around 1,000 colleges by December 2018 across India which can be used across different geographies, and are highly customized for users with availability in 40+ local languages that support automatic sticker suggestions where the application suggests the best reply for any sticker message and also allows users to "nudge", a feature used to ping the receiver. Hike started supporting user comments on friend's posts, added a specific message reply function, a redesigned camera interface to support front flash and user mentions with the help of the @ symbol. In December, 2017, Hike launched group voting, bill splitting, checklists and event reminders for group chat that supports up to 1,000 users both on iOS and Android platform. Hike launched another feature called Hike Land, which is a virtual world with beta trial to start from March 2020, that will use Hike Moji where online users with their digital avatar can hang out with other users and will be built inside the Hike Sticker Chat application. It is mainly targeted but not restricted towards 16 to 21 years age group of people. Without unveiling much about Hike Land, a separate website has been created with option to reserve spots by giving details like name, gender and phone number that will link the user profile from the Hike Sticker Chat account though it is not a necessity. ==== Hike Direct ==== The Hike Direct feature is based on the technology known as WiFi Direct, which initially was also called WiFi P2P and got introduced to users by October 2015, which enables sharing of files such as music, apps, videos without a live internet connection within a 100-meter radius by creating a wireless network between two or more devices with a transfer speed of 100MB per minute. For privacy and security reasons, Hike didn't show the recipient's location or proximity and works only when two users are connected in the same room by adding one another into the contact list. ==== Hike Wallet ==== In June 2017, Hike announced the launch of version 5.0 with multiple new features like User Chat Themes, Night Mode and Magic Selfie. along with a built-in Wallet partnered with Yes Bank. This feature was first rolled out to Android users followed by iOS users at a later stage. Hike collaborated with Airtel Payment Bank to power its digital payment wallet by November 2017 where Hike users have access to Airtel Payments Bank's merchant & utility payment services and know your customer (KYC) infrastructure with 5 million transactions happening from services like recharge and P2P. Hike formed a partnership with Ola Cabs to bring a taxi and auto-rickshaw booking facility from 14 February 2018. With Hike Wallet facility users could now book bus tickets with 3
Tute Genomics
Tute Genomics was an American genomics startup that provided a cloud-based web application for rapid and accurate annotation of human genomic data. It was built on the expertise of ANNOVAR. Tute Genomics assisted researchers in identifying disease genes and biomarkers, and assisted clinicians/labs in performing genetic diagnosis. Based in Provo, Utah, Tute was co-founded by Dr. Kai Wang, an assistant professor at the University of Southern California (USC); and Dr. Reid J. Robison, a board-certified psychiatrist with fellowship training in both neurodevelopmental genetics and bioinformatics. Tute Genomics was acquired by PierianDX in 2016. == History == The word "tute" means "personal" in the Na’vi language created for the 2009 film Avatar by Paul Frommer, a linguist and communications professor at the USC Marshall School of Business. === Timeline === 2013 Tute Genomics launched in 2013 and entered the accelerator, BoomStartup. By "demo day" of BoomStartup, Tute had raised their seed round of funding and expanded the round to include angel investors from SLC Angels, Park City Angels, Life Science Angels. Tute was the tenth ever online syndicate for AngelList and in all raised a seed round of $1.5 million. 2014 In March 2014, the company announced that Affiliated Genetics, a Utah-based CLIA-certified laboratory, selected Tute Genomics for its next-generation sequencing (NGS) analytics pipeline. In May 2014, the company announced joining the Global Alliance for Genomics and Health. In June 2014, Advanced Biological Laboratories (ABL), S.A., announced a licensing and collaboration agreement with Tute Genomics and the commercial launch of OncoChek for managing and analysing genomics data in the field of oncology. In July 2014, the company announced an agreement with Lineagen, Inc., to provide next-generation sequencing analytics for Lineagen’s NextStepDx Plus assay. Also, Brigham Young University selected the Tute Genomics genome annotation and discovery platform for analysis and interpretation of 1,000 exomes and genomes. In November 2014, the company announced addition of the Tute platform to Illumina’s BaseSpace. The company announced a Series A1 funding round of $2.3 million in December 2014. The round was led by UK-based Eurovestech. Peak Ventures and a number of angel investors also participated in this round. 2015 Tute recruits David Mittelman, founder of Arpeggi, Inc. and former CSO at FamilyTreeDNA, to Tute Genomics as Chief Scientific Officer. Tute acquires Knome and integrates the KnoSys platform into its software product. 2016 Reid Robison, Tute CEO, launches a Kickstarter campaign to sell Tute interpreted whole genome and whole exome sequencing directly to consumers. The campaign was suspended within the same month after receiving a letter from the United States Food and Drug Administration. Tute is acquired by PierianDX.
AS1 (networking)
AS1 (Applicability Statement 1) is a specification about how to transport structured business-to-business data securely and reliably over the Internet. Security is achieved by using digital certificates and encryption. == AS1 technical overview == The AS1 protocol is based on SMTP and S/MIME. It was the first AS protocol developed and uses signing, encryption and MDN conventions. In other words: Files are sent as "attachments" in a specially coded SMIME email message Messages can be signed, but do not have to be Messages can be encrypted, but do not have to be Messages may request an MDN back if all went well, but do not have to request such a message If the original AS1 message requested an MDN... Upon the receipt of the message and its successful decryption or signature validation (as necessary) a "success" MDN will be sent back to the original sender. This MDN is typically signed but not encrypted. Upon the receipt and successful verification of the signature on the MDN, the original sender will "know" that the recipient got their message (this provides the "Non-repudiation" element of AS1) If there are any problems receiving or interpreting the original AS1 message, a "failed" MDN may be sent back. Like any other AS file transfer, AS1 file transfers typically require both sides of the exchange to trade X.509 certificates and specific "trading partner" names before any transfers can take place.