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  • Visual Expert

    Visual Expert

    Visual Expert is a static code analysis tool, extracting design and technical information from software source code by reverse-engineering, used by programmers for software maintenance, modernization or optimization. It is designed to parse several programming languages at the same time (PL/SQL, Transact-SQL, PowerBuilder...) and analyze cross-language dependencies, in addition to each language's source code. Visual Expert checks source code against hundreds of code inspection rules for vulnerability assessment, bug fix, and maintenance issues. == Features == Cross-references exploration: Impact Analysis, E/R diagrams, call graphs, CRUD matrix, dependency graphs. Software documentation: a documentation generator produces technical documentation and low-level design descriptions. Inspect the code to detect bugs, security vulnerabilities and maintainability issues. Native integration with Jenkins. Reports on duplicate code, unused objects and methods and naming conventions. Calculates software metrics and source lines of code. Code comparison: finds differences between several versions of the same code. Performance analysis: identifies code parts that slow down the application because of their syntax - it extracts statistics about code execution from the database and combines it with the static analysis of the code. == Usage == Visual Expert is used in several contexts: Change impact analysis: evaluating the consequences of a change in the code or in a database. Avoiding negative side effects when evolving a system. Static Application Security Testing (SAST): detecting and removing security issues. Continuous Integration / Continuous Inspection : adding a static code analysis job in a CI/CD workflow to automatically verify the quality and security of a new build when it is released. Program comprehension: helping programmers understand and maintain existing code, or modernize legacy systems. Transferring knowledge of the code, from one programmer to another. Software sizing: calculating the size of an application, or a piece of code, in order to estimate development efforts. Code review: improving the code by finding and removing code smells, dead code, code causing poor performances or violations of coding conventions. == Limitations == As a static code analyzer, Visual Expert is limited to the programming languages supported by its code parsers - Oracle PL/SQL, SQL Server Transact-SQL, PowerBuilder. A preliminary reverse engineering is required. Visual Expert does it automatically, but its duration depends on the size of the code parsed. Users must wait for the parsing completion prior to using the features, or schedule it in advance. They must also allocate sufficient hardware resources to support their volume of code. Visual Expert is based on a client/server architecture: the code analysis is running on a Windows PC - preferably a server. The information extracted from the code is stored in a RDBMS, communicating with a client application installed on the programmer's computer - no web client is available. This requires that the code, the parsers, the RDBMS and the programmers’ computers are connected to the same LAN or VPN. == History == 1995- 1998 - Prog and Doc - Initial version distributed on the French market 2001 - Visual Expert 4.5 2003 - Visual Expert 5 2007 - Visual Expert 5.7 2010 - Visual Expert 6.0 2015 - Visual Expert 2015 - Server component added to schedule code analyses 2016 - Visual Expert 2016 - Oracle PL/SQL code parser, code inventory (lines of code, number of objects…) 2017 - Visual Expert 2017 - SQL Server T-SQL code parser, Code comparison, CRUD matrix 2018 - Visual Expert 2018 - DB Code Performance Analysis, integration with TFS 2019 - Visual Expert 2019 - Generation of E/R diagrams from the code 2020 - Visual Expert 2020 - Object dependency matrix, naming consistency verification, integration with GIT and SVN 2021 - Visual Expert 2021 - Continuous Code Inspection, integration with Jenkins 2022 - Visual Expert 2022 - Support for cloud-based repositories and large volumes of code 2023 - Visual Expert 2023 - Performance tuning for PowerBuilder 2024 - Visual Expert 2024 - New web UI to simplify deployment and use among large teams. 2025 - Visual Expert 2025 - AI-based features to explain code, generate comments, and optimize queries

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  • BeReal

    BeReal

    BeReal (stylized on the app logo as BeReal.) is a French social-networking app released in 2020, developed by Alexis Barreyat and Kévin Perreau. Currently, it is owned by Voodoo. Its main feature is a daily notification that encourages users to share photos of themselves in their day-to-day life, on any randomly selected two-minute window every day. Critics noted its emphasis on authenticity, which some felt crossed the line into the mundane. The primary reference of its name relates to its focus on users uploading unpolished photos, with it being a pun of the term B-reel. According to the app's description on Apple's App Store, BeReal encourages its users to "show their friends who they really are, for once," by removing filters and opportunities to stage or edit photos. After a couple of years of relative obscurity, it rapidly gained popularity in early and mid-2022 growing from 21.6 million to 73.5 million users between July and August, before experiencing a decrease in use in 2023 and continuing to decline to 23 million users at the beginning of 2024. == History == The app was developed by Alexis Barreyat, a former employee at GoPro, and Kévin Perreau, a graduate from 42 in Paris. Initially released in 2020, it first gained widespread popularity in early 2022. It first spread widely on college campuses, partially due to a paid ambassador program. In late August 2022, the application had over 10 million active daily users and 21.6 million active monthly users. As of February 2023, the app has grown to 13 million active daily users and 47.8 million active monthly users. In June 2021, BeReal received a $30 million funding round led by Andreessen Horowitz and Accel. In May 2022, BeReal secured $85 million in a funding round led by Yuri Milner's DST Global, increasing its valuation to about $600 million. On July 25, 2022, BeReal topped Apple's free app list in the iOS App Store, and remained until September 2022. BeReal also received Apple's iPhone App of the Year in 2022. By late spring 2023, the app's momentum was waning, as daily users dropped to about 6 million, from 15 million in October 2022. In August 2024, there was a resurgence after a campaign at the Paris Olympics 2024, with the app reportedly gaining 1000 users. In June 2024, BeReal was acquired by the French company Voodoo for a reported €500 million. Alexis Barreyat is set to step down after a transition period. == Features == Once per day, BeReal notifies all users that a two-minute window to post is open. It asks users to create a post (known eponymously as a "BeReal") which, using mandatory simultaneous photos and now short videos from both the front and back cameras, provides a visual depiction of what they are doing at that moment, with an option to caption their post. The given window varies from day to day, and is not known to users before the notification is received. Once the daily notification is sent, users lose the ability to see others' BeReals from the previous day. Furthermore, users cannot see any of the current day's BeReals until they upload their own. On-time BeReals show the time it was uploaded, meanwhile, late BeReals uploaded after the two-minute window shows how late the BeReal was taken, but the user has to long-press the BeReal to reveal the time it was uploaded. Other users can also see how many attempts the poster took to take the BeReal, as well as their location when the BeReal was taken. Users only get one chance to delete their BeReal and post another one, and they used to not be able to post more than one at any time. However, in 2023, a feature was added that allowed users to post up to two extra BeReals on days when they posted their first BeReal within the 2-minute window. In July 2024, the number of bonus BeReals was increased to 5. [1] BeReal also features a "Discovery" section, wherein users are given the option to share to a much wider, public audience. This feature, however, is limited, as users are not able to interact with the posts through commenting—unlike the "My Friends" feature. In August 2023, in an attempt to make BeReal more social, another feature was added so that users are now able to see their friends of friends' BeReal. The app reportedly uses HiveAI to automate its image moderation process. However, there is also a report function that allows users to report a photo or another user if they are posting inappropriate content. === Comparison to other platforms === Because of its daily cycle of engagement, it has been compared to Wordle, which gained popularity earlier in 2022. It also supports a platform similar to Snapchat with a theme of impermanence and brevity. BeReal has been described as designed to compete with Instagram while simultaneously de-emphasising social media addiction and overuse. The app does not allow any photo filters or other editing, and has no follower counts. Marketing material from the company said that the app "can be addictive" and that "BeReal won't make you famous." Jacob Arnott, managing director of social agency We the People, describes BeReal as "an anti-Instagram" due to its raw and unedited nature. The app's foundation on friends rather than followers resembles Facebook's platform of adding friends, which comprise the content of a user's feed. This also resembles Instagram's "close friends" story feature. Further, rather than "liking" posts, BeReal uses "RealMojis" which involves taking a photo to interact with other posts. With the popularity of BeReal, other providers have launched similar features. In July 2022, Instagram launched a "Dual Camera" feature similar to BeReal, and in August 2022 it began testing a feature called "IG Candid Challenges", where users are prompted to post once a day within two minutes. As of September 2022, TikTok has also launched a feature called TikTok Now, following the same concept. In December 2022, similar to Spotify's "Wrapped," BeReal launched a feature involving a video of a compilation of users' BeReal posts of 2022. == User characteristics == BeReal is considered to be targeted towards Generation Z users, and attempts to minimise "social media fatigue", a feeling of numbness and disconnection from reality caused by constant interaction with an idealised version of others. This is a "core generational value" that this demographic holds compared to Millennials. Further, BeReal's users have been particularly strong across universities and university-aged students, and the majority of users are in the United States, the United Kingdom, and Germany. In 2022, the majority of users were female, with 43.2% of users falling within the age range of 16 to 25 and 55.1% of users being 26 to 44 years old. BeReal, the platform encourages users to share their real time moments by sending a daily notification that gives a least two minutes to post a unedited photo using bot the front and back camera, although users can post later and retake photos from when the notification happens, this action are still visible to friends, reinforcing transparency and genuine in the moment sharing. == Reception == Jason Koebler, a writer for Vice, wrote that in contrast to Instagram, which presents an unattainable view of people's lives, BeReal instead "makes everyone look extremely boring". Niklas Myhr, a professor of social media at Chapman University, argued that depth of engagement may determine whether the app is a passing trend or has "staying power". Kelsey Weekman, a reporter for BuzzFeed News, noted that the app's unwillingness to "glamorise the banality of life" made it feel "humbling" in its emphasis on authenticity. Niloufar Haidari for The Guardian comments similarly that where the app succeeds in being "drab" in perhaps a positive way, it fails in potentially "un-inspiring" users. Likewise, Dr. Brad Ridout, a behavioral psychologist at the University of Sydney, emphasizes that the "boring" experience is what the creators are targeting for the app and, in response to Instagram's platform of flawlessness, that "perfection is the enemy of happiness". === Criticisms === Some people regularly post after the two-minute notification expires, leading to some criticism of the app, as the ability to post late undermines its aims of authenticity. In addition, BeReal's daily two-minute window has been argued to contribute to social media fatigue and a need for self-exposure, as well as constant access to phones.

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  • List of computer graphics journals

    List of computer graphics journals

    List of computer graphics journals includes notable peer-reviewed scientific and academic journals that focus on computer graphics, visualization, and related areas such as rendering, animation, image processing, and geometric modeling. == Journals == ACM Transactions on Graphics Computers & Graphics IEEE Computer Graphics and Applications IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems Graphical Models Journal of Computer Graphics Techniques Presence: Teleoperators and Virtual Environments Virtual Reality Simulation & Gaming

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  • The Future of Work and Death

    The Future of Work and Death

    The Future of Work and Death is a 2016 documentary by Sean Blacknell and Wayne Walsh about the exponential growth of technology. The film showed at several film festivals including Raindance Film Festival, International Film Festival Rotterdam, Academia Film Olomouc and CPH:DOX. In May 2017 it received an official screening at the European Commission. It was distributed by First Run Features and Journeyman Pictures and was released on iTunes, Amazon Prime and On-demand on 9 May 2017. The film was made available on Sundance Now on 27 November 2017. A companion piece to the film, The Cost of Living, a documentary concerning universal basic income in Britain, was released on Amazon Prime on 8 October 2020. == Synopsis == World experts in the fields of futurology, anthropology, neuroscience, and philosophy consider the impact of technological advances on the two 'certainties' of human life; work and death. Charting human developments from Homo habilis, past the Industrial Revolution, to the digital age and beyond, the film looks at the shocking exponential rate at which mankind has managed to create technologies to ease the process of living. As we embark on the next phase of our adaptation, with automation and artificial intelligence signifying the complete move from man to machine, the film asks what the implications are for human fulfilment in an approaching era of job obsolescence and extreme longevity. == Cast == Dudley Sutton – Narrator Aubrey de Grey – Biomedical gerontologist and CSO of the SENS Research Foundation Will Self – Writer, journalist, political commentator and Professor of Contemporary Thought at Brunel University Rudolph E. Tanzi – Professor of Neurology at Harvard University and Director of the Genetics and Aging Research Unit at Massachusetts General Hospital (MGH) Martin Ford – Futurist and author Steve Fuller – Auguste Comte Chair in Social Epistemology at the Department of sociology at University of Warwick Murray Shanahan – Professor of Cognitive Robotics at Imperial College London Gray Scott – Futurist, executive producer of this production Vivek Wadhwa – Entrepreneur, academic and Director of Research at the Center for Entrepreneurship and Research Commercialization at the Pratt School of Engineering, Duke University Zoltan Istvan – Transhumanist and journalist Joanna Cook – Anthropologist, University College London Nicholas Kamara – Physician, Kable Hospital David Pearce – Transhumanist philosopher and co-founder of Humanity+ Peter Cochrane – Futurist and entrepreneur John Harris – Bioethicist, philosopher and Director of the Institute for Science, Ethics and Innovation at the University of Manchester Riva Melissa-Tez – Entrepreneur and transhumanist Ian Pearson – Futurologist Stuart Armstrong – Artificial intelligence researcher at Future of Humanity Institute

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  • Inverse consistency

    Inverse consistency

    In image registration, inverse consistency measures the consistency of mappings between images produced by a registration algorithm. The inverse consistency error, introduced by Christiansen and Johnson in 2001, quantifies the distance between the composition of the mappings from each image to the other, produced by the registration procedure, and the identity function, and is used as a regularisation constraint in the loss function of many registration algorithms to enforce consistent mappings. Inverse consistency is necessary for good image registration but it is not sufficient, since a mapping can be perfectly consistent but not register the images at all. == Definition == Image registration is the process of establishing a common coordinate system between two images, and given two images I 1 : Ω 1 → R I 2 : Ω 2 → R {\displaystyle {\begin{aligned}I_{1}:\Omega _{1}\to \mathbb {R} \\I_{2}:\Omega _{2}\to \mathbb {R} \end{aligned}}} registering a source image I 1 {\displaystyle I_{1}} to a target image I 2 {\displaystyle I_{2}} consists of determining a transformation f 1 : Ω 2 → Ω 1 {\displaystyle f_{1}:\Omega _{2}\to \Omega _{1}} that maps points from the target space to the source space. An ideal registration algorithm should not be sensitive to which image in the pair is used as source or target, and the registration operator should be antisymmetric such that the mappings f 1 : Ω 2 → Ω 1 f 2 : Ω 1 → Ω 2 {\displaystyle {\begin{aligned}f_{1}:\Omega _{2}\to \Omega _{1}\\f_{2}:\Omega _{1}\to \Omega _{2}\end{aligned}}} produced when registering I 1 {\displaystyle I_{1}} to I 2 {\displaystyle I_{2}} and I 2 {\displaystyle I_{2}} to I 1 {\displaystyle I_{1}} respectively should be the inverse of each other, i.e. f 2 = f 1 − 1 {\displaystyle f_{2}=f_{1}^{-1}} and f 1 = f 2 − 1 {\displaystyle f_{1}=f_{2}^{-1}} or, equivalently, f 2 ∘ f 1 = id Ω 2 {\displaystyle f_{2}\circ f_{1}=\operatorname {id} _{\Omega _{2}}} and f 1 ∘ f 2 = id Ω 1 {\displaystyle f_{1}\circ f_{2}=\operatorname {id} _{\Omega _{1}}} , where ∘ {\displaystyle \circ } denotes the function composition operator. Real algorithms are not perfect, and when swapping the role of source and target image in a registration problem the so obtained transformations are not the inverse of each other. Inverse consistency can be enforced by adding to the loss function of the registration a symmetric regularisation term that penalises inconsistent transformations ∫ Ω 2 ‖ f 2 ( f 1 ( x ) ) − x ‖ 2 d x + ∫ Ω 1 ‖ f 1 ( f 2 ( x ) ) − x ‖ 2 d x . {\displaystyle \int _{\Omega _{2}}\left\Vert f_{2}(f_{1}(x))-x\right\Vert ^{2}\mathrm {d} x+\int _{\Omega _{1}}\left\Vert f_{1}(f_{2}(x))-x\right\Vert ^{2}\mathrm {d} x.} Inverse consistency can be used as a quality metric to evaluate image registration results. The inverse consistency error ( I C E {\displaystyle ICE} ) measures the distance between the composition of the two transforms and the identity function, and it can be formulated in terms of both average ( I C E a {\displaystyle ICE_{a}} ) or maximum ( I C E m {\displaystyle ICE_{m}} ) over a region of interest Ω {\displaystyle \Omega } of the image: I C E a = 1 ∫ Ω d x ∫ Ω ‖ f 2 ( f 1 ( x ) ) − x ‖ d x I C E m = max x ∈ Ω ‖ f 2 ( f 1 ( x ) ) − x ‖ . {\displaystyle {\begin{aligned}ICE_{a}&={\frac {1}{\int _{\Omega }\mathrm {d} x}}\int _{\Omega }\left\Vert f_{2}(f_{1}(x))-x\right\Vert \mathrm {d} x\\ICE_{m}&=\max _{x\in \Omega }\left\Vert f_{2}(f_{1}(x))-x\right\Vert .\end{aligned}}} While inverse consistency is a necessary property of good registration algorithms, inverse consistency error alone is not a sufficient metric to evaluate the quality of image registration results, since a perfectly consistent mapping, with no other constraint, may be not even close to correctly register a pair of images.

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  • Freemake Video Converter

    Freemake Video Converter

    Freemake Video Converter is a freemium video editing app developed by Ellora Assets Corporation. Designed primarily for entry-level users, the software offers a range of functionalities including video format conversion, DVD ripping, and the creation of photo slideshows and music visualizations. Additionally, Freemake Video Converter is capable of burning video streams that are compatible with various media, such as DVDs and Blu-ray Discs. It also features direct video uploading capabilities to platforms like YouTube., enhancing its utility for content creators. The application's user-friendly interface and broad compatibility make it accessible for individuals with minimal video editing experience. == Features == Freemake Video Converter can perform simple non-linear video editing tasks, such as cutting, rotating, flipping, and combining multiple videos into one file with transition effects. It can also create photo slideshows with background music. Users are then able to upload these videos to YouTube. Freemake Video Converter can read the majority of video, audio, and image formats, and outputs them to AVI, MP4, WMV, Matroska, FLV, SWF, 3GP, DVD, Blu-ray, MPEG and MP3. The program also prepares videos supported by various multimedia devices, including Apple devices (iPod, iPhone, iPad), Xbox, Sony PlayStation, Samsung, Nokia, BlackBerry, and Android mobile devices. The software is able to perform DVD burning and is able to convert videos, photographs, and music into DVD video. The user interface is based on Windows Presentation Foundation technology. Freemake Video Converter supports NVIDIA CUDA technology for H.264 video encoding (starting with version 1.2.0). == Important updates == Freemake Video Converter 2.0 was a major update that integrated two new functions: ripping video from online portals and Blu-ray disc creation and burning. Version 2.1 implemented suggestions from users, including support for subtitles, ISO image creation, and DVD to DVD/Blu-ray conversion. With version 2.3 (earlier 2.2 Beta), support for DXVA has been added to accelerate conversion (up to 50% for HD content). Version 3.0 added HTML5 video creation support and new presets for smartphones. Version 4.0 (introduced in April 2013) added a freemium "Gold Pack" of extra features that can be added if a "donation" is paid. Starting with version 4.0.4, released on 27 August 2013, the program adds a promotional watermark at the end of every video longer than 5 minutes unless Gold Pack is activated. Version 4.1.9, released on 25 November 2015 added support for drag-and-drop functions that were not available in prior versions. Since at least version 4.1.9.44 (1 May 2017), the Freemake Welcome Screen is added at the beginning of the video, and the big Freemake logo is watermarked in the center of the whole video. This decreases the quality of free outputs, and users are forced to pay money to remove the watermark or stop using it. Version 4.1.9.31 (11 August 2016) does not have this restriction. == Licensing issues == FFmpeg has added Freemake Video Converter v1.3 to its Hall of Shame. An issue tracker entry for this product, opened on 16 December 2010, says it is in violation of the GNU General Public License as it is distributing components of the FFmpeg project without including due credit. Ellora Assets Corporation has not responded yet. == Bundled software from sponsors == Since version 4.0, Freemake Video Converter's installer includes a potentially unwanted search toolbar from Conduit as well as SweetPacks malware. Although users can decline the software during installation, the opt-out option is rendered in gray, which could mistakenly give the impression that it's disabled.

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  • Gapo

    Gapo

    Gapo is a Vietnamese social networking service based in Hanoi, Vietnam. Users are able to create a personal profile and share text, photos and videos with others on the platform. Users can also use Gapo for live streaming, instant messaging, blogging, and online payments. Gapo was launched in July 2019 by Hà Trung Kiên and Duong Vi Khoa. == History == Gapo was founded in response to calls for Vietnam's Communist-led government to produce a domestic alternative to social media giants like Facebook and Google. Gapo officially launched on July 23, 2019 at an event in Hanoi. The company received 500 billion đồng (US$22 million) in funding from technology corporation G-Group to be utilized in the first phase of development. They also partnered with Sony Music Entertainment to provide music content to its services. == Features == Gapo features a news feed for posting content, livestreaming, instant messaging, and blogging. It also allows users to pay online and access public services. == Reception == Within two days of launch, Gapo received about 200,000 registrations. By September 2019, the user base increased to one million. Upon launch, Gapo experienced significant technical difficulties. Users complained about the inability to sign up for a new account and said that certain functions were not available for use at launch. This issue caused Gapo to temporarily suspend their services in order to perform upgrades and bug fixes. Gapo relaunched the next day, though many users reported that the access speed decreased. The mobile app also received mixed reviews from users in both the App Store and the Google Play Store, with an average rating of 3.1 and 3.5, respectively. Most users found the app to be a knockoff of Facebook, although some users praised the app for being locally developed. === Expert opinions on platform viability === Le Hong Hiep of the ISEAS - Yusof Ishak Institute was doubtful that a Vietnamese-owned social network service could be as powerful as a foreign-based service, stating that Vietnam might not be able to develop a viable social media network to compete with the likes of Facebook or Google. Others, like blogger Ann Chi, said that, due to local players complying with local censorship policy, there is a chance that locals might not trust Gapo and other local services in light of possible surveillance. Regarding the targeted user base figure for the end of 2019 and 2021, experts cautioned that the company might need an additional trillion đồng of funding to reach its planned user base targets. In response, the company stated that Gapo was never meant to compete with Facebook, but instead noted that the main difference between Gapo and Facebook is that Gapo provides a personalized user experience through customization. == Censorship == Gapo has the right to censor posts and news that are deemed offensive and inaccurate by users or not approved by the censorship curators.

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  • Signal transfer function

    Signal transfer function

    The signal transfer function (SiTF) is a measure of the signal output versus the signal input of a system such as an infrared system or sensor. There are many general applications of the SiTF. Specifically, in the field of image analysis, it gives a measure of the noise of an imaging system, and thus yields one assessment of its performance. == SiTF evaluation == In evaluating the SiTF curve, the signal input and signal output are measured differentially; meaning, the differential of the input signal and differential of the output signal are calculated and plotted against each other. An operator, using computer software, defines an arbitrary area, with a given set of data points, within the signal and background regions of the output image of the infrared sensor, i.e. of the unit under test (UUT), (see "Half Moon" image below). The average signal and background are calculated by averaging the data of each arbitrarily defined region. A second order polynomial curve is fitted to the data of each line. Then, the polynomial is subtracted from the average signal and background data to yield the new signal and background. The difference of the new signal and background data is taken to yield the net signal. Finally, the net signal is plotted versus the signal input. The signal input of the UUT is within its own spectral response. (e.g. color-correlated temperature, pixel intensity, etc.). The slope of the linear portion of this curve is then found using the method of least squares. == SiTF curve == The net signal is calculated from the average signal and background, as in signal to noise ratio (imaging)#Calculations. The SiTF curve is then given by the signal output data, (net signal data), plotted against the signal input data (see graph of SiTF to the right). All the data points in the linear region of the SiTF curve can be used in the method of least squares to find a linear approximation. Given n {\displaystyle n\,} data points ( x i , y i ) {\displaystyle (x_{i}\,,y_{i}\,)} a best fit line parameterized as y = m x + b {\displaystyle y=mx+b\,} is given by: m = ∑ x i y i n − ∑ x i n ∑ y i n ∑ x i 2 n − ( ∑ x i n ) 2 b = ∑ y i n − m ∑ x i n {\displaystyle m={\frac {{\frac {\sum x_{i}y_{i}}{n}}-{\frac {\sum x_{i}}{n}}{\frac {\sum y_{i}}{n}}}{{\frac {\sum x_{i}^{2}}{n}}-({\frac {\sum x_{i}}{n}})^{2}}}\qquad \qquad b={\frac {\sum y_{i}}{n}}-m{\frac {\sum x_{i}}{n}}}

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  • Voice search

    Voice search

    Voice search, also called voice-enabled search, allows the user to use a voice to search the Internet, a website, or an app. In a broader definition, voice search includes open-domain keyword query on any information on the Internet, for example in Google Voice Search, Cortana, Siri and Amazon Echo. Voice search is often interactive, involving several rounds of interaction that allows a system to ask for clarification. Voice search is a type of dialog system. Voice search is not a replacement for typed search. Rather the search terms, experience and use cases can differ heavily depending on the input type. == Supported language == Language is the most essential factor for a system to understand, and provide the most accurate results of what the user searches. This covers across languages, dialects, and accents, as users want a voice assistant that both understands them and speaks to them understandably. While spoken and written languages differ, voice search should support natural spoken language instead of only transforming voice into text and doing a regular text search with the help speech recognition. For example, in typed search an eCommerce user can easily copy and paste an alphanumeric product code to search field, but when speaking the search terms can be very different, such as "show me the new Bluetooth headphones by Samsung". == How it works == The difference between text and voice search is not only the input type. The mechanism must include an automatic speech recognition (ASR) for input, but it can also include natural language understanding for natural spoken search queries such as "What's the population for the United States" It can include text-to-speech (TTS) or a regular display for output modalities. Users might sometimes be required to activate the search by using a wake word. Then, the search system will detect the language spoken by the user. It will then detect the keywords and context of the sentence. Lastly, the device will return results depending on its output. A device with a screen might display the results, while a device without a screen will speak them back to the searcher.

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  • Teleradiology

    Teleradiology

    Teleradiology is the transmission of radiological patient images from procedures such as x-rays, Computed tomography (CT), and MRI imaging, from one location to another for the purposes of sharing studies with other radiologists and physicians. Teleradiology allows radiologists to provide services without actually having to be at the location of the patient. This is particularly important when a sub-specialist such as an MRI radiologist, neuroradiologist, pediatric radiologist, or musculoskeletal radiologist is needed, since these professionals are generally only located in large metropolitan areas working during daytime hours. Teleradiology allows for specialists to be available at all times. Teleradiology utilizes standard network technologies such as the Internet, telephone lines, wide area networks, local area networks (LAN) and the latest advanced technologies such as medical cloud computing. Specialized software is used to transmit the images and enable the radiologist to effectively analyze potentially hundreds of images of a given study. Technologies such as advanced graphics processing, voice recognition, artificial intelligence, and image compression are often used in teleradiology. Through teleradiology and mobile DICOM viewers, images can be sent to another part of the hospital or to other locations around the world with equal effort. Teleradiology is a growth technology given that imaging procedures are growing approximately 15% annually against an increase of only 2% in the radiologist population. == Reports == Teleradiology services commonly provide either preliminary or final interpretations of medical imaging studies. Preliminary reads are frequently used in emergency settings to support immediate clinical decisions and may include direct communication of critical findings to the referring physician. Some providers report turnaround times of approximately 30 minutes for emergency cases, with faster processing for time-sensitive conditions such as stroke. Final reads are definitive and used in official patient records and billing. These reports typically include all relevant findings and may require access to prior imaging and clinical data. Teleradiology is also employed to provide off-hour or overflow coverage for healthcare institutions lacking continuous on-site radiology staffing. == Subspecialties == Some teleradiologists are fellowship trained and have a wide variety of subspecialty expertise including such difficult-to-find areas as neuroradiology, pediatric neuroradiology, thoracic imaging, musculoskeletal radiology, mammography, and nuclear cardiology. There are also various medical practitioners who are not radiologists that take on studies in radiology to become sub specialists in their respected fields, an example of this is dentistry where oral and maxillofacial radiology allows those in dentistry to specialize in the acquisition and interpretation of radiographic imaging studies performed for diagnosis of treatment guidance for conditions affecting the maxillofacial region. == Teleultrasound == Teleradiology infrastructure has also been adapted to support point-of-care ultrasound (POCUS) in remote and austere environments. In teleultrasound—also known as telementored ultrasound—a remote expert guides a non-specialist in real time during image acquisition. This technique has been successfully demonstrated in extreme settings, including aboard the International Space Station, on Mount Everest, and during helicopter flight. == Regulations == In the United States, Medicare and Medicaid laws require the teleradiologist to be on U.S. soil in order to qualify for reimbursement of the Final Read. In addition, advanced teleradiology systems must also be HIPAA compliant, which helps to ensure patients' privacy. HIPAA (Health Insurance Portability and Accountability Act of 1996) is a uniform, federal floor of privacy protections for consumers. It limits the ways that entities can use patients' personal information and protects the privacy of all medical information no matter what form it is in. Quality teleradiology must abide by important HIPAA rules to ensure patients' privacy is protected. Also State laws governing the licensing requirements and medical malpractice insurance coverage required for physicians vary from state to state. Ensuring compliance with these laws is a significant overhead expense for larger multi-state teleradiology groups. Medicare (Australia) has identical requirements to that of the United States, where the guidelines are provided by the Department of Health and Ageing, and government based payments fall under the Health Insurance Act. The regulations in Australia are also conducted at both federal and state levels, ensuring that strict guidelines are adhered to at all times, with regular yearly updates and amendments are introduced (usually around March and November of every year), ensuring that the legislation is kept up to date with changes in the industry. One of the most recent changes to Medicare and radiology / teleradiology in Australia was the introduction of the Diagnostic Imaging Accreditation Scheme (DIAS) on 1 July 2008. DIAS was introduced to further improve the quality of Diagnostic Imaging and to amend the Health Insurance Act. == Industry growth == Until the late 1990s teleradiology was primarily used by individual radiologists to interpret occasional emergency studies from offsite locations, often in the radiologists home. The connections were made through standard analog phone lines. Teleradiology expanded rapidly as the growth of the internet and broad band combined with new CT scanner technology to become an essential tool in trauma cases in emergency rooms throughout the country. The occasional 2–3 x-ray studies a week soon became 3–10 CT scans, or more, a night. Because ER physicians are not trained to read CT scans or MRIs, radiologists went from working 8–10 hours a day, five and half days a week to a schedule of 24 hours a day, 7 days a week coverage. This became a particularly acute challenge in smaller rural facilities that only had one solo radiologist with no other to share call. These circumstances spawned a post-dot.com boom of firms and groups that provided medical outsourcing, off-site teleradiology on-call services to hospitals and Radiology Groups around the country. As an example, a teleradiology firm might cover trauma at a hospital in Indiana with doctors based in Texas. Some firms even used overseas doctors in locations like Australia and India. Nighthawk, founded by Paul Berger, was the first to station U.S. licensed radiologists overseas (initially Australia and later Switzerland) to maximize the time zone difference to provide nightcall in U.S. hospitals. Currently, teleradiology firms are facing pricing pressures. Industry consolidation is likely as there are more than 500 of these firms, large and small, throughout the United States.

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  • Lenna

    Lenna

    Lenna (or Lena) is a standard test image used in the field of digital image processing, starting in 1973. It is a picture of the Swedish model Lena Forsén, shot by photographer Dwight Hooker and cropped from the centerfold of the November 1972 issue of Playboy magazine. Lenna has attracted controversy because of its subject matter. Starting in the mid-2010s, many journals have deemed it inappropriate and discouraged its use, while others have banned it from publication outright. Forsén herself has called for it to be retired, saying "It's time I retired from tech." The spelling "Lenna" came from the model's desire to encourage the proper pronunciation of her name. "I didn't want to be called Leena [English: ]," she explained. == History == Before Lenna, the first use of a Playboy magazine image to illustrate image processing algorithms was in 1961. Lawrence G. Roberts used two cropped six-bit grayscale facsimile scanned images from Playboy's July 1960 issue featuring Playmate Teddi Smith, in his master's thesis on image dithering at Massachusetts Institute of Technology. Lenna was originally intended for high resolution color image processing study. Its history was described in the May 2001 newsletter of the IEEE Professional Communication Society, in an article by Jamie Hutchinson: Alexander Sawchuk estimates that it was in June or July of 1973 when he, then an assistant professor of electrical engineering at the University of Southern California Signal and Image Processing Institute (SIPI), along with a graduate student and the SIPI lab manager, was hurriedly searching the lab for a good image to scan for a colleague's conference paper. They got tired of their stock of usual test images, dull stuff dating back to television standards work in the early 1960s. They wanted something glossy to ensure good output dynamic range, and they wanted a human face. Just then, somebody happened to walk in with a recent issue of Playboy. The engineers tore away the top third of the centerfold so they could wrap it around the drum of their Muirhead wirephoto scanner, which they had outfitted with analog-to-digital converters (one each for the red, green, and blue channels) and a Hewlett Packard 2100 minicomputer. The Muirhead had a fixed resolution of 100 lines per inch and the engineers wanted a 512×512 image, so they limited the scan to the top 5.12 inches of the picture, effectively cropping it at the subject's shoulders. The image's reach was limited in the 1970s and 80s, which is reflected in it initially only appearing in .org domains, but in July 1991, the image featured on the cover of Optical Engineering alongside Peppers, another popular test image. This drew the attention of Playboy to the potential copyright infringement. The peak of image hits on the internet was in 1995. The scan became one of the most used images in computer history. The use of the photo in electronic imaging has been described as "clearly one of the most important events in [its] history". The image spread to over 100 different domains, particularly .com and .edu. In a 1999 issue of IEEE Transactions on Image Processing "Lena" was used in three separate articles, and the picture continued to appear in scientific journals throughout the beginning of the 21st century. Lenna is so widely accepted in the image processing community that Forsén was a guest at the 50th annual Conference of the Society for Imaging Science and Technology (IS&T) in 1997. In 2015, Lena Forsén was also guest of honor at the banquet of IEEE ICIP 2015. After delivering a speech, she chaired the best paper award ceremony. To explain why the image became a standard in the field, David C. Munson, editor-in-chief of IEEE Transactions on Image Processing, stated that it was a good test image because of its detail, flat regions, shading, and texture. He also noted that "the Lena image is a picture of an attractive woman. It is not surprising that the (mostly male) image processing research community gravitated toward an image that they found attractive." While Playboy often cracks down on illegal uses of its material and did initially send a notice to the publisher of Optical Engineering about its unauthorized use in that publication, over time it has decided to overlook the wide use of Lena. Eileen Kent, VP of new media at Playboy, said, "We decided we should exploit this, because it is a phenomenon." == Criticism == The use of the image has produced controversy because Playboy is "seen (by some) as being degrading to women". In a 1999 essay on reasons for the male predominance in computer science, applied mathematician Dianne P. O'Leary wrote: Suggestive pictures used in lectures on image processing ... convey the message that the lecturer caters to the males only. For example, it is amazing that the "Lena" pin-up image is still used as an example in courses and published as a test image in journals today. A 2012 paper on compressed sensing used a photo of the model Fabio Lanzoni as a test image to draw attention to this issue. The use of the test image at the magnet school Thomas Jefferson High School for Science and Technology in Fairfax County, Virginia, provoked a guest editorial by a senior in The Washington Post in 2015 about its detrimental impact on aspiring female students in computer science. In 2017, the Journal of Modern Optics published an editorial titled "On alternatives to Lenna" suggesting three images (Pirate, Cameraman, and Peppers) that "are reasonably close to Lenna in feature space". In 2018, the Nature Nanotechnology journal announced that they would no longer consider articles using Lenna. In the same year SPIE, the publishers of Optical Engineering, also announced that they "strongly discourage" the use of Lenna, and would no longer consider new submissions containing the image "without convincing scientific justification for its use". They noted that aside from the copyright and ethical issues, that it was also no longer useful as a standard image: "In today's age of high-resolution digital image technology, it seems difficult to argue that a 512 × 512 image produced with a 1970s-era analog scanner is the best we have to offer as an image quality test standard". Forsén stated in the 2019 documentary film Losing Lena, "I retired from modeling a long time ago. It's time I retired from tech, too... Let's commit to losing me." The Institute of Electrical and Electronics Engineers (IEEE) announced that, starting April 1, 2024, it will no longer allow use of Lenna in its publications.

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  • Exposure Notification

    Exposure Notification

    The (Google/Apple) Exposure Notification System (GAEN) is a framework and protocol specification developed by Apple Inc. and Google to facilitate digital contact tracing during the COVID-19 pandemic. When used by health authorities, it augments more traditional contact tracing techniques by automatically logging close approaches among notification system users using Android or iOS smartphones. Exposure Notification is a decentralized reporting protocol built on a combination of Bluetooth Low Energy technology and privacy-preserving cryptography. It is an opt-in feature within COVID-19 apps developed and published by authorized health authorities. Unveiled on April 10, 2020, it was made available on iOS on May 20, 2020, as part of the iOS 13.5 update and on December 14, 2020, as part of the iOS 12.5 update for older iPhones. On Android, it was added to devices via a Google Play Services update, supporting all versions since Android Marshmallow. The Apple/Google protocol is similar to the Decentralized Privacy-Preserving Proximity Tracing (DP-3T) protocol created by the European DP-3T consortium and the Temporary Contact Number (TCN) protocol by Covid Watch, but is implemented at the operating system level, which allows for more efficient operation as a background process. Since May 2020, a variant of the DP-3T protocol is supported by the Exposure Notification Interface. Other protocols are constrained in operation because they are not privileged over normal apps. This leads to issues, particularly on iOS devices where digital contact tracing apps running in the background experience significantly degraded performance. The joint approach is also designed to maintain interoperability between Android and iOS devices, which constitute nearly all of the market. The ACLU stated the approach "appears to mitigate the worst privacy and centralization risks, but there is still room for improvement". In late April, Google and Apple shifted the emphasis of the naming of the system, describing it as an "exposure notification service", rather than "contact tracing" system. == Technical specification == Digital contact tracing protocols typically have two major responsibilities: encounter logging and infection reporting. Exposure Notification only involves encounter logging which is a decentralized architecture. The majority of infection reporting is centralized in individual app implementations. To handle encounter logging, the system uses Bluetooth Low Energy to send tracking messages to nearby devices running the protocol to discover encounters with other people. The tracking messages contain unique identifiers that are encrypted with a secret daily key held by the sending device. These identifiers change every 15–20 minutes as well as Bluetooth MAC address in order to prevent tracking of clients by malicious third parties through observing static identifiers over time. The sender's daily encryption keys are generated using a random number generator. Devices record received messages, retaining them locally for 14 days. If a user tests positive for infection, the last 14 days of their daily encryption keys can be uploaded to a central server, where it is then broadcast to all devices on the network. The method through which daily encryption keys are transmitted to the central server and broadcast is defined by individual app developers. The Google-developed reference implementation calls for a health official to request a one-time verification code (VC) from a verification server, which the user enters into the encounter logging app. This causes the app to obtain a cryptographically signed certificate, which is used to authorize the submission of keys to the central reporting server. The received keys are then provided to the protocol, where each client individually searches for matches in their local encounter history. If a match meeting certain risk parameters is found, the app notifies the user of potential exposure to the infection. Google and Apple intend to use the received signal strength (RSSI) of the beacon messages as a source to infer proximity. RSSI and other signal metadata will also be encrypted to resist deanonymization attacks. === Version 1.0 === To generate encounter identifiers, first a persistent 32-byte private Tracing Key ( t k {\displaystyle tk} ) is generated by a client. From this a 16 byte Daily Tracing Key is derived using the algorithm d t k i = H K D F ( t k , N U L L , 'CT-DTK' | | D i , 16 ) {\displaystyle dtk_{i}=HKDF(tk,NULL,{\text{'CT-DTK'}}||D_{i},16)} , where H K D F ( Key, Salt, Data, OutputLength ) {\displaystyle HKDF({\text{Key, Salt, Data, OutputLength}})} is a HKDF function using SHA-256, and D i {\displaystyle D_{i}} is the day number for the 24-hour window the broadcast is in starting from Unix Epoch Time. These generated keys are later sent to the central reporting server should a user become infected. From the daily tracing key a 16-byte temporary Rolling Proximity Identifier is generated every 10 minutes with the algorithm R P I i , j = Truncate ( H M A C ( d t k i , 'CT-RPI' | | T I N j ) , 16 ) {\displaystyle RPI_{i,j}={\text{Truncate}}(HMAC(dtk_{i},{\text{'CT-RPI'}}||TIN_{j}),16)} , where H M A C ( Key, Data ) {\displaystyle HMAC({\text{Key, Data}})} is a HMAC function using SHA-256, and T I N j {\displaystyle TIN_{j}} is the time interval number, representing a unique index for every 10 minute period in a 24-hour day. The Truncate function returns the first 16 bytes of the HMAC value. When two clients come within proximity of each other they exchange and locally store the current R P I i , j {\displaystyle RPI_{i,j}} as the encounter identifier. Once a registered health authority has confirmed the infection of a user, the user's Daily Tracing Key for the past 14 days is uploaded to the central reporting server. Clients then download this report and individually recalculate every Rolling Proximity Identifier used in the report period, matching it against the user's local encounter log. If a matching entry is found, then contact has been established and the app presents a notification to the user warning them of potential infection. === Version 1.1 === Unlike version 1.0 of the protocol, version 1.1 does not use a persistent tracing key, rather every day a new random 16-byte Temporary Exposure Key ( t e k i {\displaystyle tek_{i}} ) is generated. This is analogous to the daily tracing key from version 1.0. Here i {\displaystyle i} denotes the time is discretized in 10 minute intervals starting from Unix Epoch Time. From this two 128-bit keys are calculated, the Rolling Proximity Identifier Key ( R P I K i {\displaystyle RPIK_{i}} ) and the Associated Encrypted Metadata Key ( A E M K i {\displaystyle AEMK_{i}} ). R P I K i {\displaystyle RPIK_{i}} is calculated with the algorithm R P I K i = H K D F ( t e k i , N U L L , 'EN-RPIK' , 16 ) {\displaystyle RPIK_{i}=HKDF(tek_{i},NULL,{\text{'EN-RPIK'}},16)} , and A E M K i {\displaystyle AEMK_{i}} using the algorithm A E M K i = H K D F ( t e k i , N U L L , 'EN-AEMK' , 16 ) {\displaystyle AEMK_{i}=HKDF(tek_{i},NULL,{\text{'EN-AEMK'}},16)} . From these values a temporary Rolling Proximity Identifier ( R P I i , j {\displaystyle RPI_{i,j}} ) is generated every time the BLE MAC address changes, roughly every 15–20 minutes. The following algorithm is used: R P I i , j = A E S 128 ( R P I K i , 'EN-RPI' | | 0 x 000000000000 | | E N I N j ) {\displaystyle RPI_{i,j}=AES128(RPIK_{i},{\text{'EN-RPI'}}||{\mathtt {0x000000000000}}||ENIN_{j})} , where A E S 128 ( Key, Data ) {\displaystyle AES128({\text{Key, Data}})} is an AES cryptography function with a 128-bit key, the data is one 16-byte block, j {\displaystyle j} denotes the Unix Epoch Time at the moment the roll occurs, and E N I N j {\displaystyle ENIN_{j}} is the corresponding 10-minute interval number. Next, additional Associated Encrypted Metadata is encrypted. What the metadata represents is not specified, likely to allow the later expansion of the protocol. The following algorithm is used: Associated Encrypted Metadata i , j = A E S 128 _ C T R ( A E M K i , R P I i , j , Metadata ) {\displaystyle {\text{Associated Encrypted Metadata}}_{i,j}=AES128\_CTR(AEMK_{i},RPI_{i,j},{\text{Metadata}})} , where A E S 128 _ C T R ( Key, IV, Data ) {\displaystyle AES128\_CTR({\text{Key, IV, Data}})} denotes AES encryption with a 128-bit key in CTR mode. The Rolling Proximity Identifier and the Associated Encrypted Metadata are then combined and broadcast using BLE. Clients exchange and log these payloads. Once a registered health authority has confirmed the infection of a user, the user's Temporary Exposure Keys t e k i {\displaystyle tek_{i}} and their respective interval numbers i {\displaystyle i} for the past 14 days are uploaded to the central reporting server. Clients then download this report and individually recalculate every Rolling Proximity Identifier starting from interval number i {\displaystyle i} ,

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  • Gradient vector flow

    Gradient vector flow

    Gradient vector flow (GVF), a computer vision framework introduced by Chenyang Xu and Jerry L. Prince, is the vector field that is produced by a process that smooths and diffuses an input vector field. It is usually used to create a vector field from images that points to object edges from a distance. It is widely used in image analysis and computer vision applications for object tracking, shape recognition, segmentation, and edge detection. In particular, it is commonly used in conjunction with active contour model. == Background == Finding objects or homogeneous regions in images is a process known as image segmentation. In many applications, the locations of object edges can be estimated using local operators that yield a new image called an edge map. The edge map can then be used to guide a deformable model, sometimes called an active contour or a snake, so that it passes through the edge map in a smooth way, therefore defining the object itself. A common way to encourage a deformable model to move toward the edge map is to take the spatial gradient of the edge map, yielding a vector field. Since the edge map has its highest intensities directly on the edge and drops to zero away from the edge, these gradient vectors provide directions for the active contour to move. When the gradient vectors are zero, the active contour will not move, and this is the correct behavior when the contour rests on the peak of the edge map itself. However, because the edge itself is defined by local operators, these gradient vectors will also be zero far away from the edge and therefore the active contour will not move toward the edge when initialized far away from the edge. Gradient vector flow (GVF) is the process that spatially extends the edge map gradient vectors, yielding a new vector field that contains information about the location of object edges throughout the entire image domain. GVF is defined as a diffusion process operating on the components of the input vector field. It is designed to balance the fidelity of the original vector field, so it is not changed too much, with a regularization that is intended to produce a smooth field on its output. Although GVF was designed originally for the purpose of segmenting objects using active contours attracted to edges, it has been since adapted and used for many alternative purposes. Some newer purposes including defining a continuous medial axis representation, regularizing image anisotropic diffusion algorithms, finding the centers of ribbon-like objects, constructing graphs for optimal surface segmentations, creating a shape prior, and much more. == Theory == The theory of GVF was originally described by Xu and Prince. Let f ( x , y ) {\displaystyle \textstyle f(x,y)} be an edge map defined on the image domain. For uniformity of results, it is important to restrict the edge map intensities to lie between 0 and 1, and by convention f ( x , y ) {\displaystyle \textstyle f(x,y)} takes on larger values (close to 1) on the object edges. The gradient vector flow (GVF) field is given by the vector field v ( x , y ) = [ u ( x , y ) , v ( x , y ) ] {\displaystyle \textstyle \mathbf {v} (x,y)=[u(x,y),v(x,y)]} that minimizes the energy functional In this equation, subscripts denote partial derivatives and the gradient of the edge map is given by the vector field ∇ f = ( f x , f y ) {\displaystyle \textstyle \nabla f=(f_{x},f_{y})} . Figure 1 shows an edge map, the gradient of the (slightly blurred) edge map, and the GVF field generated by minimizing E {\displaystyle \textstyle {\mathcal {E}}} . Equation 1 is a variational formulation that has both a data term and a regularization term. The first term in the integrand is the data term. It encourages the solution v {\displaystyle \textstyle \mathbf {v} } to closely agree with the gradients of the edge map since that will make v − ∇ f {\displaystyle \textstyle \mathbf {v} -\nabla f} small. However, this only needs to happen when the edge map gradients are large since v − ∇ f {\displaystyle \textstyle \mathbf {v} -\nabla f} is multiplied by the square of the length of these gradients. The second term in the integrand is a regularization term. It encourages the spatial variations in the components of the solution to be small by penalizing the sum of all the partial derivatives of v {\displaystyle \textstyle \mathbf {v} } . As is customary in these types of variational formulations, there is a regularization parameter μ > 0 {\displaystyle \textstyle \mu >0} that must be specified by the user in order to trade off the influence of each of the two terms. If μ {\displaystyle \textstyle \mu } is large, for example, then the resulting field will be very smooth and may not agree as well with the underlying edge gradients. Theoretical Solution. Finding v ( x , y ) {\displaystyle \textstyle \mathbf {v} (x,y)} to minimize Equation 1 requires the use of calculus of variations since v ( x , y ) {\displaystyle \textstyle \mathbf {v} (x,y)} is a function, not a variable. Accordingly, the Euler equations, which provide the necessary conditions for v {\displaystyle \textstyle \mathbf {v} } to be a solution can be found by calculus of variations, yielding where ∇ 2 {\displaystyle \textstyle \nabla ^{2}} is the Laplacian operator. It is instructive to examine the form of the equations in (2). Each is a partial differential equation that the components u {\displaystyle u} and v {\displaystyle v} of v {\displaystyle \mathbf {v} } must satisfy. If the magnitude of the edge gradient is small, then the solution of each equation is guided entirely by Laplace's equation, for example ∇ 2 u = 0 {\displaystyle \textstyle \nabla ^{2}u=0} , which will produce a smooth scalar field entirely dependent on its boundary conditions. The boundary conditions are effectively provided by the locations in the image where the magnitude of the edge gradient is large, where the solution is driven to agree more with the edge gradients. Computational Solutions. There are two fundamental ways to compute GVF. First, the energy function E {\displaystyle {\mathcal {E}}} itself (1) can be directly discretized and minimized, for example, by gradient descent. Second, the partial differential equations in (2) can be discretized and solved iteratively. The original GVF paper used an iterative approach, while later papers introduced considerably faster implementations such as an octree-based method, a multi-grid method, and an augmented Lagrangian method. In addition, very fast GPU implementations have been developed in Extensions and Advances. GVF is easily extended to higher dimensions. The energy function is readily written in a vector form as which can be solved by gradient descent or by finding and solving its Euler equation. Figure 2 shows an illustration of a three-dimensional GVF field on the edge map of a simple object (see ). The data and regularization terms in the integrand of the GVF functional can also be modified. A modification described in , called generalized gradient vector flow (GGVF) defines two scalar functions and reformulates the energy as While the choices g ( ∇ f | ) = μ {\displaystyle \textstyle g(\nabla f|)=\mu } and h ( | ∇ f | ) = | ∇ f | 2 {\displaystyle \textstyle h(|\nabla f|)=|\nabla f|^{2}} reduce GGVF to GVF, the alternative choices g ( | ∇ f | ) = exp ⁡ { − | ∇ f | / K } {\displaystyle \textstyle g(|\nabla f|)=\exp\{-|\nabla f|/K\}} and h ( ∇ f | ) = 1 − g ( | ∇ f | ) {\displaystyle \textstyle h(\nabla f|)=1-g(|\nabla f|)} , for K {\displaystyle K} a user-selected constant, can improve the tradeoff between the data term and its regularization in some applications. The GVF formulation has been further extended to vector-valued images in where a weighted structure tensor of a vector-valued image is used. A learning based probabilistic weighted GVF extension was proposed in to further improve the segmentation for images with severely cluttered textures or high levels of noise. The variational formulation of GVF has also been modified in motion GVF (MGVF) to incorporate object motion in an image sequence. Whereas the diffusion of GVF vectors from a conventional edge map acts in an isotropic manner, the formulation of MGVF incorporates the expected object motion between image frames. An alternative to GVF called vector field convolution (VFC) provides many of the advantages of GVF, has superior noise robustness, and can be computed very fast. The VFC field v V F C {\displaystyle \textstyle \mathbf {v} _{\mathrm {VFC} }} is defined as the convolution of the edge map f {\displaystyle f} with a vector field kernel k {\displaystyle \mathbf {k} } where The vector field kernel k {\displaystyle \textstyle \mathbf {k} } has vectors that always point toward the origin but their magnitudes, determined in detail by the function m {\displaystyle m} , decrease to zero with increasing distance from the origin. The beauty of VFC is that it can be computed very rapidly using a fast Fourier tra

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  • Single particle analysis

    Single particle analysis

    Single particle analysis is a group of related computerized image processing techniques used to analyze images from transmission electron microscopy (TEM). These methods were developed to improve and extend the information obtainable from TEM images of particulate samples, typically proteins or other large biological entities such as viruses. Individual images of stained or unstained particles are very noisy, making interpretation difficult. Combining several digitized images of similar particles together gives an image with stronger and more easily interpretable features. An extension of this technique uses single particle methods to build up a three-dimensional reconstruction of the particle. Using cryo-electron microscopy it has become possible to generate reconstructions with sub-nanometer, near-atomic resolution resolution first in the case of highly symmetric viruses, and now in smaller, asymmetric proteins as well. == Techniques == Single particle analysis can be done on both negatively stained and vitreous ice-embedded transmission electron cryomicroscopy (CryoTEM) samples. Single particle analysis methods are, in general, reliant on the sample being homogeneous, although techniques for dealing with conformational heterogeneity are being developed. Images (micrographs) are taken with an electron microscope using charged-coupled device (CCD) detectors coupled to a phosphorescent layer (in the past, they were instead collected on film and digitized using high-quality scanners). The image processing is carried out using specialized software programs, often run on multi-processor computer clusters. Depending on the sample or the desired results, various steps of two- or three-dimensional processing can be done. === Alignment and classification === Biological samples, and especially samples embedded in thin vitreous ice, are highly radiation sensitive, thus only low electron doses can be used to image the sample. This low dose, as well as variations in the metal stain used (if used) means images have high noise relative to the signal given by the particle being observed. By aligning several similar images to each other so they are in register and then averaging them, an image with higher signal-to-noise ratio can be obtained. As the noise is mostly randomly distributed and the underlying image features constant, by averaging the intensity of each pixel over several images only the constant features are reinforced. Typically, the optimal alignment (a translation and an in-plane rotation) to map one image onto another is calculated by cross-correlation. However, a micrograph often contains particles in multiple different orientations and/or conformations, and so to get more representative image averages, a method is required to group similar particle images together into multiple sets. This is normally carried out using one of several data analysis and image classification algorithms, such as multi-variate statistical analysis and hierarchical ascendant classification, or k-means clustering. Often data sets of tens of thousands of particle images are used, and to reach an optimal solution an iterative procedure of alignment and classification is used, whereby strong image averages produced by classification are used as reference images for a subsequent alignment of the whole data set. === Image filtering === Image filtering (band-pass filtering) is often used to reduce the influence of high and/or low spatial frequency information in the images, which can affect the results of the alignment and classification procedures. This is particularly useful in negative stain images. The algorithms make use of fast Fourier transforms (FFT), often employing Gaussian shaped soft-edged masks in reciprocal space to suppress certain frequency ranges. High-pass filters remove low spatial frequencies (such as ramp or gradient effects), leaving the higher frequencies intact. Low-pass filters remove high spatial frequency features and have a blurring effect on fine details. === Contrast transfer function === Due to the nature of image formation in the electron microscope, bright-field TEM images are obtained using significant underfocus. This, along with features inherent in the microscope's lens system, creates blurring of the collected images visible as a point spread function. The combined effects of the imaging conditions are known as the contrast transfer function (CTF), and can be approximated mathematically as a function in reciprocal space. Specialized image processing techniques such as phase flipping and amplitude correction / Wiener filtering can (at least partially) correct for the CTF, and allow high resolution reconstructions. === Three-dimensional reconstruction === Transmission electron microscopy images are projections of the object showing the distribution of density through the object, similar to medical X-rays. By making use of the projection-slice theorem a three-dimensional reconstruction of the object can be generated by combining many images (2D projections) of the object taken from a range of viewing angles. Proteins in vitreous ice ideally adopt a random distribution of orientations (or viewing angles), allowing a fairly isotropic reconstruction if a large number of particle images are used. This contrasts with electron tomography, where the viewing angles are limited due to the geometry of the sample/imaging set up, giving an anisotropic reconstruction. Filtered back projection is a commonly used method of generating 3D reconstructions in single particle analysis, although many alternative algorithms exist. Before a reconstruction can be made, the orientation of the object in each image needs to be estimated. Several methods have been developed to work out the relative Euler angles of each image. Some are based on common lines (common 1D projections and sinograms), others use iterative projection matching algorithms. The latter works by beginning with a simple, low resolution 3D starting model and compares the experimental images to projections of the model and creates a new 3D to bootstrap towards a solution. Methods are also available for making 3D reconstructions of helical samples (such as tobacco mosaic virus), taking advantage of the inherent helical symmetry. Both real space methods (treating sections of the helix as single particles) and reciprocal space methods (using diffraction patterns) can be used for these samples. === Tilt methods === The specimen stage of the microscope can be tilted (typically along a single axis), allowing the single particle technique known as random conical tilt. An area of the specimen is imaged at both zero and at high angle (~60-70 degrees) tilts, or in the case of the related method of orthogonal tilt reconstruction, +45 and −45 degrees. Pairs of particles corresponding to the same object at two different tilts (tilt pairs) are selected, and by following the parameters used in subsequent alignment and classification steps a three-dimensional reconstruction can be generated relatively easily. This is because the viewing angle (defined as three Euler angles) of each particle is known from the tilt geometry. 3D reconstructions from random conical tilt suffer from missing information resulting from a restricted range of orientations. Known as the missing cone (due to the shape in reciprocal space), this causes distortions in the 3D maps. However, the missing cone problem can often be overcome by combining several tilt reconstructions. Tilt methods are best suited to negatively stained samples, and can be used for particles that adsorb to the carbon support film in preferred orientations. The phenomenon known as charging or beam-induced movement makes collecting high-tilt images of samples in vitreous ice challenging. === Map visualization and fitting === Various software programs are available that allow viewing the 3D maps. These often enable the user to manually dock in protein coordinates (structures from X-ray crystallography, NMR, or a computational model such as one found in the AlphaFold Protein Structure Database) of subunits into the electron density. Several programs can also fit subunits computationally; as of the 2020s using these programs tend to produce better accuracy than manual docking because they can perform labor-intensive tasks such as: The scale of SPA-derived maps depends on knowing the pixel size (angstorms per pixel), which is not always accurate. Programs can automatically correct for this difference by using coordinate data or by using knowledge of chemical bonds. Many proteins are made up of several roughly rigid protein domains linked by flexible parts. Pre-existing coordinate data, whether experimental or computational, may not exactly match the inter-domain positioning of the cyro-EM map. Modern programs can automatically "chop" pre-existing coordinate data into individual domains and fit them in individually. For higher-resolution structures, it is pos

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  • Automatic scorer

    Automatic scorer

    An automatic scorer is the computerized scoring system to keep track of scoring in ten-pin bowling. It was introduced en masse in bowling alleys in the 1970s and combined with mechanical pinsetters to detect overturned pins. By eliminating the need for manual score-keeping, these systems have introduced new bowlers into the game who otherwise would not participate because they had to count the score themselves, as many do not understand the mathematical formula involved in bowler scoring. At first, people were skeptical about whether a computer could keep an accurate score. In the twenty-first century, automatic scorers are used in most bowling centers around the world. The three manufacturers of these specialty computers have been Brunswick Bowling, AMF Bowling (later QubicaAMF), and RCA. == History == Automatic equipment is considered a cornerstone of the modern bowling center. The traditional bowling center of the early 20th century was advanced in automation when the pinsetter person ("pin boy"), who set back up by hand the bowled down pins, was replaced by a machine that automatically replaced the pins in their proper play positions. This machine came out in the 1950s. A detection system was developed from the pinsetter mechanism in the 1960s that could tell which pins had been knocked down, and that information could be transferred to a digital computer. Automatic electronic scoring was first conceived by Robert Reynolds, who was described by a newspaper story at the time as "a West Coast electronics calculator expert." He worked with the technical staff of Brunswick Bowling to develop it. The goal was realized in the late 1960s when a specialized computer was designed for the purpose of automatic scorekeeping for bowling. The field test for the automatic scorer took place at Village Lanes bowling center, Chicago in 1967. The scoring machine received approval for official use by the American Bowling Congress in August of that year. They were first used in national official league gaming on October 10, 1967. In November, Brunswick announced that they were accepting orders for the new digital computer, which cost around $3,000 per bowling lane. Bowling centers that installed these new automatic scoring devices in the 1970s charged a ten cents extra per line of scoring for the convenience. == Description == Each Automatic Scorer computer unit kept score for four lanes. It had two bowler identification panels serving two lanes each. The bowler pushed it into his named position when his turn came up so the computer knew who was bowling and score accordingly. After the bowler rolled the bowling ball down the lane and knocked down pins, the pinsetter detected which pins were down and relayed this information back to the computer for scoring. The result was then printed on a scoresheet and projected overhead onto a large screen for all to see. The Automatic Scorer digital computer was mathematically accurate, however the detection system at the pinsetter mechanism sometimes reported the wrong number of pins knocked down. The computer could be corrected manually for any errors in the system; similarly, human errors, such as neglecting to move the bowler identification mechanism, could be corrected for by manual action. The scorer could take into account bowlers' handicaps and could adjust for late-arriving bowlers. The automatic scorer is directly connected to the foul detection unit. As a result, foul line violations are automatically scored. Brunswick had put ten years of research and development into the Automatic Scorer, and by 1972 there were over 500 of these computers installed in bowling centers around the world. AMF Bowling, competitor to Brunswick, entered into the automatic scorer computer field during the 1970s and their systems were installed into their brand of bowling centers. By 1974, RCA was also making these computers for automatic scoring. == Reception and further developments == The purposes of the computerized scoring were to avoid errors by human scorers and to prevent cheating. It had the side benefit of speeding up the progress of the game and introducing new bowlers to the game. Score-keeping for bowling is based on a formula that many new to bowling were not familiar with and thought difficult to learn. These casual bowlers unfamiliar with the formula thought the scores given by the computers were confusing. Some bowlers were not comfortable with automatic scorers when they were introduced in the 1970s, so kept score using the traditional method on paper score sheets. The introduction of this device increased the popularity of the sport. Automatic scorers came to be considered a normal part of modern bowling installations worldwide, with owners and managers saying that bowlers expect such equipment to be present in bowling establishments and that business increased following their introduction. Brunswick introduced a color television style automatic scorer in 1983. Bowling center owners could use these style automatic scorers for advertising, management, videos, and live television. By the 2010s, these types of electronic visual displays could show bowler avatars and social media connections to publicize the bowlers' scores. Some are capable of being extended entertainment systems of games for children and adults. Some scoring systems support variations on traditional bowling, such as different kinds of bingo games where certain pins have to be knocked down at certain times or practice regimes where certain spares have to be accomplished. By this point, QubicaAMF Worldwide, an outgrowth of AMF, was one of the leading providers of bowling scoring equipment.

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